Molecular Pain
SCOPUS (2005-2025)SCIE-ISI
1744-8069
Cơ quản chủ quản: BioMed Central Ltd. , SAGE Publications Inc.
Lĩnh vực:
Anesthesiology and Pain MedicineMolecular MedicineCellular and Molecular Neuroscience
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Các bài báo tiêu biểu
Patients with Fibromyalgia Display Less Functional Connectivity in the Brain's Pain Inhibitory Network
Tập 8 - Trang 1744-8069-8-32 - 2012
Background: There is evidence for augmented processing of pain and impaired
endogenous pain inhibition in Fibromyalgia syndrome (FM). In order to fully
understand the mechanisms involved in FM pathology, there is a need for closer
investigation of endogenous pain modulation. In the present study, we compared
the functional connectivity of the descending pain inhibitory network in
age-matched FM pa...
Pavlovian Fear Memory Induced by Activation in the Anterior Cingulate Cortex
- 2005
Identifying higher brain central region(s) that are responsible for the
unpleasantness of pain is the focus of many recent studies. Here we show that
direct stimulation of the anterior cingulate cortex (ACC) in mice produced
fear-like freezing responses and induced long-term fear memory, including
contextual and auditory fear memory. Auditory fear memory required the
activation of N-methyl-D-aspar...
The Antioxidant Effects of the Flavonoids Rutin and Quercetin Inhibit Oxaliplatin-Induced Chronic Painful Peripheral Neuropathy
- 2013
Background Oxaliplatin, the third-generation platinum compound, has evolved as
one of the most important therapeutic agents in colorectal cancer chemotherapy.
The main limiting factor in oxaliplatin treatment is painful neuropathy that is
difficult to treat. This side effect has been studied for several years, but its
full mechanism is still inconclusive, and effective treatment does not exist.
Da...
Transient Receptor Potential Vanilloid 1 is Essential for Cisplatin-Induced Heat Hyperalgesia in Mice
Tập 6 - Trang 1744-8069-6-15 - 2010
Background: Cisplatin is primarily used for treatment of ovarian and testicular
cancer. Oxaliplatin is the only effective treatment for metastatic colorectal
cancer. Both are known to cause dose related, cumulative toxic effects on the
peripheral nervous system and thirty to forty percent of cancer patients
receiving these agents experience painful peripheral neuropathy. The mechanisms
underlying ...
Techniques for Assessing Knee Joint Pain in Arthritis
Tập 3 - Trang 1744-8069-3-8 - 2007
The assessment of pain is of critical importance for mechanistic studies as well
as for the validation of drug targets. This review will focus on knee joint pain
associated with arthritis. Different animal models have been developed for the
study of knee joint arthritis. Behavioral tests in animal models of knee joint
arthritis typically measure knee joint pain rather indirectly. In recent years,
...
Antidepressants Inhibit P2X4 Receptor Function: a Possible Involvement in Neuropathic Pain Relief
- 2009
Background Neuropathic pain is characterized by pain hypersensitivity to
innocuous stimuli (tactile allodynia) that is nearly always resistant to known
treatments such as non-steroidal anti-inflammatory drugs or even opioids. It has
been reported that some antidepressants are effective for treating neuropathic
pain. However, the underlying molecular mechanisms are not well understood. We
have rece...
Kênh Kali như một Mục tiêu Điều trị Tiềm năng cho Đau Thần kinh và Viêm Thần kinh Vùng Trigemin Dịch bởi AI
Tập 7 - Trang 1744-8069-7-5 - 2011
Các nghiên cứu trước đây trong một số mô hình tổn thương/viêm dây thần kinh
trigeminal khác nhau đã chỉ ra rằng sự quá nhạy cảm của các nơron cảm giác thứ
cấp góp phần vào con đường đau dưới cơ chế allodynia cơ học. Mặc dù có nhiều
loại kênh ion nhạy điện liên quan đến tình trạng quá nhạy cảm của nơron, nhưng
các kênh K+ nhạy điện (Kv) là một trong những yếu tố điều hòa sinh lý quan trọng
của điện...
Peripheral Mechanisms of Neuropathic Pain — Involvement of Lysophosphatidic Acid Receptor-Mediated Demyelination
- 2008
Recent advances in pain research provide a clear picture for the molecular
mechanisms of acute pain; substantial information concerning plasticity that
occurs during neuropathic pain has also become available. The peripheral
mechanisms responsible for neuropathic pain are found in the altered
gene/protein expression of primary sensory neurons. With damage to peripheral
sensory fibers, a variety of...
The Roles of iPLA2, TRPM8 and TRPA1 in Chemically Induced Cold Hypersensitivity
- 2010
Background: The cooling agents menthol and icilin act as agonists at TRPM8 and
TRPA1. In vitro, activation of TRPM8 by icilin and cold, but not menthol, is
dependent on the activity of a sub-type of phospholipase A2, iPLA2.
Lysophospholipids (e.g. LPC) produced by PLA2 activity can also activate TRPM8.
The role of TRPA1 as a primary cold sensor in vitro is controversial, although
there is evidence...
Paroxysmal Extreme Pain Disorder M1627K Mutation in Human Nav1.7 Renders DRG Neurons Hyperexcitable
- 2008
Background: Paroxysmal extreme pain disorder (PEPD) is an autosomal dominant
painful neuropathy with many, but not all, cases linked to gain-of-function
mutations in SCN9A which encodes voltage-gated sodium channel Nav1.7. Severe
pain episodes and skin flushing start in infancy and are induced by perianal
probing or bowl movement, and pain progresses to ocular and mandibular areas
with age. Carbam...