Molecular Biology of the Cell
SCIE-ISI SCOPUS (1990-2023)
1059-1524
1939-4586
Mỹ
Cơ quản chủ quản: American Society for Cell Biology , AMER SOC CELL BIOLOGY
Lĩnh vực:
Molecular BiologyCell Biology
Các bài báo tiêu biểu
Human Adipose Tissue Is a Source of Multipotent Stem CellsMuch of the work conducted on adult stem cells has focused on mesenchymal stem cells (MSCs) found within the bone marrow stroma. Adipose tissue, like bone marrow, is derived from the embryonic mesenchyme and contains a stroma that is easily isolated. Preliminary studies have recently identified a putative stem cell population within the adipose stromal compartment. This cell population, te... ... hiện toàn bộ
Tập 13 Số 12 - Trang 4279-4295 - 2002
Xác định toàn diện các gen điều hòa chu kỳ tế bào của nấm men Saccharomyces cerevisiae bằng phương pháp lai ghép microarray Dịch bởi AI Chúng tôi đã tìm cách tạo ra một danh mục đầy đủ các gen của nấm men có mức độ phiên mã thay đổi theo chu kỳ trong chu kỳ tế bào. Để đạt được mục tiêu này, chúng tôi sử dụng microarray DNA và các mẫu từ các nền nuôi cấy nấm men được đồng bộ hóa bằng ba phương pháp độc lập: dừng bằng yếu tố α, phương pháp tách lọc, và dừng đồng bộ một đột biến nhạy với nhiệt độ cdc15. Sử dụng các thuật toán... ... hiện toàn bộ
Tập 9 Số 12 - Trang 3273-3297 - 1998
#Gen chu kỳ tế bào #Saccharomyces cerevisiae #microarray #điều hòa gen #Cln3p #Clb2p #yếu tố α #phương pháp tách lọc #đột biến cdc15 #yếu tố khởi động.
Genomic Expression Programs in the Response of Yeast Cells to Environmental ChangesWe explored genomic expression patterns in the yeastSaccharomyces cerevisiae responding to diverse environmental transitions. DNA microarrays were used to measure changes in transcript levels over time for almost every yeast gene, as cells responded to temperature shocks, hydrogen peroxide, the superoxide-generating drug menadione, the sulfhydryl-oxidizing agent diamide, the disulfide-redu... ... hiện toàn bộ
Tập 11 Số 12 - Trang 4241-4257 - 2000
Mammalian Transcription Factor ATF6 Is Synthesized as a Transmembrane Protein and Activated by Proteolysis in Response to Endoplasmic Reticulum StressThe unfolded protein response (UPR) controls the levels of molecular chaperones and enzymes involved in protein folding in the endoplasmic reticulum (ER). We recently isolated ATF6 as a candidate for mammalian UPR-specific transcription factor. We report here that ATF6 constitutively expressed as a 90-kDa protein (p90ATF6) is directly converted to a 50-kDa protein (p50ATF6) in ER-stressed ... ... hiện toàn bộ
Tập 10 Số 11 - Trang 3787-3799 - 1999
Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for AutophagyAutophagy is an intracellular degradation system, by which cytoplasmic contents are degraded in lysosomes. Autophagy is dynamically induced by nutrient depletion to provide necessary amino acids within cells, thus helping them adapt to starvation. Although it has been suggested that mTOR is a major negative regulator of autophagy, how it controls autophagy has not yet been determined. Here... ... hiện toàn bộ
Tập 20 Số 7 - Trang 1981-1991 - 2009
Identification of Genes Periodically Expressed in the Human Cell Cycle and Their Expression in TumorsThe genome-wide program of gene expression during the cell division cycle in a human cancer cell line (HeLa) was characterized using cDNA microarrays. Transcripts of >850 genes showed periodic variation during the cell cycle. Hierarchical clustering of the expression patterns revealed coexpressed groups of previously well-characterized genes involved in essential cell cycle processes su... ... hiện toàn bộ
Tập 13 Số 6 - Trang 1977-2000 - 2002
Remodeling of Yeast Genome Expression in Response to Environmental ChangesWe used genome-wide expression analysis to explore how gene expression in Saccharomyces cerevisiae is remodeled in response to various changes in extracellular environment, including changes in temperature, oxidation, nutrients, pH, and osmolarity. The results demonstrate that more than half of the genome is involved in various responses to environmental change and identify the global set ... ... hiện toàn bộ
Tập 12 Số 2 - Trang 323-337 - 2001
Evolutionarily Conserved and Nonconserved Cellular Localizations and Functions of Human SIRT Proteins Sir2 is a NAD+ -dependent protein deacetylase that extends lifespan in yeast and worms. This study examines seven human proteins homologous to Sir2 (SIRT1 through SIRT7) for cellular localization, expression profiles, protein deacetylation activity, and effects on human cell lifespan. We found that: 1) three nuclear SIRT proteins (SIRT1, SIRT6, and SIRT7) show differen... ... hiện toàn bộ
Tập 16 Số 10 - Trang 4623-4635 - 2005
The vascular endothelial growth factor (VEGF) isoforms: differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF. Vascular endothelial growth factor (VEGF)mRNA undergoes alternative splicing events that generate four different homodimeric isoforms, VEGF121, VEGF165, VEGF189, or VEGF206. VEGF121 is a nonheparin-binding acidic protein, which is freely diffusible. The longer forms, VEGF189 or VEGF206, are highly basic proteins tightly bound to extracellular heparin-containing proteoglycans. VEGF165 has ... ... hiện toàn bộ
Tập 4 Số 12 - Trang 1317-1326 - 1993
Beclin 1 Forms Two Distinct Phosphatidylinositol 3-Kinase Complexes with Mammalian Atg14 and UVRAGClass III phosphatidylinositol 3-kinase (PI3-kinase) regulates multiple membrane trafficking. In yeast, two distinct PI3-kinase complexes are known: complex I (Vps34, Vps15, Vps30/Atg6, and Atg14) is involved in autophagy, and complex II (Vps34, Vps15, Vps30/Atg6, and Vps38) functions in the vacuolar protein sorting pathway. Atg14 and Vps38 are important in inducing both complexes to exert... ... hiện toàn bộ
Tập 19 Số 12 - Trang 5360-5372 - 2008