Oral health effect of an oral rinse containing cetylpyridinium chloride: a randomized clinical trial
Molecular & Cellular Toxicology - Trang 1-8 - 2023
Tóm tắt
Regular brushing is the most popular oral hygiene technique and using additional interdental cleaning tools like dental floss and oral rinse (OR) is advised. The objective of this study was to examine the efficacy of ORs containing 0.045% cetylpyridinium chloride (CPC) on oral health-related parameters in a 4-week-long double-blinded and randomized clinical trial. Seventy-four subjects were assigned to four groups: two control groups that used non-CPC-containing ORs (C1 [n = 20], C2 [n = 19]) and two groups that used CPC-containing ORs (immediate-use CPC [IUC] [n = 16], concentrated-use CPC [CUC] [n = 19]). The subjects were instructed to gargle with 20 mL of the ORs for 30 s after brushing their teeth thrice a day for 4 weeks. There was a substantial decrease in the levels of volatile sulfur compounds after the use of the ORs. The Turesky modification of the Quigley–Hein Plaque Index and Löe and Silness Gingival Index showed a decreasing trend after the intervention, but not at a significant level. The Tongue Coating Index also showed a decrease in the intervention groups, but not in the control groups. Surprisingly, in both formulations, the inclusion of CPC in OR dramatically decreased the growth of aerobic bacteria in the mouth by expressed CFU/mL in both treatment groups. CPC-containing ORs can be recommended as an adjunct to the standard home care routine in promoting oral health. NCT05644236.
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