Resveratrol inhibits Cdk5 activity through regulation of p35 expressionMolecular Pain - Tập 7 - Trang 1-14 - 2011
Elias Utreras, Anita Terse, Jason Keller, Michael J Iadarola, Ashok B Kulkarni
We have previously reported that cyclin-dependent kinase 5 (Cdk5) participates in the regulation of nociceptive signaling. Through activation of the ERK1/2 pathway, Tumor Necrosis Factor-α (TNF-α) induces expression of Egr-1. This results in the sustained and robust expression of p35, a coactivator of Cdk5, in PC12 cells, thereby increasing Cdk5 kinase activity. The aim of our present study was to...... hiện toàn bộ
Formalin Injection Causes a Coordinated Spinal Cord CO/NO-cGMP Signaling System ResponseMolecular Pain - Tập 1 - Trang 1744-8069-1-33 - 2005
Xiaoshuang Shi, Xiangqi Li, J. David Clark
Background:The CO/NO-cGMP signalling system participates in the regulation of many physiological processes. The roles this system plays in spinal cord nociceptive signalling are particularly important. While individual components have been examined in isolation, little study has been dedicated to understanding the regulation and functioning of the system ...... hiện toàn bộ
Mitogen activated protein kinase phosphatase-1 prevents the development of tactile sensitivity in a rodent model of neuropathic painMolecular Pain - Tập 8 - Trang 1-12 - 2012
Christian Ndong, Russell P Landry, Joyce A DeLeo, Edgar Alfonso Romero-Sandoval
Neuropathic pain due to nerve injury is one of the most difficult types of pain to treat. Following peripheral nerve injury, neuronal and glial plastic changes contribute to central sensitization and perpetuation of mechanical hypersensitivity in rodents. The mitogen activated protein kinase (MAPK) family is pivotal in this spinal cord plasticity. MAPK phosphatases (MKPs) limit inflammatory proces...... hiện toàn bộ
Dietary grape seed polyphenols repress neuron and glia activation in trigeminal ganglion and trigeminal nucleus caudalisMolecular Pain - Tập 6 - Trang 1-12 - 2010
Ryan J Cady, Jeffery J Hirst, Paul L Durham
Inflammation and pain associated with temporomandibular joint disorder, a chronic disease that affects 15% of the adult population, involves activation of trigeminal ganglion nerves and development of peripheral and central sensitization. Natural products represent an underutilized resource in the pursuit of safe and effective ways to treat chronic inflammatory diseases. The goal of this study was...... hiện toàn bộ
Generation and Characterization of an Advillin-Cre Driver Mouse LineMolecular Pain - - 2011
Sandra Zurborg, Agnieszka Piszczek, Conception Martínez, Philip Hublitz, Mumna Al Banchaabouchi, Pedro Moreira, Emerald Perlas, Paul A. Heppenstall
Progress in the somatosensory field has been restricted by the limited number of genetic tools available to study gene function in peripheral sensory neurons. Here we generated a Cre-driver mouse line that expresses Cre-recombinase from the locus of the sensory neuron specific gene Advillin. These mice displayed almost exclusive Cre-mediated recombination in all peripheral sensory neurons...... hiện toàn bộ
Descending controls modulate inflammatory joint pain and regulate CXC chemokine and iNOS expression in the dorsal hornMolecular Pain - Tập 10 - Trang 1-14 - 2014
Fiona B Carr, Sandrine M Géranton, Stephen P Hunt
Descending control of nociceptive processing, by pathways originating in the rostral ventromedial medulla (RVM) and terminating in the dorsal horn, contributes to behavioural hypersensitivity in a number of pain models. Two facilitatory pathways have been identified and are characterized by serotonin (5-HT) content or expression of the mu opiate receptor. Here we investigated the contribution of t...... hiện toàn bộ
Expression of the dopaminergic D1 and D2 receptors in the anterior cingulate cortex in a model of neuropathic painMolecular Pain - Tập 7 - Trang 1-10 - 2011
J Manuel Ortega-Legaspi, Patricia de Gortari, René Garduño-Gutiérrez, María Isabel Amaya, Martha León-Olea, Ulises Coffeen, Francisco Pellicer
The anterior cingulate cortex (ACC) has been related to the affective component of pain. Dopaminergic mesocortical circuits, including the ACC, are able to inhibit neuropathic nociception measured as autotomy behaviour. We determined the changes in dopamine D1 and D2 (D1R and D2R) receptor expression in the ACC (cg1 and cg2) in an animal model of neuropathic pain. The neuropathic group had noxious...... hiện toàn bộ