Molecular Pain
SCOPUS (2005-2023)SCIE-ISI
1744-8069
Cơ quản chủ quản: BioMed Central Ltd. , SAGE Publications Inc.
Lĩnh vực:
Anesthesiology and Pain MedicineMolecular MedicineCellular and Molecular Neuroscience
Các bài báo tiêu biểu
Patients with Fibromyalgia Display Less Functional Connectivity in the Brain's Pain Inhibitory NetworkBackground: There is evidence for augmented processing of pain and impaired endogenous pain inhibition in Fibromyalgia syndrome (FM). In order to fully understand the mechanisms involved in FM pathology, there is a need for closer investigation of endogenous pain modulation. In the present study, we compared the functional connectivity of the descending p...
Tập 8 - Trang 1744-8069-8-32 - 2012
Pavlovian Fear Memory Induced by Activation in the Anterior Cingulate Cortex Identifying higher brain central region(s) that are responsible for the unpleasantness of pain is the focus of many recent studies. Here we show that direct stimulation of the anterior cingulate cortex (ACC) in mice produced fear-like freezing responses and induced long-term fear memory, including contextual and auditory fear memory. Auditory fear memory required the activation of N-methy... ... hiện toàn bộ
- 2005
The Antioxidant Effects of the Flavonoids Rutin and Quercetin Inhibit Oxaliplatin-Induced Chronic Painful Peripheral NeuropathyBackground Oxaliplatin, the third-generation platinum compound, has evolved as one of the most important therapeutic agents in colorectal cancer chemotherapy. The main limiting factor in oxaliplatin treatment is painful neuropathy that is difficult to treat. This side effect has been studied for several years, but its full mechanism is still inconclusive,...
- 2013
Transient Receptor Potential Vanilloid 1 is Essential for Cisplatin-Induced Heat Hyperalgesia in MiceBackground: Cisplatin is primarily used for treatment of ovarian and testicular cancer. Oxaliplatin is the only effective treatment for metastatic colorectal cancer. Both are known to cause dose related, cumulative toxic effects on the peripheral nervous system and thirty to forty percent of cancer patients receiving these agents experience painful periph...
Tập 6 - Trang 1744-8069-6-15 - 2010
Techniques for Assessing Knee Joint Pain in ArthritisThe assessment of pain is of critical importance for mechanistic studies as well as for the validation of drug targets. This review will focus on knee joint pain associated with arthritis. Different animal models have been developed for the study of knee joint arthritis. Behavioral tests in animal models of knee joint arthritis typically measure knee joint pain rather indirectly. In recent... ... hiện toàn bộ
Tập 3 - Trang 1744-8069-3-8 - 2007
Antidepressants Inhibit P2X4 Receptor Function: a Possible Involvement in Neuropathic Pain ReliefBackground Neuropathic pain is characterized by pain hypersensitivity to innocuous stimuli (tactile allodynia) that is nearly always resistant to known treatments such as non-steroidal anti-inflammatory drugs or even opioids. It has been reported that some antidepressants are effective for treating neuropathic pain. However, the underlying molecular mecha...
- 2009
Kênh Kali như một Mục tiêu Điều trị Tiềm năng cho Đau Thần kinh và Viêm Thần kinh Vùng Trigemin Dịch bởi AI Các nghiên cứu trước đây trong một số mô hình tổn thương/viêm dây thần kinh trigeminal khác nhau đã chỉ ra rằng sự quá nhạy cảm của các nơron cảm giác thứ cấp góp phần vào con đường đau dưới cơ chế allodynia cơ học. Mặc dù có nhiều loại kênh ion nhạy điện liên quan đến tình trạng quá nhạy cảm của nơron, nhưng các kênh K+ nhạy điện (Kv) là một trong những yếu tố điều hò... ... hiện toàn bộ
Tập 7 - Trang 1744-8069-7-5 - 2011
Peripheral Mechanisms of Neuropathic Pain — Involvement of Lysophosphatidic Acid Receptor-Mediated Demyelination Recent advances in pain research provide a clear picture for the molecular mechanisms of acute pain; substantial information concerning plasticity that occurs during neuropathic pain has also become available. The peripheral mechanisms responsible for neuropathic pain are found in the altered gene/protein expression of primary sensory neurons. With damage to peripheral sensory fibers, a v... ... hiện toàn bộ
- 2008
Paroxysmal Extreme Pain Disorder M1627K Mutation in Human Nav1.7 Renders DRG Neurons HyperexcitableBackground: Paroxysmal extreme pain disorder (PEPD) is an autosomal dominant painful neuropathy with many, but not all, cases linked to gain-of-function mutations in SCN9A which encodes voltage-gated sodium channel Nav 1.7. Severe pain episodes and skin flushing start in infancy and are induced by perianal probing or bowl movement, and...
- 2008
The Roles of iPLA2, TRPM8 and TRPA1 in Chemically Induced Cold HypersensitivityBackground: The cooling agents menthol and icilin act as agonists at TRPM8 and TRPA1. In vitro, activation of TRPM8 by icilin and cold, but not menthol, is dependent on the activity of a sub-type of phospholipase A2, iPLA2. Lysophospholipids (e.g. LPC) produced by PLA2 activity can also activate TRPM8. The role of TRPA1 as a primary cold sensor in vitro i...
- 2010