Molecular Pain

Công bố khoa học tiêu biểu

* Dữ liệu chỉ mang tính chất tham khảo

Sắp xếp:  
Resveratrol inhibits Cdk5 activity through regulation of p35 expression
Molecular Pain - Tập 7 - Trang 1-14 - 2011
Elias Utreras, Anita Terse, Jason Keller, Michael J Iadarola, Ashok B Kulkarni
We have previously reported that cyclin-dependent kinase 5 (Cdk5) participates in the regulation of nociceptive signaling. Through activation of the ERK1/2 pathway, Tumor Necrosis Factor-α (TNF-α) induces expression of Egr-1. This results in the sustained and robust expression of p35, a coactivator of Cdk5, in PC12 cells, thereby increasing Cdk5 kinase activity. The aim of our present study was to...... hiện toàn bộ
Formalin Injection Causes a Coordinated Spinal Cord CO/NO-cGMP Signaling System Response
Molecular Pain - Tập 1 - Trang 1744-8069-1-33 - 2005
Xiaoshuang Shi, Xiangqi Li, J. David Clark
Background:The CO/NO-cGMP signalling system participates in the regulation of many physiological processes. The roles this system plays in spinal cord nociceptive signalling are particularly important. While individual components have been examined in isolation, little study has been dedicated to understanding the regulation and functioning of the system ...... hiện toàn bộ
Sphingosine 1-phosphate to p38 signaling via S1P1 receptor and Gαi/o evokes augmentation of capsaicin-induced ionic currents in mouse sensory neurons
Molecular Pain - Tập 10 - Trang 1-10 - 2014
Michiel Langeslag, Serena Quarta, Michael G Leitner, Michaela Kress, Norbert Mair
The perception of painful thermal stimuli by sensory neurons is largely mediated by TRPV1. Upon tissue injury or inflammation, S1P is secreted by thrombocytes as part of an inflammatory cocktail, which sensitizes nociceptive neurons towards thermal stimuli. S1P acts on G-protein coupled receptors that are expressed in sensory neurons and sensitize TRPV1 channels towards thermal stimuli. In this st...... hiện toàn bộ
Descending serotonergic facilitation and the antinociceptive effects of pregabalin in a rat model of osteoarthritic pain
Molecular Pain - Tập 5 - Trang 1-17 - 2009
Wahida Rahman, Claudia S Bauer, Kirsty Bannister, Jean-Laurent Vonsy, Annette C Dolphin, Anthony H Dickenson
Descending facilitation, from the brainstem, promotes spinal neuronal hyperexcitability and behavioural hypersensitivity in many chronic pain states. We have previously demonstrated enhanced descending facilitation onto dorsal horn neurones in a neuropathic pain model, and shown this to enable the analgesic effectiveness of gabapentin. Here we have tested if this hypothesis applies to other pain s...... hiện toàn bộ
Short-term anesthesia inhibits formalin-induced extracellular signal-regulated kinase (ERK) activation in the rostral anterior cingulate cortex but not in the spinal cord
Molecular Pain - Tập 11 - Trang 1-6 - 2015
Keri K Tochiki, Maria Maiarù, James R C Miller, Stephen P Hunt, Sandrine M Géranton
The rostral anterior cingulate cortex (rACC) has been implicated in the negative affective response to injury, and importantly, it has been shown that activation of extracellular signal-regulated kinase (ERK) signaling in the rACC contributes to the full expression of the affective component of pain in rodents. In this study, we investigated whether administration of anesthesia at the time of inju...... hiện toàn bộ
Activation of Voltage-Gated KCNQ/Kv7 Channels by Anticonvulsant Retigabine Attenuates Mechanical Allodynia of Inflammatory Temporomandibular Joint in Rats
Molecular Pain - Tập 6 - Trang 1744-8069-6-49 - 2010
Wen Xu, Yuwei Wu, Yeping Bi, Lei Tan, Yehua Gan, KeWei Wang
Background: Temporomandibular disorders (TMDs) are characterized by persistent orofacial pain and have diverse etiologic factors that are not well understood. It is thought that central sensitization leads to neuronal hyperexcitability and contributes to hyperalgesia and spontaneous pain. Nonsteroidal anti-inflammatory drugs (NSAIDs) are currently the fir...... hiện toàn bộ
Mitogen activated protein kinase phosphatase-1 prevents the development of tactile sensitivity in a rodent model of neuropathic pain
Molecular Pain - Tập 8 - Trang 1-12 - 2012
Christian Ndong, Russell P Landry, Joyce A DeLeo, Edgar Alfonso Romero-Sandoval
Neuropathic pain due to nerve injury is one of the most difficult types of pain to treat. Following peripheral nerve injury, neuronal and glial plastic changes contribute to central sensitization and perpetuation of mechanical hypersensitivity in rodents. The mitogen activated protein kinase (MAPK) family is pivotal in this spinal cord plasticity. MAPK phosphatases (MKPs) limit inflammatory proces...... hiện toàn bộ
Dietary grape seed polyphenols repress neuron and glia activation in trigeminal ganglion and trigeminal nucleus caudalis
Molecular Pain - Tập 6 - Trang 1-12 - 2010
Ryan J Cady, Jeffery J Hirst, Paul L Durham
Inflammation and pain associated with temporomandibular joint disorder, a chronic disease that affects 15% of the adult population, involves activation of trigeminal ganglion nerves and development of peripheral and central sensitization. Natural products represent an underutilized resource in the pursuit of safe and effective ways to treat chronic inflammatory diseases. The goal of this study was...... hiện toàn bộ
Generation and Characterization of an Advillin-Cre Driver Mouse Line
Molecular Pain - - 2011
Sandra Zurborg, Agnieszka Piszczek, Conception Martínez, Philip Hublitz, Mumna Al Banchaabouchi, Pedro Moreira, Emerald Perlas, Paul A. Heppenstall
Progress in the somatosensory field has been restricted by the limited number of genetic tools available to study gene function in peripheral sensory neurons. Here we generated a Cre-driver mouse line that expresses Cre-recombinase from the locus of the sensory neuron specific gene Advillin. These mice displayed almost exclusive Cre-mediated recombination in all peripheral sensory neurons...... hiện toàn bộ
Descending controls modulate inflammatory joint pain and regulate CXC chemokine and iNOS expression in the dorsal horn
Molecular Pain - Tập 10 - Trang 1-14 - 2014
Fiona B Carr, Sandrine M Géranton, Stephen P Hunt
Descending control of nociceptive processing, by pathways originating in the rostral ventromedial medulla (RVM) and terminating in the dorsal horn, contributes to behavioural hypersensitivity in a number of pain models. Two facilitatory pathways have been identified and are characterized by serotonin (5-HT) content or expression of the mu opiate receptor. Here we investigated the contribution of t...... hiện toàn bộ
Tổng số: 538   
  • 1
  • 2
  • 3
  • 4
  • 5
  • 6
  • 10