Journal of Clinical Pharmacology
SCOPUS (1973-2023)SCIE-ISI
1552-4604
0091-2700
Mỹ
Cơ quản chủ quản: WILEY , Wiley-Blackwell
Lĩnh vực:
Pharmacology (medical)Pharmacology
Các bài báo tiêu biểu
Danshen: An Overview of Its Chemistry, Pharmacology, Pharmacokinetics, and Clinical UseDanshen, the dried root of Salvia miltiorrhiza, has been widely used in China and, to a lesser extent, in Japan, the United States, and other European countries for the treatment of cardiovascular and cerebrovascular diseases. In China, the specific clinical use is angina pectoris, hyperlipidemia, and acute ischemic stroke. The current review covers ...
Tập 45 Số 12 - Trang 1345-1359 - 2005
The Anticholinergic Drug Scale as a Measure of Drug‐Related Anticholinergic Burden: Associations With Serum Anticholinergic ActivityAnticholinergic Drug Scale (ADS) scores were previously associated with serum anticholinergic activity (SAA) in a pilot study. To replicate these results, the association between ADS scores and SAA was determined using simple linear regression in subjects from a study of delirium in 201 long‐term care facility residents who were not included in the pilot study. Simple and multiple linear r... ...
Tập 46 Số 12 - Trang 1481-1486 - 2006
DHEA and DHEA‐S: A ReviewDehydroepiandrosterone (DHEA) and its sulfated metabolite DHEA‐S are endogenous hormones secreted by the adrenal cortex in response to adrenocorticotrophin (ACTH). Much has been published regarding potential effects on various systems. Despite the identification of DHEA and DHEA‐S more than 50 years ago, there is still considerable controversy as to their biological significance. This arti... ...
Tập 39 Số 4 - Trang 327-348 - 1999
Global Burden of Disease (GBD) for Hepatitis CHepatitis C virus (HCV) infection is now a global public health issue. However, the global burden of disease attributable to HCV infection is unknown. The objectives of this WHO informal consultation included the following: (1) defining a strategy to estimate the global burden of disease (GBD) associated with HCV infection in terms of morbidity and mortality, (2) describing the natural his... ...
Tập 44 Số 1 - Trang 20-29 - 2004
Stability and Performance of a Population Pharmacokinetic ModelThis study aimed to determine the stability (in terms of covariate selection) of a population pharmacokinetic model and evaluate its performance in the absence of a test data set. Data from 88 full‐term infants, 11 of whom were human immunodeficiency virus (HIV)–seropositive, taking an antiinfective agent were analyzed using exploratory data analysis methods and the nonlinear mixed‐effects... ...
Tập 37 Số 6 - Trang 486-495 - 1997
Developmental Changes in Pharmacokinetics and PharmacodynamicsAbstract Effective drug therapy to optimally influence disease requires an understanding of a drug's pharmacokinetic, pharmacodynamic, and pharmacogenomic interrelationships. In pediatrics, age is a continuum that can and does add variability in drug disposition and effect. This article addresses the many important factors that influence drug disposition and effect ... ...
Tập 58 Số S10 - 2018
Hemodynamic Response to the Upright PostureThe authors' objective was to review previous studies of immediate (first 30 seconds) and stabilized (30 seconds to 20 minutes) hemodynamic responses of healthy adults to the head‐up posture, with particular reference to alteration of such responses in the elderly and the usefulness of such data in the diagnosis of orthostatic hypotension. The immediate response in healthy young adults is ... ...
Tập 34 Số 5 - Trang 375-386 - 1994
Pharmacokinetic Profile of the Oral Direct Thrombin Inhibitor Dabigatran Etexilate in Healthy Volunteers and Patients Undergoing Total Hip ReplacementDabigatran etexilate is an oral low‐molecular‐weight direct thrombin inhibitor. Following oral administration, dabigatran etexilate is rapidly converted to its active form, dabigatran. The authors investigated the absorption, distribution, and elimination of a single 150‐mg dose capsule formulation of dabigatran etexilate in healthy volunteers and patients undergoing total hip replacement.... ...
Tập 45 Số 5 - Trang 555-565 - 2005
Adulteration by Synthetic Therapeutic Substances of Traditional Chinese Medicines in TaiwanThe adulteration by synthetic therapeutic substances of traditional Chinese medicines has been reported on various occasions and has been a public health concern in Taiwan over the past several years. A large‐scale effort was initiated in 1992 to screen traditional Chinese medicines that were suspected of adulteration with synthetic therapeutic substances. The term “adulteration” refers to... ...
Tập 37 Số 4 - Trang 344-350 - 1997
HawthornA review with 54 references covers all aspects of hawthorn, the genus Crataegus, including its traditional uses, chemical constituents, pharmacological activities, and clinical effects. Although the effectiveness of hawthorn on the treatment of cardiovascular diseases has received extensive attention worldwide, further scientific research on various areas such as pharmacokinetics, mechanis... ...
Tập 42 Số 6 - Trang 605-612 - 2002