Valerie Voon1,2, Tracy R. Butler2, Vindhya Ekanayake2, Cécile Gallea2, Rezvan Ameli3, Dennis L. Murphy3, Mark Hallett2
1Behavioral and Clinical Neurosciences Institute, University of Cambridge, Cambridge, UK
2National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
3National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
Tóm tắt
AbstractMyoclonus dystonia and idiopathic dystonia are associated with a greater frequency of obsessive compulsive disorder (OCD) and major depression. We investigated the frequency of OCD in 39 patients with primary focal hand dystonia (FHD) using a semistructured interview. OCD and subsyndromal OCD was diagnosed in 5 of 39 (12.82%) patients with FHD, whereas OCD occurs in 2.3% of the general population. Recurrent depression occurred in (7 of 39) 17.95% of patients with FHD along with a family history of depression in (16 of 39) 41.02%. Overlapping mechanisms manifesting as FHD may also predispose to OC symptoms and likely implicates a common striatal dysfunction. © 2010 Movement Disorder Society
