In-vitro Metabolic Interaction of Bunitrolol Enantiomers in Rabbit Liver MicrosomesJournal of Pharmacy and Pharmacology - Tập 48 Số 11 - Trang 1185-1189 - 2011
Shizuo Narimatsu, Takao Mizukami, Yong Huang, Yasuhiro Masubuchi, Tokuji Suzuki
Abstract
We have examined the 4-hydroxylation of bunitrolol in rabbit and rat liver microsomes.
Significant species differences (rabbit < rat of both sexes) and sex (male > female of both species) were observed in the formation of 4-hydroxybunitrolol from racemic bunitrolol (10 μM). The 4-hydroxylation of...... hiện toàn bộ
Anti-inflammatory Effects of South American Tanacetum vulgareJournal of Pharmacy and Pharmacology - Tập 50 Số 9 - Trang 1069-1074 - 1998
Guillermo Schinella, Rosa M. Giner, Marı́a del Carmen Recio, Perla M. de Buschiazzo, José-Luis Rı́os, Salvador Máñez
Abstract
In recent years the role of phenolic compounds and sesquiterpene lactones, particularly parthenolide, in the anti-migraine and anti-inflammatory effects of Tanacetum parthenium (Asteraceae) has attracted much attention. However, the closely-related cosmopolitan species T. vulgare has remained outside the mainstream of research in this field....... hiện toàn bộ
Skin Delivery of Oestradiol from Deformable and Traditiona Liposomes: Mechanistic StudiesJournal of Pharmacy and Pharmacology - Tập 51 Số 10 - Trang 1123-1134 - 1999
Gamal M. El Maghraby, Adrian C. Williams, Brian Barry
AbstractDeformable vesicles and traditional liposomes were compared as delivery systems for oestradiol to elucidate possible mechanisms of drug delivery through human skin. Accordingly, epidermal permeation of oestradiol from optimized deformable vesicles and traditional liposome formulations was studied under low dose non-occluded conditions. Five mechanisms were ...... hiện toàn bộ
Natural products as targeted modulators of the nuclear factor-κB pathwayJournal of Pharmacy and Pharmacology - Tập 54 Số 4 - Trang 453-472 - 2002
Paul Bremner, Michael Heinrich
Abstract
The use of plant extracts to alleviate inflammatory diseases is centuries old and continues to this day. This review assesses the current understanding of the use of such plants and natural products isolated from them in terms of their action against the ubiquitous transcription factor, nuclear factor kappa B (NF-κB). As an activator of many...... hiện toàn bộ