Visual Sensory Processing is Altered in Myoclonus Dystonia

Movement Disorders - Tập 35 Số 1 - Trang 151-160 - 2020
Alexandre Carpentier1,2,3, Nicolas Wattiez4, Cécile Delorme1,3, Eavan McGovern1,5, Vanessa Brochard6, Stéphane Thobois7, Christine Tranchant8, David Grabli1,3, Bertrand Degos9, Jean‐Christophe Corvol1, Jean-Michel Pédespan10, Pierre Krystkoviak11, Jean‐Luc Houéto12, Adrian Degardin13, Luc Defebvre14, Romain Valabrègue15,3, Marie Vidailhet1,3, Pierre Pouget3, Emmanuel Roze1,3, Yulia Worbe16,3
1Assistance Publique‐Hôpitaux de Paris, Centre d'Investigation Clinique Neurosciences, Hôpital Pitié‐Salpêtrière, Paris, France; Department of Neurology Groupe Hospitalier Pitié‐Salpêtrière Paris France
2Department of Neurology CHU Côte de Nacre, Université Caen Normandie Caen France
3Sorbonne Université Paris, France; Inserm U1127, CNRS UMR 7225, UM 75, ICM Paris France
4Sorbonne Université, inserm, UMRS1158 neurophysiologie respiratoire expérimentale et clinique, Paris, France
5Department of Neurology St Vincent's University Hospital Dublin Dublin Ireland
6Centre d'Investigation Clinique 1422, INSERM/APHP, Paris, France
7University of Lyon, Institut des Sciences Cognitives Marc Jeannerod, CNRS, UMR 5229, Bron, France; Hospices Civils de Lyon, Hôpital Neurologique Pierre Wertheimer, Service de Neurologie C Bron France
8Service de Neurologie Hôpitaux Universitaires de Strasbourg, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), INSERM‐U964/CNRS‐UMR7104/Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg Strasbourg France
9Assistance Publique‐Hôpitaux de Paris, Department of Neurology Hôpital Avicennes Bobigny France
10Unité de Neuropédiatrie, CHU Pellegrin Bordeaux France
11Department of Neurology, Amiens University Medical Center, Amiens, France
12Service de Neurologie, CIC-INSERM 1402, CHU de Poitiers, Poitiers, France
13Department of Neurology, Centre hospitalier de Tourcoing, Tourcoing, France
14Université de Lille, CHU Lille, INSERM, U1171–Degenerative & Vascular Cognitive Disorders, Lille, France; Lille Centre of Excellence for Neurodegenerative Diseases (LiCEND) Lille France
15Centre de NeuroImagerie de Recherche (CENIR) Sorbonne Université, UMR S 975, CNRS UMR 7225, ICM Paris France
16Department of Neurophysiology Saint‐Antoine Hospital, Assistance Publique‐Hôpitaux de Paris Paris France

Tóm tắt

ABSTRACTBackgroundAbnormal sensory processing, including temporal discrimination threshold, has been described in various dystonic syndromes.ObjectiveTo investigate visual sensory processing in DYT‐SGCE and identify its structural correlates.MethodsDYT‐SGCE patients without DBS (DYT‐SGCE‐non‐DBS) and with DBS (DYT‐SGCE‐DBS) were compared to healthy volunteers in three tasks: a temporal discrimination threshold, a movement orientation discrimination, and movement speed discrimination. Response times attributed to accumulation of sensory visual information were computationally modelized, with μ parameter indicating sensory mean growth rate. We also identified the structural correlates of behavioral performance for temporal discrimination threshold.ResultsTwenty‐four DYT‐SGCE‐non‐DBS, 13 DYT‐SGCE‐DBS, and 25 healthy volunteers were included in the study. In DYT‐SGCE‐DBS, the discrimination threshold was higher in the temporal discrimination threshold (P = 0.024), with no difference among the groups in other tasks. The sensory mean growth rate (μ) was lower in DYT‐SGCE in all three tasks (P < 0.01), reflecting a slower rate of sensory accumulation for the visual information in these patients independent of DBS. Structural imaging analysis showed a thicker left primary visual cortex (P = 0.001) in DYT‐SGCE‐non‐DBS compared to healthy volunteers, which also correlated with lower μ in temporal discrimination threshold (P = 0.029). In DYT‐SGCE‐non‐DBS, myoclonus severity also correlated with a lower μ in the temporal discrimination threshold task (P = 0.048) and with thicker V1 on the left (P = 0.022).ConclusionIn DYT‐SGCE, we showed an alteration of the visual sensory processing in the temporal discrimination threshold that correlated with myoclonus severity and structural changes in the primary visual cortex. © 2019 International Parkinson and Movement Disorder Society

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Movement Disorders

Tập 35 Số 1

151-160

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