Journal of Molecular Psychiatry
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Association study in siblings and case-controls of serotonin- and oxytocin-related genes with high functioning autism
Journal of Molecular Psychiatry - - 2014
mGluR2/3 blockade produces rapid and long-lasting reversal of anhedonia caused by chronic stress exposure
Journal of Molecular Psychiatry - Tập 1 - Trang 1-4 - 2013
Depression is a prevalent neuropsychiatric disorder that affects an estimated 350 million people worldwide. Currently available treatments for depression are lacking in both speed of onset and efficacy. Recent pharmacological efforts have targeted the glutamatergic neurotransmitter system using the N-methyl-D-aspartate (NMDA) receptor antagonist ketamine to produce rapid and robust antidepressant ......
A systematic review of agomelatine-induced liver injury
Journal of Molecular Psychiatry - Tập 3 - Trang 1-12 - 2015
Agomelatine is an antidepressant with a unique mechanism of action. Since its marketing in 2009, concerns have been raised regarding its potential to induce liver injury. The authors therefore address the need to comprehensively evaluate the potential risk posed by agomelatine of inducing liver injury by reviewing data from published and unpublished clinical trials in both the pre- and postmarketi......
Mitochondrial complex I and III gene mRNA levels in schizophrenia, and their relationship with clinical features
Journal of Molecular Psychiatry - Tập 2 - Trang 1-6 - 2014
The etiology of schizophrenia is not precisely known; however, mitochondrial function and cerebral energy metabolism abnormalities were determined to be possible factors associated with the etiology of schizophrenia. Impaired mitochondrial function negatively affects neuronal plasticity, and can cause cognitive deficits and behavioral abnormalities observed during the clinical course of schizophre......
αT-catenin in restricted brain cell types and its potential connection to autism
Journal of Molecular Psychiatry - Tập 4 - Trang 1-13 - 2016
Recent genetic association studies have linked the cadherin-based adherens junction protein alpha-T-catenin (αT-cat, CTNNA3) with the development of autism. Where αT-cat is expressed in the brain, and how its loss could contribute to this disorder, are entirely unknown. We used the αT-cat knockout mouse to examine the localization of αT-cat in the brain, and we used histology and immunofluorescenc......
Unified theory of Alzheimer’s disease (UTAD): implications for prevention and curative therapy
Journal of Molecular Psychiatry - Tập 4 - Trang 1-52 - 2016
The aim of this review is to propose a Unified Theory of Alzheimer’s disease (UTAD) that integrates all key behavioural, genetic and environmental risk factors in a causal chain of etiological and pathogenetic events. It is based on three concepts that emanate from human’s evolutionary history: (1) The grandmother-hypothesis (GMH), which explains human longevity due to an evolutionary advantage in......
Preparation for teacher collaboration in inclusive classrooms – stress reduction for special education students via acceptance and commitment training: A controlled study
Journal of Molecular Psychiatry - - 2015
Genetics and epigenetics of alcohol dependence
Journal of Molecular Psychiatry - Tập 1 - Trang 1-6 - 2013
Alcohol dependence is a severe and common disorder associated with high morbidity and mortality rates. Genetic as well as environmental factors are known to modulate susceptibility to alcohol dependence. There is a growing body of evidence suggesting that this interaction between the genome and the environment is mediated by epigenetic mechanisms, e.g. DNA methylation at CpG sites. Following an in......
Erratum to: Methylphenidate enhances neural stem cell differentiation
Journal of Molecular Psychiatry - Tập 1 - Trang 1-2 - 2013
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