Journal of Molecular Psychiatry
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2049-9256
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Genetics and epigenetics of alcohol dependence
Tập 1 - Trang 1-6 - 2013
Alcohol dependence is a severe and common disorder associated with high
morbidity and mortality rates. Genetic as well as environmental factors are
known to modulate susceptibility to alcohol dependence. There is a growing body
of evidence suggesting that this interaction between the genome and the
environment is mediated by epigenetic mechanisms, e.g. DNA methylation at CpG
sites. Following an in...
Neurotrophin levels at admission did not change significantly upon alcohol deprivation and were positively correlated with the BMI and LDL levels
Tập 1 - Trang 1-7 - 2013
The neurotrophins brain-derived neurotrophic factor (BDNF) and neurotrophic
factor 3 (NT3) could play a role in addictive behavior. Interactions between
BDNF and dopamine transmission influence the alcohol intake. It has been
hypothesized that extensive alcohol consumption leads to diminished circulating
BDNF levels and impaired BDNF-mediated protective mechanisms. What is more,
alcohol dependency...
A systematic review of agomelatine-induced liver injury
Tập 3 - Trang 1-12 - 2015
Agomelatine is an antidepressant with a unique mechanism of action. Since its
marketing in 2009, concerns have been raised regarding its potential to induce
liver injury. The authors therefore address the need to comprehensively evaluate
the potential risk posed by agomelatine of inducing liver injury by reviewing
data from published and unpublished clinical trials in both the pre- and
postmarketi...
Sleep hygiene awareness: its relation to sleep quality and diurnal preference
Tập 3 - Trang 1-7 - 2015
Sleep hygiene is a core component for psychological treatments of insomnia and
essential for maintaining a satisfactory sleep. Our study aimed to measure the
sleep hygiene awareness and the self-reported quality of sleep among three age
groups (young adults, adults and middle-aged adults) and to determine their
relation. We also measured their relation with diurnal preference. Using an
online ques...
Unified theory of Alzheimer’s disease (UTAD): implications for prevention and curative therapy
Tập 4 - Trang 1-52 - 2016
The aim of this review is to propose a Unified Theory of Alzheimer’s disease
(UTAD) that integrates all key behavioural, genetic and environmental risk
factors in a causal chain of etiological and pathogenetic events. It is based on
three concepts that emanate from human’s evolutionary history: (1) The
grandmother-hypothesis (GMH), which explains human longevity due to an
evolutionary advantage in...
αT-catenin in restricted brain cell types and its potential connection to autism
Tập 4 - Trang 1-13 - 2016
Recent genetic association studies have linked the cadherin-based adherens
junction protein alpha-T-catenin (αT-cat, CTNNA3) with the development of
autism. Where αT-cat is expressed in the brain, and how its loss could
contribute to this disorder, are entirely unknown. We used the αT-cat knockout
mouse to examine the localization of αT-cat in the brain, and we used histology
and immunofluorescenc...
Mitochondrial complex I and III gene mRNA levels in schizophrenia, and their relationship with clinical features
Tập 2 - Trang 1-6 - 2014
The etiology of schizophrenia is not precisely known; however, mitochondrial
function and cerebral energy metabolism abnormalities were determined to be
possible factors associated with the etiology of schizophrenia. Impaired
mitochondrial function negatively affects neuronal plasticity, and can cause
cognitive deficits and behavioral abnormalities observed during the clinical
course of schizophre...