Molecular & Cellular Toxicology

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S-Adenosylmethionine enhances the inhibitory effect of gemcitabine against pancreatic cancer cells via suppression of the EGFR/AKT pathways
Molecular & Cellular Toxicology - Tập 18 - Trang 499-508 - 2022
Yan Liu, Linxun Liu, Yang Zhang, Lei Qin
Natural chemical SAM (S-adenosylmethionine) is present in all living cells and plays an important role in biological transmethylation. Recent studies have shown that SAM possesses many pharmacological activities including anti-cancer effects. However, the complex formation of SAM with gemcitabine on pancreatic carcinoma cells, as well as the specific mechanism, remains unknown. Pancreatic cancer c...... hiện toàn bộ
Role of brominated diphenyl ether-209 in the proliferation and apoptosis of rat cultured neural stem cells in vitro
Molecular & Cellular Toxicology - - 2016
Chunfang Zhang, Dunjin Chen, Xianbao Liu, Lili Du
O6-methylguanine DNA methyltransferase gene promoter methylation status in glioblastoma and its correlation with other prognostic markers
Molecular & Cellular Toxicology - Tập 7 Số 4 - Trang 425-430 - 2011
Sung Hak Lee, Suk Woo Nam, Yong Gil Hong, Chang Suk Kang, Youn Soo Lee
NME1 functions as a metastasis suppressor in pancreatic cancer
Molecular & Cellular Toxicology - Tập 19 - Trang 767-773 - 2022
Do Yeon Kim, Hyeseon Yun, Ji-Eun You, Dong-In Koh, Yea Seong Ryu, Dong-Il Yoon, Chul Hee Kim, Ji-U Lee, Dong- Hee Kang, Dong-Hoon Jin
A known metastasis suppressor gene, NME1 (Nm23), downregulated in melanoma, breast cancer, and other cancers, suppresses migration and invasion of tumor cells. However, in pancreatic cancer (PC), one of the common and deadly cancers worldwide that largely eludes early diagnosis, NME1 function remains unstudied, prompting us to investigate its role. The aim of this study is to investigate biologica...... hiện toàn bộ
Cardiotoxicity associated with tyrosine kinase-targeted anticancer therapy
Molecular & Cellular Toxicology - Tập 14 - Trang 247-254 - 2018
Wang-Soo Lee, Jaetaek Kim
Tyrosine kinase inhibitors (TKIs) have shown clear survival benefits as effective targeted therapies in various hematological and solid malignancies. Important evidence, however, has shown that TKIs may lead to adverse effects such as cardiovascular toxicities, via off-target as well as on-target mechanisms. This review presents an overview of TKI-induced cardiotoxicity mechanisms, clinical manife...... hiện toàn bộ
Network-based toxicogenomic approach to explore oral benzo(a)pyrene exposure effect on respiratory system
Molecular & Cellular Toxicology - Tập 18 - Trang 521-529 - 2022
Su Ji Kim, Dong Yeop Shin, Yujin Jang, Sang Min Lee, Cheol Min Lee, Yeon Soon Ahn, Young Rok Seo
Benzo(a)pyrene is known as a ubiquitous environmental pollutant. The general population can be exposed to benzo(a)pyrene through ambient air, tobacco smoke, water, and food. Genotoxicity and carcinogenicity are well-known adverse effects of benzo(a)pyrene exposure. However, few studies have focused on the effects of oral benzo(a)pyrene exposure on the respiratory system in terms of gene expression...... hiện toàn bộ
Comparative toxicity of polyhexamethylene guanidine phosphate in three strains of rats
Molecular & Cellular Toxicology - Tập 18 - Trang 57-69 - 2021
Jong-Hwan Woo, Ki Cheon Kim, Hyeon-Young Kim, In-Hyeon Kim, Sung-Hwan Kim, Kyuhong Lee
Although polyhexamethylene guanidine phosphate (PHMG) is the main antibacterial ingredient in humidifier disinfectants, inhalation of PHMG causes severe respiratory diseases, including pulmonary fibrosis and asthma. Many studies using animal models have been conducted to investigate the molecular mechanisms of PHMG-induced pulmonary diseases. However, there have been no comparative studies analyzi...... hiện toàn bộ
Molecular hydrogen protects against oxidative stress-induced RAW 264.7 macrophage cells through the activation of Nrf2 and inhibition of MAPK signaling pathway
Molecular & Cellular Toxicology - Tập 16 - Trang 103-118 - 2020
Rahima Begum, Cheol-Su Kim, Ailyn Fadriquela, Johny Bajgai, Xingyu Jing, Dong-Heui Kim, Soo-Ki Kim, Kyu-Jae Lee
Oxidative stress is involved in the development of many inflammatory, metabolic and aging diseases. In this study we investigated, the protective effects of H2 on RAW 264.7 macrophage cell against LPS-and H2O2-induced oxidative stress by the inhibition of MAPK pathway and also activate the Nrf2 pathway. Our results showed H2 increased the macrophage cell proliferation and generated ROS and NO agai...... hiện toàn bộ
Cytotoxic effect of proparacaine on human corneal epithelial cells and its possible mechanisms
Molecular & Cellular Toxicology - - 2017
Suran Bai, Ting-Jun Fan
Genomic comparison of insecticides and herbicide in human hepatoma (HepG2) cell line
Molecular & Cellular Toxicology - Tập 6 - Trang 378-383 - 2010
Yu Ri An, Seung-Jun Kim, Hey-Won Park, Moon-Ju Oh, Youn-Jung Kim, Jae-Chun Ryu, Seung Yong Hwang
Pesticide is a chemical substance, biological agent, antimicrobial, disinfectant or device used against any pest, and it can be grouped in several different ways. Atrazine is one of the most commonly used herbicides found in the rural environments, permethrin and prallethrin are pyrethroid insecticides. In this study, we compared the characters of herbicide and insecticide by cytotoxicity and micr...... hiện toàn bộ
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