Journal of Virology

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The Influenza Virus M2 Protein Cytoplasmic Tail Interacts with the M1 Protein and Influences Virus Assembly at the Site of Virus Budding
Journal of Virology - Tập 82 Số 20 - Trang 10059-10070 - 2008
Benjamin J. Chen, George P. Leser, David J. Jackson, Robert A. Lamb
ABSTRACTThe cytoplasmic tail of the influenza A virus M2 proton-selective ion channel has been shown to be important for virus replication. Previous analysis of M2 cytoplasmic tail truncation mutants demonstrated a defect in incorporation of viral RNA (vRNA) into virions, suggesting a role for M2 in the recruitment of M1-vRNA complexes. To further characterize the ...... hiện toàn bộ
Formation of Wild-Type and Chimeric Influenza Virus-Like Particles following Simultaneous Expression of Only Four Structural Proteins
Journal of Virology - Tập 75 Số 13 - Trang 6154-6165 - 2001
Theresa Latham, Jose M. Galarza
ABSTRACT We are studying the structural proteins and molecular interactions required for formation and release of influenza virus-like particles (VLPs) from the cell surface. To investigate these events, we generated a quadruple baculovirus recombinant that simultaneously expresses in Sf9 cells the hemagglutinin (HA), neuraminidase (NA), matrix (M1), and ...... hiện toàn bộ
Treatment of Transmissible Spongiform Encephalopathy by Intraventricular Drug Infusion in Animal Models
Journal of Virology - Tập 78 Số 10 - Trang 4999-5006 - 2004
Katsumi Doh‐ura, Kazuo Ishikawa, Ikuko Murakami-Kubo, Kensuke Sasaki, Satoshi Mohri, Richard Race, Toru Iwaki
ABSTRACT The therapeutic efficacy of direct drug infusion into the brain, the target organ of transmissible spongiform encephalopathies, was assessed in transgenic mice intracerebrally infected with 263K scrapie agent. Pentosan polysulfate (PPS) gave the most dramatic prolongation of the incubation period, and amphotericin B had intermediate effects, but ...... hiện toàn bộ
The Interferon-Inducible Chemokines MuMig and Crg-2 Exhibit Antiviral Activity In Vivo
Journal of Virology - Tập 73 Số 2 - Trang 1479-1491 - 1999
Suresh Mahalingam, Joshua Μ. Farber, Gunasegaran Karupiah
ABSTRACTMuMig (murine monokine induced by gamma interferon) and Crg-2 (cytokine responsive gene 2) are two murine chemokines of the CXC family that are induced by the interferons (IFNs): MuMig specifically by IFN-γ and Crg-2 by IFN-α, IFN-β, and IFN-γ. To investigate the biological roles of these chemokines, recombinant vaccinia viruses (rVVs) encoding either MuMig...... hiện toàn bộ
Influenza A Virus NEP (NS2 Protein) Downregulates RNA Synthesis of Model Template RNAs
Journal of Virology - Tập 75 Số 10 - Trang 4912-4917 - 2001
Rosario Bullido, Paulino Gómez‐Puertas, Marı́a José Saiz, Agustı́n Portela
ABSTRACT The influenza A virus NEP (NS2) protein is an structural component of the viral particle. To investigate whether this protein has an effect on viral RNA synthesis, we examined the expression of an influenza A virus-like chloramphenicol acetyltransferase (CAT) RNA in cells synthesizing the four influenza A virus core proteins (nucleoprotein, PB1, ...... hiện toàn bộ
Contribution of Ebola Virus Glycoprotein, Nucleoprotein, and VP24 to Budding of VP40 Virus-Like Particles
Journal of Virology - Tập 78 Số 14 - Trang 7344-7351 - 2004
Jillian M. Licata, Reed F. Johnson, Ziying Han, Ronald N. Harty
ABSTRACT The VP40 matrix protein of Ebola virus buds from cells in the form of virus-like particles (VLPs) and plays a central role in virus assembly and budding. In this study, we utilized a functional budding assay and cotransfection experiments to examine the contributions of the glycoprotein (GP), nucleoprotein (NP), and VP24 of Ebola virus in facilit...... hiện toàn bộ
Temperate Bacteriophage Which Causes the Production of a New Major Outer Membrane Protein by Escherichia coli
Journal of Virology - Tập 15 Số 5 - Trang 1121-1130 - 1975
Carl A. Schnaitman, Deborah H. Smith, Montserrat Forn de Salsas
Under most conditions of growth, the most abundant protein in the outer membrane of most strains of Escherichia coli is a protein designated as “protein 1” or “matrix protein”. In E. coli B, this protein has been shown to be a single polypeptide with a molecular mass of 36,500...... hiện toàn bộ
Human Papillomavirus Type 16 E7 Oncoprotein Can Induce Abnormal Centrosome Duplication through a Mechanism Independent of Inactivation of Retinoblastoma Protein Family Members
Journal of Virology - Tập 77 Số 22 - Trang 12331-12335 - 2003
Stefan Duensing, Karl Münger
ABSTRACT The human papillomavirus type 16 (HPV-16) E7 oncoprotein rapidly induces centrosome duplication errors in primary human cells, thereby increasing the propensity for multipolar mitoses, which can lead to chromosome missegregation and aneuploidy. We analyzed a series of HPV-16 E7 mutants and demonstrate that this biological activity of the E7 oncop...... hiện toàn bộ
Induction of hepatitis A virus-neutralizing antibody by a virus-specific synthetic peptide
Journal of Virology - Tập 55 Số 3 - Trang 836-839 - 1985
Emilio A. Emini, J V Hughes, Debra S. Perlow, Joshua Boger
Comparative surface feature analyses of the VP1 sequences of hepatitis A virus (HAV) and poliovirus type 1 allowed an alignment of the two sequences and an identification of probable HAV neutralization antigenic sites. A synthetic peptide containing the HAV-specific amino acid sequence of one of these sites induced anti-HAV-neutralizing antibodies. It is concluded that a structural homolog...... hiện toàn bộ
The Differential Sensitivity of Human and Rhesus Macaque CCR5 to Small-Molecule Inhibitors of Human Immunodeficiency Virus Type 1 Entry Is Explained by a Single Amino Acid Difference and Suggests a Mechanism of Action for These Inhibitors
Journal of Virology - Tập 78 Số 8 - Trang 4134-4144 - 2004
Erika Billick, Christoph Seibert, Pavel Pugach, Tom Ketas, Alexandra Trkola, M. Endres, Nicholas Murgolo, Elizabeth Coates, Gregory R. Reyes, Bahige M. Baroudy, Thomas P. Sakmar, John P. Moore, Shawn E. Kuhmann
ABSTRACTAD101 and SCH-C are two chemically related small molecules that inhibit the entry of human immunodeficiency virus type 1 (HIV-1) via human CCR5. AD101 also inhibits HIV-1 entry via rhesus macaque CCR5, but SCH-C does not. Among the eight residues that differ between the human and macaque versions of the coreceptor, only one, methionine-198, accounts for the...... hiện toàn bộ
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