Interaction Between Substance P and β-Adrenergic Agonists in the Modulation of the Secretion of Fluid and Protein by the Rat Submandibular Gland

Journal of Pharmacy and Pharmacology - Tập 50 Số 3 - Trang 335-341 - 2011
Yoshiki Iwabuchi1, Tomohiko Kimura1
1Department of Dental Pharmacology, School of Dentistry at Niigata, The Nippon Dental University, Niigata, Niigata 951, Japan

Tóm tắt

AbstractThe interactions between substance P and β-adrenergic agonists such as isoprenaline, dobutamine and terbutaline in the control of the secretion of fluid and protein from the rat submandibular gland have been examined.Substance P elicited large volumes of saliva whereas isoprenaline, dobutamine and terbutaline elicited small volumes only. The secretion of fluid in response to substance P was markedly enhanced when substance P was administered in combination with isoprenaline or dobutamine but not when it was administered in combination with terbutaline. Isoprenaline elicited large amounts of protein, whereas substance P elicited small amounts. The secretion of protein in response to isoprenaline did not change when isoprenaline was administered in combination with substance P. The secretion of fluid and protein induced by substance P in combination with isoprenaline was antagonized by metoprolol and by spantide, but it was unaffected by pretreatment with ICI118551.These results suggest that in the rat submandibular gland stimulation of β1-adrenoceptors but not of β2-adrenoceptors potentiates the secretion of fluid that is induced by stimulation of tachykinin receptors, whereas stimulation of tachykinin receptors does not enhance the secretion of protein that is induced by stimulation of β1-adrenoceptors.

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Tài liệu tham khảo

Abe, 1985, Effects of the selective β2-adrenergic agonists, procaterole and terbutaline, on protein secretion by rat submandibular glands, J. Dent. Res., 64, 886, 10.1177/00220345850640060501

Åblad, 1975, A survey of the pharmacological properties of metoprolol in animals and man, Acta Pharmacol. Toxicol., 36, 7, 10.1111/j.1600-0773.1975.tb03318.x

Bergman, 1969, Two new groups of selective stimulants of β-receptors, Experientia, 25, 899, 10.1007/BF01898049

Bilski, 1980, ICI118551, a potent β2 adrenoceptor antagonist, Br. J. Pharmacol., 69, 292

Bobyock, 1986, Effects of substance P and substance P antagonists on rat salivary secretion, J. Dent. Res., 65, 1427, 10.1177/00220345860650121001

Ekström, 1979, Salivary secretion evoked by H80/62, (±)-1-(4-hydroxyphenoxy)-3-isopropylamino-2-propranol, a new β1-selective adrenoceptor agonist, Acta Pharmacol. Toxicol., 45, 325, 10.1111/j.1600-0773.1979.tb02400.x

Ekström, 1987, Neuropeptides and secretion, J. Dent. Res., 66, 524, 10.1177/00220345870660022301

Ekström, 1983, Relative secretory contributions of the three major salivary glands of the rat in response to substance P and super-sensitivity, Arch. Oral Biol., 28, 859, 10.1016/0003-9969(83)90044-4

Ekström, 1988, Calcitonin gene-related peptide in rat salivary glands: neuronal localization, depletion upon nerve stimulation, and effects on salivation in relation to substance P, Neuroscience, 26, 933, 10.1016/0306-4522(88)90110-8

Fleming, 1984, Effect of substance P on exocrine secretion by rat submandibular gland cells, J. Dent. Res., 63, 1022, 10.1177/00220345840630080101

Hökfelt, 1977, Immunohisto-chemical detection of substance P, Substance P, 117

Iwabuchi, 1994, Effects of vasoactive intestinal peptide and its homologues on the substance P-mediated secretion of fluid and protein from the rat submandibular gland, Gen. Pharmacol., 25, 705, 10.1016/0306-3623(94)90249-6

Iwabuchi, 1986, Effects of substance P on glycoprotein secretion from acinar cells of the rat submandibular gland, Jpn J. Pharmacol., 42, 453, 10.1254/jjp.42.453

Iwabuchi, 1988, Effects of dobutamine and terbutaline on the secretion of glycoproteins from the acinar cells of the rat submandibular gland, Jpn J. Pharmacol., 47, 301, 10.1016/S0021-5198(19)43214-9

Larsson, 1989, The enhancement of carbachol-induced salivary secretion in rat parotid gland by VIP and CGRP is mimicked by forskolin, Acta Physiol. Scand., 137, 231, 10.1111/j.1748-1716.1989.tb08743.x

Lowry, 1951, Protein measurement with the Folin phenol reagent, J. Biol. Chem., 193, 265, 10.1016/S0021-9258(19)52451-6

Maccarrone, 1984, β-Adrenoceptor selectivity of dobutamine: in vivo and in vitro studies, J. Cardiovasc. Pharmacol., 6, 132, 10.1097/00005344-198401000-00021

Martinez, 1981, Stimulatory and inhibitory effects of substance P on rat submandibular secretion, J. Dent. Res., 60, 1031, 10.1177/00220345810600060501

Miyamoto, 1984, β1-Adrenergic regulation of cyclic nucleotide levels and potassium fluxes in rat parotid gland, Jpn J. Pharmacol., 36, 100, 10.1254/jjp.36.100

Pernow, 1983, Substance P, Pharmacol. Rev., 35, 85

Pointon, 1979, Alpha- and beta-adrenergic receptors of the rat salivary gland. Elevation after chemical sympathectomy, Biochim. Biophys. Acta., 584, 231, 10.1016/0304-4165(79)90267-8

Ruffolo, 1981, Alpha and beta adrenergic effects of the stereoisomers of dobutamine, J. Pharmacol. Exp. Ther., 219, 447

Schneyer, 1987, β-Adrenergic and muscarinic receptor densities of rat submandibular main duct, Proc. Soc. Exp. Biol. Med., 185, 81, 10.3181/00379727-185-42520

Schneyer, 1985, Modification of dobutamine- and terbutaline-induced calcium and fluid secretion from rat salivary glands by atenolol and butoxamine, J. Auton. Nerv. Syst., 13, 275, 10.1016/0165-1838(85)90017-7

Suzuki, 1985, β1-Adrenoceptor-mediated amylase release and cyclic AMP accumulation in rat parotid gland tissue, Jpn J. Pharmacol., 37, 212, 10.1254/jjp.37.212

Thulin, 1972, On the β-adrenergic receptors in salivary glands of rat and dogs, Experientia, 28, 420, 10.1007/BF02008314

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Journal of Pharmacy and Pharmacology

Tập 50 Số 3

335-341

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