Molecular Biology of the Cell

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Conformational plasticity of JRAB/MICAL-L2 provides “law and order” in collective cell migration
Molecular Biology of the Cell - Tập 27 Số 20 - Trang 3095-3108 - 2016
Ayuko Sakane, S. Yoshizawa, Masaomi Nishimura, Yuko Tsuchiya, Natsuki Matsushita, Kazuhisa Miyake, Kazuki Horikawa, Issei Imoto, Chiharu Mizuguchi, Hiroyuki Saito, Takato Ueno, Sachi Matsushita, Hisashi Haga, Shinji Deguchi, Kenji Mizuguchi, Hideo Yokota, Takuya Sasaki
In fundamental biological processes, cells often move in groups, a process termed collective cell migration. Collectively migrating cells are much better organized than a random assemblage of individual cells. Many molecules have been identified as factors involved in collective cell migration, and no one molecule is adequate to explain the whole picture. Here we show that JRAB/MICAL-L2, a...... hiện toàn bộ
Mammalian Transcription Factor ATF6 Is Synthesized as a Transmembrane Protein and Activated by Proteolysis in Response to Endoplasmic Reticulum Stress
Molecular Biology of the Cell - Tập 10 Số 11 - Trang 3787-3799 - 1999
Kyosuke Haze, Hiderou Yoshida, Hideki Yanagi, Takashi Yura, Kazutoshi Mori
The unfolded protein response (UPR) controls the levels of molecular chaperones and enzymes involved in protein folding in the endoplasmic reticulum (ER). We recently isolated ATF6 as a candidate for mammalian UPR-specific transcription factor. We report here that ATF6 constitutively expressed as a 90-kDa protein (p90ATF6) is directly converted to a 50-kDa protein (p50ATF6) in ER-stressed ...... hiện toàn bộ
Functional Interactions between the p35 Subunit of the Arp2/3 Complex and Calmodulin in Yeast
Molecular Biology of the Cell - Tập 11 Số 4 - Trang 1113-1127 - 2000
Claudia Schaerer-Brodbeck, Howard Riezman
The end9-1 (arc35-1) mutant was identified as an endocytosis mutant and is a mutant allele ofARC35 that encodes a subunit of the Arp2/3 complex. As for other mutants in the Arp2/3 complex, arc35-1 is defective for endocytosis and organization of the actin cytoskeleton. Both defects can be suppressed by overexpression of calmodulin. Analysis of a collection of temperature-sensitive cmd1muta...... hiện toàn bộ
WRN Is Required for ATM Activation and the S-Phase Checkpoint in Response to Interstrand Cross-Link–Induced DNA Double-Strand Breaks
Molecular Biology of the Cell - Tập 19 Số 9 - Trang 3923-3933 - 2008
Wen‐Hsing Cheng, Diana Muftic, Meltem Müftüoğlu, Lale Dawut, Christa Morris, Thomas Helleday, Yosef Shiloh, Vilhelm A. Bohr
Werner syndrome (WS) is a human genetic disorder characterized by extensive clinical features of premature aging. Ataxia-telengiectasia (A-T) is a multisystem human genomic instability syndrome that includes premature aging in some of the patients. WRN and ATM, the proteins defective in WS and A-T, respectively, play significant roles in the maintenance of genomic stability and are involve...... hiện toàn bộ
Inhibition of the mitochondrial fission protein dynamin-related protein 1 (Drp1) impairs mitochondrial fission and mitotic catastrophe after x-irradiation
Molecular Biology of the Cell - Tập 26 Số 25 - Trang 4607-4617 - 2015
Tohru Yamamori, Satoshi Ike, Tomoki Bo, Tomoya Sasagawa, Yuri Sakai, Motofumi Suzuki, Kumiko Yamamoto, Masaki Nagane, Hironobu Yasui, Osamu Inanami
Accumulating evidence suggests that mitochondrial dynamics is crucial for the maintenance of cellular quality control and function in response to various stresses. However, the role of mitochondrial dynamics in cellular responses to ionizing radiation (IR) is still largely unknown. In this study, we provide evidence that IR triggers mitochondrial fission mediated by the mitochondrial fiss...... hiện toàn bộ
A Mitotic GlcNAcylation/Phosphorylation Signaling Complex Alters the Posttranslational State of the Cytoskeletal Protein Vimentin
Molecular Biology of the Cell - Tập 19 Số 10 - Trang 4130-4140 - 2008
Chad Slawson, T. Lakshmanan, Spencer Knapp, Gerald W. Hart
O-linked β-N-acetylglucosamine (O-GlcNAc) is a highly dynamic intracellular protein modification responsive to stress, hormones, nutrients, and cell cycle stage. Alterations in O-GlcNAc addition or removal (cycling) impair cell cycle progression and cytokinesis, but the mechanisms are not well understood. Here, we demonstrate that the enzymes responsible for O-GlcNAc cycling, O-GlcNAc tran...... hiện toàn bộ
Rotational Coupling of the Transmembrane and Kinase Domains of the Neu Receptor Tyrosine Kinase
Molecular Biology of the Cell - Tập 11 Số 10 - Trang 3589-3599 - 2000
Charlotte A. Bell, John A. Tynan, Kristen C. Hart, April N. Meyer, Scott C. Robertson, Daniel J. Donoghue
Ligand binding to receptor tyrosine kinases (RTKs) regulates receptor dimerization and activation of the kinase domain. To examine the role of the transmembrane domain in regulation of RTK activation, we have exploited a simplified transmembrane motif, [VVVEVVV]n, previously shown to activate the Neu receptor. Here we demonstrate rotational linkage of the transmembrane...... hiện toàn bộ
β1 integrin regulates Arg to promote invadopodial maturation and matrix degradation
Molecular Biology of the Cell - Tập 24 Số 11 - Trang 1661-1675 - 2013
Brian T. Beaty, Ved P. Sharma, Jose Javier Bravo‐Cordero, Mark A. Simpson, Robert J. Eddy, Anthony J. Koleske, John S. Condeelis
β1 integrin has been shown to promote metastasis in a number of tumor models, including breast, ovarian, pancreatic, and skin cancer; however, the mechanism by which it does so is poorly understood. Invasive membrane protrusions called invadopodia are believed to facilitate extracellular matrix degradation and intravasation during metastasis. Previous work showed that β1 integrin localizes...... hiện toàn bộ
Paxillin Phosphorylation Controls Invadopodia/Podosomes Spatiotemporal Organization
Molecular Biology of the Cell - Tập 19 Số 2 - Trang 633-645 - 2008
Cédric Badowski, Géraldine Pawlak, Alexeï Grichine, Anne Chabadel, Christiane Oddou, Pierre Jurdic, Martin Pfaff, Corinne Albigès‐Rizo, Marc R. Block
In Rous sarcoma virus (RSV)-transformed baby hamster kidney (BHK) cells, invadopodia can self-organize into rings and belts, similarly to podosome distribution during osteoclast differentiation. The composition of individual invadopodia is spatiotemporally regulated and depends on invadopodia localization along the ring section: the actin core assembly precedes the recruitment of surroundi...... hiện toàn bộ
BiP and Immunoglobulin Light Chain Cooperate to Control the Folding of Heavy Chain and Ensure the Fidelity of Immunoglobulin Assembly
Molecular Biology of the Cell - Tập 10 Số 7 - Trang 2209-2219 - 1999
Young Kwang Lee, Joseph W. Brewer, Rachel Hellman, Linda M. Hendershot
The immunoglobulin (Ig) molecule is composed of two identical heavy chains and two identical light chains (H2L2). Transport of this heteromeric complex is dependent on the correct assembly of the component parts, which is controlled, in part, by the association of incompletely assembled Ig heavy chains with the endoplasmic reticulum (ER) chaperone,...... hiện toàn bộ
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