Surface-Tailored Zein Nanoparticles: Strategies and Applications

Maham, 2009, Protein-Based Nanomedicine Platforms for Drug Delivery, Small, 5, 1706, 10.1002/smll.200801602

Kasaai, 2018, Zein and zein -based nano-materials for food and nutrition applications: A review, Trends Food Sci. Technol., 79, 184, 10.1016/j.tifs.2018.07.015

Madani, 2020, Molecular Design of Soluble Zein Protein Sequences, Biophys. J., 118, 45a

Weissmueller, 2016, Nanocarriers from GRAS Zein Proteins to Encapsulate Hydrophobic Actives, Biomacromolecules, 17, 3828, 10.1021/acs.biomac.6b01440

Han, 2014, Preparation of transparent zein films for cell culture applications, Colloids Surfaces B: Biointerfaces, 120, 55, 10.1016/j.colsurfb.2014.04.019

Inchaurraga, 2020, Zein-based nanoparticles for the oral delivery of insulin, Drug Deliv. Transl. Res., 10, 1601, 10.1007/s13346-020-00796-3

Patel, 2010, Synthesis and characterisation of zein–curcumin colloidal particles, Soft Matter, 6, 6192, 10.1039/c0sm00800a

Dong, 2004, Basic study of corn protein, zein, as a biomaterial in tissue engineering, surface morphology and biocompatibility, Biomaterials, 25, 4691, 10.1016/j.biomaterials.2003.10.084

Murdan, 2005, Formulation and characterisation of zein microspheres as delivery vehicles, J. Drug Deliv. Sci. Technol., 15, 267, 10.1016/S1773-2247(05)50048-0

Schwestka, 2020, Plant-derived protein bodies as delivery vehicles for recombinant proteins into mammalian cells, Biotechnol. Bioeng., 117, 1037, 10.1002/bit.27273

Xu, 2011, Hollow nanoparticles from zein for potential medical applications, J. Mater. Chem., 21, 18227, 10.1039/c1jm11163a

Aytac, 2017, Antioxidant electrospun zein nanofibrous web encapsulating quercetin/cyclodextrin inclusion complex, J. Mater. Sci., 53, 1527, 10.1007/s10853-017-1580-x

Podaralla, 2012, Synthesis of Novel Biodegradable Methoxy Poly(ethylene glycol)–Zein Micelles for Effective Delivery of Curcumin, Mol. Pharm., 9, 2778, 10.1021/mp2006455

Labib, 2018, Overview on zein protein: A promising pharmaceutical excipient in drug delivery systems and tissue engineering, Expert Opin. Drug Deliv., 15, 65, 10.1080/17425247.2017.1349752

Tran, 2019, The use of zein in the controlled release of poorly water-soluble drugs, Int. J. Pharm., 566, 557, 10.1016/j.ijpharm.2019.06.018

Paliwal, 2014, Zein in controlled drug delivery and tissue engineering, J. Control. Release, 189, 108, 10.1016/j.jconrel.2014.06.036

Zhang, 2015, Zein-based films and their usage for controlled delivery: Origin, classes and current landscape, J. Control. Release, 206, 206, 10.1016/j.jconrel.2015.03.030

Shukla, 2001, Zein: The industrial protein from corn, Ind. Crop. Prod., 13, 171, 10.1016/S0926-6690(00)00064-9

Deo, 2003, Surfactant Interactions with Zein Protein, Langmuir, 19, 5083, 10.1021/la020854s

Parris, 2001, Extraction and solubility characteristics of zein proteins from dry-milled corn, J. Agric. Food Chem., 49, 3757, 10.1021/jf0011790

Esen, 1986, Separation of Alcohol-Soluble Proteins (Zeins) from Maize into Three Fractions by Differential Solubility, Plant Physiol., 80, 623, 10.1104/pp.80.3.623

Matsushima, 1997, Three-dimensional structure of maize α-zein proteins studied by small-angle X-ray scattering, Biochim. Biophys. Acta (BBA), 1339, 14, 10.1016/S0167-4838(96)00212-9

Zhang, 2016, Design, fabrication and biomedical applications of zein-based nano/micro-carrier systems, Int. J. Pharm., 513, 191, 10.1016/j.ijpharm.2016.09.023

Elzoghby, 2018, Zein-based Nanocarriers as Potential Natural Alternatives for Drug and Gene Delivery: Focus on Cancer Therapy, Curr. Pharm. Des., 23, 5261, 10.2174/1381612823666170622111250

Catelam, 2010, Morphological and Structural Characteris-tics of Zein Biofilms with Added Xanthan Gum, Food Technol. Biotechnol., 48, 19

Chuacharoen, 2017, Zein nanoparticles as delivery systems for covalently linked and physically entrapped folic acid, J. Nanoparticle Res., 19, 81, 10.1007/s11051-017-3763-4

Lee, 2016, Zein-alginate based oral drug delivery systems: Protection and release of therapeutic proteins, Int. J. Pharm., 515, 300, 10.1016/j.ijpharm.2016.10.023

Dai, 2018, Fabrication of zein and rhamnolipid complex nanoparticles to enhance the stability and in vitro release of curcumin, Food Hydrocoll., 77, 617, 10.1016/j.foodhyd.2017.11.003

Zhou, 2017, Heat and/or ultrasound pretreatments motivated enzymolysis of corn gluten meal: Hydrolysis kinetics and protein structure, LWT, 77, 488, 10.1016/j.lwt.2016.06.048

Sun, 2016, Effect of heat treatment on physical, structural, thermal and morphological characteristics of zein in ethanol-water solution, Food Hydrocoll., 58, 11, 10.1016/j.foodhyd.2016.02.014

Sun, 2016, Simultaneous treatment of heat and high pressure homogenization of zein in ethanol–water solution: Physical, structural, thermal and morphological characteristics, Innov. Food Sci. Emerg. Technol., 34, 161, 10.1016/j.ifset.2016.01.016

Gagliardi, 2018, Sodium deoxycholate-decorated zein nanoparticles for a stable colloidal drug delivery system, Int. J. Nanomed., 13, 601, 10.2147/IJN.S156930

Cabra, 2007, Effect of Alkaline Deamidation on the Structure, Surface Hydrophobicity, and Emulsifying Properties of the Z19 α-Zein, J. Agric. Food Chem., 55, 439, 10.1021/jf061002r

Wang, 2019, Heat-induced self-assembly of zein nanoparticles: Fabrication, stabilization and potential application as oral drug delivery, Food Hydrocoll., 90, 403, 10.1016/j.foodhyd.2018.12.040

Podaralla, 2012, Influence of Formulation Factors on the Preparation of Zein Nanoparticles, AAPS PharmSciTech, 13, 919, 10.1208/s12249-012-9816-1

Zhang, 2011, Effect of acid and base treatments on structural, rheological, and antioxidant properties of α-zein, Food Chem., 124, 210, 10.1016/j.foodchem.2010.06.019

Li, 2020, High dispersity, stability and bioaccessibility of curcumin by assembling with deamidated zein peptide, Food Chem., 319, 126577, 10.1016/j.foodchem.2020.126577

Chen, 2019, Zein-hyaluronic acid binary complex as a delivery vehicle of quercetagetin: Fabrication, structural characterization, physicochemical stability and in vitro release property, Food Chem., 276, 322, 10.1016/j.foodchem.2018.10.034

2018, Zein-polysaccharide nanoparticles as matrices for antioxidant compounds: A strategy for prevention of chronic degenerative diseases, Food Res. Int., 111, 451, 10.1016/j.foodres.2018.05.036

Dai, 2016, The Interaction between Zein and Lecithin in Ethanol-Water Solution and Characterization of Zein–Lecithin Composite Colloidal Nanoparticles, PLoS ONE, 11, e0167172, 10.1371/journal.pone.0167172

Podaralla, 2010, Preparation of zein nanoparticles by pH controlled nanoprecipitation, J. Biomed. Nanotechnol., 6, 312, 10.1166/jbn.2010.1137

Elgindy, 2018, Lactoferrin-decorated vs PEGylated zein nanospheres for combined aromatase inhibitor and herbal therapy of breast cancer, Expert Opin. Drug Deliv., 15, 835, 10.1080/17425247.2018.1505858

Pan, 2016, Low energy, organic solvent-free co-assembly of zein and caseinate to prepare stable dispersions, Food Hydrocoll., 52, 600, 10.1016/j.foodhyd.2015.08.014

Ahmed, 2015, Optimization of caseinate-coated simvastatin-zein nanoparticles: Improved bioavailability and modified release characteristics, Drug Des. Dev. Ther., 9, 655, 10.2147/DDDT.S76194

Luo, 2013, Cellular Uptake and Transport of Zein Nanoparticles: Effects of Sodium Caseinate, J. Agric. Food Chem., 61, 7621, 10.1021/jf402198r

Alqahtani, 2017, Food Protein Based Core–Shell Nanocarriers for Oral Drug Delivery: Effect of Shell Composition on in Vitro and in Vivo Functional Performance of Zein Nanocarriers, Mol. Pharm., 14, 757, 10.1021/acs.molpharmaceut.6b01017

Ji, 2018, Preparation and Characterization of Insulin-Loaded Zein/Carboxymethylated Short-Chain Amylose Complex Nanoparticles, J. Agric. Food Chem., 66, 9335, 10.1021/acs.jafc.8b02630

Pascoli, 2018, Zein Nanoparticles and Strategies to Improve Colloidal Stability: A Mini-Review, Front. Chem., 6, 6, 10.3389/fchem.2018.00006

Wusigale, 2021, Partition and Stability of Folic Acid and Caffeic Acid in Hollow Zein Particles Coated with Chitosan, Int. J. Biol. Macromol., 183, 2282, 10.1016/j.ijbiomac.2021.05.216

Khan, 2019, Alginate/chitosan-coated zein nanoparticles for the delivery of resveratrol, J. Food Eng., 258, 45, 10.1016/j.jfoodeng.2019.04.010

Park, 2015, Effects of a chitosan coating on properties of retinol-encapsulated zein nanoparticles, Food Sci. Biotechnol., 24, 1725, 10.1007/s10068-015-0224-7

Baspinar, 2018, Curcumin and piperine loaded zein-chitosan nanoparticles: Development and in-vitro characterisation, Saudi Pharm. J., 26, 323, 10.1016/j.jsps.2018.01.010

Li, 2018, The formation of zein-chitosan complex coacervated particles: Relationship to encapsulation and controlled release properties, Int. J. Biol. Macromol., 116, 1232, 10.1016/j.ijbiomac.2018.05.107

Ma, 2018, Cellular Uptake and Intracellular Antioxidant Activity of Zein/Chitosan Nanoparticles Incorporated with Quercetin, J. Agric. Food Chem., 66, 12783, 10.1021/acs.jafc.8b04571

Luo, 2012, Development of Zein Nanoparticles Coated with Carboxymethyl Chitosan for Encapsulation and Controlled Release of Vitamin D3, J. Agric. Food Chem., 60, 836, 10.1021/jf204194z

Lin, 2020, Natamycin-loaded zein nanoparticles stabilized by carboxymethyl chitosan: Evaluation of colloidal/chemical performance and application in postharvest treatments, Food Hydrocoll., 106, 105871, 10.1016/j.foodhyd.2020.105871

Piai, 2011, Preparation and Characterization of Zein and Zein-Chitosan Microspheres with Great Prospective of Application in Controlled Drug Release, J. Nanomater., 2011, 1

Luo, 2013, Encapsulation of indole-3-carbinol and 3,3′-diindolylmethane in zein/carboxymethyl chitosan nanoparticles with controlled release property and improved stability, Food Chem., 139, 224, 10.1016/j.foodchem.2013.01.113

Farris, 2017, Chitosan-zein nano-in-microparticles capable of mediating in vivo transgene expression following oral delivery, J. Control. Release, 249, 150, 10.1016/j.jconrel.2017.01.035

Hu, 2015, Fabrication of biopolymer nanoparticles by antisolvent precipitation and electrostatic deposition: Zein-alginate core/shell nanoparticles, Food Hydrocoll., 44, 101, 10.1016/j.foodhyd.2014.09.015

Vozza, 2019, Nutraceutical formulation, characterisation, and in-vitro evaluation of methylselenocysteine and selenocystine using food derived chitosan:zein nanoparticles, Food Res. Int., 120, 295, 10.1016/j.foodres.2019.02.028

Schrauzer, 2000, Selenomethionine: A Review of Its Nutritional Significance, Metabolism and Toxicity, J. Nutr., 130, 1653, 10.1093/jn/130.7.1653

Vozza, 2018, Application of Box-Behnken experimental design for the formulation and optimisation of selenomethionine-loaded chitosan nanoparticles coated with zein for oral delivery, Int. J. Pharm., 551, 257, 10.1016/j.ijpharm.2018.08.050

Cheng, 2016, Sorafenib-fortified zein–chondroitin sulphate biopolymer nanoparticles as a novel therapeutic system in gastric cancer treatment, RSC Adv., 6, 57266, 10.1039/C6RA06775A

Lee, 2021, Chondroitin sulfate-hybridized zein nanoparticles for tumor-targeted delivery of docetaxel, Carbohydr. Polym., 253, 117187, 10.1016/j.carbpol.2020.117187

Liu, 2019, Encapsulation of curcumin in zein/ caseinate/sodium alginate nanoparticles with improved physicochemical and controlled release properties, Food Hydrocoll., 93, 432, 10.1016/j.foodhyd.2019.02.003

Chang, 2017, Pectin coating improves physicochemical properties of caseinate/zein nanoparticles as oral delivery vehicles for curcumin, Food Hydrocoll., 70, 143, 10.1016/j.foodhyd.2017.03.033

Chang, 2017, Zein/caseinate/pectin complex nanoparticles: Formation and characterization, Int. J. Biol. Macromol., 104, 117, 10.1016/j.ijbiomac.2017.05.178

Yao, 2018, Tailoring zein nanoparticle functionality using biopolymer coatings: Impact on curcumin bioaccessibility and antioxidant capacity under simulated gastrointestinal conditions, Food Hydrocoll., 79, 262, 10.1016/j.foodhyd.2017.12.029

Lai, 2011, Preparation of new 5-fluorouracil-loaded zein nanoparticles for liver targeting, Int. J. Pharm., 404, 317, 10.1016/j.ijpharm.2010.11.025

Luo, 2011, (Lucy); Wang, Q. Preparation and characterization of zein/chitosan complex for encapsulation of α-tocopherol, and its in vitro controlled release study, Colloids Surf. B Biointerfaces, 85, 145, 10.1016/j.colsurfb.2011.02.020

Murdan, 2006, Zein microspheres as drug/antigen carriers: A study of their degradation and erosion, in the presence and absence of enzymes, J. Microencapsul., 23, 303, 10.1080/02652040500444149

Imhof, 2019, Color-tunable particles through affinity interactions between water-insoluble protein and soluble dyes, Colloids Surfaces A Physicochem. Eng. Asp., 562, 154, 10.1016/j.colsurfa.2018.11.021

Niu, 2020, Electrospinning of zein-ethyl cellulose hybrid nanofibers with improved water resistance for food preservation, Int. J. Biol. Macromol., 142, 592, 10.1016/j.ijbiomac.2019.09.134

Turasan, 2017, Advances in Understanding the Molecular Structures and Functionalities of Biodegradable Zein-Based Materials Using Spectroscopic Techniques: A Review, Biomacromolecules, 18, 331, 10.1021/acs.biomac.6b01455

Jiang, 2010, Cytocompatible Cross-Linking of Electrospun Zein Fibers for the Development of Water-Stable Tissue Engineering Scaffolds, Acta Biomater., 6, 4042, 10.1016/j.actbio.2010.04.024

Zou, 2016, Enhancing the bioaccessibility of hydrophobic bioactive agents using mixed colloidal dispersions: Curcumin-loaded zein nanoparticles plus digestible lipid nanoparticles, Food Res. Int., 81, 74, 10.1016/j.foodres.2015.12.035

Wang, 2015, Amphiphilic zein hydrolysate as a novel nano-delivery vehicle for curcumin, Food Funct., 6, 2636, 10.1039/C5FO00422E

Dai, 2019, Curcumin encapsulation in zein-rhamnolipid composite nanoparticles using a pH-driven method, Food Hydrocoll., 93, 342, 10.1016/j.foodhyd.2019.02.041

Li, 2019, Fabrication of stable zein nanoparticles coated with soluble soybean polysaccharide for encapsulation of quercetin, Food Hydrocoll., 87, 342, 10.1016/j.foodhyd.2018.08.002

Sun, 2015, Physical, structural, thermal and morphological characteristics of zeinquercetagetin composite colloidal nanoparticles, Ind. Crop. Prod., 77, 476, 10.1016/j.indcrop.2015.09.028

Chuacharoen, 2016, Stability and controlled release of lutein loaded in zein nanoparticles with and without lecithin and pluronic F127 surfactants, Colloids Surfaces A Physicochem. Eng. Asp., 503, 11, 10.1016/j.colsurfa.2016.04.038

Cheng, 2019, Fate of lutein-containing zein nanoparticles following simulated gastric and intestinal digestion, Food Hydrocoll., 87, 229, 10.1016/j.foodhyd.2018.08.013

Jain, 2018, Beta carotene-loaded zein nanoparticles to improve the biopharmaceutical attributes and to abolish the toxicity of methotrexate: A preclinical study for breast cancer, Artif. Cells Nanomed. Biotechnol., 46, 402, 10.1080/21691401.2018.1428811

Liu, 2018, Fabrication and characterization of protein-phenolic conjugate nanoparticles for co-delivery of curcumin and resveratrol, Food Hydrocoll., 79, 450, 10.1016/j.foodhyd.2018.01.017

Chen, 2015, A novel method of preparing stable zein nanoparticle dispersions for encapsulation of peppermint oil, Food Hydrocoll., 43, 593, 10.1016/j.foodhyd.2014.07.018

Zhang, 2014, Fabrication, characterization and antimicrobial activities of thymol-loaded zein nanoparticles stabilized by sodium caseinate–chitosan hydrochloride double layers, Food Chem., 142, 269, 10.1016/j.foodchem.2013.07.058

Wu, 2012, Antioxidant and antimicrobial properties of essential oils encapsulated in zein nanoparticles prepared by liquid–liquid dispersion method, LWT, 48, 283, 10.1016/j.lwt.2012.03.027

Dong, 2016, Doxorubicin-loaded biodegradable self-assembly zein nanoparticle and its anti-cancer effect: Preparation, in vitro evaluation, and cellular uptake, Colloids Surfaces B Biointerfaces, 140, 324, 10.1016/j.colsurfb.2015.12.048

Zha, 2020, Preparation, characterization and preliminary pharmacokinetic study of pH-sensitive Hydroxyapatite/Zein nano-drug delivery system for doxorubicin hydrochloride, J. Pharm. Pharmacol., 72, 496, 10.1111/jphp.13223

Thapa, 2017, Synergistic anticancer activity of combined histone deacetylase and proteasomal inhibitor-loaded zein nanoparticles in metastatic prostate cancers, Nanomed. Nanotechnol. Biol. Med., 13, 885, 10.1016/j.nano.2016.12.010

Tarhini, 2017, Protein-based nanoparticles: From preparation to encapsulation of active molecules, Int. J. Pharm., 522, 172, 10.1016/j.ijpharm.2017.01.067

Aswathy, 2012, Biocompatible fluorescent zein nanoparticles for simultaneous bioimaging and drug delivery application, Adv. Nat. Sci. Nanosci. Nanotechnol., 3, 6

Wang, 2017, Facile encapsulation of hydroxycamptothecin nanocrystals into zein-based nanocomplexes for active targeting in drug delivery and cell imaging, Acta Biomater., 61, 88, 10.1016/j.actbio.2017.04.017

Hadavi, 2018, Zein nanoparticle as a novel BMP6 derived peptide carrier for enhanced osteogenic differentiation of C2C12 cells, Artif. Cells Nanomed. Biotechnol., 46, 559, 10.1080/21691401.2018.1431649

Turner, 2020, Evaluating the cytocompatibility and differentiation of bone progenitors on electrospun zein scaffolds, J. Tissue Eng. Regen. Med., 14, 173, 10.1002/term.2984

Chen, 2020, Fabrication, characterization, physicochemical stability of zein-chitosan nanocomplex for co-encapsulating curcumin and resveratrol, Carbohydr. Polym., 236, 116090, 10.1016/j.carbpol.2020.116090

Chen, 2020, Co-delivery of curcumin and piperine in zein-carrageenan core-shell nanoparticles: Formation, structure, stability and in vitro gastrointestinal digestion, Food Hydrocoll., 99, 105334, 10.1016/j.foodhyd.2019.105334

Chen, 2020, Core-shell nanoparticles for co-encapsulation of coenzyme Q10 and piperine: Surface engineering of hydrogel shell around protein core, Food Hydrocoll., 103, 105651, 10.1016/j.foodhyd.2020.105651

Zhan, 2020, Entrapment of curcumin in whey protein isolate and zein composite nanoparticles using pH-driven method, Food Hydrocoll., 106, 105839, 10.1016/j.foodhyd.2020.105839

Sun, 2020, Stabilization of zein nanoparticles with k-carrageenan and tween 80 for encapsulation of curcumin, Int. J. Biol. Macromol., 146, 549, 10.1016/j.ijbiomac.2020.01.053

Cai, 2020, A novel pectin from Akebia trifoliata var. australis fruit peel and its use as a wall-material to coat curcumin-loaded zein nanoparticle, Int. J. Biol. Macromol., 152, 40, 10.1016/j.ijbiomac.2020.02.234

Li, 2020, Zein/soluble soybean polysaccharide composite nanoparticles for encapsulation and oral delivery of lutein, Food Hydrocoll., 103, 105715, 10.1016/j.foodhyd.2020.105715

Suganya, 2017, Biopolymer zein-coated gold nanoparticles: Synthesis, antibacterial potential, toxicity and histopathological effects against the Zika virus vector Aedes aegypti, J. Photochem. Photobiol. B Biol., 173, 404, 10.1016/j.jphotobiol.2017.06.004

Chen, 2020, Fabrication and characterization of zein/lactoferrin composite nanoparticles for encapsulating 7,8-dihydroxyflavone: Enhancement of stability, water solubility and bioaccessibility, Int. J. Biol. Macromol., 146, 179, 10.1016/j.ijbiomac.2019.12.251

Ma, 2020, Fabrication and characterization of zein/tea saponin composite nanoparticles as delivery vehicles of lutein, LWT, 125, 109270, 10.1016/j.lwt.2020.109270

Yu, 2020, Zein nanoparticles as nontoxic delivery system for maytansine in the treatment of non-small cell lung cancer, Drug Deliv., 27, 100, 10.1080/10717544.2019.1704942

Ewais, 2017, PTEN and TRAIL genes loaded zein nanoparticles as potential therapy for hepatocellular carcinoma, J. Drug Target., 25, 513, 10.1080/1061186X.2017.1289536

Hu, 2016, Development of tannic acid cross-linked hollow zein nanoparticles as potential oral delivery vehicles for curcumin, Food Hydrocoll., 61, 821, 10.1016/j.foodhyd.2016.07.006

Tsai, 2018, Drug release and antioxidant/antibacterial activities of silymarin-zein nanoparticle/bacterial cellulose nanofiber composite films, Carbohydr. Polym., 180, 286, 10.1016/j.carbpol.2017.09.100

Gagliardi, 2019, Paclitaxel-loaded sodium deoxycholate-stabilized zein nanoparticles: Characterization and in vitro cytotoxicity, Heliyon, 5, e02422, 10.1016/j.heliyon.2019.e02422

Kamel, 2020, Inhalable Dual-Targeted Hybrid Lipid Nanocore–Protein Shell Composites for Combined Delivery of Genistein and All-Trans Retinoic Acid to Lung Cancer Cells, ACS Biomater. Sci. Eng., 6, 71, 10.1021/acsbiomaterials.8b01374

Sunab, 2020, Self-enriched mesoporous silica nanoparticle composite membrane with remarkable photodynamic antimicrobial performances, J. Colloid Interface Sci., 559, 197, 10.1016/j.jcis.2019.10.021

Lee, E.-H., Lee, M.-K., and Lim, S.-J. (2021). Enhanced Stability of Indocyanine Green by Encapsulation in Zein-Phosphatidylcholine Hybrid Nanoparticles for Use in the Phototherapy of Cancer. Pharmaceutics, 13.

Seok, 2018, CD44 targeting biocompatible and biodegradable hyaluronic acid cross-linked zein nanogels for curcumin delivery to cancer cells: In vitro and in vivo evaluation, J. Control. Release, 280, 20, 10.1016/j.jconrel.2018.04.050

Zhang, 2020, Targeted delivery of honokiol by zein/hyaluronic acid core-shell nanoparticles to suppress breast cancer growth and metastasis, Carbohydr. Polym., 240, 116325, 10.1016/j.carbpol.2020.116325

Wei, 2021, Structural design of zein-cellulose nanocrystals core–shell microparticles for delivery of curcumin, Food Chem., 357, 129849, 10.1016/j.foodchem.2021.129849

Nunes, 2020, Zein nanoparticles as low-cost, safe, and effective carriers to improve the oral bioavailability of resveratrol, Drug Deliv. Transl. Res., 10, 826, 10.1007/s13346-020-00738-z

Chen, 2021, A stable polyamine-modified zein-based nanoformulation with high foliar affinity and lowered toxicity for sustained avermectin release, Pest Manag. Sci., 77, 3300, 10.1002/ps.6374

Monteiro, 2021, Zein based-nanoparticles loaded botanical pesticides in pest control: An enzyme stimuli-responsive approach aiming sustainable agriculture, J. Hazard. Mater., 417, 126004, 10.1016/j.jhazmat.2021.126004

Zhang, 2021, Encapsulation of curcumin using fucoidan stabilized zein nanoparticles: Preparation, characterization, and in vitro release performance, J. Mol. Liq., 329, 115586, 10.1016/j.molliq.2021.115586

Liu, 2021, Fabrication, characterization, physicochemical stability and simulated gastrointestinal digestion of pterostilbene loaded zein-sodium caseinate-fucoidan nanoparticles using pH-driven method, Food Hydrocoll., 119, 106851, 10.1016/j.foodhyd.2021.106851

Mo, 2021, Development of antifungal gelatin-based nanocomposite films functionalized with natamycin-loaded zein/casein nanoparticles, Food Hydrocoll., 113, 106506, 10.1016/j.foodhyd.2020.106506

Fu, 2021, Preparation and evaluation of lecithin/zein hybrid nanoparticles for the oral delivery of Panax notoginseng saponins, Eur. J. Pharm. Sci., 164, 105882, 10.1016/j.ejps.2021.105882

Liu, 2021, Fabrication, characterization and properties of DHA-loaded nanoparticles based on zein and PLGA, Food Chem., 360, 129957, 10.1016/j.foodchem.2021.129957

Meng, 2021, Preparation and characterization of zein/carboxymethyl dextrin nanoparticles to encapsulate curcumin: Physicochemical stability, antioxidant activity and controlled release properties, Food Chem., 340, 127893, 10.1016/j.foodchem.2020.127893

Bartlett, 2007, Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imaging, Proc. Natl. Acad. Sci. USA, 104, 15549, 10.1073/pnas.0707461104

Liu, 2017, Self-Assembled Nanospheres of Folate-Decorated Zein for the Targeted Delivery of 10-Hydroxycamptothecin, Ind. Eng. Chem. Res., 56, 8517, 10.1021/acs.iecr.7b01632

Liu, 2016, Self-assembly of zein microspheres with controllable particle size and narrow distribution using a novel built-in ultrasonic dialysis process, Chem. Eng. J., 284, 1094, 10.1016/j.cej.2015.09.067

Liu, 2016, Incorporation of 10-hydroxycamptothecin nanocrystals into zein microspheres, Chem. Eng. Sci., 155, 405, 10.1016/j.ces.2016.08.029

Pang, 2018, Folate-conjugated zein/Fe3O4 nanocomplexes for the enhancement of cellular uptake and cytotoxicity of gefitinib, J. Mater. Sci., 53, 14907, 10.1007/s10853-018-2684-7

Hou, 2019, Bilayer Nanocarriers with Protein–Acid Conjugation for Prolonged Release and Enhanced Anticancer Effects, Langmuir, 35, 3710, 10.1021/acs.langmuir.8b02882

Soe, Z.C., Ou, W., Gautam, M., Poudel, K., Kim, B.K., Pham, L.M., Phung, C.D., Jeong, J.-H., Jin, S.G., and Choi, H.-G. (2019). Development of Folate-Functionalized PEGylated Zein Nanoparticles for Ligand-Directed Delivery of Paclitaxel. Pharmaceutics, 11.

Pereira, 2016, Lactoferrin selectively triggers apoptosis in highly metastatic breast cancer cells through inhibition of plasmalemmal V-H+-ATPase, Oncotarget, 7, 62144, 10.18632/oncotarget.11394

Gopal, 2016, Role of Lactoferrin in the Carcinogenesis of Triple-Negative Breast Cancer, J. Cancer Clin. Trials, 1, 6

Sabra, 2018, Self-assembled amphiphilic zein-lactoferrin micelles for tumor targeted co-delivery of rapamycin and wogonin to breast cancer, Eur. J. Pharm. Biopharm., 128, 156, 10.1016/j.ejpb.2018.04.023

Li, 2019, Nanoparticle ferritin-bound erastin and rapamycin: A nanodrug combining autophagy and ferroptosis for anticancer therapy, Biomater. Sci., 7, 3779, 10.1039/C9BM00653B

Chirumbolo, 2013, Anticancer properties of the flavone wogonin, Toxicology, 314, 60, 10.1016/j.tox.2013.08.016

Li, 2019, The Effect of Size, Dose, and Administration Route on Zein Nanoparticle Immunogenicity in BALB/c Mice, Int. J. Nanomed., 14, 9917, 10.2147/IJN.S226466

Suk, 2016, PEGylation as a strategy for improving nanoparticle-based drug and gene delivery, Adv. Drug Deliv. Rev., 99, 28, 10.1016/j.addr.2015.09.012

Chen, 2020, Long-circulating zein-polysulfobetaine conjugate-based nanocarriers for enhancing the stability and pharmacokinetics of curcumin, Mater. Sci. Eng. C, 109, 110636, 10.1016/j.msec.2020.110636