Neural Development

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Amplification of neural stem cell proliferation by intermediate progenitor cells in Drosophila brain development
Neural Development - Tập 3 - Trang 1-18 - 2008
Bruno C Bello, Natalya Izergina, Emmanuel Caussinus, Heinrich Reichert
In the mammalian brain, neural stem cells divide asymmetrically and often amplify the number of progeny they generate via symmetrically dividing intermediate progenitors. Here we investigate whether specific neural stem cell-like neuroblasts in the brain of Drosophila might also amplify neuronal proliferation by generating symmetrically dividing intermediate progenitors. Cell lineage-tracing and g... hiện toàn bộ
Axon-Schwann cell interactions during peripheral nerve regeneration in zebrafish larvae
Neural Development - Tập 9 Số 1 - 2014
María Laura Ceci, Camila Mardones-Krsulovic, Mario Sánchez, Leonardo E Valdivia, Miguel L. Allende
Electroporation-based methods for in vivo, whole mount and primary culture analysis of zebrafish brain development
Neural Development - Tập 2 - Trang 1-11 - 2007
Michael Hendricks, Suresh Jesuthasan
Electroporation is a technique for the introduction of nucleic acids and other macromolecules into cells. In chick embryos it has been a particularly powerful technique for the spatial and temporal control of gene expression in developmental studies. Electroporation methods have also been reported for Xenopus, zebrafish, and mouse. We present a new protocol for zebrafish brain electroporation. Usi... hiện toàn bộ
DFsn collaborates with Highwire to down-regulate the Wallenda/DLK kinase and restrain synaptic terminal growth
Neural Development - Tập 2 - Trang 1-15 - 2007
Chunlai Wu, Richard W Daniels, Aaron DiAntonio
The growth of new synapses shapes the initial formation and subsequent rearrangement of neural circuitry. Genetic studies have demonstrated that the ubiquitin ligase Highwire restrains synaptic terminal growth by down-regulating the MAP kinase kinase kinase Wallenda/dual leucine zipper kinase (DLK). To investigate the mechanism of Highwire action, we have identified DFsn as a binding partner of Hi... hiện toàn bộ
Pharmacological manipulation of GABA-driven activity in ovo disrupts the development of dendritic morphology but not the maturation of spinal cord network activity
Neural Development - Tập 5 - Trang 1-17 - 2010
Yone J Yoon, Alexander P Gokin, Miguel Martin-Caraballo
In the adult nervous system, GABA acts as a major inhibitory neurotransmitter; however, at early stages of neurodevelopment, GABA receptor activation leads to membrane depolarization and accumulation of [Ca2+]i. The role of excitatory GABAergic neurotransmission in the development of the nervous system is not fully understood. In this study, we investigated the role of excitatory GABA-driven activ... hiện toàn bộ
Meningeal defects alter the tangential migration of cortical interneurons in Foxc1hith/hith mice
Neural Development - - 2012
Konstantinos Zarbalis, Youngshik Choe, Julie A. Siegenthaler, Lori Orosco, Samuel J. Pleasure
Olfactory discrimination largely persists in mice with defects in odorant receptor expression and axon guidance
Neural Development - Tập 7 - Trang 1-14 - 2012
Thomas K Knott, Pasil A Madany, Ashley A Faden, Mei Xu, Jörg Strotmann, Timothy R Henion, Gerald A Schwarting
The defining feature of the main olfactory system in mice is that each olfactory sensory neuron expresses only one of more than a thousand different odorant receptor genes. Axons expressing the same odorant receptor converge onto a small number of targets in the olfactory bulb such that each glomerulus is made up of axon terminals expressing just one odorant receptor. It is thought that this preci... hiện toàn bộ
In vivo functional analysis of Drosophila Robo1 immunoglobulin-like domains
Neural Development - - 2016
Marie C. Reichert, Haley E. Brown, Tony Evans
FGF signaling controls Shh-dependent oligodendroglial fate specification in the ventral spinal cord
Neural Development - Tập 13 - Trang 1-19 - 2018
Marie-Amélie Farreny, Eric Agius, Sophie Bel-Vialar, Nathalie Escalas, Nagham Khouri-Farah, Chadi Soukkarieh, Cathy Danesin, Fabienne Pituello, Philippe Cochard, Cathy Soula
Most oligodendrocytes of the spinal cord originate from ventral progenitor cells of the pMN domain, characterized by expression of the transcription factor Olig2. A minority of oligodendrocytes is also recognized to emerge from dorsal progenitors during fetal development. The prevailing view is that generation of ventral oligodendrocytes depends on Sonic hedgehog (Shh) while dorsal oligodendrocyte... hiện toàn bộ
Lrig1 expression identifies quiescent stem cells in the ventricular-subventricular zone from postnatal development to adulthood and limits their persistent hyperproliferation
Neural Development - Tập 18 - Trang 1-18 - 2023
Hyung-song Nam, Mario R. Capecchi
We previously identified Leucine-rich repeats and immunoglobulin-like domains 1 (Lrig1) as a marker of long-term neurogenic stem cells in the lateral wall of the adult mouse brain. The morphology of the stem cells thus identified differed from the canonical B1 type stem cells, raising a question about their cellular origin. Thus, we investigated the development of these stem cells in the postnatal... hiện toàn bộ
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