Praful U. Jani, Gavin Halbert, John Langridge, Alexander T. Florence
Abstract Polystyrene microspheres in the size range 50 nm to 3 μm were fed by
gavage to female Sprague Dawley rats daily for 10 days at a dose of 1.25 mg
kg−1. Previous histological evidence of the uptake of these particles and their
absorption across the gastrointestinal tract and passage via the mesentery lymph
supply and lymph nodes to the liver and spleen was confirmed by analysis of
tissues f... hiện toàn bộ
Vandana Patravale, Abhijit A. Date, Rishikesh M. Kulkarni
Abstract Nanosuspensions have emerged as a promising strategy for the efficient
delivery of hydrophobic drugs because of their versatile features and unique
advantages. Techniques such as media milling and high-pressure homogenization
have been used commercially for producing nanosuspensions. Recently, the
engineering of nanosuspensions employing emulsions and microemulsions as
templates has been ... hiện toàn bộ
Joanne Barnes, Linda A. Anderson, J. David Phillipson
Abstract The chemical composition of St. John's wort has been well-studied.
Documented pharmacological activities, including antidepressant, antiviral, and
antibacterial effects, provide supporting evidence for several of the
traditional uses stated for St John's wort. Many pharmacological activities
appear to be attributable to hypericin and to the flavonoid constituents;
hypericin is also report... hiện toàn bộ
Abstract Some pharmacological actions of curcumin (diferuloyl methane) have been
examined in rats, mice and cats. The compound possesses significant
anti-inflammatory activity in acute as well as in chronic models of
inflammation. It is as potent as phenylbutazone in the carrageenan oedema test
but only half as potent in chronic tests. Curcumin possesses a much lower
ulcerogenic index than phenylb... hiện toàn bộ
Abstract Many patients find it difficult to swallow tablets and hard gelatin
capsules and do not take their medication as prescribed. It is estimated that
50% of the population is affected by this problem which results in a high
incidence of non-compliance and ineffective therapy. The difficulty is
experienced in particular by paediatric and geriatric patients, but it also
applies to people who ar... hiện toàn bộ
Kerry L. Allen, Peter C. Molan, Gordon McGregor Reid
Abstract To assess the variation in antibacterial activity of honey a survey was
carried out on 345 samples of unpasteurized honey obtained from commercial
apiarists throughout New Zealand. Most of the honeys were considered to be
monofloral, from 26 different floral sources. The honeys were tested against
Staphylococcus aureus in an agar well diffusion assay, with reference to phenol
as a standar... hiện toàn bộ
Abstract An in-vitro test system was developed to investigate the adhesiveness
of various materials to mucus. The results obtained showed good agreement with
the findings of previous in-vivo evaluations of mucosa-adhesives. Further
investigations found that these materials become adhesive on hydration. Chain
length, and the presence of ionizable groups in the molecule, were found to be
determinate... hiện toàn bộ