Journal of Clinical Pharmacology
SCOPUS (1973-2025)SCIE-ISI
1552-4604
0091-2700
Mỹ
Cơ quản chủ quản: WILEY , Wiley-Blackwell
Lĩnh vực:
Pharmacology (medical)Pharmacology
Phân tích ảnh hưởng
Các bài báo tiêu biểu
Danshen: An Overview of Its Chemistry, Pharmacology, Pharmacokinetics, and Clinical Use
Tập 45 Số 12 - Trang 1345-1359 - 2005
Danshen, the dried root of Salvia miltiorrhiza, has been widely used in China
and, to a lesser extent, in Japan, the United States, and other European
countries for the treatment of cardiovascular and cerebrovascular diseases. In
China, the specific clinical use is angina pectoris, hyperlipidemia, and acute
ischemic stroke. The current review covers its traditional uses, chemical
constituents, pha...
The Anticholinergic Drug Scale as a Measure of Drug‐Related Anticholinergic Burden: Associations With Serum Anticholinergic Activity
Tập 46 Số 12 - Trang 1481-1486 - 2006
Anticholinergic Drug Scale (ADS) scores were previously associated with serum
anticholinergic activity (SAA) in a pilot study. To replicate these results, the
association between ADS scores and SAA was determined using simple linear
regression in subjects from a study of delirium in 201 long‐term care facility
residents who were not included in the pilot study. Simple and multiple linear
regressio...
DHEA and DHEA‐S: A Review
Tập 39 Số 4 - Trang 327-348 - 1999
Dehydroepiandrosterone (DHEA) and its sulfated metabolite DHEA‐S are endogenous
hormones secreted by the adrenal cortex in response to adrenocorticotrophin
(ACTH). Much has been published regarding potential effects on various systems.
Despite the identification of DHEA and DHEA‐S more than 50 years ago, there is
still considerable controversy as to their biological significance. This article
revi...
Global Burden of Disease (GBD) for Hepatitis C
Tập 44 Số 1 - Trang 20-29 - 2004
Hepatitis C virus (HCV) infection is now a global public health issue. However,
the global burden of disease attributable to HCV infection is unknown. The
objectives of this WHO informal consultation included the following: (1)
defining a strategy to estimate the global burden of disease (GBD) associated
with HCV infection in terms of morbidity and mortality, (2) describing the
natural history of ...
Stability and Performance of a Population Pharmacokinetic Model
Tập 37 Số 6 - Trang 486-495 - 1997
This study aimed to determine the stability (in terms of covariate selection) of
a population pharmacokinetic model and evaluate its performance in the absence
of a test data set. Data from 88 full‐term infants, 11 of whom were human
immunodeficiency virus (HIV)–seropositive, taking an antiinfective agent were
analyzed using exploratory data analysis methods and the nonlinear mixed‐effects
modelin...
Developmental Changes in Pharmacokinetics and Pharmacodynamics
Tập 58 Số S10 - 2018
AbstractEffective drug therapy to optimally influence disease requires an
understanding of a drug's pharmacokinetic, pharmacodynamic, and pharmacogenomic
interrelationships. In pediatrics, age is a continuum that can and does add
variability in drug disposition and effect. This article addresses the many
important factors that influence drug disposition and effect relative to age.
What is known ab...
Hemodynamic Response to the Upright Posture
Tập 34 Số 5 - Trang 375-386 - 1994
The authors' objective was to review previous studies of immediate (first 30
seconds) and stabilized (30 seconds to 20 minutes) hemodynamic responses of
healthy adults to the head‐up posture, with particular reference to alteration
of such responses in the elderly and the usefulness of such data in the
diagnosis of orthostatic hypotension. The immediate response in healthy young
adults is characte...
Pharmacokinetic Profile of the Oral Direct Thrombin Inhibitor Dabigatran Etexilate in Healthy Volunteers and Patients Undergoing Total Hip Replacement
Tập 45 Số 5 - Trang 555-565 - 2005
Dabigatran etexilate is an oral low‐molecular‐weight direct thrombin inhibitor.
Following oral administration, dabigatran etexilate is rapidly converted to its
active form, dabigatran. The authors investigated the absorption, distribution,
and elimination of a single 150‐mg dose capsule formulation of dabigatran
etexilate in healthy volunteers and patients undergoing total hip replacement.
In an o...
Adulteration by Synthetic Therapeutic Substances of Traditional Chinese Medicines in Taiwan
Tập 37 Số 4 - Trang 344-350 - 1997
The adulteration by synthetic therapeutic substances of traditional Chinese
medicines has been reported on various occasions and has been a public health
concern in Taiwan over the past several years. A large‐scale effort was
initiated in 1992 to screen traditional Chinese medicines that were suspected of
adulteration with synthetic therapeutic substances. The term “adulteration”
refers to traditi...
Hawthorn
Tập 42 Số 6 - Trang 605-612 - 2002
A review with 54 references covers all aspects of hawthorn, the genus Crataegus,
including its traditional uses, chemical constituents, pharmacological
activities, and clinical effects. Although the effectiveness of hawthorn on the
treatment of cardiovascular diseases has received extensive attention worldwide,
further scientific research on various areas such as pharmacokinetics, mechanism
of act...