Journal of Molecular Psychiatry
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2049-9256
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mGluR2/3 blockade produces rapid and long-lasting reversal of anhedonia caused by chronic stress exposure
Tập 1 - Trang 1-4 - 2013
Depression is a prevalent neuropsychiatric disorder that affects an estimated
350 million people worldwide. Currently available treatments for depression are
lacking in both speed of onset and efficacy. Recent pharmacological efforts have
targeted the glutamatergic neurotransmitter system using the
N-methyl-D-aspartate (NMDA) receptor antagonist ketamine to produce rapid and
robust antidepressant ...
Neurotrophin levels at admission did not change significantly upon alcohol deprivation and were positively correlated with the BMI and LDL levels
Tập 1 - Trang 1-7 - 2013
The neurotrophins brain-derived neurotrophic factor (BDNF) and neurotrophic
factor 3 (NT3) could play a role in addictive behavior. Interactions between
BDNF and dopamine transmission influence the alcohol intake. It has been
hypothesized that extensive alcohol consumption leads to diminished circulating
BDNF levels and impaired BDNF-mediated protective mechanisms. What is more,
alcohol dependency...
The amygdala between sensation and affect: a role in pain
Tập 1 - Trang 1-14 - 2013
The amygdala is a structure of the temporal lobe thought to be involved in
assigning emotional significance to environmental information and triggering
adapted physiological, behavioral and affective responses. A large body of
literature in animals and human implicates the amygdala in fear. Pain having a
strong affective and emotional dimension, the amygdala, especially its central
nucleus (CeA), ...
Centenary of Karl Jaspers’s general psychopathology: implications for molecular psychiatry
Tập 2 - Trang 1-5 - 2014
Modern molecular psychiatry benefits immensely from the scientific and
technological advances of general neuroscience (including genetics, epigenetics,
and proteomics). This “progress” of molecular psychiatry, however, will be to a
degree “unbalanced” and “epiphytic” should the development of the corresponding
theoretical frameworks and conceptualization tools that allow contextualization
of the i...
Insights into the origin of DNA methylation differences between monozygotic twins discordant for schizophrenia
Tập 3 - Trang 1-10 - 2015
DNA methylation differences between monozygotic twins discordant for
schizophrenia have been previously reported. However, the origin of methylation
differences between monozygotic twins discordant for schizophrenia is not clear.
The findings here argue that all DNA methylation differences may not necessarily
represent the cause of the disease; rather some may result from the effect of
antipsychot...
Sleep hygiene awareness: its relation to sleep quality and diurnal preference
Tập 3 - Trang 1-7 - 2015
Sleep hygiene is a core component for psychological treatments of insomnia and
essential for maintaining a satisfactory sleep. Our study aimed to measure the
sleep hygiene awareness and the self-reported quality of sleep among three age
groups (young adults, adults and middle-aged adults) and to determine their
relation. We also measured their relation with diurnal preference. Using an
online ques...
Mitochondrial complex I and III gene mRNA levels in schizophrenia, and their relationship with clinical features
Tập 2 - Trang 1-6 - 2014
The etiology of schizophrenia is not precisely known; however, mitochondrial
function and cerebral energy metabolism abnormalities were determined to be
possible factors associated with the etiology of schizophrenia. Impaired
mitochondrial function negatively affects neuronal plasticity, and can cause
cognitive deficits and behavioral abnormalities observed during the clinical
course of schizophre...