PLoS Biology
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Superspreading events in the transmission dynamics of SARS-CoV-2: Opportunities for interventions and control Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the etiological agent of the Coronavirus Disease 2019 (COVID-19) disease, has moved rapidly around the globe, infecting millions and killing hundreds of thousands. The basic reproduction number, which has been widely used—appropriately and less appropriately—to characterize the transmissibility of the virus, hides the fact that transmission is stochastic, often dominated by a small number of individuals, and heavily influenced by superspreading events (SSEs). The distinct transmission features of SARS-CoV-2, e.g., high stochasticity under low prevalence (as compared to other pathogens, such as influenza), and the central role played by SSEs on transmission dynamics cannot be overlooked. Many explosive SSEs have occurred in indoor settings, stoking the pandemic and shaping its spread, such as long-term care facilities, prisons, meat-packing plants, produce processing facilities, fish factories, cruise ships, family gatherings, parties, and nightclubs. These SSEs demonstrate the urgent need to understand routes of transmission, while posing an opportunity to effectively contain outbreaks with targeted interventions to eliminate SSEs. Here, we describe the different types of SSEs, how they influence transmission, empirical evidence for their role in the COVID-19 pandemic, and give recommendations for control of SARS-CoV-2.
PLoS Biology - Tập 18 Số 11 - Trang e3000897
Synthetic Biology and Conservation of Nature: Wicked Problems and Wicked Solutions
PLoS Biology - Tập 11 Số 4 - Trang e1001530
Biphasic Synaptic Ca Influx Arising from Compartmentalized Electrical Signals in Dendritic Spines
PLoS Biology - Tập 7 Số 9 - Trang e1000190
PGC-1α Deficiency Causes Multi-System Energy Metabolic Derangements: Muscle Dysfunction, Abnormal Weight Control and Hepatic Steatosis
PLoS Biology - Tập 3 Số 4 - Trang e101
Transcript Specificity in Yeast Pre-mRNA Splicing Revealed by Mutations in Core Spliceosomal Components
PLoS Biology - Tập 5 Số 4 - Trang e90
Saccades are phase-locked to alpha oscillations in the occipital and medial temporal lobe during successful memory encoding
PLoS Biology - Tập 15 Số 12 - Trang e2003404
Myc Dynamically and Preferentially Relocates to a Transcription Factory Occupied by Igh
PLoS Biology - Tập 5 Số 8 - Trang e192
MHC class I H2-Kb negatively regulates neural progenitor cell proliferation by inhibiting FGFR signaling Proteins of the major histocompatibility complex class I (MHC I), predominantly known for antigen presentation in the immune system, have recently been shown to be necessary for developmental neural refinement and adult synaptic plasticity. However, their roles in nonneuronal cell populations in the brain remain largely unexplored. Here, we identify classical MHC I molecule H2-Kb as a negative regulator of proliferation in neural stem and progenitor cells (NSPCs). Using genetic knockout mouse models and in vivo viral-mediated RNA interference (RNAi) and overexpression, we delineate a role for H2-Kb in negatively regulating NSPC proliferation and adult hippocampal neurogenesis. Transcriptomic analysis of H2-Kb knockout NSPCs, in combination with in vitro RNAi, overexpression, and pharmacological approaches, further revealed that H2-Kb inhibits cell proliferation by dampening signaling pathways downstream of fibroblast growth factor receptor 1 (Fgfr1). These findings identify H2-Kb as a critical regulator of cell proliferation through the modulation of growth factor signaling.
PLoS Biology - Tập 19 Số 6 - Trang e3001311
Insulin Signaling and Dietary Restriction Differentially Influence the Decline of Learning and Memory with Age
PLoS Biology - Tập 8 Số 5 - Trang e1000372
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