Tcf7L2 is essential for neurogenesis in the developing mouse neocortexNeural Development - Tập 13 - Trang 1-10 - 2018
Olga Chodelkova, Jan Masek, Vladimir Korinek, Zbynek Kozmik, Ondrej Machon
Generation of neurons in the embryonic neocortex is a balanced process of proliferation and differentiation of neuronal progenitor cells. Canonical Wnt signalling is crucial for expansion of radial glial cells in the ventricular zone and for differentiation of intermediate progenitors in the subventricular zone. We detected abundant expression of two transcrtiption factors mediating canonical Wnt ...... hiện toàn bộ
Eph/Ephrin Signaling Controls Progenitor Identities In The Ventral Spinal CordNeural Development - Tập 12 - Trang 1-11 - 2017
Julien Laussu, Christophe Audouard, Anthony Kischel, Poincyane Assis-Nascimento, Nathalie Escalas, Daniel J. Liebl, Cathy Soula, Alice Davy
In the vertebrate spinal cord, motor neurons (MN) are generated in stereotypical numbers from a pool of dedicated progenitors (pMN) whose number depends on signals that control their specification but also their proliferation and differentiation rates. Although the initial steps of pMN specification have been extensively studied, how pMN numbers are regulated over time is less well characterized. ...... hiện toàn bộ
Linking neuronal lineage and wiring specificityNeural Development - Tập 13 - Trang 1-19 - 2018
Hongjie Li, S. Andrew Shuster, Jiefu Li, Liqun Luo
Brain function requires precise neural circuit assembly during development. Establishing a functional circuit involves multiple coordinated steps ranging from neural cell fate specification to proper matching between pre- and post-synaptic partners. How neuronal lineage and birth timing influence wiring specificity remains an open question. Recent findings suggest that the relationships between li...... hiện toàn bộ
Midline crossing is not required for subsequent pathfinding decisions in commissural neuronsNeural Development - Tập 7 - Trang 1-13 - 2012
Jennifer Bonner, Michael Letko, Oliver Brant Nikolaus, Lisa Krug, Alexandria Cooper, Benjamin Chadwick, Phoebe Conklin, Amy Lim, Chi-Bin Chien, Richard I Dorsky
Growth cone navigation across the vertebrate midline is critical in the establishment of nervous system connectivity. While midline crossing is achieved through coordinated signaling of attractive and repulsive cues, this has never been demonstrated at the single cell level. Further, though growth cone responsiveness to guidance cues changes after crossing the midline, it is unclear whether midlin...... hiện toàn bộ
Development, functional organization, and evolution of vertebrate axial motor circuitsNeural Development - Tập 13 - Trang 1-12 - 2018
Kristen P. D’Elia, Jeremy S. Dasen
Neuronal control of muscles associated with the central body axis is an ancient and essential function of the nervous systems of most animal species. Throughout the course of vertebrate evolution, motor circuits dedicated to control of axial muscle have undergone significant changes in their roles within the motor system. In most fish species, axial circuits are critical for coordinating muscle ac...... hiện toàn bộ