Molecular Biology of the Cell
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Conformational plasticity of JRAB/MICAL-L2 provides “law and order” in collective cell migrationIn fundamental biological processes, cells often move in groups, a process termed collective cell migration. Collectively migrating cells are much better organized than a random assemblage of individual cells. Many molecules have been identified as factors involved in collective cell migration, and no one molecule is adequate to explain the whole picture. Here we show that JRAB/MICAL-L2, a... ...
Molecular Biology of the Cell - Tập 27 Số 20 - Trang 3095-3108 - 2016
Functional Interactions between the p35 Subunit of the Arp2/3 Complex and Calmodulin in YeastThe end9-1 (arc35-1) mutant was identified as an endocytosis mutant and is a mutant allele ofARC35 that encodes a subunit of the Arp2/3 complex. As for other mutants in the Arp2/3 complex, arc35-1 is defective for endocytosis and organization of the actin cytoskeleton. Both defects can be suppressed by overexpression of calmodulin. Analysis of a collection of temperature-sensitive cmd1muta... ...
Molecular Biology of the Cell - Tập 11 Số 4 - Trang 1113-1127 - 2000
WRN Is Required for ATM Activation and the S-Phase Checkpoint in Response to Interstrand Cross-Link–Induced DNA Double-Strand BreaksWerner syndrome (WS) is a human genetic disorder characterized by extensive clinical features of premature aging. Ataxia-telengiectasia (A-T) is a multisystem human genomic instability syndrome that includes premature aging in some of the patients. WRN and ATM, the proteins defective in WS and A-T, respectively, play significant roles in the maintenance of genomic stability and are involve... ...
Molecular Biology of the Cell - Tập 19 Số 9 - Trang 3923-3933 - 2008
A Mitotic GlcNAcylation/Phosphorylation Signaling Complex Alters the Posttranslational State of the Cytoskeletal Protein VimentinO-linked β-N-acetylglucosamine (O-GlcNAc) is a highly dynamic intracellular protein modification responsive to stress, hormones, nutrients, and cell cycle stage. Alterations in O-GlcNAc addition or removal (cycling) impair cell cycle progression and cytokinesis, but the mechanisms are not well understood. Here, we demonstrate that the enzymes responsible for O-GlcNAc cycling, O-GlcNAc tran... ...
Molecular Biology of the Cell - Tập 19 Số 10 - Trang 4130-4140 - 2008
ATP-2 Interacts with the PLAT Domain of LOV-1 and Is Involved inCaenorhabditis elegansPolycystin SignalingCaenorhabditis elegans is a powerful model to study the molecular basis of autosomal dominant polycystic kidney disease (ADPKD). ADPKD is caused by mutations in the polycystic kidney disease (PKD)1 or PKD2 gene, encoding polycystin (PC)-1 or PC-2, respectively. The C. elegans polycystins LOV-1 and PKD-2 are required for male mating behaviors and are localized to sensory cilia. The function... ...
Molecular Biology of the Cell - Tập 16 Số 2 - Trang 458-469 - 2005
Calcium-dependent Clustering of Inositol 1,4,5-Trisphosphate ReceptorsRat basophilic leukemia (RBL-2H3) cells predominantly express the type II receptor for inositol 1,4,5-trisphosphate (InsP3 ), which operates as an InsP3 -gated calcium channel. In these cells, cross-linking the high-affinity immunoglobulin E receptor (FcεR1) leads to activation of phospholipase C γ isoforms via tyrosine kinase- and phosphatidylinosit... ...
Molecular Biology of the Cell - Tập 9 Số 6 - Trang 1465-1478 - 1998
Long-Term Self-Renewal of Postnatal Muscle-derived Stem CellsThe ability to undergo self-renewal is a defining characteristic of stem cells. Self-replenishing activity sustains tissue homeostasis and regeneration. In addition, stem cell therapy strategies require a heightened understanding of the basis of the self-renewal process to enable researchers and clinicians to obtain sufficient numbers of undifferentiated stem cells for cell and gene therap... ...
Molecular Biology of the Cell - Tập 16 Số 7 - Trang 3323-3333 - 2005
Oligomeric Bax Is a Component of the Putative CytochromecRelease Channel MAC, Mitochondrial Apoptosis-induced ChannelBcl-2 family proteins regulate apoptosis, in part, by controlling formation of the mitochondrial apoptosis-induced channel (MAC), which is a putative cytochrome c release channel induced early in the intrinsic apoptotic pathway. This channel activity was never observed in Bcl-2–overexpressing cells. Furthermore, MAC appears when Bax translocates to mitochondria and cytochrome c is released... ...
Molecular Biology of the Cell - Tập 16 Số 5 - Trang 2424-2432 - 2005
REDOX Reaction at ASK1-Cys250 Is Essential for Activation of JNK and Induction of ApoptosisASK1 cysteine oxidation allows JNK activation upon oxidative stress. Trx1 negatively regulates this pathway by reducing the oxidized cysteines of ASK1. However, precisely how oxidized ASK1 is involved in JNK activation and how Trx1 regulates ASK1 oxidoreduction remains elusive. Here, we describe two different thiol reductase activities of Trx1 on ASK1. First, in H2 O...
Molecular Biology of the Cell - Tập 20 Số 16 - Trang 3628-3637 - 2009
Microtubules Have Opposite Orientation in Axons and Dendrites of Drosophila NeuronsIn vertebrate neurons, axons have a uniform arrangement of microtubules with plus ends distal to the cell body (plus-end-out), and dendrites have equal numbers of plus- and minus-end-out microtubules. To determine whether microtubule orientation is a conserved feature of axons and dendrites, we analyzed microtubule orientation in invertebrate neurons. Using microtubule plus end dynamics, w... ...
Molecular Biology of the Cell - Tập 19 Số 10 - Trang 4122-4129 - 2008
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