Hair Cortisol as a Potential Biologic Marker of Chronic Stress in Hospitalized Neonates

Neonatology - Tập 92 Số 1 - Trang 42-49 - 2007
J. Yamada1, Bonnie Stevens2, Nicole de Silva1, Sharyn Gibbins3, Martin Offringa1, Anna Taddio1, Christine Newman4, Gideon Koren1
1Research Institute
2Faculties of Nursing and Medicine, University of Toronto,
3Sunnybrook & Women’s College Health Sciences Centre, and
4Clinical Pharmacology and Toxicology, The Hospital for Sick Children (SickKids), Toronto, Ont., Canada

Tóm tắt

<i>Background:</i> As preterm and term infants in the neonatal intensive care unit (NICU) undergo multiple stressful/painful procedures, research is required that addresses chronic stress. <i>Objectives:</i> To determine whether (a) hair cortisol levels differed between term and preterm infants exposed to stress in the NICU and (b) an association exists between hair cortisol levels and severity of illness or indicators of acute stress. <i>Methods:</i> Hair cortisol levels were determined using the ELISA method (solid-phase enzyme-linked immunoassay, Alpco Diagnostics, Windham, N.H., USA) in 60 infants >25 weeks gestational age at birth. <i>Results:</i> No significant differences were found between the hair cortisol levels of term infants compared to preterm infants in the NICU. When compared to a group of healthy term infants, hospitalized infants had significantly higher hair cortisol levels (t (76) = 2.755, p = 0.004). A subgroup analysis of the term NICU infants showed a statistically significant association between total number of ventilator days and hair cortisol levels. For every extra day on the ventilator, hair cortisol levels increased on average by 0.2 nmol/g (p = 0.03). 21% of the variance in hair cortisol levels was explained by the total number of days on the ventilator. <i>Conclusions:</i> Hair cortisol is influenced by days of ventilation in NICU term infants. This is a potentially valid outcome for chronic neonatal stress in these infants and warrants further investigation.

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10.2165%2F00148581-200507040-00004

10.1016%2FS0304-3959%2803%2900136-2

10.1016%2FS0140-6736%2894%2991279-3

10.1016%2FS0022-3476%2888%2980126-4

10.1016%2FS0095-5108%2802%2900014-3

10.1159%2F000183798

10.1055%2Fs-2007-994127

10.3109%2F01460869709028262

10.1016%2FS0379-0738%2899%2900180-2

10.1016%2FS0378-4347%2899%2900059-6

10.1016%2Fj.adnc.2003.09.005

10.1016%2Fj.ygcen.2006.01.005

10.2307%2F2685389

10.1016%2Fj.clinbiochem.2004.02.010

10.1097%2F00006199-199901000-00006

10.1097%2F00006199-200211000-00005

10.1097%2F00003246-197403000-00001

10.1067%2Fmpd.2001.109608

10.1016%2FS0960-0760%2898%2900120-4

10.1016%2Fj.adnc.2005.02.010

10.1016%2Fj.pain.2004.10.020

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Neonatology

Tập 92 Số 1

42-49

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