Discovery and Evaluation of Entry Inhibitors for SARS-CoV-2 and Its Emerging VariantsJournal of Virology - Tập 95 Số 24 - 2021
Arpan Acharya, Siddappa N. Byrareddy, Michellie Thurman, Elizabeth Klug, Jay Trivedi, Kalicharan Sharma, Christian L. Lorson, Kamal Singh
The ongoing coronavirus infectious disease 2019 (COVID-19) pandemic is caused by a novel coronavirus named Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). More than 207 million people have been infected globally, and 4.3 million have died due to this viral outbreak.
Paramyxovirus V Proteins Interact with the RNA Helicase LGP2 To Inhibit RIG-I-Dependent Interferon InductionJournal of Virology - Tập 86 Số 7 - Trang 3411-3421 - 2012
Kay Childs, Richard E. Randall, Stephen Goodbourn
ABSTRACT
RIG-I and mda-5 are activated by viral RNA and stimulate type I interferon production. Laboratory of genetics and physiology 2 (LGP2) shares homology with RIG-I and mda-5 but lacks the CARD domains required for signaling. The V proteins of paramyxoviruses limit interferon induction by binding mda-5 and preventing its activation; however, they do ...... hiện toàn bộ
RNA- and Virus-Independent Inhibition of Antiviral Signaling by RNA Helicase LGP2Journal of Virology - Tập 80 Số 24 - Trang 12332-12342 - 2006
Akihiko Komuro, Curt M. Horvath
ABSTRACT
Antiviral innate immune responses can be triggered by accumulation of intracellular nucleic acids resulting from virus infections. Double-stranded RNA (dsRNA) can be detected by the cytoplasmic RNA helicase proteins RIG-I and MDA5, two proteins that share sequence similarities within a caspase recruitment domain (CARD) and a DExD/H box RNA helica...... hiện toàn bộ
Role of the first and third extracellular domains of CXCR-4 in human immunodeficiency virus coreceptor activityJournal of Virology - Tập 71 Số 6 - Trang 4744-4751 - 1997
Anne Brelot, Olivier Pleskoff, Nathalie Sol‐Foulon, Marc Alizon
The CXCR-4 chemokine receptor and CD4 behave as coreceptors for cell line-adapted human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2) and for dual-tropic HIV strains, which also use the CCR-5 coreceptor. The cell line-adapted HIV-1 strains LAI and NDK and the dual-tropic HIV-2 strain ROD were able to infect CD4+ cells expressing human CXCR-4, while only LAI was able to infect cell...... hiện toàn bộ
Three monoclonal antibodies against measles virus F protein cross-react with cellular stress proteinsJournal of Virology - Tập 52 Số 3 - Trang 995-999 - 1984
Hooshmand Sheshberadaran, Erling Norrby
In a group of 11 monoclonal antibodies specifically reacting with the measles virus fusion protein, three antibodies also immunoprecipitated other proteins, in particular a 79,000-molecular-weight protein from virus-infected cells. The cross-reacting 79,000-molecular-weight protein was shown to be a virus-induced host stress protein. This protein could be induced by (i) different paramyxov...... hiện toàn bộ
RNA-RNA hybridization identifies a human rotavirus that is genetically related to feline rotavirusJournal of Virology - Tập 63 Số 3 - Trang 1431-1434 - 1989
Toyoko Nakagomi, Osamu Nakagomi
A human rotavirus AU228 strain which resembled the AU-1 strain (O. Nakagomi, T. Nakagomi, Y. Hoshino, J. Flores, and A. Z. Kapikian, J. Clin. Microbiol. 25:1159-1164, 1987) in its novel characteristics (that it belonged to subgroup I yet possessed a long RNA pattern) was compared with various human and animal strains by RNA-RNA hybridization in solution. This strain showed a high degree of...... hiện toàn bộ
Length and shape variants of the bacteriophage T4 head: mutations in the scaffolding core genes 68 and 22Journal of Virology - Tập 62 Số 8 - Trang 2960-2969 - 1988
Beat Keller, J DUBOCHET, Marc Adrian, Muriel Maeder, M. Würtz, E. Kellenberger
The shape and size of the bacteriophage T4 head are dependent on genes that determine the scaffolding core and the shell of the prohead. Mutants of the shell proteins affect mainly the head length. Two recently identified genes (genes 67 and 68) and one already known gene (gene 22), whose products are scaffold constituents, have been investigated. Different types of mutants were shown to s...... hiện toàn bộ