PLoS Biology
1544-9173
1545-7885
Mỹ
Cơ quản chủ quản: PUBLIC LIBRARY SCIENCE , Public Library of Science
Lĩnh vực:
Agricultural and Biological Sciences (miscellaneous)Neuroscience (miscellaneous)Biochemistry, Genetics and Molecular Biology (miscellaneous)Immunology and Microbiology (miscellaneous)
Phân tích ảnh hưởng
Thông tin về tạp chí
PLOS Biology is the flagship PLOS journal in the life sciences and features works of exceptional significance, originality, and relevance in all areas of biological science and at every scale; from molecules to ecosystems, including works at the interface of other disciplines. We also welcome data-driven meta-research articles that evaluate and aim to improve the standards of research in the life sciences and beyond. We evaluate research based on the important questions it answers as well as its potential to impact an international scientific community as well as educators, policy makers, patient advocacy groups, and society more broadly.
Các bài báo tiêu biểu
Synthetic Biology and Conservation of Nature: Wicked Problems and Wicked Solutions
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Biphasic Synaptic Ca Influx Arising from Compartmentalized Electrical Signals in Dendritic Spines
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PGC-1α Deficiency Causes Multi-System Energy Metabolic Derangements: Muscle Dysfunction, Abnormal Weight Control and Hepatic Steatosis
Tập 3 Số 4 - Trang e101
Transcript Specificity in Yeast Pre-mRNA Splicing Revealed by Mutations in Core Spliceosomal Components
Tập 5 Số 4 - Trang e90
Saccades are phase-locked to alpha oscillations in the occipital and medial temporal lobe during successful memory encoding
Tập 15 Số 12 - Trang e2003404
Myc Dynamically and Preferentially Relocates to a Transcription Factory Occupied by Igh
Tập 5 Số 8 - Trang e192
MHC class I H2-Kb negatively regulates neural progenitor cell proliferation by inhibiting FGFR signaling Proteins of the major histocompatibility complex class I (MHC I), predominantly known for antigen presentation in the immune system, have recently been shown to be necessary for developmental neural refinement and adult synaptic plasticity. However, their roles in nonneuronal cell populations in the brain remain largely unexplored. Here, we identify classical MHC I molecule H2-Kb as a negative regulator of proliferation in neural stem and progenitor cells (NSPCs). Using genetic knockout mouse models and in vivo viral-mediated RNA interference (RNAi) and overexpression, we delineate a role for H2-Kb in negatively regulating NSPC proliferation and adult hippocampal neurogenesis. Transcriptomic analysis of H2-Kb knockout NSPCs, in combination with in vitro RNAi, overexpression, and pharmacological approaches, further revealed that H2-Kb inhibits cell proliferation by dampening signaling pathways downstream of fibroblast growth factor receptor 1 (Fgfr1). These findings identify H2-Kb as a critical regulator of cell proliferation through the modulation of growth factor signaling.
Tập 19 Số 6 - Trang e3001311
Insulin Signaling and Dietary Restriction Differentially Influence the Decline of Learning and Memory with Age
Tập 8 Số 5 - Trang e1000372
A Novel CpG Island Set Identifies Tissue-Specific Methylation at Developmental Gene Loci
Tập 6 Số 1 - Trang e22