An in-vitro investigation of mucosa-adhesive materials for use in controlled drug delivery

Journal of Pharmacy and Pharmacology - Tập 36 Số 5 - Trang 295-299 - 2011
John D. Smart1, I.W. Kellaway1, H E C Worthington2
1The Welsh School of Pharmacy, U.W.I.S.T., Cardiff, UK
2Roche Products Limited, Welwyn Garden City, UK

Tóm tắt

Abstract An in-vitro test system was developed to investigate the adhesiveness of various materials to mucus. The results obtained showed good agreement with the findings of previous in-vivo evaluations of mucosa-adhesives. Further investigations found that these materials become adhesive on hydration. Chain length, and the presence of ionizable groups in the molecule, were found to be determinate factors. The physical nature of the gel, and the location at which the mucoadhesive materials hydrated, were of less importance.

Từ khóa


Tài liệu tham khảo

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Thông tin xuất bản

Journal of Pharmacy and Pharmacology

Tập 36 Số 5

295-299

Thông tin tác giả