Association and Familial Coaggregation of Idiopathic Dystonia With Psychiatric Outcomes

Movement Disorders - Tập 35 Số 12 - Trang 2270-2278 - 2020
Davide Martino1, Gustaf Brander2,3,4, Per Svenningsson5,4, Henrik Larsson6,7, Lorena Fernández de la Cruz2,4
1Department of Clinical Neurosciences and Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada
2Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
3Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
4Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden
5Neuro Division, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
6Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
7School of Medical Sciences, Örebro University, Örebro, Sweden

Tóm tắt

AbstractBackgroundPsychiatric comorbidities are common and major determinants of quality of life in idiopathic dystonia. Their prevalence estimates from service‐based studies are heterogeneous.ObjectiveWe explored the association between idiopathic dystonia and depressive disorders, anxiety disorders, suicide attempts, and death by suicide using Swedish population‐based registers.MethodsDiagnoses of idiopathic dystonia and psychiatric outcomes from inpatient and outpatient specialist services (1997–2013) were collected from the National Patient Register and the Cause of Death Register. Familial associations were explored using the Multi‐Generation Register. Adjusted logistic regression analyses measured associations with psychiatric disorders in individuals with dystonia compared with general population individuals and their unaffected siblings, as well as in full siblings of individuals with dystonia compared with full siblings of unaffected individuals.ResultsIndividuals with dystonia were more likely than those without to have a diagnosis of depressive disorder (adjusted odds ratio = 2.00, 95% confidence interval: 1.77–2.26), anxiety disorder (adjusted odds ratio = 2.13, 95% confidence interval: 1.90–2.39), and suicide attempts/death by suicide combined (adjusted odds ratio = 1.80, 95% confidence interval: 1.50–2.17), with odds higher in most idiopathic dystonia forms. In the full sibling comparison, estimates followed the same pattern, with overall attenuated magnitude. Full siblings of individuals with dystonia had higher likelihood of depressive or anxiety disorders and suicide attempts/death by suicide combined compared with siblings of individuals without dystonia.ConclusionsDifferent forms of idiopathic dystonia confirm its association with increased risk for depressive and anxiety disorders and suicide attempts. Familial coaggregation of dystonia and these psychiatric comorbidities supports shared genetic and extragenetic factors. © 2020 International Parkinson and Movement Disorder Society

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Movement Disorders

Tập 35 Số 12

2270-2278

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