Developmental Changes in Pharmacokinetics and Pharmacodynamics

Journal of Clinical Pharmacology - Tập 58 Số S10 - 2018
John van den Anker1,2,3, Michael D. Reed4, Karel Allegaert5,6,3, Gregory L. Kearns7
1Division of Clinical Pharmacology, Children's National Health System, Washington, DC, USA
2Division of Paediatric Pharmacology and Pharmacometrics, University of Basel Children’s Hospital, Basel, Switzerland
3Intensive Care and Department of Pediatric Surgery, Erasmus Medical Center-Sophia Children’s Hospital, Rotterdam, The Netherlands
4Emeritus Professor of Pediatrics, School of Medicine, Case Western Reserve University, Cleveland, OH, USA
5Department of Development and Regeneration, KU Leuven, Leuven, Belgium
6Department of Pediatrics, Division of Neonatology, Erasmus Medical Center-Sophia Children's Hospital, Rotterdam, the Netherlands
7Arkansas Children’s Research Institute, Little Rock, AR USA

Tóm tắt

AbstractEffective drug therapy to optimally influence disease requires an understanding of a drug's pharmacokinetic, pharmacodynamic, and pharmacogenomic interrelationships. In pediatrics, age is a continuum that can and does add variability in drug disposition and effect. This article addresses the many important factors that influence drug disposition and effect relative to age. What is known about the influence of maturation on the processes of drug absorption, distribution, metabolism, excretion, and drug receptor dynamics are outlined. Our state of understanding of many of these factors remains in flux, however, and only with additional study will we be able to better anticipate and model drug‐response relationships across the age continuum. Being able to continuously improve our care of the ill pediatric patient while simultaneously being able to accurately determine the utility of new drugs and chemical entities in this population requires our enhanced understanding of these disposition characteristics.

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Journal of Clinical Pharmacology

Tập 58 Số S10

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