Molecular Biology of the Cell
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Rho/Rho-associated Kinase-II Signaling Mediates Disassembly of Epithelial Apical Junctions Apical junctional complex (AJC) plays a vital role in regulation of epithelial barrier function. Disassembly of the AJC is observed in diverse physiological and pathological states; however, mechanisms governing this process are not well understood. We previously reported that the AJC disassembly is driven by the formation of apical contractile acto-myosin rings. In the present study, we ... ... hiện toàn bộ
Molecular Biology of the Cell - Tập 18 Số 9 - Trang 3429-3439 - 2007
Selective Stimulation of Caveolar Endocytosis by Glycosphingolipids and CholesterolInternalization of some plasma membrane constituents, bacterial toxins, and viruses occurs via caveolae; however, the factors that regulate caveolar internalization are still unclear. Here, we demonstrate that a brief treatment of cultured cells with natural or synthetic glycosphingolipids (GSLs) or elevation of cholesterol (either by acute treatment with mβ-cyclodextrin/cholesterol or by ... ... hiện toàn bộ
Molecular Biology of the Cell - Tập 15 Số 7 - Trang 3114-3122 - 2004
Eukaryotic homologues of Escherichia coli dnaJ: a diverse protein family that functions with hsp70 stress proteins.
Molecular Biology of the Cell - Tập 4 Số 6 - Trang 555-563 - 1993
In vivo expression of mammalian BiP ATPase mutants causes disruption of the endoplasmic reticulum. BiP possesses ATP binding/hydrolysis activities that are thought to be essential for its ability to chaperone protein folding and assembly in the endoplasmic reticulum (ER). We have produced a series of point mutations in a hamster BiP clone that inhibit ATPase activity and have generated a species-specific anti-BiP antibody to monitor the effects of mutant hamster BiP expression in COS m... ... hiện toàn bộ
Molecular Biology of the Cell - Tập 6 Số 3 - Trang 283-296 - 1995
Long-Term Self-Renewal of Postnatal Muscle-derived Stem CellsThe ability to undergo self-renewal is a defining characteristic of stem cells. Self-replenishing activity sustains tissue homeostasis and regeneration. In addition, stem cell therapy strategies require a heightened understanding of the basis of the self-renewal process to enable researchers and clinicians to obtain sufficient numbers of undifferentiated stem cells for cell and gene therap... ... hiện toàn bộ
Molecular Biology of the Cell - Tập 16 Số 7 - Trang 3323-3333 - 2005
Regulation of ATP utilization during metastatic cell migration by collagen architectureCell migration in a three-dimensional matrix requires that cells either remodel the surrounding matrix fibers and/or squeeze between the fibers to move. Matrix degradation, matrix remodeling, and changes in cell shape each require cells to expend energy. While significant research has been performed to understand the cellular and molecular mechanisms guiding metastatic migration, less is k... ... hiện toàn bộ
Molecular Biology of the Cell - Tập 29 Số 1 - Trang 1-9 - 2018
Genetically encoded lipid biosensors Lipids convey both structural and functional properties to eukaryotic membranes. Understanding the basic lipid composition and the dynamics of these important molecules, in the context of cellular membranes, can shed light on signaling, metabolism, trafficking, and even membrane identity. The development of genetically encoded lipid biosensors has allowed for the visualization of specific... ... hiện toàn bộ
Molecular Biology of the Cell - Tập 29 Số 13 - Trang 1526-1532 - 2018
Delineation of glutamate pathways and secretory responses in pancreatic islets with β-cell–specific abrogation of the glutamate dehydrogenaseIn pancreatic β-cells, glutamate dehydrogenase (GDH) modulates insulin secretion, although its function regarding specific secretagogues is unclear. This study investigated the role of GDH using a β-cell–specific GDH knockout mouse model, called βGlud1−/− . The absence of GDH in islets isolated from βGlud1–/– mice resulted in abrogation of insulin re... ... hiện toàn bộ
Molecular Biology of the Cell - Tập 23 Số 19 - Trang 3851-3862 - 2012
Synthesis and trafficking of prion proteins in cultured cells. Scrapie prions are composed largely, if not entirely, of the scrapie prion protein (PrPSc) that is encoded by a chromosomal gene. Scrapie-infected mouse neuroblastoma (ScN2a) and hamster brain (ScHaB) cells synthesize PrPSc from the normal PrP isoform (PrPC) or a precursor through a posttranslational process. In pulse-chase radiolabeling experiments, we found that presence of brefeldin A ... ... hiện toàn bộ
Molecular Biology of the Cell - Tập 3 Số 8 - Trang 851-863 - 1992
The E3 Ubiquitin Ligase Atrophin Interacting Protein 4 Binds Directly To The Chemokine Receptor CXCR4 Via a Novel WW Domain-mediated Interaction The E3 ubiquitin ligase atrophin interacting protein 4 (AIP4) mediates ubiquitination and down-regulation of the chemokine receptor CXCR4. AIP4 belongs to the Nedd4-like homologous to E6-AP carboxy terminus domain family of E3 ubiquitin ligases, which typically bind proline-rich motifs within target proteins via the WW domains. The intracellular domains of CXCR4 lack canonical WW domain b... ... hiện toàn bộ
Molecular Biology of the Cell - Tập 20 Số 5 - Trang 1324-1339 - 2009
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