Journal of Molecular Psychiatry
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2049-9256
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Centenary of Karl Jaspers’s general psychopathology: implications for molecular psychiatry
Tập 2 - Trang 1-5 - 2014
Modern molecular psychiatry benefits immensely from the scientific and
technological advances of general neuroscience (including genetics, epigenetics,
and proteomics). This “progress” of molecular psychiatry, however, will be to a
degree “unbalanced” and “epiphytic” should the development of the corresponding
theoretical frameworks and conceptualization tools that allow contextualization
of the i...
mGluR2/3 blockade produces rapid and long-lasting reversal of anhedonia caused by chronic stress exposure
Tập 1 - Trang 1-4 - 2013
Depression is a prevalent neuropsychiatric disorder that affects an estimated
350 million people worldwide. Currently available treatments for depression are
lacking in both speed of onset and efficacy. Recent pharmacological efforts have
targeted the glutamatergic neurotransmitter system using the
N-methyl-D-aspartate (NMDA) receptor antagonist ketamine to produce rapid and
robust antidepressant ...
Sleep hygiene awareness: its relation to sleep quality and diurnal preference
Tập 3 - Trang 1-7 - 2015
Sleep hygiene is a core component for psychological treatments of insomnia and
essential for maintaining a satisfactory sleep. Our study aimed to measure the
sleep hygiene awareness and the self-reported quality of sleep among three age
groups (young adults, adults and middle-aged adults) and to determine their
relation. We also measured their relation with diurnal preference. Using an
online ques...
The amygdala between sensation and affect: a role in pain
Tập 1 - Trang 1-14 - 2013
The amygdala is a structure of the temporal lobe thought to be involved in
assigning emotional significance to environmental information and triggering
adapted physiological, behavioral and affective responses. A large body of
literature in animals and human implicates the amygdala in fear. Pain having a
strong affective and emotional dimension, the amygdala, especially its central
nucleus (CeA), ...
αT-catenin in restricted brain cell types and its potential connection to autism
Tập 4 - Trang 1-13 - 2016
Recent genetic association studies have linked the cadherin-based adherens
junction protein alpha-T-catenin (αT-cat, CTNNA3) with the development of
autism. Where αT-cat is expressed in the brain, and how its loss could
contribute to this disorder, are entirely unknown. We used the αT-cat knockout
mouse to examine the localization of αT-cat in the brain, and we used histology
and immunofluorescenc...
Methylphenidate enhances neural stem cell differentiation
Tập 1 - Trang 1-5 - 2013
The psychostimulant methylphenidate (MPH) is the first choice of drug treatment
in Attention-Deficit/Hyperactivity Disorder (ADHD). Since therapy often begins
at a time when the brain is still developing and the long-term consequences of
MPH are still not fully clarified, we examined the influences of an acute
treatment with MPH on the differentiation and proliferation of murine neural
stem cells ...
NRXN1 deletions identified by array comparative genome hybridisation in a clinical case series – further understanding of the relevance of NRXN1 to neurodevelopmental disorders
Tập 1 - Trang 1-7 - 2013
Microdeletions in the NRXN1 gene have been associated with a range of
neurodevelopmental disorders, including autism spectrum disorders,
schizophrenia, intellectual disability, speech and language delay, epilepsy and
hypotonia. In the present study we performed array CGH analysis on 10,397
individuals referred for diagnostic cytogenetic analysis, using a custom
oligonucleotide array, which include...