The Anticholinergic Drug Scale as a Measure of Drug‐Related Anticholinergic Burden: Associations With Serum Anticholinergic Activity

Journal of Clinical Pharmacology - Tập 46 Số 12 - Trang 1481-1486 - 2006
Ryan M. Carnahan1, Brian C. Lund2, Paul J. Perry3,4, Bruce G. Pollock5, Kennith Culp6
1University of Oklahoma College of Pharmacy, Department of Pharmacy: Clinical and Administrative Sciences, Tulsa, Oklahoma
2Laureate Psychiatric Research Center, Tulsa, Oklahoma
3Touro University—California College of Pharmacy, Vallejo, California
4University of Iowa Roy J. and Lucille A. Carver College of Medicine, Department of Psychiatry, Iowa City, Iowa
5Rotman Research Institute, Baycrest Centre for Geriatric Care, University of Toronto, Toronto, Ontario, Canada
6University of Iowa College of Nursing, Iowa City, Iowa,

Tóm tắt

Anticholinergic Drug Scale (ADS) scores were previously associated with serum anticholinergic activity (SAA) in a pilot study. To replicate these results, the association between ADS scores and SAA was determined using simple linear regression in subjects from a study of delirium in 201 long‐term care facility residents who were not included in the pilot study. Simple and multiple linear regression models were then used to determine whether the ADS could be modified to more effectively predict SAA in all 297 subjects. In the replication analysis, ADS scores were significantly associated with SAA (R 2 = .0947, P <.0001). In the modification analysis, each model significantly predicted SAA, including ADS scores (R 2 = .0741, P <.0001). The modifications examined did not appear useful in optimizing the ADS. This study replicated findings on the association of the ADS with SAA. Future work will determine whether the ADS is clinically useful for preventing anticholinergic adverse effects.

Từ khóa


Tài liệu tham khảo

10.1001/archinte.1989.00390110020006

Carnahan RM, 2002, A critical appraisal of the utility of the serum anticholinergic activity assay in research and clinical practice, Psychopharmacol Bull., 36, 24

Carnahan RM, 2002, The relationship of an anticholinergic rating scale with serum anticholinergic activity in elderly nursing home residents, Psychopharmacol Bull., 36, 14

10.1001/archinte.161.8.1099

10.1093/gerona/59.8.M813

10.1001/archpsyc.1980.01780160063007

10.1592/phco.2005.25.11.1592

10.1001/archinte.163.22.2716

Thông tin
Thông tin xuất bản

Journal of Clinical Pharmacology

Tập 46 Số 12

1481-1486

Thông tin tác giả