Journal of Molecular Psychiatry
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2049-9256
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mGluR2/3 blockade produces rapid and long-lasting reversal of anhedonia caused by chronic stress exposure
Tập 1 - Trang 1-4 - 2013
Depression is a prevalent neuropsychiatric disorder that affects an estimated
350 million people worldwide. Currently available treatments for depression are
lacking in both speed of onset and efficacy. Recent pharmacological efforts have
targeted the glutamatergic neurotransmitter system using the
N-methyl-D-aspartate (NMDA) receptor antagonist ketamine to produce rapid and
robust antidepressant ...
Neurotrophin levels at admission did not change significantly upon alcohol deprivation and were positively correlated with the BMI and LDL levels
Tập 1 - Trang 1-7 - 2013
The neurotrophins brain-derived neurotrophic factor (BDNF) and neurotrophic
factor 3 (NT3) could play a role in addictive behavior. Interactions between
BDNF and dopamine transmission influence the alcohol intake. It has been
hypothesized that extensive alcohol consumption leads to diminished circulating
BDNF levels and impaired BDNF-mediated protective mechanisms. What is more,
alcohol dependency...
αT-catenin in restricted brain cell types and its potential connection to autism
Tập 4 - Trang 1-13 - 2016
Recent genetic association studies have linked the cadherin-based adherens
junction protein alpha-T-catenin (αT-cat, CTNNA3) with the development of
autism. Where αT-cat is expressed in the brain, and how its loss could
contribute to this disorder, are entirely unknown. We used the αT-cat knockout
mouse to examine the localization of αT-cat in the brain, and we used histology
and immunofluorescenc...
Sleep hygiene awareness: its relation to sleep quality and diurnal preference
Tập 3 - Trang 1-7 - 2015
Sleep hygiene is a core component for psychological treatments of insomnia and
essential for maintaining a satisfactory sleep. Our study aimed to measure the
sleep hygiene awareness and the self-reported quality of sleep among three age
groups (young adults, adults and middle-aged adults) and to determine their
relation. We also measured their relation with diurnal preference. Using an
online ques...
The neurobiology of suicide - A Review of post-mortem studies
Tập 1 - Trang 1-22 - 2013
The neurobiology of suicidal behaviour, which constitutes one of the most
serious problems both in psychiatry and general medical practice, still remains
to a large degree unclear. As a result, scientists constantly look for new
opportunities of explaining the causes underlying suicidality. In order to
elucidate the biological changes occurring in the brains of the suicide victims,
studies based o...
NRXN1 deletions identified by array comparative genome hybridisation in a clinical case series – further understanding of the relevance of NRXN1 to neurodevelopmental disorders
Tập 1 - Trang 1-7 - 2013
Microdeletions in the NRXN1 gene have been associated with a range of
neurodevelopmental disorders, including autism spectrum disorders,
schizophrenia, intellectual disability, speech and language delay, epilepsy and
hypotonia. In the present study we performed array CGH analysis on 10,397
individuals referred for diagnostic cytogenetic analysis, using a custom
oligonucleotide array, which include...