Journal of Pharmacy and Pharmacology

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PLASMA-SALICYLATE CONCENTRATIONS AFTER SMALL DOSES OF ACETYLSALICYLIC ACID
Journal of Pharmacy and Pharmacology - Tập 3 Số 1 - Trang 409-414 - 2011
M. J. H. Smith
Development of a Lyophilization Formulation that Preserves the Biological Activity of the Platelet-inducing Cytokine Interleukin-11 at Low Concentrations
Journal of Pharmacy and Pharmacology - Tập 52 Số 1 - Trang 19-26 - 2010
Christopher Page, Peter J. Dawson, David Woollacott, Robin Thorpe, Anthony R. Mire‐Sluis
AbstractRecombinant human interleukin-11 (rhIL-11) is a licensed biological therapeutic product in at least one country and is used to combat thrombocytopenia during chemotherapeutic regimens, as well as undergoing clinical trials for a range of other disorders. Following attempts to lyophilize IL-11 at low concentrations, it was clear that a significant loss of recoverable biological activity occ... hiện toàn bộ
In-vitro Metabolic Interaction of Bunitrolol Enantiomers in Rabbit Liver Microsomes
Journal of Pharmacy and Pharmacology - Tập 48 Số 11 - Trang 1185-1189 - 2011
Shizuo Narimatsu, Takao Mizukami, Yong Huang, Yasuhiro Masubuchi, Tokuji Suzuki
Abstract We have examined the 4-hydroxylation of bunitrolol in rabbit and rat liver microsomes. Significant species differences (rabbit < rat of both sexes) and sex (male > female of both species) were observed in the formation of 4-hydroxybunitrolol from racemic bunitrolol (10 μM). The 4-hydroxylation of bunitrolol racemate and enantiomers showed biphasic kinetics, a low-Km system and a hig... hiện toàn bộ
Effect of the Chloroform Extract of Tanacetum vulgare and one of its Active Principles, Parthenolide, on Experimental Gastric Ulcer in Rats
Journal of Pharmacy and Pharmacology - Tập 51 Số 2 - Trang 215-219 - 1999
Horacio Tournier, Guillermo Schinella, Elba M De Balsa, H. Buschiazzo, Salvador Máñez, Perla M. de Buschiazzo
Abstract This study examines the anti-ulcerogenic activity of a chloroform extract of Tanacetum vulgare and purified parthenolide, the major sesquiterpene lactone found in the extract. Gastric ulcers induced by oral administration of absolute ethanol to rats were reduced dose-dependently by oral pretreatment of animals with the chloroform extract (2.5–80 mg kg−1) or parthenolide (5–40 mgkg−1). Whe... hiện toàn bộ
Anti-inflammatory Effects of South American Tanacetum vulgare
Journal of Pharmacy and Pharmacology - Tập 50 Số 9 - Trang 1069-1074 - 1998
Guillermo Schinella, Rosa M. Giner, Marı́a del Carmen Recio, Perla M. de Buschiazzo, José-Luis Rı́os, Salvador Máñez
Abstract In recent years the role of phenolic compounds and sesquiterpene lactones, particularly parthenolide, in the anti-migraine and anti-inflammatory effects of Tanacetum parthenium (Asteraceae) has attracted much attention. However, the closely-related cosmopolitan species T. vulgare has remained outside the mainstream of research in this field. After treating the aerial parts of T. vulgare w... hiện toàn bộ
Cyclooxygenase-1 and cyclooxygenase-2 selectivity of non-steroidal anti-inflammatory drugs: investigation using human peripheral monocytes
Journal of Pharmacy and Pharmacology - Tập 53 Số 12 - Trang 1679-1685 - 2010
Mototoshi Kato, Shinichi Nishida, Hidero Kitasato, Natsue Sakata, Shinichi Kawai
Abstract Since the pharmacological profiles of various non-steroidal anti-inflammatory drugs (NSAIDs) might depend on their differing selectivity for cyclooxygenase 1 (COX-1) and 2 (COX-2), we developed a new screening method using human peripheral monocytes. Monocytes from healthy volunteers were separated, and the cells were incubated with or without lipopoly-saccharide (LPS). Monocytes without ... hiện toàn bộ
Interaction Between Substance P and β-Adrenergic Agonists in the Modulation of the Secretion of Fluid and Protein by the Rat Submandibular Gland
Journal of Pharmacy and Pharmacology - Tập 50 Số 3 - Trang 335-341 - 2011
Yoshiki Iwabuchi, Tomohiko Kimura
AbstractThe interactions between substance P and β-adrenergic agonists such as isoprenaline, dobutamine and terbutaline in the control of the secretion of fluid and protein from the rat submandibular gland have been examined.Substance P elicited large volumes of saliva whereas isoprenaline, dobutamine and terbutaline elicited small volumes only. The secretion of fluid in response to substance P wa... hiện toàn bộ
Skin Delivery of Oestradiol from Deformable and Traditiona Liposomes: Mechanistic Studies
Journal of Pharmacy and Pharmacology - Tập 51 Số 10 - Trang 1123-1134 - 1999
Gamal M. El Maghraby, Adrian C. Williams, Brian Barry
AbstractDeformable vesicles and traditional liposomes were compared as delivery systems for oestradiol to elucidate possible mechanisms of drug delivery through human skin. Accordingly, epidermal permeation of oestradiol from optimized deformable vesicles and traditional liposome formulations was studied under low dose non-occluded conditions. Five mechanisms were investigated. A free drug mechani... hiện toàn bộ
The genus Cratoxylum: traditional use, phytochemistry and pharmacology
Journal of Pharmacy and Pharmacology - Tập 75 Số 10 - Trang 1259-1293 - 2023
Huong, Nguyen Thi, Hop, Nguyen Quang, Son, Ninh The
Natural products as targeted modulators of the nuclear factor-κB pathway
Journal of Pharmacy and Pharmacology - Tập 54 Số 4 - Trang 453-472 - 2002
Paul Bremner, Michael Heinrich
Abstract The use of plant extracts to alleviate inflammatory diseases is centuries old and continues to this day. This review assesses the current understanding of the use of such plants and natural products isolated from them in terms of their action against the ubiquitous transcription factor, nuclear factor kappa B (NF-κB). As an activator of many pro-inflammatory cytokines and inflammatory pro... hiện toàn bộ
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