Journal of Molecular Psychiatry
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2049-9256
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mGluR2/3 blockade produces rapid and long-lasting reversal of anhedonia caused by chronic stress exposure
Tập 1 - Trang 1-4 - 2013
Depression is a prevalent neuropsychiatric disorder that affects an estimated
350 million people worldwide. Currently available treatments for depression are
lacking in both speed of onset and efficacy. Recent pharmacological efforts have
targeted the glutamatergic neurotransmitter system using the
N-methyl-D-aspartate (NMDA) receptor antagonist ketamine to produce rapid and
robust antidepressant ...
αT-catenin in restricted brain cell types and its potential connection to autism
Tập 4 - Trang 1-13 - 2016
Recent genetic association studies have linked the cadherin-based adherens
junction protein alpha-T-catenin (αT-cat, CTNNA3) with the development of
autism. Where αT-cat is expressed in the brain, and how its loss could
contribute to this disorder, are entirely unknown. We used the αT-cat knockout
mouse to examine the localization of αT-cat in the brain, and we used histology
and immunofluorescenc...
Post-stroke depression and the aging brain
Tập 1 - Trang 1-10 - 2013
Ageing is associated with changes in the function of various organ systems.
Changes in the cardiovascular system affect both directly and indirectly the
function in a variety of organs, including the brain, with consequent
neurological (motor and sensory performance) and cognitive impairments, as well
as leading to the development of various psychiatric diseases. Post-stroke
depression (PSD) is am...
Mitochondrial complex I and III gene mRNA levels in schizophrenia, and their relationship with clinical features
Tập 2 - Trang 1-6 - 2014
The etiology of schizophrenia is not precisely known; however, mitochondrial
function and cerebral energy metabolism abnormalities were determined to be
possible factors associated with the etiology of schizophrenia. Impaired
mitochondrial function negatively affects neuronal plasticity, and can cause
cognitive deficits and behavioral abnormalities observed during the clinical
course of schizophre...
Insights into the origin of DNA methylation differences between monozygotic twins discordant for schizophrenia
Tập 3 - Trang 1-10 - 2015
DNA methylation differences between monozygotic twins discordant for
schizophrenia have been previously reported. However, the origin of methylation
differences between monozygotic twins discordant for schizophrenia is not clear.
The findings here argue that all DNA methylation differences may not necessarily
represent the cause of the disease; rather some may result from the effect of
antipsychot...
Genetics and epigenetics of alcohol dependence
Tập 1 - Trang 1-6 - 2013
Alcohol dependence is a severe and common disorder associated with high
morbidity and mortality rates. Genetic as well as environmental factors are
known to modulate susceptibility to alcohol dependence. There is a growing body
of evidence suggesting that this interaction between the genome and the
environment is mediated by epigenetic mechanisms, e.g. DNA methylation at CpG
sites. Following an in...