Toxicogenomic and signaling pathway analysis of low-dose exposure to cadmium chloride in rat liver

Fay, R. M. & Mumtaz, M. M. Development of a priority list of chemicalmixtures occurring at 1188 hazardous waste sites, using the HazDatdatabase. Fd Chem Toxic 34:1163–1165 (1996).

Liao, V. H. C. & Freeman, J. H. Cadmium-regulated genes from the nematode Caenorhabditiselegans. Identification and cloning of new cadmium-responsivegenes by differential display. J Biol Chem 273:31962–31970 (1998).

International Agency for Research on Cancer Monographs on the Evaluation of Carcinogenic Risks to Humans. Beryllium, cadmium, mercury and exposures inthe glass manufacturing industry. IARC 58:41–117 (1993).

Yongxi, T. et al. Integrating time-course microarray gene expression profiles with cytotoxicity for identification of biomarkers in primary rat hepatocytes exposed to cadmium. Bioinformatics 22:77–87 (2006).

Yang, J. M. et al. Cadmium-induced damage to primary cultures of rat Leydig cells. Reprod Toxicol 17: 553–560 (2003).

Schwerdtle, T. et al. Genotoxicityofsoluble and particulate cadmium compounds: Impact on oxidative DNA damage and nucleotide excision repair. Chem Res Toxicol 23:432–442 (2010).

Joelle, N. et al. Urinary neutral endopeptidase in workers exposedto cadmium: interaction with cigarette smoking. Int J Occup Environ Med 54:432–436 (1997).

Bagchi, D. et al. Induction of oxidative stress by chronic administration of sodium dichromate [chromium VI] and cadmium chloride [cadmium II] to rats. Free Radic Biol Med 22:471–478 (1997).

Koedrith, P., Kim, H. L., Weon, J. I. & Seo, Y. R. Toxicogenomic approaches for understanding molecular mechanisms of heavymetal mutagenicity and carcinogenicity. Int J Hyg Envir Heal 216:587–598 (2013).

Draghici, S. et al. A systems biology approach for pathway level analysis. Genome Res 17:1537–1545 (2007).

Watanabe, T. et al. Isolation of estrogen-responsive genes with a CpG island library. Mol Cell Biol 18:442–449 (1998).

Tsuchiya, F. et al. Molecular cloning and characterization ofmouse EBAG9, homolog of a human cancer associated surface antigen:expression and regulation by estrogen. Biochem Biophys Res Commun 284:2–10 (2001).

Hong, X. et al. EBAG9 inducing hyporesponsiveness of T cellspromotes tumor growth and metastasis in 4T1murine mammary carcinoma. Jpn J Cancer Res 100:961–969 (2009).

Suzuki, T. et al. EBAG9/RCAS1 in human breastcarcinoma: a possible factor in endocrineimmune interactions. Br J Cancer 85:1731–1737 (2001).

Akahira, J. I. et al. Expression of EBAG9/RCAS1 isassociated with advanced disease in human epithelial ovarian cancer. Br J Cancer 90:2197–2202 (2004).

Takahashi, S. et al. EBAG9/RCAS1 expression and itsprognostic significance in prostatic cancer. Int J Cancer 106:310–315 (2003).

Aoki, T. et al. EBAG9/RCAS1 expression inhepatocellular carcinoma: correlation with tumour dedifferentiation andproliferation. Eur J Cancer 39:1552–1561 (2003).

Moore, S. W., Sidler, D. & Zaahl, M. G. The ITGB2 immunomodulatory gene (CD18), enterocolitis, and Hirschsprung’s disease. J Pediatr Surg 43:1439–1344 (2008).

Di Stefano, V., Mattiussi, M., Sacchi, A. & D’Orazi, G. HIPK2 inhibits both MDM2 gene and protein by, respectively, p53-dependent and independent regulations. FEBS Lett 579:5473–5480 (2005).

Artem, Y. et al. Regulation of the Ste20-like Kinase, Slk Involvement of Activation Segment Phosphorylation. J. Biol. Chem 287:5446–5458 (2012).

Cybulsky, A. V. et al. The Ste20-like kinase SLK promotes p53 transactivation and apoptosis. Am J Physiol Renal Physiol 297:971–980 (2009).