The Biology of Erythropoietin in the Central Nervous System and Its Neurotrophic and Neuroprotective Potential

Neonatology - Tập 79 Số 3-4 - Trang 228-235 - 2001
Christof Dame1, Sandra E. Juul, Robert D. Christensen
1Division of Neonatology, Department of Pediatrics, University of Florida, Gainesville 32610-0296, USA.

Tóm tắt

This review summarizes published as well as preliminary data on the biology of erythropoietin (Epo) in the developing and mature human central nervous system (CNS). Both Epo receptor (Epo-R) and Epo gene expression underlie developmental changes and a brain-specific regulation. These features suggest a different role of Epo in normal brain development than in neuroprotection and neuronal tissue repair after brain injury. Epo concentrations in the cerebrospinal fluid may have primary paracrine effects. While the transport of Epo across the intact blood brain barrier (BBB) is generally limited in humans, systemically produced or administrated Epo may cross during BBB dysfunction. Summarized data of the in vivo and in vitro effects of Epo in the CNS show significant neuroprotective and neurotrophic effects of this molecule. These effects are mediated by several mechanisms, including the activation of a variety of genes and their consecutive protein production. Therapeutic strategies involving activation of the CNS Epo-R are discussed, including the potential use of Epo mimetic peptides.

Từ khóa


Tài liệu tham khảo

10.1002/(SICI)1097-4652(199606)167:3<461::AID-JCP10>3.0.CO;2-7

10.1074/jbc.272.51.32395

10.1016/0736-5748(94)00020-4

10.1016/0006-8993(93)90850-M

10.1007/s100249900103

10.1073/pnas.97.19.10526

10.1016/S0169-328X(00)00157-1

10.1006/dbio.1994.1304

10.1073/pnas.95.8.4635

10.1016/S0165-3806(00)00118-8

10.1002/(SICI)1098-1136(200005)30:3<271::AID-GLIA6>3.0.CO;2-H

10.1016/S0014-2999(00)00691-9

10.1016/S0014-2999(00)00081-9

10.1046/j.1471-4159.1999.0722565.x

10.1016/S0304-3940(00)01361-6

10.1074/jbc.274.32.22165

10.1016/S0898-6568(99)00063-7

10.1097/00004647-199906000-00007

Thông tin
Thông tin xuất bản

Neonatology

Tập 79 Số 3-4

228-235

Thông tin tác giả