Relationship of Sleep Duration With All‐Cause Mortality and Cardiovascular Events: A Systematic Review and Dose‐Response Meta‐Analysis of Prospective Cohort Studies

Jiawei Yin1,2, Xiaoling Jin1,2, Zhilei Shan1,3,2, Shuzhen Li1,2, Hao Huang1,2, Peiyun Li1,2, Xiaobo Peng1,2, Peng Zhao1,2, YU Kai-feng1,2, Wei Bao4, Wei Yang1,2, Xiaoyi Chen5, Liegang Liu1,2
1Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China
2MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China
3Departments of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA
4Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA
5School of Public Health, Guangzhou Medical University, Xinzao, Panyu District, Guangzhou, China

Tóm tắt

Background Effects of extreme sleep duration on risk of mortality and cardiovascular outcomes remain controversial. We aimed to quantify the dose‐response relationships of sleep duration with risk of all‐cause mortality, total cardiovascular disease, coronary heart disease, and stroke.

Methods and Results PubMed and Embase were systematically searched for prospective cohort studies published before December 1, 2016, that examined the associations between sleep duration and at least 1 of the 4 outcomes in generally healthy populations. U‐shaped associations were indicated between sleep duration and risk of all outcomes, with the lowest risk observed for ≈7‐hour sleep duration per day, which was varied little by sex. For all‐cause mortality, when sleep duration was <7 hours per day, the pooled relative risk (RR) was 1.06 (95% CI , 1.04–1.07) per 1‐hour reduction; when sleep duration was >7 hours per day, the pooled RR was 1.13 (95% CI , 1.11–1.15) per 1‐hour increment. For total cardiovascular disease, the pooled RR was 1.06 (95% CI , 1.03–1.08) per 1‐hour reduction and 1.12 (95% CI , 1.08–1.16) per 1‐hour increment of sleep duration. For coronary heart disease, the pooled RR was 1.07 (95% CI , 1.03–1.12) per 1‐hour reduction and 1.05 (95% CI , 1.00–1.10) per 1‐hour increment of sleep duration. For stroke, the pooled RR was 1.05 (95% CI , 1.01–1.09) per 1‐hour reduction and 1.18 (95% CI , 1.14–1.21) per 1‐hour increment of sleep duration.

Conclusions Our findings indicate that both short and long sleep duration is associated with an increased risk of all‐cause mortality and cardiovascular events.

Từ khóa


Tài liệu tham khảo

World Heart Federation . World congress of cardiology & cardiovascular health 2016. Available at: www.world-heart-federation.org/resources/world-congress-cardiology-cardiovascular-health-2016/. Accessed December 1 2016.

World Health Organization . Global action plan for the prevention and control of NCDS 2013–2020. Available at: www.Who.Int/nmh/publications/ncd-action-plan/en/. Accessed December 1 2016.

10.1016/j.tins.2015.10.001

10.1161/CIR.0000000000000444

10.2337/dc14-2073

10.1002/ijc.28452

10.1186/1471-2458-14-290

10.5665/sleep.4564

10.1093/aje/kwt280

10.3961/jpmph.2013.46.5.271

10.1016/j.ypmed.2013.06.017

10.1016/j.sleep.2010.07.021

10.1093/sleep/32.3.295

10.1016/S1389-9457(02)00016-3

10.5665/sleep.1382

10.1016/j.ijcard.2016.01.044

10.1371/journal.pone.0134480

10.5665/sleep.4394

10.1038/srep21480

10.1016/j.smrv.2016.02.005

10.1093/eurheartj/ehr007

10.1001/jama.283.15.2008

Wells GS Shea B O'Connell D Robertson J Peterson J Welch V Losos M Tugwell P. The Newcastle‐Ottawa Scale (NOS) for assessing the quality of nonrandomized studies in meta‐analyses. Available at: www.ohri.ca/programs/clinical_epidemiology/oxford.asp. Accessed December 1 2016.

Higgins JPT, Green S, eds. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0. The cochrane collaboration; 2011. Available at: www.Cochrane-handbook.Org. Accessed December 1, 2016.

10.1001/jama.280.19.1690

10.1093/aje/kwn005

10.1002/sim.3013

10.1002/sim.3602

10.1093/aje/kwr265

10.1093/oxfordjournals.aje.a116237

10.1016/0197-2456(86)90046-2

10.1136/bmj.327.7414.557

10.1136/bmj.315.7109.629

10.2307/2533446

10.1111/j.0006-341X.2000.00455.x

10.1186/1471-2288-9-80

10.1016/j.sleep.2015.09.027

10.1093/aje/kwu222

10.1371/journal.pone.0091965

10.1016/j.sleep.2013.02.002

10.1016/j.sleep.2012.08.020

10.1016/j.sleep.2012.06.004

10.1111/jsr.12020

10.5665/sleep.2884

10.1016/j.sleep.2011.04.014

10.1111/j.1365-2869.2010.00884.x

10.1111/j.1532-5415.2010.03071.x

10.1093/sleep/33.2.177

10.2188/jea.JE20090053

10.1016/j.ypmed.2009.06.016

Gangwisch JE, Heymsfield SB, Boden‐Albala B, Buijs RM, Kreier F, Opler MG, Pickering TG, Rundle AG, Zammit GK, Malaspina D. Sleep duration associated with mortality in elderly, but not middle‐aged, adults in a large US sample. Sleep. 2008;31:1087–1096.

10.1093/sleep/27.3.440

10.1001/archpsyc.59.2.131

10.1111/j.1365-2869.2012.01053.x

10.1111/j.1532-5415.2008.02171.x

10.1093/sleep/30.9.1105

10.2188/jea.14.124

10.2188/jea.10.87

10.1136/bmj.317.7174.1675

10.1007/s10654-013-9802-2

10.1089/jwh.2012.3918

10.1371/journal.pone.0082305

10.5271/sjweh.3168

10.1371/journal.pone.0030972

10.1093/sleep/33.6.739

10.1093/aje/kwn281

10.1093/sleep/30.9.1121

10.1001/archinte.163.2.205

10.5665/sleep.5544

10.1016/j.jstrokecerebrovasdis.2013.09.009

10.1161/strokeaha.114.005181

10.2188/jea.JE20140272

10.1161/STROKEAHA.108.521773

10.1093/sleep/30.12.1659

10.1001/jamainternmed.2016.5451

10.5665/sleep.2646

10.1093/sleep/29.7.878

10.1001/jama.2011.710

10.1016/j.smrv.2008.07.007

10.1016/S0140-6736(95)92600-3

10.1016/j.jacc.2015.12.005

10.1001/jama.2008.867

10.1371/journal.pmed.0010062

10.7326/0003-4819-141-11-200412070-00008

10.1161/01.cir.0000081427.01306.7d

10.1159/000360837

10.1073/pnas.1516953113

10.1056/NEJMe1404501

10.1016/j.smrv.2003.10.002

10.1161/strokeaha.115.011608

10.1097/01.PSY.0000107881.53228.4D

10.5665/sleep.5036

10.1093/aje/kwu245

10.1186/s12966-015-0201-9

10.1093/sleep/30.10.1245

10.1056/NEJMoa043104