Journal of Molecular Psychiatry
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2049-9256
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Methylphenidate enhances neural stem cell differentiation
Tập 1 - Trang 1-5 - 2013
The psychostimulant methylphenidate (MPH) is the first choice of drug treatment
in Attention-Deficit/Hyperactivity Disorder (ADHD). Since therapy often begins
at a time when the brain is still developing and the long-term consequences of
MPH are still not fully clarified, we examined the influences of an acute
treatment with MPH on the differentiation and proliferation of murine neural
stem cells ...
The amygdala between sensation and affect: a role in pain
Tập 1 - Trang 1-14 - 2013
The amygdala is a structure of the temporal lobe thought to be involved in
assigning emotional significance to environmental information and triggering
adapted physiological, behavioral and affective responses. A large body of
literature in animals and human implicates the amygdala in fear. Pain having a
strong affective and emotional dimension, the amygdala, especially its central
nucleus (CeA), ...
Sleep hygiene awareness: its relation to sleep quality and diurnal preference
Tập 3 - Trang 1-7 - 2015
Sleep hygiene is a core component for psychological treatments of insomnia and
essential for maintaining a satisfactory sleep. Our study aimed to measure the
sleep hygiene awareness and the self-reported quality of sleep among three age
groups (young adults, adults and middle-aged adults) and to determine their
relation. We also measured their relation with diurnal preference. Using an
online ques...
A systematic review of agomelatine-induced liver injury
Tập 3 - Trang 1-12 - 2015
Agomelatine is an antidepressant with a unique mechanism of action. Since its
marketing in 2009, concerns have been raised regarding its potential to induce
liver injury. The authors therefore address the need to comprehensively evaluate
the potential risk posed by agomelatine of inducing liver injury by reviewing
data from published and unpublished clinical trials in both the pre- and
postmarketi...
The neurobiology of suicide - A Review of post-mortem studies
Tập 1 - Trang 1-22 - 2013
The neurobiology of suicidal behaviour, which constitutes one of the most
serious problems both in psychiatry and general medical practice, still remains
to a large degree unclear. As a result, scientists constantly look for new
opportunities of explaining the causes underlying suicidality. In order to
elucidate the biological changes occurring in the brains of the suicide victims,
studies based o...
αT-catenin in restricted brain cell types and its potential connection to autism
Tập 4 - Trang 1-13 - 2016
Recent genetic association studies have linked the cadherin-based adherens
junction protein alpha-T-catenin (αT-cat, CTNNA3) with the development of
autism. Where αT-cat is expressed in the brain, and how its loss could
contribute to this disorder, are entirely unknown. We used the αT-cat knockout
mouse to examine the localization of αT-cat in the brain, and we used histology
and immunofluorescenc...