Movement Disorders
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Clinical symptoms and possible anticipation in a large kindred of familial restless legs syndromeAbstract Idiopathic restless legs syndrome (RLS) frequently follows an autosomal dominant inheritance with a variable clinical expressivity of symptoms. We describe the largest German kindred of familial RLS with 20 affected and investigated members in four generations with a variety of clinical symptoms. Patients were examined clinically, and polysomnography was pe... ...
Movement Disorders - Tập 11 Số 4 - Trang 389-394 - 1996
Low brain iron content in idiopathic restless legs syndrome patients detected by phase imagingABSTRACT Background The objective of this study was to use phase imaging to evaluate brain iron content in patients with idiopathic restless legs syndrome (RLS). Methods Fifteen RLS patients and 15 healthy controls were studied using gradient‐echo imaging. Phase analysis w...
Movement Disorders - Tập 28 Số 13 - Trang 1886-1890 - 2013
Systematic review of severity scales and screening instruments for tics: Critique and recommendationsABSTRACT Background : Several clinician, informant, and self‐report instruments for tics and associated phenomena have been developed that differ in construct, comprehensiveness, and ease of administration.Objective : A Movement Disorders Society subcommittee aimed to rate psychometric quality of severity ...
Movement Disorders - Tập 32 Số 3 - Trang 467-473 - 2017
Restless legs in Tourette syndromeAbstract Restless legs syndrome (RLS) and Tourette's syndrome (TS) share some common features, including the phenomenology of sensations relieved by movements, but few studies have examined the links between RLS and TS. We examined RLS and other TS comorbidities in 144 probands with TS or chronic tics and their parents. RLS was present in 10% of probands and 23% of ... ...
Movement Disorders - Tập 19 Số 9 - Trang 1084-1087 - 2004
Premonitory sensory phenomenon in Tourette's syndromeAbstract We administered a questionnaire designed to probe for premonitory sensations associated with motor tics to 50 patients with Tourette's syndrome (TS). Premonitory sensations were reported by 46 (92%) patients, and the most common sensation was an urge to move and an impulse to tic (“had to do it”). Intensification of premonitory sensations, if prevented from... ...
Movement Disorders - Tập 18 Số 12 - Trang 1530-1533 - 2003
Tics and Tourette syndrome — surplus of actions rather than disorder?
Movement Disorders - Tập 33 Số 2 - Trang 238-242 - 2018
Deficits in rapid adjustments of movements according to task constraints in Parkinson's diseaseAbstract The role of the basal ganglia in the adaptive control of movement was investigated by unexpectedly perturbing movements in 8 patients with Parkinson's disease (PD) tested off medication and in 6 aged‐matched healthy subjects. Subjects performed two movement components simultaneously and without visual feedback: touching the nose with the finger while leanin... ...
Movement Disorders - Tập 19 Số 8 - Trang 897-906 - 2004
Kappa‐opioid receptor agonists increase locomotor activity in the monoamine‐depleted rat model of parkinsonismAbstract Excessive glutamate transmission in the basal ganglia is a major factor in the neural mechanisms underlying parkinsonian akinesia. Activation of K opioid receptors causes a presynaptic reduction in glutamate release. K opioid receptors are concentrated in those regions of the basal ganglia associated with increased glut... ...
Movement Disorders - Tập 13 Số 2 - Trang 228-233 - 1998
Amantadine reduces levodopa‐induced dyskinesias in parkinsonian monkeysAbstract The antidyskinetic potential of the glutamate NMDA receptor channel blocker amantadine was evaluated in four levodopa‐primed parkinsonian monkeys using two different regimens (1.25 or 2.5 mg/kg administered subcutaneously twice daily for 3–6 days). When administered with a relatively low dose of levodopa, amantadine produced a near‐total suppression of chor... ...
Movement Disorders - Tập 13 Số 5 - Trang 798-802 - 1998
Prevalence and Incidence of Huntington's Disease: An Updated Systematic Review and Meta‐AnalysisABSTRACT The incidence and prevalence of Huntington's disease (HD) based on a systematic review and meta‐analysis of 20 studies published from 1985 to 2010 was estimated at 0.38 per 100,000 person‐years (95% confidence interval [CI], 0.16–0.94) and 2.71 per 100,000 persons (95% CI, 1.55–4.72), respectively. Since 2010, there have been many new epidemiological studie... ...
Movement Disorders - Tập 37 Số 12 - Trang 2327-2335 - 2022
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