Efficacy of chitosan microspheres for controlled intra-articular delivery of celecoxib in inflamed jointsJournal of Pharmacy and Pharmacology - Tập 56 Số 9 - Trang 1091-1099 - 2010
Hetal Thakkar, Rakesh Kumar Sharma, Anil K. Mishra, Krishna Chuttani, R. S. R. Murthy
Abstract
The use of polymeric carriers in formulations of therapeutic drug delivery systems has gained widespread application, due to their advantage of being biodegradable and biocompatible. In this study, we aimed to prepare celecoxib-loaded chitosan microspheres for intra-articular administration and to compare the retention of the celecoxib solut...... hiện toàn bộ
Nanosuspensions: a promising drug delivery strategyJournal of Pharmacy and Pharmacology - Tập 56 Số 7 - Trang 827-840 - 2010
Vandana Patravale, Abhijit A. Date, Rishikesh M. Kulkarni
Abstract
Nanosuspensions have emerged as a promising strategy for the efficient delivery of hydrophobic drugs because of their versatile features and unique advantages. Techniques such as media milling and high-pressure homogenization have been used commercially for producing nanosuspensions. Recently, the engineering of nanosuspensions employing emu...... hiện toàn bộ
Do Biocides Select for Antibiotic Resistance?Journal of Pharmacy and Pharmacology - Tập 52 Số 2 - Trang 227-233 - 2010
A. D. Russell
Abstract
Some similarities exist between bacterial resistance to antibiotics and to biocides, and gram-negative bacteria that have developed resistance to cationic biocides may also be insusceptible to some antibiotics. Outer membrane changes are believed to be responsible for this non-specific increase in resistance. Efflux, another important resist...... hiện toàn bộ
In-vitro Metabolic Interaction of Bunitrolol Enantiomers in Rabbit Liver MicrosomesJournal of Pharmacy and Pharmacology - Tập 48 Số 11 - Trang 1185-1189 - 2011
Shizuo Narimatsu, Takao Mizukami, Yong Huang, Yasuhiro Masubuchi, Tokuji Suzuki
Abstract
We have examined the 4-hydroxylation of bunitrolol in rabbit and rat liver microsomes.
Significant species differences (rabbit < rat of both sexes) and sex (male > female of both species) were observed in the formation of 4-hydroxybunitrolol from racemic bunitrolol (10 μM). The 4-hydroxylation of...... hiện toàn bộ