Nanosuspensions: a promising drug delivery strategy

Journal of Pharmacy and Pharmacology - Tập 56 Số 7 - Trang 827-840 - 2010
Vandana Patravale1, Abhijit A. Date2, Rishikesh M. Kulkarni3
1Pharmaceutical Division, University Institute of Chemical Technology, Matunga, Mumbai-400 019, India
2Department of Pharmaceutics, Bombay College of Pharmacy, Kalina, Santacruz (E.), Mumbai-400 098, India
3Department of Cell Biology, Neurobiology and Anatomy, University of Cincinnati Medical Center, Cincinnati, OH 45267-0521, USA

Tóm tắt

Abstract

Nanosuspensions have emerged as a promising strategy for the efficient delivery of hydrophobic drugs because of their versatile features and unique advantages. Techniques such as media milling and high-pressure homogenization have been used commercially for producing nanosuspensions. Recently, the engineering of nanosuspensions employing emulsions and microemulsions as templates has been addressed in the literature. The unique features of nanosuspensions have enabled their use in various dosage forms, including specialized delivery systems such as mucoadhesive hydrogels. Rapid strides have been made in the delivery of nanosuspensions by parenteral, peroral, ocular and pulmonary routes. Currently, efforts are being directed to extending their applications in site-specific drug delivery.

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Tài liệu tham khảo

Adachi, 1992, Tumoricidal activity of Kupffer cells augmented by anticancer drugs, Life Sci., 51, 177, 10.1016/0024-3205(92)90073-X

Akers, 2002, Excipient-drug interactions in parenteral formulations, J. Pharm. Sci., 91, 2283, 10.1002/jps.10154

Allen, 1997, Liposomes: opportunities in drug delivery, Drugs, 54, 8, 10.2165/00003495-199700544-00004

Aungst, 1993, Novel formulation strategies for improving oral bioavailability of drugs with poor membrane permeation or presystemic metabolism, J. Pharm. Sci., 82, 979, 10.1002/jps.2600821008

Aungst, 2000, Intestinal permeation enhancers, J. Pharm. Sci., 89, 429, 10.1002/(SICI)1520-6017(200004)89:4<429::AID-JPS1>3.0.CO;2-J

Aungst, 1994, Improved oral bioavailability of an HIV protease inhibitor using Gelucire 44/14 and Labrasol vehicles, B.T. Gattefosse, 87, 49

Benet, 1999, Intestinal MDR transport proteins and P-450 enzymes as barriers to oral drug delivery, J. Control. Release, 62, 25, 10.1016/S0168-3659(99)00034-6

Blunk, 1993, Colloidal carriers for intravenous drug targeting: Plasma protein adsorption patterns on surface-modified latex particles evaluated by two-dimensional polyacrylamide gel electrophoresis, Electrophoresis, 14, 1382, 10.1002/elps.11501401214

Blunk, 1996, Kinetics of plasma protein adsorption on model particles for controlled drug delivery and drug targeting, Eur. J. Pharm. Biopharm., 42, 262

Bodmeier, 1998, Solvent selection in the preparation of poly (DL-lactide) microspheres prepared by solvent evaporation method, Int. J. Pharm., 43, 179, 10.1016/0378-5173(88)90073-7

Breitenbach, 2002, Melt extrusion: from process to drug delivery technology, Eur. J. Pharm. Biopharm., 54, 107, 10.1016/S0939-6411(02)00061-9

Buchmann, 1996, Aqueous suspension, an alternative intravenous formulation for animal studies, Eur. J. Pharm. Biopharm., 42, S10

Bucolo, 2002, Enhanced ocular anti-inflammatory activity of ibuprofen carried by an Eudragit RS 100® nanoparticle suspension, Ophthalmic Res., 34, 319, 10.1159/000065608

Chowdhary, 2003, A novel approach for controlled release of nifedipine through cyclodextrin complexation, 133

Constantinides, 1994, Formulation and intestinal absorption enhancement evaluation of water in oil microemulsions incorporating medium-chain triglycerides, Pharm. Res., 11, 1385, 10.1023/A:1018927402875

Constantinides, 1995, Enhanced intestinal absorption of a RGD peptide from w/o microemulsion of different composition and particle size, J. Control. Release, 34, 109, 10.1016/0168-3659(94)00129-I

Dressman, 1998, Dissolution testing as a prognostic tool for oral drug adsorption: immediate release dosage forms, Pharm. Res., 15, 11, 10.1023/A:1011984216775

Dupont, 2002, Overview of the lipid formulations of amphotericin B, J. Antimicrob. Chemother., S1, 31, 10.1093/jac/49.suppl_1.31

Eccleston, 1992, Microemulsions, Encyclopedia of pharmaceutical technology, 375

Floyd, 1999, Top ten considerations in the development of parenteral emulsions, Pharm. Sci. Technol., 4, 134, 10.1016/S1461-5347(99)00141-8

Gasco, 1997, Solid lipid nanospheres form warm micro-emulsions, Pharm. Technol. Eur., 9, 32

Grau, 2000, Nanosuspensions of poorly soluble drugs — reproducibility of small-scale production, Int. J. Pharm., 196, 155, 10.1016/S0378-5173(99)00411-1

Gregoriades, 1995, Engineering liposomes for drug delivery: progress and problems, TIBTECH, 13, 527, 10.1016/S0167-7799(00)89017-4

Horter, 2001, Influence of physicochemical properties on dissolution of drugs in the gastrointestinal tract, Adv. Drug Deliv. Rev., 46, 75

Illum, 1982, Blood clearance and organ disposition of intravenously administered colloidal particles. Effect of particle size, nature, and shape, Int. J. Pharm., 2, 135, 10.1016/0378-5173(82)90113-2

Jahnke, 1998, The theory of high-pressure homogenization, Emulsions and nanosuspensions for the formulation of poorly soluble drugs, 177

Juliano, 1988, Factors affecting the clearance kinetics and tissue distribution of liposomes, microspheres and emulsions, Adv. Drug Deliv. Rev., 2, 31, 10.1016/0169-409X(88)90004-X

Kawakami, 2002, Microemulsion formulation for enhanced absorption of poorly soluble drugs I. Prescription design, J. Control. Release, 81, 65, 10.1016/S0168-3659(02)00049-4

Kayser, 2000, Nanosuspensions for the formulation of aphidicolin to improve drug targeting effects against Leishmania infected macrophages, Int. J. Pharm., 196, 253, 10.1016/S0378-5173(99)00434-2

Kayser, 2001, A new approach for targeting to Cryptosporidium parvum using mucoadhesive nanosuspensions: research and applications, Int. J. Pharm., 214, 83, 10.1016/S0378-5173(00)00640-2

Kayser, 2003, Formulation of amphotericin B as nanosuspension for oral administration, Int. J. Pharm., 254, 73, 10.1016/S0378-5173(02)00686-5

Kim, 1998, Physicochemical characterization and evaluation of a microemulsion system for oral delivery of cyclosporin A, Int. J. Pharm., 161, 75, 10.1016/S0378-5173(97)00325-6

Kim, 2001, Development of a novel dosage form for intramuscular injection of titrated extract of Centella asiatica in a mixed micellar system, Int. J. Pharm., 220, 141, 10.1016/S0378-5173(01)00661-5

Kohno, 1997, Amphotericin B encapsulated in polyethylene glycol-immunoliposomes for infectious diseases, Adv. Drug Del. Rev., 24, 325, 10.1016/S0169-409X(96)00474-7

Krause, 2001, Production and characterisation of highly concentrated nanosuspensions by high pressure homogenization, Int. J. Pharm., 214, 21, 10.1016/S0378-5173(00)00626-8

Kreuter, 2001, Nanoparticulate systems for brain delivery of drugs, Adv Drug Del. Rev., 47, 65, 10.1016/S0169-409X(00)00122-8

Kreuter, 1997, Influence of the type of surfactant on the analgesic effects induced by the peptide dalargin after 1st delivery across the blood-brain barrier using surfactant coated nanoparticles, J. Control. Release, 49, 81, 10.1016/S0168-3659(97)00061-8

Kusuhara, 1998, The role of p-glycoprotein and canalicular multispecific organic anion transporter in the hepato-biliary excretion of drugs, J. Pharm. Sci., 87, 1025, 10.1021/js970100b

Lasic, 1997, Stealth liposomes: from theory to product, Adv. Drug Del. Rev., 24, 165, 10.1016/S0169-409X(96)00456-5

Lawrence, 2000, Microemulsion-based media as novel drug delivery systems, Adv. Drug Del. Rev., 45, 89, 10.1016/S0169-409X(00)00103-4

Leuner, 2000, Improving drug solubility for oral delivery using solid dispersions, Eur. J. Pharm. Biopharm., 50, 47, 10.1016/S0939-6411(00)00076-X

Lipinski, 2002, Poor aqueous solubility — an industry wide problem in drug discovery, Am. Pharm. Rev., 5, 82

Liu, 2000, Pharmacokinetic and hepatic disposition of Bis [1-ethoxycarbonyl)propyl)5-acetylamino-2,3,6-triiodoisophthalate in rats and isolated perfused rat livers, Drug Metab. Dispos., 28, 731

Liversidge, 1995, Drug particle size reduction for decreasing gastric irritancy and enhancing absorption of naproxen in rats, Int. J. Pharm., 125, 309, 10.1016/0378-5173(95)00148-C

Liversidge, 1995, Particle size reduction for improvement of oral bioavailability of hydrophobic drugs. I Absolute oral bioavailability of nanocrystalline danazole in beagle dogs, Int. J. Pharm., 127, 91, 10.1016/0378-5173(95)00122-Y

Liversidge, 1992, Surface modified drug nanoparticles

Loftsson, 1996, Pharmaceutical applications of cyclodextrins, J. Pharm. Sci., 85, 1017, 10.1021/js950534b

Looareesuwan, 1999, Atovaquone and proguanil hydrochloride followed by primaquine for treatment of Plasmodium vivax malaria in Thailand, Trans. R. Soc. Trop. Med. Hyg., 93, 637, 10.1016/S0035-9203(99)90079-2

Lück, 1997, Identification of plasma proteins facilitated by enrichment on particulate surfaces: Analysis by two-dimensional electrophoresis and N-terminal microsequencing, Electrophoresis, 18, 2961, 10.1002/elps.1150181538

Lück, 1997, Analysis of plasma protein adsorption on polymeric nanoparticles with different surface characteristics, J. Biomed. Mater. Res., 1, 478

Martin, 1982, Tumoricidal effect of macrophages exposed to adriamycin in vivo or in vitro, Cancer Res., 42, 3851

Merisko-Liversidge, 1996, Formulation and anti-tumor activity evaluation of nanocrystalline suspensions of poorly soluble anti-cancer drugs, Pharm. Res., 13, 272, 10.1023/A:1016051316815

Merisko-Liversidge, 2003, Nanosizing: a formulation approach for poorly-water-soluble compounds, Eur. J. Pharm. Sci., 18, 113, 10.1016/S0928-0987(02)00251-8

Moghimi, 2001, Long-circulating and target-specific nanoparticles: theory to practice, Pharmacol. Rev., 53, 283

Mosharraf, 1995, The effect of particle size and shape on the surface specific dissolution rate of micronized practically insoluble drugs, Int. J. Pharm., 122, 35, 10.1016/0378-5173(95)00033-F

Müller, 1984, Particle size analysis of latex suspensions and microemulsions by photon correlation spectroscopy, J. Pharm. Sci., 73, 915, 10.1002/jps.2600730713

Müller, 1989, Differential opsonization: A new approach for the targeting of colloidal drug carriers, Arch. Pharm., 322, 700

Müller, 1998, Nanosuspensions, Emulsions and nanosuspensions for the formulation of poorly soluble drugs, 149

Müller, 1998, Increase of dissolution velocity and solubility of poorly water soluble drugs as nanosuspension, Proceedings, World Meeting APGI/APV, Paris, 2, 623

Müller, 1998, Nanosuspensions for the formulation of poorly soluble drugs I: Preparation by a size-reduction technique, Int. J. Pharm., 160, 229, 10.1016/S0378-5173(97)00311-6

Müller, 2002, Buparvaquone mucoadhesive nanosuspension: preparation, optimisation and long-term stability, Int. J. Pharm., 237, 151, 10.1016/S0378-5173(02)00040-6

Müller, 2002, Production and characterization of a budesonide nanosuspension for pulmonary administration, Pharm. Res., 19, 189, 10.1023/A:1014276917363

Müller, 1998, Pharmaceutical nanosuspensions for medicament administration as system of increased saturation solubility and rate of solution

Nakano, 2000, Places of emulsions in drug delivery, Adv. Drug Del. Rev., 45, 1, 10.1016/S0169-409X(00)00096-X

Neal, 1998, Modification of copolymers poloxamer 407 and poloxamine 908 can affect the physical and biological properties of surface modified nanospheres, Pharm. Res., 15, 318, 10.1023/A:1011987206722

Nyström, 1988, Physiochemical aspects of drug release. VIII. The relation between particle size and surface specific dissolution rate in agitated suspensions, Int. J. Pharm., 47, 223, 10.1016/0378-5173(88)90235-9

Papisov, 1998, Theoretical considerations of RES-avoiding liposomes: molecular mechanics and chemistry of liposome interactions, Adv. Drug Del. Rev., 32, 119, 10.1016/S0169-409X(97)00135-X

Park, 1999, Preparation and evaluation of flurbiprofen-loaded microemulsion for parenteral delivery, Int. J. Pharm., 181, 173, 10.1016/S0378-5173(99)00029-0

Peters, 1996, Nanosuspensions for the oral application of poorly soluble drugs, 330

Peters, 2000, Preparation of a clofazimine nanosuspension for intravenous use and evaluation of its therapeutic efficacy in murine Mycobacterium avium infection, J. Antimicrob. Chemother., 45, 77, 10.1093/jac/45.1.77

Pignatello, 2002, Flurbiprofen-loaded acrylate polymer nanosuspensions for ophthalmic application, Biomaterials, 23, 3247, 10.1016/S0142-9612(02)00080-7

Pignatello, 2002, Eudragit RS100 nanosuspensions for the ophthalmic controlled delivery of ibuprofen, Eur. J. Pharm. Sci., 16, 53, 10.1016/S0928-0987(02)00057-X

Pignatello, 2002, Ocular tolerability of Eudragit RS 100 and RL 100 nanosuspensions as carrier for ophthalmic controlled delivery, J. Pharm. Sci., 91, 2636, 10.1002/jps.10227

Ponchel, 1997, Mucoadhesion of colloidal particulate systems in the gastrointestinal tract, Eur. J. Pharm. Biopharm., 4, 25, 10.1016/S0939-6411(97)00098-2

Pouton, 2000, Lipid formulations for oral administration of drugs: non-emulsifying, self-emulsifying and ‘self-micro-emulsifying’ drug delivery systems, Eur. J. Pharm. Sci., 11, S93, 10.1016/S0928-0987(00)00167-6

Rades, 2002, Effects of formulation variables on characteristics of poly (ethylcyanoacrylates) nanocapsules prepared from w/o micro-emulsions, Int. J. Pharm., 235, 237, 10.1016/S0378-5173(02)00002-9

Rawlins, 1982, Solutions, Bentley's textbook of pharmaceutics, 8th edn, 6

Remon, 2001, An oral controlled release matrix pellet formulation containing nanocrystalline ketoprofen, Int. J. Pharm., 219, 81, 10.1016/S0378-5173(01)00628-7

Sah, 1997, Microencapsulation technique using ethyl acetate as a dispersed solvent: effects on its extraction rate on the characteristics of PLGA microspheres, J. Control. Release, 47, 233, 10.1016/S0168-3659(97)01647-7

Sah, 2000, Ethyl formate — alternative dispersed solvent useful in preparing PLGA microspheres, Int. J. Pharm., 195, 103, 10.1016/S0378-5173(99)00379-8

Schöler, 2001, Atovaquone nanosuspensions show excellent therapeutic effect in a new murine model of reactivated toxoplasmosis, Antimicrob. Agents Chemother., 45, 1771, 10.1128/AAC.45.6.1771-1779.2001

Schröeder, 1998, Nanoparticulate technology for delivery of drugs across the blood-brain barrier, J. Pharm. Sci., 87, 1305, 10.1021/js980084y

Schwendener, 1996, Lipophilic 1-beta-D-arabinofuranosyl cytosine derivatives in liposomal formulations for oral and parenteral antileukemic therapy in the murine L1210 leukemia model, J. Cancer Res. Clin. Oncol., 122, 723, 10.1007/BF01209119

Serajuddin, 1999, Solid dispersion of poorly water-soluble drugs: early promises, subsequent problems, and recent breakthroughs, J. Pharm. Sci., 88, 1058, 10.1021/js980403l

Shanthakumar, 2004, Comparative pharmacokinetic data of DRF-4367 using nanosuspension and HP-β-CD formulation, 75

Soma, 2000, Investigation of the role of macrophages on the cytotoxicity of doxorubicin and doxorubicin-loaded nanoparticles on M5076 cells in vitro, J. Control. Release, 68, 283, 10.1016/S0168-3659(00)00269-8

Stella, 1997, Cyclodextrins: their future in drug formulation and delivery, Pharm. Res., 14, 556, 10.1023/A:1012136608249

Stolnik, 1995, Long circulating micro-particulate drug carriers, Adv. Drug Del. Rev., 16, 195, 10.1016/0169-409X(95)00025-3

Toster, 1990, Modification of the body distribution of poly (methylmethacrylate) nanoparticles in rats by coating with surfactants, Int. J. Pharm., 61, 85, 10.1016/0378-5173(90)90047-8

Trotta, 2001, Emulsions containing partially water miscible solvents for the preparation of drug nanosuspensions, J. Control. Release, 76, 119, 10.1016/S0168-3659(01)00432-1

Trotta, 2003, Preparation of griseofulvin nanoparticles from water-dilutable microemulsions, Int. J. Pharm., 254, 235, 10.1016/S0378-5173(03)00029-2

Vyas, 2000, Ligand directed macrophage targeting of amphotericin B loaded liposomes, Int. J. Pharm., 210, 1, 10.1016/S0378-5173(00)00522-6

Wallis, 1993, Determination of the surface hydrophobicity of colloidal dispersions by mini-hydrophobic interaction chromatography, Pharm. Ind., 55, 1124

Washington, 1996, Stability of lipid emulsions for drug delivery, Adv. Drug Del. Rev., 20, 131, 10.1016/0169-409X(95)00116-O

Woodle, 1998, Controlling liposome blood clearance by surface-grafted polymers, Adv. Drug Del. Rev., 32, 139, 10.1016/S0169-409X(97)00136-1