Rapamycin directly activates lysosomal mucolipin TRP channels independent of mTOR

PLoS Biology - Tập 17 Số 5 - Trang e3000252
Xiaoli Zhang1, W. Chen1, Qinghong Gao1, Junsheng Yang2,1, Xueni Yan2, Han Zhao2, Lin Su2, Meimei Yang1,3, Chenlang Gao1, Yao Yao4, Ken Inoki4, Dan Li2, Rong Shao2, Shiyi Wang1, Nirakar Sahoo1, Fumitaka Kudo5, Tadashi Eguchi5, Benfang Helen Ruan2, Haoxing Xu1
1Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America
2Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, China
3Department of Neurology, The Fourth Hospital of Harbin Medical University, Harbin, China
4Department of Integrative and Molecular Physiology and Internal Medicine, Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, United States of America
5Department of Chemistry, Tokyo Institute of Technology, Ookayama, Meguro-ku, Tokyo, Japan

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