Neonatology
SCIE-ISI SCOPUS (1959-1997,2007-2025)
1661-7800
1661-7819
Thụy Sĩ
Cơ quản chủ quản: S. Karger AG , KARGER
Lĩnh vực:
Developmental BiologyPediatrics, Perinatology and Child Health
Các bài báo tiêu biểu
Can Adverse Neonatal Experiences Alter Brain Development and Subsequent Behavior?
Tập 77 Số 2 - Trang 69-82 - 2000
Self-destructive behavior in current society promotes a search for
psychobiological factors underlying this epidemic. Perinatal brain plasticity
increases the vulnerability to early adverse experiences, thus leading to
abnormal development and behavior. Although several epidemiological
investigations have correlated perinatal and neonatal complications with
abnormal adult behavior, our understandi...
Clinical Importance of Pain and Stress in Preterm Neonates
Tập 73 Số 1 - Trang 1-9 - 1998
Clinical and laboratory investigations of neonatal pain suggest that preterm
neonates have an increased sensitivity to pain and that acute painful stimuli
lead to the development of prolonged periods of hyperalgesia. Non-noxious
stimuli during these periods of hyperalgesia may expose preterm neonates to
established or chronic pain. Acute physiologic changes caused by painful or
stressful stimuli c...
Development of the Epidermis in the Newborn
Tập 49 Số 2 - Trang 74-80 - 1986
Histological development of the epidermis was studied on skin samples from 169
infants (gestation 24–40 weeks, age up to 1 year). Gestation markedly influenced
epidermal development. Before 30 weeks, the epidermis is thin, has few cell
layers and a poorly formed stratum corneum, but by 34 weeks it has largely
matured. Postnatal influence on epidermal development is marked in the preterm
infant, so...
The Biology of Erythropoietin in the Central Nervous System and Its Neurotrophic and Neuroprotective Potential
Tập 79 Số 3-4 - Trang 228-235 - 2001
This review summarizes published as well as preliminary data on the biology of
erythropoietin (Epo) in the developing and mature human central nervous system
(CNS). Both Epo receptor (Epo-R) and Epo gene expression underlie developmental
changes and a brain-specific regulation. These features suggest a different role
of Epo in normal brain development than in neuroprotection and neuronal tissue
re...
Hair Cortisol as a Potential Biologic Marker of Chronic Stress in Hospitalized Neonates
Tập 92 Số 1 - Trang 42-49 - 2007
Background: As preterm and term infants in the neonatal intensive care
unit (NICU) undergo multiple stressful/painful procedures, research is required
that addresses chronic stress. Objectives: To determine whether (a) hair
cortisol levels differed between term and preterm infants exposed to stress in
the NICU and (b) an association exists between hair cortisol levels and severity
of...
Neurodevelopmental Outcome of Extremely Low Birth Weight Infants from the Vermont Oxford Network: 1998–2003
Tập 97 Số 4 - Trang 329-338 - 2010
Background: Physicians and parents face significant uncertainties when
making care decisions for extremely low birth weight (ELBW) infants. Many
published estimates of death and developmental outcome are from well-funded
university programs and may not reflect outcomes of infants from a variety of
settings. The best estimates of the probabilities of death and severe disability
combine local...
Inflammatory Mediators and Neonatal Brain Damage
Tập 79 Số 3-4 - Trang 224-227 - 2001
Inflammatory mediators are multifunctional cytokines that play important roles
both in normal central nervous system (CNS) development and in the response of
the brain to diverse forms of injury. Interleukin (IL)-1β, tumor necrosis
factor-α and IL-6 are among the best-characterized early-response cytokines.
Recent data suggest that they may be synthesized and secreted by several CNS
cell types, in...
Hypoxia-Ischemia in the Neonatal Rat Brain: Histopathology after Post-Treatment with NMDA and Non NMDA Receptor Antagonists
Tập 66 Số 4 - Trang 205-213 - 1994
In a model of perinatal hypoxic-ischemic brain damage, we examined the
neuroprotective efficacy of posttreatment with the NMDA receptor antagonist
MK-801 and the AMPA receptor antagonist NBQX. Unilateral brain damage developed
in 95% of rat pups subjected to hypoxia-ischemia with a 27.8 ± 1.2% weight
deficit of the damaged hemisphere. MK-801 in doses of 0.3 and 0.5 mg/kg i.p.
reduced the brain dam...
Erythropoietin Concentrations in Cerebrospinal Fluid of Nonhuman Primates and Fetal Sheep following High-Dose Recombinant Erythropoietin
Tập 85 Số 2 - Trang 138-144 - 2004
Erythropoietin (Epo) decreases neuronal injury and cell death in vitro and in
vivo. To lay the groundwork for use of Epo as a potential therapy for brain
injury, we tested the hypothesis that systemic dosing of high-dose recombinant
Epo (rEpo) would result in neuroprotective rEpo concentrations in the spinal
fluid of adult and developing animals. This report characterizes the
pharmacokinetics of h...
Tác Động Của Áp Lực Dương Liên Tục Đến Cơ Chế Phổi Và Thể Tích Phổi Ở Trẻ Sơ Sinh Dịch bởi AI
Tập 29 Số 3-4 - Trang 178-186 - 1976
Chúng tôi đã nghiên cứu tác động của áp lực dương liên tục (CPAP) đến cơ chế
phổi và thể tích khí trong lồng ngực ở 15 lần quan sát trên 12 trẻ sơ sinh khỏe
mạnh. Như dự đoán, thể tích khí trong lồng ngực tăng lên và tổng kháng trở phổi
giảm. Độ co giãn động giảm xuống trong tất cả các lần quan sát. 43% áp lực được
áp dụng đã được truyền qua các cấu trúc trung thất.