Surface-Tailored Zein Nanoparticles: Strategies and Applications

Pharmaceutics - Tập 13 Số 9 - Trang 1354
Ahmed Mohamed Abdelsalam1,2, Ahmed Somaida1, Abdallah M. Ayoub1,3, Fahd M. Alsharif2, Eduard Preis1, Matthias Wojcik1, Udo Bakowsky1
1Department of Pharmaceutics and Biopharmaceutics, University of Marburg, Robert-Koch Straße 4, 35037 Marburg, Germany
2Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt
3Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt

Tóm tắt

Plant-derived proteins have emerged as leading candidates in several drug and food delivery applications in diverse pharmaceutical designs. Zein is considered one of the primary plant proteins obtained from maize, and is well known for its biocompatibility and safety in biomedical fields. The ability of zein to carry various pharmaceutically active substances (PAS) position it as a valuable contender for several in vitro and in vivo applications. The unique structure and possibility of surface covering with distinct coating shells or even surface chemical modifications have enabled zein utilization in active targeted and site-specific drug delivery. This work summarizes up-to-date studies on zein formulation technology based on its structural features. Additionally, the multiple applications of zein, including drug delivery, cellular imaging, and tissue engineering, are discussed with a focus on zein-based active targeted delivery systems and antigenic response to its potential in vivo applicability.

Từ khóa


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