Journal of Molecular Psychiatry
2049-9256
Cơ quản chủ quản: N/A
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Centenary of Karl Jaspers’s general psychopathology: implications for molecular psychiatry
Tập 2 - Trang 1-5 - 2014
Modern molecular psychiatry benefits immensely from the scientific and technological advances of general neuroscience (including genetics, epigenetics, and proteomics). This “progress” of molecular psychiatry, however, will be to a degree “unbalanced” and “epiphytic” should the development of the corresponding theoretical frameworks and conceptualization tools that allow contextualization of the i......
Unified theory of Alzheimer’s disease (UTAD): implications for prevention and curative therapy
Tập 4 - Trang 1-52 - 2016
The aim of this review is to propose a Unified Theory of Alzheimer’s disease (UTAD) that integrates all key behavioural, genetic and environmental risk factors in a causal chain of etiological and pathogenetic events. It is based on three concepts that emanate from human’s evolutionary history: (1) The grandmother-hypothesis (GMH), which explains human longevity due to an evolutionary advantage in......
mGluR2/3 blockade produces rapid and long-lasting reversal of anhedonia caused by chronic stress exposure
Tập 1 - Trang 1-4 - 2013
Depression is a prevalent neuropsychiatric disorder that affects an estimated 350 million people worldwide. Currently available treatments for depression are lacking in both speed of onset and efficacy. Recent pharmacological efforts have targeted the glutamatergic neurotransmitter system using the N-methyl-D-aspartate (NMDA) receptor antagonist ketamine to produce rapid and robust antidepressant ......
The amygdala between sensation and affect: a role in pain
Tập 1 - Trang 1-14 - 2013
The amygdala is a structure of the temporal lobe thought to be involved in assigning emotional significance to environmental information and triggering adapted physiological, behavioral and affective responses. A large body of literature in animals and human implicates the amygdala in fear. Pain having a strong affective and emotional dimension, the amygdala, especially its central nucleus (CeA), ......
Neurotrophin levels at admission did not change significantly upon alcohol deprivation and were positively correlated with the BMI and LDL levels
Tập 1 - Trang 1-7 - 2013
The neurotrophins brain-derived neurotrophic factor (BDNF) and neurotrophic factor 3 (NT3) could play a role in addictive behavior. Interactions between BDNF and dopamine transmission influence the alcohol intake. It has been hypothesized that extensive alcohol consumption leads to diminished circulating BDNF levels and impaired BDNF-mediated protective mechanisms. What is more, alcohol dependency......
Post-stroke depression and the aging brain
Tập 1 - Trang 1-10 - 2013
Ageing is associated with changes in the function of various organ systems. Changes in the cardiovascular system affect both directly and indirectly the function in a variety of organs, including the brain, with consequent neurological (motor and sensory performance) and cognitive impairments, as well as leading to the development of various psychiatric diseases. Post-stroke depression (PSD) is am......