Marine Drugs
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A Submarine Journey: The Pyrrole-Imidazole Alkaloids
Marine Drugs - Tập 7 Số 4 - Trang 705-753
In his most celebrated tale “The Picture of Dorian Gray”, Oscar Wilde stated
that “those who go beneath the surface do so at their peril”. This sentence
could be a prophetical warning for the practitioner who voluntarily challenges
himself with trying to synthesize marine sponge-deriving pyrrole-imidazole
alkaloids. This now nearly triple-digit membered community has been growing
exponentially in ...
Twenty-Nine New Limonoids with Skeletal Diversity from the Mangrove Plant, Xylocarpus moluccensis
Marine Drugs - Tập 16 Số 1 - Trang 38
Twenty-nine new limonoids—named xylomolins A1–A7, B1–B2, C1–C2, D–F, G1–G5, H–I,
J1–J2, K1–K2, L1–L2, and M–N, were isolated from the seeds of the mangrove
plant, Xylocarpus moluccensis. Compounds 1–13 are mexicanolides with one double
bond or two conjugated double bonds, while 14 belongs to a small group of
mexicanolides with an oxygen bridge between C1 and C8. Compounds 15–19 are
khayanolides co...
Limonoids Containing a C1–O–C29 Moiety: Isolation, Structural Modification, and Antiviral Activity
Marine Drugs - Tập 16 Số 11 - Trang 434
Five new limonoids named thaigranatins A–E (1–5), containing a C1–O–C29 moiety,
were isolated from seeds of the Thai Xylocarpus granatum, collected at the
mangrove swamp of Trang Province, together with the known limonoid, granatumin L
(6). The structures of these compounds were established by HR-ESIMS and
extensive NMR spectroscopic data. The absolute configuration of 1 was
unequivocally determin...
Anticancer Properties of Lamellarins
Marine Drugs - Tập 13 Số 3 - Trang 1105-1123
In 1985 the first lamellarins were isolated from a small oceanic sea snail.
Today, more than 50 lamellarins have been inventoried and numerous derivatives
synthesized and tested as antiviral or anticancer agents. The lead compound in
the family is lamellarin D, characterized as a potent inhibitor of both nuclear
and mitochondrial topoisomerase I but also capable of directly interfering with
mitoch...
Verrucarin A Inhibition of MAP Kinase Activation in a PMA-stimulated Promyelocytic Leukemia Cell Line
Marine Drugs - Tập 3 Số 2 - Trang 64-73
Verrucarin A is an inhibitor of protein synthesis. In this study, we examined
the inhibitory action of verrucarin A on signal molecules. Verrucarin A
partially inhibited the IL-8 production of a PMA-stimulated promyelocytic
leukemia cell line (HL-60 cells), and the effect was related to the inhibition
of NF-κB activation at noncytotoxic concentrations. Moreover, the inhibition of
mitogen activated...
Secomycalolide A: A New Proteasome Inhibitor Isolated from a Marine Sponge of the Genus Mycale
Marine Drugs - Tập 3 Số 2 - Trang 29-35
A new oxazole-containing proteasome inhibitor, secomycalolide A, together with
known mycalolide A and 30-hydroxymycalolide A, was isolated from a marine sponge
of the genus Mycale. They showed proteasome inhibitory activities with IC50
values of 11-45 μg/mL.
Functional Characterization of OXYL, A SghC1qDC LacNAc-specific Lectin from The Crinoid Feather Star Anneissia Japonica
Marine Drugs - Tập 17 Số 2 - Trang 136
We identified a lectin (carbohydrate-binding protein) belonging to the
complement 1q(C1q) family in the feather star Anneissia japonica (a crinoid
pertaining to the phylum Echinodermata). The combination of Edman degradation
and bioinformatics sequence analysis characterized the primary structure of this
novel lectin, named OXYL, as a secreted 158 amino acid-long globular head
(sgh)C1q domain cont...
Microalgal Carotenoids: A Review of Production, Current Markets, Regulations, and Future Direction
Marine Drugs - Tập 17 Số 11 - Trang 640
Microalgae produce a variety of compounds that are beneficial to human and
animal health. Among these compounds are carotenoids, which are microalgal
pigments with unique antioxidant and coloring properties. The objective of this
review is to evaluate the potential of using microalgae as a commercial
feedstock for carotenoid production. While microalgae can produce some of the
highest concentratio...
Eicosapentaenoic Acid Extraction from Nannochloropsis gaditana Using Carbon Dioxide at Supercritical Conditions
Marine Drugs - Tập 17 Số 2 - Trang 132
This research shows that carbon dioxide supercritical fluid (CO2-SF) is an
emerging technology for the extraction of high interest compounds for
applications in the manufacturing of pharmaceuticals, nutraceuticals, and
cosmetics from microalgae. The purpose of this study is to recover fatty acids
(FAs) and, more precisely, eicosapentaenoic acid (EPA) from Nannochloropsis
gaditana biomass by CO2-SF...
Antioxidant, Hypolipidemic and Hepatic Protective Activities of Polysaccharides from Phascolosoma esculenta
Marine Drugs - Tập 18 Số 3 - Trang 158
The aims of this study were to investigate the antioxidant, hypolipidemic and
hepatic protective effects of Phascolosoma esculenta polysaccharides (PEP). PEP
was prepared from Phascolosoma esculenta by enzyme hydrolysis and its
characterization was analyzed. The antioxidant activities of PEP were evaluated
by the assays of scavenging 1,1-Diphenyl-2-picrylhydrazyl (DPPH), superoxide
anion, hydroxyl...
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