Ubiquitination of the Human Immunodeficiency Virus Type 1 Env Glycoprotein

Journal of Virology - Tập 74 Số 11 - Trang 5373-5376 - 2000
Andreas Bültmann1, Josef Eberle1, Jürgen Haas1
1Max-von-Pettenkofer Institut, Genzentrum, LMU München, 81377 Munich, Germany

Tóm tắt

ABSTRACTExpression of the human immunodeficiency virus type 1 (HIV-1) Env glycoprotein is stringently regulated in infected cells. The majority of the glycoprotein does not reach the cell surface but rather is retained in the endoplasmic reticulum or acis-Golgi compartment and subsequently degraded. We here report that Env of various HIV-1 isolates is ubiquitinated at the extracellular domain of gp41 and that Env expression could be increased by lactacystin, a specific proteasome inhibitor, suggesting that the ubiquitin/proteasome system is involved in control of expression and degradation.

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Journal of Virology

Tập 74 Số 11

5373-5376

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