Discovery and Evaluation of Entry Inhibitors for SARS-CoV-2 and Its Emerging VariantsJournal of Virology - Tập 95 Số 24 - 2021
Arpan Acharya, Siddappa N. Byrareddy, Michellie Thurman, Elizabeth Klug, Jay Trivedi, Kalicharan Sharma, Christian L. Lorson, Kamal Singh
The ongoing coronavirus infectious disease 2019 (COVID-19) pandemic is caused by a novel coronavirus named Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). More than 207 million people have been infected globally, and 4.3 million have died due to this viral outbreak.
Ion channel activity of influenza A virus M2 protein: characterization of the amantadine blockJournal of Virology - Tập 67 Số 9 - Trang 5585-5594 - 1993
Chenhui Wang, Kaoru Takeuchi, Lawrence H. Pinto, Robert A. Lamb
The influenza A virus M2 integral membrane protein has ion channel activity which can be blocked by the antiviral drug amantadine. The M2 protein transmembrane domain is highly conserved in amino acid sequence for all the human, swine, equine, and avian strains of influenza A virus, and thus, known amino acid differences could lead to altered properties of the M2 ion channel. We have expre...... hiện toàn bộ
Paramyxovirus V Proteins Interact with the RNA Helicase LGP2 To Inhibit RIG-I-Dependent Interferon InductionJournal of Virology - Tập 86 Số 7 - Trang 3411-3421 - 2012
Kay Childs, Richard E. Randall, Stephen Goodbourn
ABSTRACT
RIG-I and mda-5 are activated by viral RNA and stimulate type I interferon production. Laboratory of genetics and physiology 2 (LGP2) shares homology with RIG-I and mda-5 but lacks the CARD domains required for signaling. The V proteins of paramyxoviruses limit interferon induction by binding mda-5 and preventing its activation; however, they do ...... hiện toàn bộ
RNA- and Virus-Independent Inhibition of Antiviral Signaling by RNA Helicase LGP2Journal of Virology - Tập 80 Số 24 - Trang 12332-12342 - 2006
Akihiko Komuro, Curt M. Horvath
ABSTRACT
Antiviral innate immune responses can be triggered by accumulation of intracellular nucleic acids resulting from virus infections. Double-stranded RNA (dsRNA) can be detected by the cytoplasmic RNA helicase proteins RIG-I and MDA5, two proteins that share sequence similarities within a caspase recruitment domain (CARD) and a DExD/H box RNA helica...... hiện toàn bộ
Role of the first and third extracellular domains of CXCR-4 in human immunodeficiency virus coreceptor activityJournal of Virology - Tập 71 Số 6 - Trang 4744-4751 - 1997
Anne Brelot, Olivier Pleskoff, Nathalie Sol‐Foulon, Marc Alizon
The CXCR-4 chemokine receptor and CD4 behave as coreceptors for cell line-adapted human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2) and for dual-tropic HIV strains, which also use the CCR-5 coreceptor. The cell line-adapted HIV-1 strains LAI and NDK and the dual-tropic HIV-2 strain ROD were able to infect CD4+ cells expressing human CXCR-4, while only LAI was able to infect cell...... hiện toàn bộ
Three monoclonal antibodies against measles virus F protein cross-react with cellular stress proteinsJournal of Virology - Tập 52 Số 3 - Trang 995-999 - 1984
Hooshmand Sheshberadaran, Erling Norrby
In a group of 11 monoclonal antibodies specifically reacting with the measles virus fusion protein, three antibodies also immunoprecipitated other proteins, in particular a 79,000-molecular-weight protein from virus-infected cells. The cross-reacting 79,000-molecular-weight protein was shown to be a virus-induced host stress protein. This protein could be induced by (i) different paramyxov...... hiện toàn bộ
Functions of the Two Particles of Tobacco Rattle VirusJournal of Virology - Tập 3 Số 3 - Trang 304-312 - 1969
Heinz L. Sänger
Functions of long and short particles of five different tobacco rattle virus (TRV) systems were studied by complementation experiments with the corresponding long and short species of ribonucleic acid (RNA). The progeny of long RNA species alone was proteinless or “free” infectious long RNA, whereas short RNA species alone did not replicate by themselves but appeared to be dependent on lon...... hiện toàn bộ