Neural Development
SCIE-ISI SCOPUS (2006-2024)
1749-8104
Cơ quản chủ quản: BioMed Central Ltd. , BMC
Lĩnh vực:
Developmental Neuroscience
Phân tích ảnh hưởng
Các bài báo tiêu biểu
Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1
Tập 3 Số 1 - 2008
Abstract Background β-Amyloid precursor protein (APP) has been reported to play
a role in the outgrowth of neurites from cultured neurons. Both cell-surface APP
and its soluble, ectodomain cleavage product (APPs-α) have been implicated in
regulating the length and branching of neurites in a variety of assays, but the
mechanism by which APP performs this function is not understood. Results Here,
we...
Context-dependent functions of specific microRNAs in neuronal development
Tập 5 Số 1 - Trang 25 - 2010
Sp8 exhibits reciprocal induction with Fgf8 but has an opposing effect on anterior-posterior cortical area patterning
Tập 2 Số 1 - 2007
Abstract Telencephalic patterning centers, defined by the discrete expression
domains of distinct morphogens, Fgf s in the commissural plate (CoP), Wnt s and
Bmp s in the cortical hem, and a ventral domain of Sonic hedgehog (Shh), are
postulated to establish during development the initial patterning of the
telencepahlon, including the neocortex. We show that the expression patterns of
Sp5, Sp8, an...
Glypican-1 controls brain size through regulation of fibroblast growth factor signaling in early neurogenesis
- 2009
AbstractBackgroundCell surface heparan sulfate proteoglycans (HSPGs) act as
co-receptors for multiple families of growth factors that regulate animal cell
proliferation, differentiation and patterning. Elimination of heparan sulfate
during brain development is known to produce severe structural abnormalities.
Here we investigate the developmental role played by one particular HSPG,
glypican-1 (Gpc...
Meningeal cells and glia establish a permissive environment for axon regeneration after spinal cord injury in newts
- 2011
Abstract Background Newts have the remarkable ability to regenerate their spinal
cords as adults. Their spinal cords regenerate with the regenerating tail after
tail amputation, as well as after a gap-inducing spinal cord injury (SCI), such
as a complete transection. While most studies on newt spinal cord regeneration
have focused on events occurring after tail amputation, less attention has been
...
Semaphorin-6A controls guidance of corticospinal tract axons at multiple choice points
- 2008
Abstract Background The trajectory of corticospinal tract (CST) axons from
cortex to spinal cord involves a succession of choice points, each of which is
controlled by multiple guidance molecules. To assess the involvement of
transmembrane semaphorins and their plexin receptors in the guidance of CST
axons, we have examined this tract in mutants of Semaphorin-6A (Sema6A),
Plexin-A2 (PlxnA2) and Pl...
DFsn collaborates with Highwire to down-regulate the Wallenda/DLK kinase and restrain synaptic terminal growth
Tập 2 - Trang 1-15 - 2007
The growth of new synapses shapes the initial formation and subsequent
rearrangement of neural circuitry. Genetic studies have demonstrated that the
ubiquitin ligase Highwire restrains synaptic terminal growth by down-regulating
the MAP kinase kinase kinase Wallenda/dual leucine zipper kinase (DLK). To
investigate the mechanism of Highwire action, we have identified DFsn as a
binding partner of Hi...
Developmental patterning of glutamatergic synapses onto retinal ganglion cells
- 2008
AbstractBackgroundNeurons receive excitatory synaptic inputs that are
distributed across their dendritic arbors at densities and with spatial patterns
that influence their output. How specific synaptic distributions are attained
during development is not well understood. The distribution of glutamatergic
inputs across the dendritic arbors of mammalian retinal ganglion cells (RGCs)
has long been co...
Brain asymmetry is encoded at the level of axon terminal morphology
- 2008
Abstract Background Functional lateralization is a conserved feature of the
central nervous system (CNS). However, underlying left-right asymmetries within
neural circuitry and the mechanisms by which they develop are poorly described.
Results In this study, we use focal electroporation to examine the morphology
and connectivity of individual neurons of the lateralized habenular nuclei.
Habenular ...
Spinal cord regeneration in Xenopus tadpoles proceeds through activation of Sox2-positive cells
- 2012
Abstract Background In contrast to mammals, amphibians, such as adult urodeles
(for example, newts) and anuran larvae (for example, Xenopus) can regenerate
their spinal cord after injury. However, the cellular and molecular mechanisms
involved in this process are still poorly understood. Results Here, we report
that tail amputation results in a global increase of Sox2 levels and
proliferation of S...