Rapamycin directly activates lysosomal mucolipin TRP channels independent of mTOR
Tóm tắt
Từ khóa
Tài liệu tham khảo
SN Sehgal, 1975, Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization, J Antibiot (Tokyo), 28, 727, 10.7164/antibiotics.28.727
AW Thomson, 2009, Immunoregulatory functions of mTOR inhibition, Nat Rev Immunol, 9, 324, 10.1038/nri2546
B Ruan, 2008, Binding of rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activities, Proc Natl Acad Sci U S A, 105, 33, 10.1073/pnas.0710424105
DW Lamming, 2013, Rapalogs and mTOR inhibitors as anti-aging therapeutics, J Clin Invest, 123, 980, 10.1172/JCI64099
J Heitman, 1991, Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast, Science, 253, 905, 10.1126/science.1715094
M Laplante, 2012, mTOR signaling in growth control and disease, Cell, 149, 274, 10.1016/j.cell.2012.03.017
Y Sancak, 2010, Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids, Cell, 141, 290, 10.1016/j.cell.2010.02.024
SA Kang, 2013, mTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin, Science, 341, 1236566, 10.1126/science.1236566
C Settembre, 2011, TFEB links autophagy to lysosomal biogenesis, Science, 332, 1429, 10.1126/science.1204592
J Bove, 2011, Fighting neurodegeneration with rapamycin: mechanistic insights, Nat Rev Neurosci, 12, 437, 10.1038/nrn3068
J Kaur, 2015, Autophagy at the crossroads of catabolism and anabolism, Nat Rev Mol Cell Biol, 16, 461, 10.1038/nrm4024
D Benjamin, 2011, Rapamycin passes the torch: a new generation of mTOR inhibitors, Nat Rev Drug Discov, 10, 868, 10.1038/nrd3531
C Malagelada, 2010, Rapamycin protects against neuron death in in vitro and in vivo models of Parkinson's disease, J Neurosci, 30, 1166, 10.1523/JNEUROSCI.3944-09.2010
J Zhou, 2013, Activation of lysosomal function in the course of autophagy via mTORC1 suppression and autophagosome-lysosome fusion, Cell Res, 23, 508, 10.1038/cr.2013.11
C Settembre, 2013, Signals from the lysosome: a control centre for cellular clearance and energy metabolism, Nat Rev Mol Cell Biol, 14, 283, 10.1038/nrm3565
C Settembre, 2012, A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB, EMBO J, 31, 1095, 10.1038/emboj.2012.32
A Roczniak-Ferguson, 2012, The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis, Sci Signal, 5, ra42, 10.1126/scisignal.2002790
JA Martina, 2012, MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB, Autophagy, 8, 903, 10.4161/auto.19653
DL Medina, 2015, Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB, Nat Cell Biol, 17, 288, 10.1038/ncb3114
X Zhang, 2016, MCOLN1 is a ROS sensor in lysosomes that regulates autophagy, Nat Commun, 7, 12109, 10.1038/ncomms12109
W Wang, 2015, Up-regulation of lysosomal TRPML1 channels is essential for lysosomal adaptation to nutrient starvation, Proc Natl Acad Sci U S A, 112, E1373, 10.1073/pnas.1419669112
D Shen, 2012, Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release, Nat Commun, 3, 731, 10.1038/ncomms1735
X Wang, 2012, TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes, Cell, 151, 372, 10.1016/j.cell.2012.08.036
XP Dong, 2010, PI(3,5)P(2) controls membrane trafficking by direct activation of mucolipin Ca(2+) release channels in the endolysosome, Nat Commun, 1, 38, 10.1038/ncomms1037
C Cang, 2013, mTOR regulates lysosomal ATP-sensitive two-pore Na(+) channels to adapt to metabolic state, Cell, 152, 778, 10.1016/j.cell.2013.01.023
RU Onyenwoke, 2015, The mucolipidosis IV Ca2+ channel TRPML1 (MCOLN1) is regulated by the TOR kinase, Biochemical Journal, 470, 331, 10.1042/BJ20150219
CC Thoreen, 2009, An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1, J Biol Chem, 284, 8023, 10.1074/jbc.M900301200
F Tabatabaian, 2010, Mammalian target of rapamycin (mTOR) and S6 kinase down-regulate phospholipase D2 basal expression and function, J Biol Chem, 285, 18991, 10.1074/jbc.M110.111542
A Jha, 2014, Convergent regulation of the lysosomal two-pore channel-2 by Mg<sup>2</sup>⁺, NAADP, PI(3,5)P₂ and multiple protein kinases, EMBO J, 33, 501, 10.1002/embj.201387035
BC Grabiner, 2014, A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity, Cancer Discov, 4, 554, 10.1158/2159-8290.CD-13-0929
RU Onyenwoke, 2015, The mucolipidosis IV Ca2+ channel TRPML1 (MCOLN1) is regulated by the TOR kinase, Biochem J, 470, 331, 10.1042/BJ20150219
S Faivre, 2006, Current development of mTOR inhibitors as anticancer agents, Nat Rev Drug Discov, 5, 671, 10.1038/nrd2062
CJ Cortes, 2014, Polyglutamine-expanded androgen receptor interferes with TFEB to elicit autophagy defects in SBMA, Nat Neurosci, 17, 1180, 10.1038/nn.3787
J Jia, 2018, Galectins Control mTOR in Response to Endomembrane Damage, Mol Cell, 70, 120, 10.1016/j.molcel.2018.03.009
N Mizushima, 2010, Methods in mammalian autophagy research, Cell, 140, 313, 10.1016/j.cell.2010.01.028
J Kim, 2011, AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1, Nat Cell Biol, 13, 132, 10.1038/ncb2152
P Yellen, 2011, High-dose rapamycin induces apoptosis in human cancer cells by dissociating mTOR complex 1 and suppressing phosphorylation of 4E-BP1, Cell Cycle, 10, 3948, 10.4161/cc.10.22.18124
RJ Li, 2016, Regulation of mTORC1 by lysosomal calcium and calmodulin, Elife, 5
OA Ogunbayo, 2018, mTORC1 controls lysosomal Ca(2+) release through the two-pore channel TPC2, Sci Signal, 11, 10.1126/scisignal.aao5775
X Sun, 2018, A negative feedback regulation of MTORC1 activity by the lysosomal Ca(2+) channel MCOLN1 (mucolipin 1) using a CALM (calmodulin)-dependent mechanism, Autophagy, 14, 38, 10.1080/15548627.2017.1389822
P Schmiege, 2017, Human TRPML1 channel structures in open and closed conformations, Nature, 550, 366, 10.1038/nature24036
X Zhou, 2017, Cryo-EM structures of the human endolysosomal TRPML3 channel in three distinct states, Nat Struct Mol Biol
YC Kim, 2014, Rag GTPases are cardioprotective by regulating lysosomal function, Nat Commun, 5, 4241, 10.1038/ncomms5241
H Zhang, 2003, Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR, J Clin Invest, 112, 1223, 10.1172/JCI200317222
NE Sanjana, 2014, Improved vectors and genome-wide libraries for CRISPR screening, Nat Methods, 11, 783, 10.1038/nmeth.3047
J Cerny, 2004, The small chemical vacuolin-1 inhibits Ca(2+)-dependent lysosomal exocytosis but not cell resealing, EMBO Rep, 5, 883, 10.1038/sj.embor.7400243