Remodeling of Yeast Genome Expression in Response to Environmental Changes

Molecular Biology of the Cell - Tập 12 Số 2 - Trang 323-337 - 2001
Helen C. Causton1, Bing Ren2, Sang Seok Koh2, Christopher Harbison3,2, Elenita I. Kanin2, Ezra G. Jennings3,2, Tong Ihn Lee3,2, Heather L. True4, Eric S. Lander3,2, Richard A. Young3,2
1Whitehead Institute for Biomedical Research Nine Cambridge Center Cambridge, Massachusetts 02142 USA
2Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts, 02142
3Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 and
4Howard Hughes Medical Institute, Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, Illinois 60637.

Tóm tắt

We used genome-wide expression analysis to explore how gene expression in Saccharomyces cerevisiae is remodeled in response to various changes in extracellular environment, including changes in temperature, oxidation, nutrients, pH, and osmolarity. The results demonstrate that more than half of the genome is involved in various responses to environmental change and identify the global set of genes induced and repressed by each condition. These data implicate a substantial number of previously uncharacterized genes in these responses and reveal a signature common to environmental responses that involves ∼10% of yeast genes. The results of expression analysis with MSN2/MSN4 mutants support the model that the Msn2/Msn4 activators induce the common response to environmental change. These results provide a global description of the transcriptional response to environmental change and extend our understanding of the role of activators in effecting this response.

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Tài liệu tham khảo

Adams C.C., 1991, J. Bacteriol., 173, 7429, 10.1128/jb.173.23.7429-7435.1991

Ali A., 1998, Mol. Cell. Biol., 18, 4949, 10.1128/MCB.18.9.4949

Beck T., 1999, Nature, 402, 689, 10.1038/45287

Bharadwaj S., 1999, Mol. Cell. Biol., 19, 8033, 10.1128/MCB.19.12.8033

Bihler H., 1999, FEBS Lett., 447, 115, 10.1016/S0014-5793(99)00281-1

Borkovich K.A., 1989, Mol. Cell. Biol., 9, 3919, 10.1128/MCB.9.9.3919

Boy-Marcotte E., 1998, J. Bacteriol., 180, 1044, 10.1128/JB.180.5.1044-1052.1998

Carratù L., 1996, Proc. Natl. Acad. Sci. USA, 93, 3870, 10.1073/pnas.93.9.3870

Chapman R., 1998, Annu. Rev. Cell Dev. Biol, 14, 459, 10.1146/annurev.cellbio.14.1.459

Cho R.J., 1998, Mol. Cell., 2, 65, 10.1016/S1097-2765(00)80114-8

Craven R.A., 1996, EMBO J., 15, 2640, 10.1002/j.1460-2075.1996.tb00624.x

Deckert J., 1995, Genetics, 139, 1149, 10.1093/genetics/139.3.1149

Deckert J., 1995, Mol. Cell. Biol., 15, 6109, 10.1128/MCB.15.11.6109

DeRisi J.L., 1997, Science, 278, 680, 10.1126/science.278.5338.680

Duina A.A., 1998, J. Biol. Chem., 273, 18974, 10.1074/jbc.273.30.18974

Eisen M.B., 1998, Proc. Natl. Acad. Sci. USA, 95, 14863, 10.1073/pnas.95.25.14863

Ellis R.J., 1999, Curr. Biol., 9, R137, 10.1016/S0960-9822(99)80082-7

Estruch F., 1993, Mol. Cell. Biol., 13, 3872, 10.1128/MCB.13.7.3872

Görner W., 1998, Genes Dev., 12, 586, 10.1101/gad.12.4.586

Holstege F.C.P., 1998, Cell, 95, 717, 10.1016/S0092-8674(00)81641-4

Holyoak C.D., 1999, J. Bacteriol., 181, 4644, 10.1128/JB.181.15.4644-4652.1999

Jelinsky S.A., 1999, Proc. Natl. Acad. Sci. USA, 96, 1486, 10.1073/pnas.96.4.1486

Kim C.H., 1983, Mol. Cell. Biol., 3, 457, 10.1128/MCB.3.3.457

Kingston R.E., 1987, Mol. Cell. Biol., 7, 1530, 10.1128/MCB.7.4.1530

Klein C., 1994, Mol. Cell. Biol., 14, 1920, 10.1128/MCB.14.3.1920

Ko C.H., 1990, Genetics, 125, 305, 10.1093/genetics/125.2.305

Lashkari D.A., 1997, Proc. Natl. Acad. Sci. USA, 94, 13057, 10.1073/pnas.94.24.13057

Lewis J.G., 1995, Microbiology, 141, 687, 10.1099/13500872-141-3-687

Li B., 1999, Mol. Cell. Biol., 19, 5393, 10.1128/MCB.19.8.5393

Lindquist S., 1992, Curr. Opin. Genet. Dev., 2, 748, 10.1016/S0959-437X(05)80135-2

Mager W.H., 1995, Microbiol. Rev., 59, 506, 10.1128/MMBR.59.3.506-531.1995

Marchler G., 1993, EMBO J., 12, 1997, 10.1002/j.1460-2075.1993.tb05849.x

Martinez P., 1998, Mol. Gen. Genet., 258, 628, 10.1007/s004380050776

Martinez-Pastor M.T., 1996, EMBO J., 15, 2227, 10.1002/j.1460-2075.1996.tb00576.x

Miller M., 1982, J. Bacteriol., 151, 311, 10.1128/JB.151.1.311-327.1982

Miller M.J., 1979, Proc. Natl. Acad. Sci. USA, 76, 5222, 10.1073/pnas.76.10.5222

Moradas-Ferreira P., 1996, Mol. Microbiol., 19, 651, 10.1046/j.1365-2958.1996.403940.x

Moskvina E., 1998, Yeast, 14, 1041, 10.1002/(SICI)1097-0061(199808)14:11<1041::AID-YEA296>3.0.CO;2-4

Neuman-Silberg F.S., 1995, Mol. Cell. Biol., 15, 3187, 10.1128/MCB.15.6.3187

Nierras C.R., 1999, J. Biol. Chem., 274, 13235, 10.1074/jbc.274.19.13235

Park J.-I., 1997, Appl. Environ. Microbiol., 63, 3818, 10.1128/AEM.63.10.3818-3824.1997

Parker C.S., 1984, Cell, 37, 273, 10.1016/0092-8674(84)90323-4

Piper P., 1998, EMBO J., 17, 4257, 10.1093/emboj/17.15.4257

Piper P.W., 1995, FEMS Microbiol. Lett, 134, 121, 10.1111/j.1574-6968.1995.tb07925.x

Rep M., 2000, J. Biol. Chem., 275, 8290, 10.1074/jbc.275.12.8290

Rep M., 1999, Mol. Cell. Biol., 19, 5474, 10.1128/MCB.19.8.5474

Rutherford S.L., 1998, Nature, 396, 336, 10.1038/24550

Saris N., 1998, J. Cell Sci., 111, 1575, 10.1242/jcs.111.11.1575

Schmitt A.P., 1996, Proc. Natl. Acad. Sci. USA, 93, 5777, 10.1073/pnas.93.12.5777

Schmitt M.E., 1990, Nucleic Acids Res., 18, 3091, 10.1093/nar/18.10.3091

Smith A., 1998, EMBO J., 13, 3556, 10.1093/emboj/17.13.3556

Sorger P.K., 1987, EMBO J., 6, 3035, 10.1002/j.1460-2075.1987.tb02609.x

10.1091/mbc.9.12.3273

Travers K.J., 2000, Cell, 101, 249, 10.1016/S0092-8674(00)80835-1

Treger J.M., 1998, J. Biol. Chem., 273, 26875, 10.1074/jbc.273.41.26875

Warner J., 1999, Trends Biochem. Sci., 24, 437, 10.1016/S0968-0004(99)01460-7

Winzeler E.A., 1999, Science, 285, 901, 10.1126/science.285.5429.901

Wolfe K.H., 1997, Nature, 387, 708, 10.1038/42711

Wu C., 1985, Nature, 317, 84, 10.1038/317084a0

Zou J., 1998, Cell, 94, 471, 10.1016/S0092-8674(00)81588-3

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Thông tin xuất bản

Molecular Biology of the Cell

Tập 12 Số 2

323-337

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