Simple Risk Model Predicts Incidence of Atrial Fibrillation in a Racially and Geographically Diverse Population: the CHARGE‐AF Consortium Tập 2 Số 2 - 2013
Álvaro Alonso, Bouwe P. Krijthe, Thor Aspelund, Katherine A. Stepas, Michael Pencina, Carlee Moser, Moritz F. Sinner, Nona Sotoodehnia, João D. Fontes, A. Cecile J.W. Janssens, Richard A. Kronmal, Jared W. Magnani, Jacqueline C.M. Witteman, Alanna M. Chamberlain, Steven A. Lubitz, Renate B. Schnabel, Sunil Agarwal, David D. McManus, Patrick T. Ellinor, Martin G. Larson, Gregory L. Burke, Lenore J. Launer, Albert Hofman, Daniel Levy, John S. Gottdiener, Stefan Kääb, David Couper, Tamara B. Harris, Elsayed Z. Soliman, Bruno H. Stricker, Vilmundur Guðnason, Susan R. Heckbert, Emelia J. Benjamin
Background Tools for the prediction of atrial fibrillation ( AF ) may identify
high‐risk individuals more likely to benefit from preventive interventions and
serve as a benchmark to test novel putative risk factors. Methods and Results
Individual‐level data from 3 large cohorts in the U nited S tates
(Atherosclerosis Risk in Communities [ ARIC ] study, the Cardiovascular Health
Study [ CHS ], and ... hiện toàn bộ
Relationship of Sleep Duration With All‐Cause Mortality and Cardiovascular Events: A Systematic Review and Dose‐Response Meta‐Analysis of Prospective Cohort Studies Tập 6 Số 9 - 2017
Jiawei Yin, Xiaoling Jin, Zhilei Shan, Shuzhen Li, Hao Huang, Peiyun Li, Xiaobo Peng, Peng Zhao, YU Kai-feng, Wei Bao, Wei Yang, Xiaoyi Chen, Liegang Liu
Background Effects of extreme sleep duration on risk of mortality and
cardiovascular outcomes remain controversial. We aimed to quantify the
dose‐response relationships of sleep duration with risk of all‐cause mortality,
total cardiovascular disease, coronary heart disease, and stroke. Methods and
Results PubMed and Embase were systematically searched for prospective cohort
studies published befor... hiện toàn bộ
Risk Profiles for Aortic Dissection and Ruptured or Surgically Treated Aneurysms: A Prospective Cohort Study Tập 4 Số 1 - 2015
Maya Landenhed, Gunnar Engström, Anders Gottsäter, Michael P. Caulfield, Bo Hedblad, Christopher Newton‐Cheh, Olle Melander, J. G. Smith
Background Community screening to guide preventive interventions for acute
aortic disease has been recommended in high‐risk individuals. We sought to
prospectively assess risk factors in the general population for aortic
dissection ( AD ) and severe aneurysmal disease in the thoracic and abdominal
aorta. Methods and Results We studied the incidence of AD and ruptured or
surgically treated aneurysm... hiện toàn bộ
Association of Anxiety and Depression With All‐Cause Mortality in Individuals With Coronary Heart Disease Tập 2 Số 2 - 2013
Lana L. Watkins, Gary G. Koch, Andrew Sherwood, James A. Blumenthal, Jonathan Davidson, Christopher O’Connor, Michael H. Sketch
Background Depression has been related to mortality in coronary heart disease (
CHD ) patients, but few studies have evaluated the role of anxiety or the role
of the co‐occurrence of depression and anxiety. We examined whether anxiety is
associated with increased risk of mortality after accounting for depression in
individuals with established CHD . Methods and Results The cohort was composed
of 9... hiện toàn bộ
DNA Hypomethylation, Ambient Particulate Matter, and Increased Blood Pressure: Findings From Controlled Human Exposure Experiments Tập 2 Số 3 - 2013
Andrea Bellavia, Bruce Urch, Mary Speck, Robert D. Brook, Jeremy A. Scott, Benedetta Albetti, Behrooz Behbod, Michelle L. North, Linda Valeri, Pier Alberto Bertazzi, Frances Silverman, Diane R. Gold, Andrea Baccarelli
Background Short‐term exposures to fine (<2.5 μm aerodynamic diameter) ambient
particulate‐matter ( PM ) have been related with increased blood pressure ( BP )
in controlled‐human exposure and community‐based studies. However, whether
coarse (2.5 to 10 μm) PM exposure increases BP is uncertain. Recent
observational studies have linked PM exposures with blood DNA hypomethylation,
an epigenetic alte... hiện toàn bộ
MicroRNA‐33 Deficiency Reduces the Progression of Atherosclerotic Plaque in ApoE −/− Mice Tập 1 Số 6 - 2012
Takahiro Horie, Osamu Baba, Yasuhide Kuwabara, Yoshimasa Chujo, Shin Watanabe, Minako Kinoshita, Masahito Horiguchi, Tomoyuki Nakamura, Kazuhisa Chonabayashi, Masakatsu Hishizawa, Koji Hasegawa, Noriaki Kume, Masayuki Yokode, Toru Kita, Takeshi Kimura, Koh Ono
Background Cholesterol efflux from cells to apolipoprotein A‐I (apoA‐I)
acceptors via the ATP ‐binding cassette transporters ABCA 1 and ABCG 1 is
thought to be central in the antiatherogenic mechanism. Micro RNA (miR)‐33 is
known to target ABCA 1 and ABCG 1 in vivo. Methods and Results We assessed the
impact of the genetic loss of miR‐33 in a mouse model of atherosclerosis. MiR‐33
and apoE double‐... hiện toàn bộ
Clinical Implications of the New York Heart Association Classification Tập 8 Số 23 - 2019
César Caraballo, Nihar R. Desai, Hillary Mulder, Brooke Alhanti, F. Perry Wilson, Mona Fiuzat, G. Michael Felker, Ileana L. Piña, Christopher M. O’Connor, J. Lindenfeld, James L. Januzzi, Lawrence S. Cohen, Tariq Ahmad
Background The New York Heart Association ( NYHA ) classification has served as
a fundamental tool for risk stratification of heart failure ( HF ) and
determines clinical trial eligibility and candidacy for drugs and devices.
However, its ability to adequately stratify risk is unclear. Methods and Results
To compare NYHA class with objective assessments and survival in patients with
HF , we perfor... hiện toàn bộ
Impact of Fine Particulate Matter (PM 2.5 ) Exposure During Wildfires on Cardiovascular Health Outcomes Tập 4 Số 7 - 2015
Anjali Haikerwal, Muhammad Akram, Anthony Del Monaco, Karen Smith, Malcolm Sim, Mick Meyer, Andrew Tonkin, Michael J. Abramson, Martine Dennekamp
Background Epidemiological studies investigating the role of fine particulate
matter ( PM 2.5 ; aerodynamic diameter <2.5 μm) in triggering acute coronary
events, including out‐of‐hospital cardiac arrests and ischemic heart disease (
IHD ), during wildfires have been inconclusive. Methods and Results We examined
the associations of out‐of‐hospital cardiac arrests, IHD , acute myocardial
infarction... hiện toàn bộ