Journal of Molecular Psychiatry
SCOPUS
2049-9256
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Insights into the origin of DNA methylation differences between monozygotic twins discordant for schizophrenia
Tập 3 - Trang 1-10 - 2015
DNA methylation differences between monozygotic twins discordant for
schizophrenia have been previously reported. However, the origin of methylation
differences between monozygotic twins discordant for schizophrenia is not clear.
The findings here argue that all DNA methylation differences may not necessarily
represent the cause of the disease; rather some may result from the effect of
antipsychot...
Mitochondrial complex I and III gene mRNA levels in schizophrenia, and their relationship with clinical features
Tập 2 - Trang 1-6 - 2014
The etiology of schizophrenia is not precisely known; however, mitochondrial
function and cerebral energy metabolism abnormalities were determined to be
possible factors associated with the etiology of schizophrenia. Impaired
mitochondrial function negatively affects neuronal plasticity, and can cause
cognitive deficits and behavioral abnormalities observed during the clinical
course of schizophre...
αT-catenin in restricted brain cell types and its potential connection to autism
Tập 4 - Trang 1-13 - 2016
Recent genetic association studies have linked the cadherin-based adherens
junction protein alpha-T-catenin (αT-cat, CTNNA3) with the development of
autism. Where αT-cat is expressed in the brain, and how its loss could
contribute to this disorder, are entirely unknown. We used the αT-cat knockout
mouse to examine the localization of αT-cat in the brain, and we used histology
and immunofluorescenc...
A systematic review of agomelatine-induced liver injury
Tập 3 - Trang 1-12 - 2015
Agomelatine is an antidepressant with a unique mechanism of action. Since its
marketing in 2009, concerns have been raised regarding its potential to induce
liver injury. The authors therefore address the need to comprehensively evaluate
the potential risk posed by agomelatine of inducing liver injury by reviewing
data from published and unpublished clinical trials in both the pre- and
postmarketi...
mGluR2/3 blockade produces rapid and long-lasting reversal of anhedonia caused by chronic stress exposure
Tập 1 - Trang 1-4 - 2013
Depression is a prevalent neuropsychiatric disorder that affects an estimated
350 million people worldwide. Currently available treatments for depression are
lacking in both speed of onset and efficacy. Recent pharmacological efforts have
targeted the glutamatergic neurotransmitter system using the
N-methyl-D-aspartate (NMDA) receptor antagonist ketamine to produce rapid and
robust antidepressant ...
Centenary of Karl Jaspers’s general psychopathology: implications for molecular psychiatry
Tập 2 - Trang 1-5 - 2014
Modern molecular psychiatry benefits immensely from the scientific and
technological advances of general neuroscience (including genetics, epigenetics,
and proteomics). This “progress” of molecular psychiatry, however, will be to a
degree “unbalanced” and “epiphytic” should the development of the corresponding
theoretical frameworks and conceptualization tools that allow contextualization
of the i...
The neurobiology of suicide - A Review of post-mortem studies
Tập 1 - Trang 1-22 - 2013
The neurobiology of suicidal behaviour, which constitutes one of the most
serious problems both in psychiatry and general medical practice, still remains
to a large degree unclear. As a result, scientists constantly look for new
opportunities of explaining the causes underlying suicidality. In order to
elucidate the biological changes occurring in the brains of the suicide victims,
studies based o...