Molecular Biology of the Cell

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Conformational plasticity of JRAB/MICAL-L2 provides “law and order” in collective cell migration
Molecular Biology of the Cell - Tập 27 Số 20 - Trang 3095-3108 - 2016
Ayuko Sakane, S. Yoshizawa, Masaomi Nishimura, Yuko Tsuchiya, Natsuki Matsushita, Kazuhisa Miyake, Kazuki Horikawa, Issei Imoto, Chiharu Mizuguchi, Hiroyuki Saito, Takato Ueno, Sachi Matsushita, Hisashi Haga, Shinji Deguchi, Kenji Mizuguchi, Hideo Yokota, Takuya Sasaki
In fundamental biological processes, cells often move in groups, a process termed collective cell migration. Collectively migrating cells are much better organized than a random assemblage of individual cells. Many molecules have been identified as factors involved in collective cell migration, and no one molecule is adequate to explain the whole picture. Here we show that JRAB/MICAL-L2, a...... hiện toàn bộ
WRN Is Required for ATM Activation and the S-Phase Checkpoint in Response to Interstrand Cross-Link–Induced DNA Double-Strand Breaks
Molecular Biology of the Cell - Tập 19 Số 9 - Trang 3923-3933 - 2008
Wen‐Hsing Cheng, Diana Muftic, Meltem Müftüoğlu, Lale Dawut, Christa Morris, Thomas Helleday, Yosef Shiloh, Vilhelm A. Bohr
Werner syndrome (WS) is a human genetic disorder characterized by extensive clinical features of premature aging. Ataxia-telengiectasia (A-T) is a multisystem human genomic instability syndrome that includes premature aging in some of the patients. WRN and ATM, the proteins defective in WS and A-T, respectively, play significant roles in the maintenance of genomic stability and are involve...... hiện toàn bộ
A Mitotic GlcNAcylation/Phosphorylation Signaling Complex Alters the Posttranslational State of the Cytoskeletal Protein Vimentin
Molecular Biology of the Cell - Tập 19 Số 10 - Trang 4130-4140 - 2008
Chad Slawson, T. Lakshmanan, Spencer Knapp, Gerald W. Hart
O-linked β-N-acetylglucosamine (O-GlcNAc) is a highly dynamic intracellular protein modification responsive to stress, hormones, nutrients, and cell cycle stage. Alterations in O-GlcNAc addition or removal (cycling) impair cell cycle progression and cytokinesis, but the mechanisms are not well understood. Here, we demonstrate that the enzymes responsible for O-GlcNAc cycling, O-GlcNAc tran...... hiện toàn bộ
Calcium-dependent Clustering of Inositol 1,4,5-Trisphosphate Receptors
Molecular Biology of the Cell - Tập 9 Số 6 - Trang 1465-1478 - 1998
Bridget S. Wilson, Janet R. Pfeiffer, Alexander J. Smith, Janet M. Oliver, Jon Oberdorf, Richard J.H. Wojcikiewicz
Rat basophilic leukemia (RBL-2H3) cells predominantly express the type II receptor for inositol 1,4,5-trisphosphate (InsP3), which operates as an InsP3-gated calcium channel. In these cells, cross-linking the high-affinity immunoglobulin E receptor (FcεR1) leads to activation of phospholipase C γ isoforms via tyrosine kinase- and phosphatidylinosit...... hiện toàn bộ
Long-Term Self-Renewal of Postnatal Muscle-derived Stem Cells
Molecular Biology of the Cell - Tập 16 Số 7 - Trang 3323-3333 - 2005
Bridget M. Deasy, Burhan Gharaibeh, Jonathan B. Pollett, Marion Jones, Michael Lucas, Yasunari Kanda, Johnny Huard
The ability to undergo self-renewal is a defining characteristic of stem cells. Self-replenishing activity sustains tissue homeostasis and regeneration. In addition, stem cell therapy strategies require a heightened understanding of the basis of the self-renewal process to enable researchers and clinicians to obtain sufficient numbers of undifferentiated stem cells for cell and gene therap...... hiện toàn bộ
Oligomeric Bax Is a Component of the Putative CytochromecRelease Channel MAC, Mitochondrial Apoptosis-induced Channel
Molecular Biology of the Cell - Tập 16 Số 5 - Trang 2424-2432 - 2005
Laurent M. Dejean, Sonia Martínez-Caballero, Liang Guo, Cynthia Hughes, Oscar Teijido, Thomas Ducret, François Ichas, Stanley J. Korsmeyer, Bruno Antonsson, Elizabeth A. Jonas, Kathleen W. Kinnally
Bcl-2 family proteins regulate apoptosis, in part, by controlling formation of the mitochondrial apoptosis-induced channel (MAC), which is a putative cytochrome c release channel induced early in the intrinsic apoptotic pathway. This channel activity was never observed in Bcl-2–overexpressing cells. Furthermore, MAC appears when Bax translocates to mitochondria and cytochrome c is released...... hiện toàn bộ
REDOX Reaction at ASK1-Cys250 Is Essential for Activation of JNK and Induction of Apoptosis
Molecular Biology of the Cell - Tập 20 Số 16 - Trang 3628-3637 - 2009
Paul Nadeau, Steve J. Charette, Jacques Landry
ASK1 cysteine oxidation allows JNK activation upon oxidative stress. Trx1 negatively regulates this pathway by reducing the oxidized cysteines of ASK1. However, precisely how oxidized ASK1 is involved in JNK activation and how Trx1 regulates ASK1 oxidoreduction remains elusive. Here, we describe two different thiol reductase activities of Trx1 on ASK1. First, in H2O... hiện toàn bộ
Local Phosphatidylinositol 3,4,5-Trisphosphate Accumulation Recruits Vav2 and Vav3 to Activate Rac1/Cdc42 and Initiate Neurite Outgrowth in Nerve Growth Factor-stimulated PC12 Cells
Molecular Biology of the Cell - Tập 16 Số 5 - Trang 2207-2217 - 2005
Kazuhiro Aoki, Takeshi Nakamura, Keiko Fujikawa, Michiyuki Matsuda
Neurite outgrowth is an important process in the formation of neuronal networks. Rac1 and Cdc42, members of the Rho-family GTPases, positively regulate neurite extension through reorganization of the actin cytoskeleton. Here, we examine the dynamic linkage between Rac1/Cdc42 and phosphatidylinositol 3-kinase (PI3-kinase) during nerve growth factor (NGF)-induced neurite outgrowth in PC12 c...... hiện toàn bộ
Posttranslational Modifications of Tubulin and the Polarized Transport of Kinesin-1 in Neurons
Molecular Biology of the Cell - Tập 21 Số 4 - Trang 572-583 - 2010
Jennetta W. Hammond, Chun-Fang Huang, Stefanie Kaech, Catherine Jacobson, Gary Banker, Kristen J. Verhey
Polarized transport by microtubule-based motors is critical for neuronal development and function. Selective translocation of the Kinesin-1 motor domain is the earliest known marker of axonal identity, occurring before morphological differentiation. Thus, Kinesin-1–mediated transport may contribute to axonal specification. We tested whether posttranslational modifications of tubulin influe...... hiện toàn bộ
Elevation of cell cycle control proteins during spontaneous immortalization of human keratinocytes.
Molecular Biology of the Cell - Tập 4 Số 2 - Trang 185-194 - 1993
Robert H. Rice, Kathleen E. Steinmann, Linda A. deGraffenried, Qin Q, Nicolas L. Taylor, Richard Schlegel
A human line of spontaneously immortalized keratinocytes (SIK cells) has been derived from ostensibly normal epidermis and has proven useful in dissecting molecular changes associated with immortalization. The original cultures had a normal karyotype and a colony forming efficiency of approximately 3% through 10 passages. At passage 15, after which normal strains ordinarily senesce, these...... hiện toàn bộ
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