Journal of Virology

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Complete Genome Sequence of a Novel Marine Siphovirus, pVp-1, Infecting Vibrio parahaemolyticus
Journal of Virology - Tập 86 Số 12 - Trang 7013-7014 - 2012
Ji Hyung Kim, Jin Woo Jun, Casiano H. Choresca, Sang Phil Shin, Jee Eun Han, Se Chang Park
ABSTRACT Among the abundant bacteriophages that belong to the order Caudovirales in the ocean, the genome sequences of marine siphoviruses are poorly investigated in comparison to those of myo- or podoviruses. Here we report the complete genome seque...... hiện toàn bộ
Native but not denatured recombinant human immunodeficiency virus type 1 gp120 generates broad-spectrum neutralizing antibodies in baboons
Journal of Virology - Tập 66 Số 1 - Trang 172-182 - 1992
Nancy L. Haigwood, Peter L. Nara, Ellena Brooks, G A Van Nest, Gary Ott, Keith Higgins, Nancy M. Dunlop, Carl J. Scandella, J W Eichberg, Kathelyn S. Steimer
The protection of individuals from human immunodeficiency virus type 1 (HIV-1) infection with an envelope subunit derived from a single isolate will require the presentation of conserved epitopes in gp120. The objective of the studies presented here was to test whether a native recombinant gp120 (rgp120) immunogen would elicit responses to conserved neutralization epitopes that are not pre...... hiện toàn bộ
Discovery and Evaluation of Entry Inhibitors for SARS-CoV-2 and Its Emerging Variants
Journal of Virology - Tập 95 Số 24 - 2021
Arpan Acharya, Siddappa N. Byrareddy, Michellie Thurman, Elizabeth Klug, Jay Trivedi, Kalicharan Sharma, Christian L. Lorson, Kamal Singh
The ongoing coronavirus infectious disease 2019 (COVID-19) pandemic is caused by a novel coronavirus named Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). More than 207 million people have been infected globally, and 4.3 million have died due to this viral outbreak.
Glycan Shield and Fusion Activation of a Deltacoronavirus Spike Glycoprotein Fine-Tuned for Enteric Infections
Journal of Virology - Tập 92 Số 4 - 2018
Xiaoli Xiong, M. Alejandra Tortorici, Joost Snijder, Craig Yoshioka, Alexandra C. Walls, Wentao Li, Andrew T. McGuire, F.A. Rey, Berend‐Jan Bosch, David Veesler
ABSTRACT Coronaviruses recently emerged as major human pathogens causing outbreaks of severe acute respiratory syndrome and Middle East respiratory syndrome. They utilize the spike (S) glycoprotein anchored in the viral envelope to mediate host attachment and fusion of the viral and cellular membranes to initiate infection. The S protein is a...... hiện toàn bộ
Baculovirus Stimulates Antiviral Effects in Mammalian Cells
Journal of Virology - Tập 73 Số 12 - Trang 9944-9951 - 1999
Ann M Gronowski, David M. Hilbert, Kathleen C. F. Sheehan, Gianni Garotta, Robert D. Schreiber
ABSTRACTHerein, we report thatAutographa californicanucleopolyhedrovirus, a member of theBaculoviridaefamily, is capable of stimulating antiviral activity in mammalian cells. Baculoviruses are not pathogenic to mammalian cells. Nevertheless, live baculovirus is shown here to induce interferons (IFN) from murine ...... hiện toàn bộ
O-Linked N -Acetylglucosaminylation of Sp1 Inhibits the Human Immunodeficiency Virus Type 1 Promoter
Journal of Virology - Tập 83 Số 8 - Trang 3704-3718 - 2009
Ramona Jochmann, Mathias Thurau, Susan Jung, Christian Hofmann, Elisabeth Naschberger, Elisabeth Kremmer, Thomas Harrer, Matthew Miller, Niels Schaft, Michael Stürzl
ABSTRACT Human immunodeficiency virus type 1 (HIV-1) gene expression and replication are regulated by the promoter/enhancer located in the U3 region of the proviral 5′ long terminal repeat (LTR). The binding of cellular transcription factors to specific regulatory sites in the 5′ LTR is a key event in the replication cycle of HIV-1. Since tra...... hiện toàn bộ
DNA immunization: ubiquitination of a viral protein enhances cytotoxic T-lymphocyte induction and antiviral protection but abrogates antibody induction
Journal of Virology - Tập 71 Số 11 - Trang 8497-8503 - 1997
Fernando Rodrı́guez, Jie Zhang, J. Lindsay Whitton
DNA immunization can induce cytotoxic T lymphocytes (CTL), antibodies, and protection against microbial challenge. The underlying mechanisms remain obscure and must be understood to permit rational manipulation and optimization of the technique. We set out to enhance the intracellular degradation of a viral antigen, with the intent of improving antigen entry into, and presentation by, the ...... hiện toàn bộ
Ubiquitination of the Human Immunodeficiency Virus Type 1 Env Glycoprotein
Journal of Virology - Tập 74 Số 11 - Trang 5373-5376 - 2000
Andreas Bültmann, Josef Eberle, Jürgen Haas
ABSTRACTExpression of the human immunodeficiency virus type 1 (HIV-1) Env glycoprotein is stringently regulated in infected cells. The majority of the glycoprotein does not reach the cell surface but rather is retained in the endoplasmic reticulum or acis-Golgi compartment and subsequently degraded. We here report that Env of various HIV-...... hiện toàn bộ
Antiviral Activity of the Proteasome on Incoming Human Immunodeficiency Virus Type 1
Journal of Virology - Tập 72 Số 5 - Trang 3845-3850 - 1998
Olivier Schwartz, Valérie Maréchal, Bertrand Friguet, Fernando Arenzana‐Seisdedos, Jean‐Michel Heard
ABSTRACT Following cell surface receptor binding and membrane fusion, human immunodeficiency virus (HIV) virion cores are released in the cytoplasm. Incoming viral proteins represent potential targets for cytosolic proteases. We show that treatment of target cells with the proteasome inhibitors MG132 and lactacystin increased the efficiency o...... hiện toàn bộ
Lipopolysaccharide, Tumor Necrosis Factor Alpha, or Interleukin-1β Triggers Reactivation of Latent Cytomegalovirus in Immunocompetent Mice
Journal of Virology - Tập 80 Số 18 - Trang 9151-9158 - 2006
Charles H. Cook, Joanne Trgovcich, Peter D. Zimmerman, Yingxue Zhang, Daniel D. Sedmak
ABSTRACTWe have previously shown that cytomegalovirus (CMV) can reactivate in lungs of nonimmunosuppressed patients during critical illness. Our recent work has shown that polymicrobial bacterial sepsis can trigger reactivation of latent murine CMV (MCMV). We hypothesize that MCMV reactivation following bacterial sepsis may be caused by inflammatory mediators. To t...... hiện toàn bộ
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