Journal of Pharmacy and Pharmacology

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Interaction Between Substance P and β-Adrenergic Agonists in the Modulation of the Secretion of Fluid and Protein by the Rat Submandibular Gland
Journal of Pharmacy and Pharmacology - Tập 50 Số 3 - Trang 335-341 - 2011
Yoshiki Iwabuchi, Tomohiko Kimura
AbstractThe interactions between substance P and β-adrenergic agonists such as isoprenaline, dobutamine and terbutaline in the control of the secretion of fluid and protein from the rat submandibular gland have been examined.Substance P elicited large volumes of saliva whereas isoprenaline, dobutamine and terbutaline elicited small volumes only. Th...... hiện toàn bộ
Blockade by pimozide of (+)-amphetamine-induced hyperkinesia in mice
Journal of Pharmacy and Pharmacology - Tập 24 Số 5 - Trang 408-409 - 2011
Jay M. Schlechter, Larry L. Butcher
Duration of the effects of α-ethyl-4-methyl-m-tyramine, (H75/12) on brain 5-hydroxyindole concentrations in rats
Journal of Pharmacy and Pharmacology - Tập 28 Số 8 - Trang 649-650 - 2011
Ray W. Fuller, Kenneth W. Perry, John C. Baker
Efficacy of chitosan microspheres for controlled intra-articular delivery of celecoxib in inflamed joints
Journal of Pharmacy and Pharmacology - Tập 56 Số 9 - Trang 1091-1099 - 2010
Hetal Thakkar, Rakesh Kumar Sharma, Anil K. Mishra, Krishna Chuttani, R. S. R. Murthy
Abstract The use of polymeric carriers in formulations of therapeutic drug delivery systems has gained widespread application, due to their advantage of being biodegradable and biocompatible. In this study, we aimed to prepare celecoxib-loaded chitosan microspheres for intra-articular administration and to compare the retention of the celecoxib solut...... hiện toàn bộ
Nanosuspensions: a promising drug delivery strategy
Journal of Pharmacy and Pharmacology - Tập 56 Số 7 - Trang 827-840 - 2010
Vandana Patravale, Abhijit A. Date, Rishikesh M. Kulkarni
Abstract Nanosuspensions have emerged as a promising strategy for the efficient delivery of hydrophobic drugs because of their versatile features and unique advantages. Techniques such as media milling and high-pressure homogenization have been used commercially for producing nanosuspensions. Recently, the engineering of nanosuspensions employing emu...... hiện toàn bộ
Do Biocides Select for Antibiotic Resistance?
Journal of Pharmacy and Pharmacology - Tập 52 Số 2 - Trang 227-233 - 2010
A. D. Russell
Abstract Some similarities exist between bacterial resistance to antibiotics and to biocides, and gram-negative bacteria that have developed resistance to cationic biocides may also be insusceptible to some antibiotics. Outer membrane changes are believed to be responsible for this non-specific increase in resistance. Efflux, another important resist...... hiện toàn bộ
Modification of Ca2+ Metabolism in the Rabbit Aorta as a Mechanism of Spasmolytic Action of Warifteine, a Bisbenzylisoquinoline Alkaloid Isolated from the Leaves of Cissampelos sympodialis Eichl. (Menispermaceae)
Journal of Pharmacy and Pharmacology - Tập 48 Số 3 - Trang 332-336 - 2011
Maria Regina de Freitas, Steyner F. Côrtes, George Thomas, José Maria Barbosa‐Filho
Abstract The regulation of intracellular Ca2+ as a mechanism of spasmolytic activity of a bisbenzylisoquinoline alkaloid, warifteine, isolated from the leaves of Cissampelos sympodialis, Eichl (Menispermaceae) was studied in the rabbit aorta. Warifteine (pD'2 4.12 ± 0.09) similar to verapamil (pD'2 6.89 · 0.05) antagon...... hiện toàn bộ
PLASMA-SALICYLATE CONCENTRATIONS AFTER SMALL DOSES OF ACETYLSALICYLIC ACID
Journal of Pharmacy and Pharmacology - Tập 3 Số 1 - Trang 409-414 - 2011
M. J. H. Smith
Development of a Lyophilization Formulation that Preserves the Biological Activity of the Platelet-inducing Cytokine Interleukin-11 at Low Concentrations
Journal of Pharmacy and Pharmacology - Tập 52 Số 1 - Trang 19-26 - 2010
Christopher Page, Peter J. Dawson, David Woollacott, Robin Thorpe, Anthony R. Mire‐Sluis
AbstractRecombinant human interleukin-11 (rhIL-11) is a licensed biological therapeutic product in at least one country and is used to combat thrombocytopenia during chemotherapeutic regimens, as well as undergoing clinical trials for a range of other disorders. Following attempts to lyophilize IL-11 at low concentrations, it was clear that a significant loss of re...... hiện toàn bộ
In-vitro Metabolic Interaction of Bunitrolol Enantiomers in Rabbit Liver Microsomes
Journal of Pharmacy and Pharmacology - Tập 48 Số 11 - Trang 1185-1189 - 2011
Shizuo Narimatsu, Takao Mizukami, Yong Huang, Yasuhiro Masubuchi, Tokuji Suzuki
Abstract We have examined the 4-hydroxylation of bunitrolol in rabbit and rat liver microsomes. Significant species differences (rabbit < rat of both sexes) and sex (male > female of both species) were observed in the formation of 4-hydroxybunitrolol from racemic bunitrolol (10 μM). The 4-hydroxylation of...... hiện toàn bộ
Tổng số: 209   
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