Molecular mechanisms of interaction of polycationic peptides with serpentine type receptors and heterotrimeric G-proteins in rat tissuesJournal of Evolutionary Biochemistry and Physiology - Tập 42 - Trang 399-407 - 2006
A. O. Shpakov, I. A. Gur’yanov, G. P. Vlasov, M. N. Pertseva
The key step in the hormonal signal transduction into cell is interaction of receptors with heterotrimeric G-proteins. We and other authors have shown that G-proteins may be activated as a result of their direct interaction with polycationic peptides. The goal of this work was to study molecular mechanisms of effect of hydrophobic peptide I, C-εAhx-WKK(C10)-KKK(C10)-KKKK(C10)-YKK(C10)-KK, and bran...... hiện toàn bộ
Some Components of the Serotonergic System in the Eyes of Two Species of Freshwater MolluscsJournal of Evolutionary Biochemistry and Physiology - Tập 59 - Trang 1954-1965 - 2024
I. N. Dominova, A. A. Husenova, V. V. Kotova, M. V. Sidorova, V. V. Zhukov
Labeling of 5-HT-immunoreactive structures was performed on
eye slices of freshwater molluscs Lymnaea
stagnalis and Pomacea canaliculata.
In the periocular region of both species an increased density of
5-HTergic fibers forming structurally distinct plexuses and partially penetrating
into the retina was detected. Transcription of serotonin receptor
genes was detected in eye tissues: two types in L...... hiện toàn bộ
Prenatal hypoxia modifies working memory and the activity of hippocampal polyphosphoinositide system in ratsJournal of Evolutionary Biochemistry and Physiology - Tập 51 - Trang 131-138 - 2015
E. I. Tyul’kova, L. A. Vataeva, O. V. Vetrovoi, D. Yu. Romanovskii
The aim of the present study was to explore spatial learning abilities in the Morris water maze (working memory) as well as hippocampal levels of phosphatidylinositol 4,5-diphosphates (TPI), phosphatidylinositol 4-phosphates (DPI), phosphotidylinositols (MPI), and expression of the type 1 inositol 1,4,5-trisphosphate receptor (IP3R1) in rats exposed to severe hypobaric hypoxia (ascent to 11 km, 3 ...... hiện toàn bộ