Journal of the American Heart Association
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Impact of the Metabolic Syndrome on Mortality is Modified by Objective Short Sleep Duration
Journal of the American Heart Association - Tập 6 Số 5 - 2017
Background To examine whether objective sleep duration is an effect modifier of
the impact of metabolic syndrome (MetS) on all‐cause and cardiovascular
disease/cerebrovascular mortality. Methods and Results We addressed this
question in the Penn State Adult Cohort, a random, general population sample of
1344 men and women (48.8±14.2 years) who were studied in the sleep laboratory
and followed up f...
Coronavirus Disease 2019 (COVID‐19) Pandemic Implications in Pediatric and Adult Congenital Heart Disease
Journal of the American Heart Association - Tập 9 Số 12 - 2020
Abstract The corona virus disease ‐2019 (COVID‐19) is a recently described
infectious disease caused by the severe acute respiratory syndrome corona virus
2 with significant cardiovascular implications. Given the increased risk for
severe COVID‐19 observed in adults with underlying cardiac involvement, there is
concern that patients with pediatric and congenital heart disease (CHD) may
likewise be...
Nonlethal Inhibition of Gut Microbial Trimethylamine N‐oxide Production Improves Cardiac Function and Remodeling in a Murine Model of Heart Failure
Journal of the American Heart Association - Tập 9 Số 10 - 2020
Background Patients at increased risk for coronary artery disease and adverse
prognosis during heart failure exhibit increased levels of circulating
trimethylamine N‐oxide ( TMAO ), a metabolite formed in the metabolism of
dietary phosphatidylcholine. We investigated the efficacy of dietary withdrawal
of TMAO as well as use of a gut microbe‐targeted inhibitor of TMAO production,
on cardiac functio...
Concomitant Use of Single Antiplatelet Therapy With Edoxaban or Warfarin in Patients With Atrial Fibrillation: Analysis From the ENGAGE AF‐TIMI48 Trial
Journal of the American Heart Association - Tập 5 Số 2 - 2016
Background We studied the concomitant use of single antiplatelet therapy ( SAPT
) on the efficacy and safety of the anti‐Xa agent edoxaban in patients with
atrial fibrillation ( AF ). Methods and Results ENGAGE AF ‐ TIMI 48 was a
randomized trial that compared 2 dose regimens of edoxaban with warfarin. We
studied both the approved higher‐dose edoxaban regimen ( HDER ; 60 mg daily
reduced by one ha...
Socioeconomic Mediators of Racial and Ethnic Disparities in Congenital Heart Disease Outcomes: A Population‐Based Study in California
Journal of the American Heart Association - Tập 7 Số 20 - 2018
Background Racial/ethnic and socioeconomic disparities exist in outcomes for
children with congenital heart disease. We sought to determine the influence of
race/ethnicity and mediating socioeconomic factors on 1‐year outcomes for
live‐born infants with hypoplastic left heart syndrome and dextro‐Transposition
of the great arteries. Methods and Results The authors performed a
population‐based cohor...
Physiological Bases for the Superiority of Apolipoprotein B Over Low‐Density Lipoprotein Cholesterol and Non–High‐Density Lipoprotein Cholesterol as a Marker of Cardiovascular Risk
Journal of the American Heart Association - Tập 11 Số 20 - 2022
In 2019, the European Society of Cardiology/European Atherosclerosis Society
stated that apolipoprotein B (apoB) was a more accurate marker of cardiovascular
risk than low‐density lipoprotein cholesterol (LDL‐C) and non–high‐density
lipoprotein cholesterol. Since then, the evidence has continued to mount in
favor of apoB. This review explicates the physiological mechanisms responsible
for the supe...
Left Atrial Volume and Mortality in Patients With Aortic Stenosis
Journal of the American Heart Association - Tập 6 Số 11 - 2017
Background Left atrium ( LA ) enlargement is common in patients with aortic
stenosis ( AS ), yet its prognostic implications are unclear. This study
investigates the value of left atrial volume ( LAV ) and LAV normalized to body
size for predicting mortality in AS . Methods and Results We included 1351
patients with AS in sinus rhythm at diagnosis and analyzed the occurrence of
all‐cause death dur...
Cardiovascular Effects of Long‐Term Exposure to Air Pollution: A Population‐Based Study With 900 845 Person‐Years of Follow‐up
Journal of the American Heart Association - Tập 6 Số 11 - 2017
Background Studies have shown that long‐term exposure to air pollution such as
fine particulate matter (≤2.5 μm in aerodynamic diameter [ PM 2.5 ]) increases
the risk of all‐cause and cardiovascular mortality. To date, however, there are
limited data on the impact of air pollution on specific cardiovascular diseases.
This study aimed to evaluate cardiovascular effects of long‐term exposure to air
...
Diabetes and Reduced Risk for Thoracic Aortic Aneurysms and Dissections: A Nationwide Case‐Control Study
Journal of the American Heart Association - Tập 1 Số 2 - 2012
Background Vascular diseases are the principal causes of death and disability in
people with diabetes. At the same time, studies suggest a protective role of
diabetes in the development of abdominal aortic aneurysms. We sought to
determine whether diabetes is associated with decreased hospitalization due to
thoracic aortic aneurysms and dissections (TAAD). Methods and Results We used
the 2006 and ...
Perivascular Adipose Tissue Is a Major Source of Nitric Oxide in Saphenous Vein Grafts Harvested via the No‐Touch Technique
Journal of the American Heart Association - Tập 11 Số 3 - 2022
Background Saphenous vein grafts (SVGs) are broadly used in coronary artery
bypass grafting despite their inferior patency compared with arterial grafts.
Recently, the no‐touch technique (NT), in which an SVG is harvested with a
pedicle of perivascular adipose tissue (PVAT) without conduit distension, was
shown to improve long‐term patency compared with conventional preparation (CV),
wherein outer...
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