Journal of Molecular Psychiatry
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2049-9256
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mGluR2/3 blockade produces rapid and long-lasting reversal of anhedonia caused by chronic stress exposure
Tập 1 - Trang 1-4 - 2013
Depression is a prevalent neuropsychiatric disorder that affects an estimated
350 million people worldwide. Currently available treatments for depression are
lacking in both speed of onset and efficacy. Recent pharmacological efforts have
targeted the glutamatergic neurotransmitter system using the
N-methyl-D-aspartate (NMDA) receptor antagonist ketamine to produce rapid and
robust antidepressant ...
Methylphenidate enhances neural stem cell differentiation
Tập 1 - Trang 1-5 - 2013
The psychostimulant methylphenidate (MPH) is the first choice of drug treatment
in Attention-Deficit/Hyperactivity Disorder (ADHD). Since therapy often begins
at a time when the brain is still developing and the long-term consequences of
MPH are still not fully clarified, we examined the influences of an acute
treatment with MPH on the differentiation and proliferation of murine neural
stem cells ...
Post-stroke depression and the aging brain
Tập 1 - Trang 1-10 - 2013
Ageing is associated with changes in the function of various organ systems.
Changes in the cardiovascular system affect both directly and indirectly the
function in a variety of organs, including the brain, with consequent
neurological (motor and sensory performance) and cognitive impairments, as well
as leading to the development of various psychiatric diseases. Post-stroke
depression (PSD) is am...
Mitochondrial complex I and III gene mRNA levels in schizophrenia, and their relationship with clinical features
Tập 2 - Trang 1-6 - 2014
The etiology of schizophrenia is not precisely known; however, mitochondrial
function and cerebral energy metabolism abnormalities were determined to be
possible factors associated with the etiology of schizophrenia. Impaired
mitochondrial function negatively affects neuronal plasticity, and can cause
cognitive deficits and behavioral abnormalities observed during the clinical
course of schizophre...
Genetics and epigenetics of alcohol dependence
Tập 1 - Trang 1-6 - 2013
Alcohol dependence is a severe and common disorder associated with high
morbidity and mortality rates. Genetic as well as environmental factors are
known to modulate susceptibility to alcohol dependence. There is a growing body
of evidence suggesting that this interaction between the genome and the
environment is mediated by epigenetic mechanisms, e.g. DNA methylation at CpG
sites. Following an in...
Neurotrophin levels at admission did not change significantly upon alcohol deprivation and were positively correlated with the BMI and LDL levels
Tập 1 - Trang 1-7 - 2013
The neurotrophins brain-derived neurotrophic factor (BDNF) and neurotrophic
factor 3 (NT3) could play a role in addictive behavior. Interactions between
BDNF and dopamine transmission influence the alcohol intake. It has been
hypothesized that extensive alcohol consumption leads to diminished circulating
BDNF levels and impaired BDNF-mediated protective mechanisms. What is more,
alcohol dependency...