Generation and Characterization of an Advillin-Cre Driver Mouse Line

Sandra Zurborg1, Agnieszka Piszczek1, Conception Martínez1, Philip Hublitz1, Mumna Al Banchaabouchi1, Pedro Moreira1, Emerald Perlas1, Paul A. Heppenstall1
1Mouse Biology Unit. European Molecular Biology Laboratory (EMBL), Via Ramarini 32, 00016 Monterotondo (Roma), Italy

Tóm tắt

Progress in the somatosensory field has been restricted by the limited number of genetic tools available to study gene function in peripheral sensory neurons. Here we generated a Cre-driver mouse line that expresses Cre-recombinase from the locus of the sensory neuron specific gene Advillin. These mice displayed almost exclusive Cre-mediated recombination in all peripheral sensory neurons. As such, the Advillin-Cre-driver line will be a powerful tool for targeting peripheral neurons in future investigations.

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