Effects of uni- and bilateral destructions of the caudate nucleus head by kainic acid on electroencephalogram in the wakefulness—sleep cycle in wistar rats
Tóm tắt
Changes in characteristics of the wakefulness—sleep cycle were studied in Wistar rats after a uni- and bilateral destruction of the head of nucleus caudatus by kainic acid that produces a selective destruction of neuronal elements but does not damage conducting pathways passing through this structure. It is established that changes of the cycle after injections of the acid did not last long (not more than 4 days) and were due to the presence of foci of paroxysmal activity resulted from a strong excitatory effect of this selective neurotoxin. It is revealed that the consequences of the bilateral injury of the nucleus caudatus were less pronounced and easier tolerated by animals than those of the unilateral one. The appearance of spindle-like discharges on rat EEG during the fast wave sleep was observed after the unilateral but not the bilateral destruction. A possible role in the genesis of this activity played by a disbalance in the work of the system of the caudate inhibitory control of the activity of non-specific thalamic nuclei is discussed.
Tài liệu tham khảo
Arushanyan, E.B., Striatum in the System of the Central Apparatus Controlling Biorhythms,Zh. Vyssh. Nervn. Deyateln., 1998, vol. 48, pp. 296–303.
Parmeggiani, P.L., Telencephalo-Diencephalic Aspects of Sleep Mechanisms,Brain Res., 1968, vol. 7, pp. 350–359.
Gogichadze, M.V. and Oniani, T.N., Role of the Caudate Nucleus in Regulation of the Wakefulness-Sleep Cycle,Striarnaya sistema i povedenie v norme i patologii (Striatal System and Behavior in Norm and Pathology), Leningrad, 1984, pp. 50-57.
Hess, W.R., Koella, W.P., and Akert, K., Cortical and Subcortical Recording in Natural and Artificially Induced Sleep in Cats,EEG Clin. Neurophysiol., 1953, vol. 5, pp. 79–90.
Buchwald, N.A., Wyers, E.L., Lauprecht, C.W., and Heuser, G., The “Caudate Spindle.” IV. A Behavioral Index of Caudate Induced Inhibition,EEG Clin. Neurophysiol., 1961, vol. 13, pp. 531–537.
Arushanyan, E.B. and Shishlyannikova, L.V., Inhibition of Behavioral Reactions in Cats after the Cessation of the Caudate Nucleus Electric Stimulation,Zh. Vyssh. Nern. Deyateln., 1979, vol. 29, pp. 80–87.
Bekhtereva, N.P.,Neirofiziologicheskie aspekty psikhicheskoi deyatelnosti cheloveka (Neurophysiological Aspects of the Human Psychic Activity), Leningrad, 1974.
Villablanca, J.R., Marcus, R.J., and Olmstead, C.E., Effect of Caudate Nuclei or Frontal Cortex Ablations in Cats. II. Sleep-Wakefulness, EEG and Motor Activity,Experim. Neurol., 1976, vol. 53, pp. 31–50.
Suvorov, N.F.,Striarnaya sistema i povedenie (Striatal System and Behavior), Leningrad, 1980.
Vataev, S.I., Dem’yanenko, G.P., Titkov, E.S., and Oganesyan, G.A., Effect of Unilateral Destruction of the Caudate Nucleus Head by Kainic Acid on the Wakefulness-Sleep Cycle Structure and EEG in Rats,Zh. Evol. Biokhim. Fiziol, 1996, vol. 32, pp. 434–439.
Vataev, S.I., Titkov, E.S., and Oganesyan, G.A., Effect of Unilateral Destruction of Caudate Nucleus by Kainic Acid on the Character of Electric Activity of the Rat Brain in the Wakefulness-Sleep Cycle,Zh. Evol. Biokhim. Fiziol, 1996, vol. 32, pp. 613–618.
Fifkova, E. and Marsala, J.,Stereotaxic Atlases for Cat, Rabbit and Rat Brains, Praha, 1960.
Vataev, S.I., Spectral and Correlation Analysis of EEG in the Wakefulness-Sleep Cycle in Rats with Genetic Predisposition to Audiogenic Seizures,Fiziol. Zh., 1995, vol. 81, no. 12, pp. 70–80.
Coyle, J.T., Molliver, M.E., and Kunar, M.J.,In situ Injection of Kainic Acid: a New Method for Selectively Lesioning Neuronal Cell Bodies While Sparing Axons of Passage,J. Comp. Neurol, 1978, vol. 180, pp. 301–324.
Marini, G., Giglio, R., Macchi, G., and Manchia, M., Nucleus Reticularis Thalami and Neocortical paroxysms in the Rat,Eur. J. Neurosci., 1995, vol. 7, pp. 2301–2307.