Human MicroRNA Targets

2003, The Caenorhabditis elegans hunchback-like gene lin-57/hbl-1 controls developmental time and is regulated by microRNAs., Dev Cell, 4, 625, 10.1016/S1534-5807(03)00127-8

1990, Basic local alignment search tool., J Mol Biol, 215, 403, 10.1016/S0022-2836(05)80360-2

1999, TGF-beta(1), regulation of alzheimer amyloid precursor protein mRNA expression in a normal human astrocyte cell line: mRNA stabilization., Brain Res Mol Brain Res, 71, 42, 10.1016/S0169-328X(99)00158-8

2000, Control of developmental timing in Caenorhabditis elegans., Curr Opin Genet Dev, 10, 428, 10.1016/S0959-437X(00)00108-8

2003, MicroRNA pathways in flies and worms: Growth, death, fat, stress, and timing., Cell, 113, 673, 10.1016/S0092-8674(03)00428-8

2003a, A uniform system for microRNA annotation., RNA, 9, 277, 10.1261/rna.2183803

2003b, MicroRNAs and other tiny endogenous RNAs in C. elegans., Curr Biol, 13, 807, 10.1016/S0960-9822(03)00287-2

2003, Sunrise at the synapse: The FMRP mRNP shaping the synaptic interface., Neuron, 37, 555, 10.1016/S0896-6273(03)00090-4

2003, The small RNA profile during Drosophila melanogaster development., Dev Cell, 5, 337, 10.1016/S1534-5807(03)00228-4

2002, On ontologies for biologists: The Gene Ontology—Untangling the web., Novartis Found Symp, 247, 66, 10.1002/0470857897.ch6

2004, MicroRNAs: Genomics, biogenesis, mechanism, and function., Cell, 116, 281, 10.1016/S0092-8674(04)00045-5

2004, Micromanagers of gene expression: The potentially widespread influence of metazoan microRNAs., Nat Rev Genet, 5, 396, 10.1038/nrg1328

2003, AMPA- and NMDA-associated postsynaptic protein expression in the human dorsolateral prefrontal cortex., Ann N Y Acad Sci, 1003, 352, 10.1196/annals.1300.024

2004, Ensembl 2004., Nucleic Acids Res, 32, D468, 10.1093/nar/gkh038

2003, Arabidopsis HEN1: A genetic link between endogenous miRNA controlling development and siRNA controlling transgene silencing and virus resistance., Curr Biol, 13, 843, 10.1016/S0960-9822(03)00293-8

2003, AVID: A global alignment program., Genome Res, 13, 97, 10.1101/gr.789803

2003, bantam encodes a developmentally regulated microrna that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila., Cell, 113, 25, 10.1016/S0092-8674(03)00231-9

2001, Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome., Cell, 107, 477, 10.1016/S0092-8674(01)00568-2

2002, Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia., Proc Natl Acad Sci U S A, 99, 15524, 10.1073/pnas.242606799

2004, Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers., Proc Natl Acad Sci U S A, 101, 2999, 10.1073/pnas.0307323101

2002, Fragile X-related protein and VIG associate with the RNA interference machinery., Genes Dev, 16, 2491, 10.1101/gad.1025202

1999, Isolation of an FMRP-associated messenger ribonucleoprotein particle and identification of nucleolin and the fragile X-related proteins as components of the complex., Mol Cell Biol, 19, 7925, 10.1128/MCB.19.12.7925

1981, Mutations that lead to reiterations in the cell lineages of C. elegans., Cell, 24, 59, 10.1016/0092-8674(81)90501-8

2004, MicroRNAs modulate hematopoietic lineage differentiation., Science, 303, 83, 10.1126/science.1091903

2003, The fragile X mental retardation protein binds and regulates a novel class of mRNAs containing U rich target sequences., Neuroscience, 120, 1005, 10.1016/S0306-4522(03)00406-8

2001, Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function., Cell, 107, 489, 10.1016/S0092-8674(01)00566-9

2003, Deja vu all over again: FMRP binds U-rich target mRNAs., Biochem Biophys Res Commun, 310, 1, 10.1016/j.bbrc.2003.08.071

2004, Specificity of microRNA target selection in translational repression., Genes Dev, 18, 504, 10.1101/gad.1184404

2003, siRNAs can function as miRNAs., Genes Dev, 17, 438, 10.1101/gad.1064703

2003, The fragile X mental retardation protein interacts with U-rich RNAs in a yeast three-hybrid system., Biochem Biophys Res Commun, 305, 434, 10.1016/S0006-291X(03)00766-6

2003, Numerous microRNPs in neuronal cells containing novel microRNAs., RNA, 9, 180, 10.1261/rna.2141503

2001, RNA interference is mediated by 21 and 22 nt RNAs., Genes Dev, 15, 188, 10.1101/gad.862301

2003, MicroRNA targets in Drosophila., Genome Biol, 5, R1

2003, Analysis of the transcription regulator, CNOT7, as a candidate chromosome 8 tumor suppressor gene in colorectal cancer., Int J Cancer, 106, 505, 10.1002/ijc.11264

1995, A conserved family of elav-like genes in vertebrates., Proc Natl Acad Sci U S A, 92, 4557, 10.1073/pnas.92.10.4557

2003, Computational and experimental identification of C. elegans microRNAs., Mol Cell, 11, 1253, 10.1016/S1097-2765(03)00153-9

2004, The microRNA Registry., Nucleic Acids Res, 32, D109, 10.1093/nar/gkh023

1994, CPEB is a specificity factor that mediates cytoplasmic polyadenylation during Xenopus oocyte maturation., Cell, 79, 617, 10.1016/0092-8674(94)90547-9

2001, Argonaute2, a link between genetic and biochemical analyses of RNAi., Science, 293, 1146, 10.1126/science.1064023

2003, Embryonic stem cell-specific MicroRNAs., Dev Cell, 5, 351, 10.1016/S1534-5807(03)00227-2

2003, Facilitation of dendritic mRNA transport by CPEB., Genes Dev, 17, 638, 10.1101/gad.1053003

2002a, A microRNA in a multiple-turnover RNAi enzyme complex., Science, 297, 2056, 10.1126/science.1073827

2002b, RNAi: Nature abhors a double-strand., Curr Opin Genet Dev, 12, 225, 10.1016/S0959-437X(02)00290-3

2002, A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins., Genes Dev, 16, 2497, 10.1101/gad.1022002

2003, Expression profiling reveals off-target gene regulation by RNAi., Nat Biotechnol, 21, 635, 10.1038/nbt831

2004, Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway., Nat Neurosci, 7, 113, 10.1038/nn1174

2003, A microRNA controlling left/right neuronal asymmetry in Caenorhabditis elegans., Nature, 426, 845, 10.1038/nature02255

2004, Regulation of RNA polymerase II transcription by sequence-specific DNA binding factors., Cell, 116, 247, 10.1016/S0092-8674(03)01078-X

2004, EnsMart: A generic system for fast and flexible access to biological data., Genome Res, 14, 160, 10.1101/gr.1645104

2003, Functional siRNAs and miRNAs exhibit strand bias., Cell, 115, 209, 10.1016/S0092-8674(03)00801-8

2004, Identification of many microRNAs that copurify with polyribosomes in mammalian neurons., Proc Natl Acad Sci U S A, 101, 360, 10.1073/pnas.2333854100

2004, A combined computational-experimental approach predicts human microRNA targets., Genes Dev, 18, 1165, 10.1101/gad.1184704

2003, A microRNA array reveals extensive regulation of microRNAs during brain development., RNA, 9, 1274, 10.1261/rna.5980303

2001, Identification of novel genes coding for small expressed RNAs., Science, 294, 853, 10.1126/science.1064921

2002, Identification of tissue-specific microRNAs from mouse., Curr Biol, 12, 735, 10.1016/S0960-9822(02)00809-6

2003, New microRNAs from mouse and human., RNA, 9, 175, 10.1261/rna.2146903

2003, microRNAs: Runts of the genome assert themselves., Curr Biol, 13, R925, 10.1016/j.cub.2003.11.017

2003, Computational identification of Drosophila microRNA genes., Genome Biol, 4, R42, 10.1186/gb-2003-4-7-r42

2001, An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans., Science, 294, 858, 10.1126/science.1065062

2001, An extensive class of small RNAs in Caenorhabditis elegans., Science, 294, 862, 10.1126/science.1065329

1993, The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14., Cell, 75, 843, 10.1016/0092-8674(93)90529-Y

2002, MicroRNA maturation: Stepwise processing and subcellular localization., EMBO J, 21, 4663, 10.1093/emboj/cdf476

2003, The nuclear RNase III Drosha initiates microRNA processing., Nature, 425, 415, 10.1038/nature01957

2003, Prediction of mammalian microRNA targets., Cell, 115, 787, 10.1016/S0092-8674(03)01018-3

2003a, Vertebrate microRNA genes., Science, 299, 1540, 10.1126/science.1080372

2003b, The microRNAs of Caenorhabditis elegans., Genes Dev, 17, 991, 10.1101/gad.1074403

2003, The C. elegans hunchback homolog, hbl-1, controls temporal patterning and is a probable microRNA target., Dev Cell, 4, 639, 10.1016/S1534-5807(03)00124-2

2003, Structure and nucleic-acid binding of the Drosophila Argonaute 2 PAZ domain., Nature, 426, 465, 10.1038/nature02123

2002a, Endogenous and silencing-associated small RNAs in plants., Plant Cell, 14, 1605, 10.1105/tpc.003210

2002b, Cleavage of Scarecrow-like mRNA targets directed by a class of Arabidopsis miRNA., Science, 297, 2053, 10.1126/science.1076311

2003, Nuclear export of microRNA precursors., Science, 303, 95

2004, Structural basis for overhang specific small interfering RNA recognition by the PAZ domain., Nature, 429, 318, 10.1038/nature02519

2002, Single-stranded antisense siRNAs guide target RNA cleavage in RNAi., Cell, 110, 563, 10.1016/S0092-8674(02)00908-X

2001, Translational control by CPEB: A means to the end., Nat Rev Mol Cell Biol, 2, 521, 10.1038/35080081

2000, Phosphorylation of CPE binding factor by Eg2 regulates translation of c-mos mRNA., Nature, 404, 302, 10.1038/35005126

2002, Differential mRNA translation and meiotic progression require Cdc2-mediated CPEB destruction., EMBO J, 21, 1833, 10.1093/emboj/21.7.1833

2002, Short RNAs can identify new candidate transposable element families in Arabidopsis., Plant Physiol, 130, 6, 10.1104/pp.007047

2004, High expression of precursor microRNA-155/BIC RNA in children with Burkitt lymphoma., Genes Chromosomes Cancer, 39, 167, 10.1002/gcc.10316

2003, Reduced accumulation of specific microRNAs in colorectal neoplasia., Mol Cancer Res, 1, 882

2003, RNA cargoes associating with FMRP reveal deficits in cellular functioning in Fmr1 null mice., Neuron, 37, 417, 10.1016/S0896-6273(03)00034-5

2003, Conservation of the heterochronic regulator Lin-28, its developmental expression and microRNA complementary sites., Dev Biol, 258, 432, 10.1016/S0012-1606(03)00126-X

1997, The cold shock domain protein LIN-28 controls developmental timing in C. elegans and is regulated by the lin-4 RNA., Cell, 88, 637, 10.1016/S0092-8674(00)81906-6

2002, miRNPs: A novel class of ribonucleoproteins containing numerous microRNAs., Genes Dev, 16, 720, 10.1101/gad.974702

2003, The InterPro Database, 2003 brings increased coverage and new features., Nucleic Acids Res, 31, 315, 10.1093/nar/gkg046

2004, SUMO: A regulator of gene expression and genome integrity., Oncogene, 23, 1998, 10.1038/sj.onc.1207415

2002, RNAi related mechanisms affect both transcriptional and posttranscriptional transgene silencing in Drosophila., Mol Cell, 9, 315, 10.1016/S1097-2765(02)00440-9

2003, Control of leaf morphogenesis by microRNAs., Nature, 425, 257, 10.1038/nature01958

2001, Cloning, mapping, and characterization of a human homologue of the yeast longevity assurance gene LAG1., Genomics, 77, 58, 10.1006/geno.2001.6614

2002, CARPEL FACTORY, a Dicer homolog, and HEN1, a novel protein, act in microRNA metabolism in Arabidopsis thaliana., Curr Biol, 12, 1484, 10.1016/S0960-9822(02)01017-5

2001, Emerging roles for semaphorins in neural regeneration., Brain Res Brain Res Rev, 35, 36, 10.1016/S0165-0173(00)00050-3

1988, Improved tools for biological sequence comparison., Proc Natl Acad Sci U S A, 85, 2444, 10.1073/pnas.85.8.2444

2002, Role of HuD and other RNA-binding proteins in neural development and plasticity., J Neurosci Res, 68, 121, 10.1002/jnr.10175

2004, Identification of virus-encoded microRNAs., Science, 304, 734, 10.1126/science.1096781

2000, Growth factor-mediated stabilization of amyloid precursor protein mRNA is mediated by a conserved 29-nucleotide sequence in the 3′-untranslated region., J Neurochem, 74, 52, 10.1046/j.1471-4159.2000.0740052.x

2003, Computational identification of microRNA targets., Dev Biol, 267, 529

2003, G-quartet-dependent recognition between the FMRP RGG box and RNA., RNA, 9, 1198, 10.1261/rna.5960503

2004, Fast and effective prediction of microRNA/target duplexes.

2000, The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans., Nature, 403, 901, 10.1038/35002607

2002, MicroRNAs in plants., Genes Dev, 16, 1616, 10.1101/gad.1004402

2004, Rational siRNA design for RNA interference., Nat Biotechnol, 22, 326, 10.1038/nbt936

2001, Think globally, translate locally: What mitotic spindles and neuronal synapses have in common., Proc Natl Acad Sci U S A, 98, 7069, 10.1073/pnas.111146498

2003, Identification of eight members of the Argonaute family in the human genome., Genomics, 82, 323, 10.1016/S0888-7543(03)00129-0

2003, Asymmetry in the assembly of the RNAi enzyme complex., Cell, 115, 199, 10.1016/S0092-8674(03)00759-1

2003, Imprinted microRNA genes transcribed antisense to a reciprocally imprinted retrotransposon-like gene., Nat Genet, 34, 261, 10.1038/ng1171

2004, Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation., Genome Biol, 5, R13

2003, p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity., Cancer Res, 63, 2373

2003, The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes., Nat Struct Biol, 10, 1026, 10.1038/nsb1016

2003, Identification of Drosophila microRNA targets., PLoS Biol, 1, e60, 10.1371/journal.pbio.0000060

2003, Compartmentalized synthesis and degradation of proteins in neurons., Neuron, 40, 347, 10.1016/S0896-6273(03)00635-4

2003, A gene-coexpression network for global discovery of conserved genetic modules., Science, 302, 249, 10.1126/science.1087447

2001, An autoregulatory feedback loop directs the localized expression of the Drosophila CPEB protein Orb in the developing oocyte., Development, 128, 1159, 10.1242/dev.128.7.1159

2001, Changes in gene expression during progression of ovarian carcinoma., Cancer Genet Cytogenet, 128, 1, 10.1016/S0165-4608(01)00386-7

2000, Identifying mRNA subsets in messenger ribonucleoprotein complexes by using cDNA arrays., Proc Natl Acad Sci U S A, 97, 14085, 10.1073/pnas.97.26.14085

2003, The fragile X mental retardation protein is required for type-I metabotropic glutamate receptor-dependent translation of PSD-95., Proc Natl Acad Sci U S A, 100, 14374, 10.1073/pnas.2336265100

1999, Targeted mRNA degradation by double-stranded RNA in vitro., Genes Dev, 13, 3191, 10.1101/gad.13.24.3191

2004, The C. elegans microRNA let-7 binds to imperfect let-7 complementary sites from the lin-41 3′UTR., Genes Dev, 18, 132, 10.1101/gad.1165404

2003, Identification of mRNAs associated with alphaCP2-containing RNP complexes., Mol Cell Biol, 23, 7055, 10.1128/MCB.23.19.7055-7067.2003

2001, Differential expression of Hox A5 in human colon cancer cell differentiation: A quantitative study using real-time RT-PCR., Int J Oncol, 18, 617

2004, Expression of Dlx and Lhx family homeobox genes in fetal thymus and thymocytes., Gene Expr Patterns, 4, 315, 10.1016/j.modgep.2003.10.003

2003, The Drosophila microRNA mir-14 suppresses cell death and is required for normal fat metabolism., Curr Biol, 13, 790, 10.1016/S0960-9822(03)00250-1

2003, Structure and conserved RNA binding of the PAZ domain., Nature, 426, 468

2003, Gab1, SHP-2 and other novel regulators of Ras: Targets for anticancer drug discovery?, Curr Cancer Drug Targets, 3, 177, 10.2174/1568009033481976

2004, MicroRNA-directed cleavage of HOXB8 mRNA., Science, 304, 594, 10.1126/science.1097434

2003, Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs., Genes Dev, 17, 3011, 10.1101/gad.1158803

2004, Identification of differentially expressed and developmentally regulated genes in medulloblastoma using suppression subtraction hybridization., Oncogene, 23, 3444, 10.1038/sj.onc.1207475

2000, RNAi: Double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals., Cell, 101, 25, 10.1016/S0092-8674(00)80620-0

2003, Mfold web server for nucleic acid folding and hybridization prediction., Nucleic Acids Res, 31, 3406, 10.1093/nar/gkg595