Journal of Clinical Pharmacology

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Population Pharmacokinetics of Ibuprofen Enantiomers in Very Premature Neonates
Journal of Clinical Pharmacology - Tập 44 Số 10 - Trang 1114-1124 - 2004
Nicolas Grégoire, Virginie Gualano, Anne Geneteau, L Millérioux, Murielle Brault, A Mignot, Jean‐Christophe Rozé
The objective of the present study was to evaluate the pharmacokinetic parameters for both S‐ and R‐ibuprofen enantiomers in very premature neonates (gestational age strictly inferior to 28 weeks) and possible relationships between the pharmacokinetic parameters and various covariates. Newborns were randomized to receive ibuprofen or placebo for the prophylactic treatment of patent ductus ...... hiện toàn bộ
The Antinociceptive Effects of Intrathecally Administered Levonantradol and Desacetyllevonantradol in the Rat
Journal of Clinical Pharmacology - Tập 21 Số S1 - 1981
Tony L. Yaksh
Abstract: Levonantradol and its desacetylated metabolite (desacetyllevonantradol) produced a dose‐dependent increase in the hot plate and tail flick response latencies following intrathecal administration in a dose range from 4 to 40 μg. No difference in potency between the two drugs was observed, as defined by the ED50... hiện toàn bộ
A Comparison of THC, Nantradol, Nabilone, and Morphine in the Chronic Spinal Dog
Journal of Clinical Pharmacology - Tập 21 Số S1 - 1981
Paul E. Gilbert
Abstract: Morphine and Δ9‐tetrahydrocannabinol (THC) have been shown to have certain pharmacologic characteristics in common. Among these are antinociception, hypothermia, and the suppression of precipitated abstinence in morphine‐dependent rats. In the present study the effects of morphine were compared with the effects of THC and two synthetic...... hiện toàn bộ
Multiple‐Dose, Linear, Dose‐Proportional Pharmacokinetics of Retigabine in Healthy Volunteers
Journal of Clinical Pharmacology - Tập 42 Số 2 - Trang 175-182 - 2002
Géraldine M. Ferron, Jeffrey Paul, Richard J. Fruncillo, Lyette S Richards, Norbert Knebel, John Getsy, Steven Troy
Retigabine, a first‐in‐class selective M‐current potassium channel opener, is a novel antiepileptic compound currently in clinical development. The purpose of this randomized placebo‐controlled study was to assess retigabine oral safety and pharmacokinetics in healthy male volunteers (N = 45). Subjects received one dose on day 1 and doses every 12 hours for the next 14 days. Fixed doses we...... hiện toàn bộ
Mechanisms of Action of Adrenergic Receptor Blockers on Lipids During Antihypertensive Drug Treatment
Journal of Clinical Pharmacology - Tập 33 Số 3 - Trang 286-291 - 1993
Rabkin Sw
The objective of this article is to focus on the antihypertensive agents blocking adrenergic receptors, both alpha and beta blockers, and attempt to construct potential explanations for their effects on lipids in a mechanistic manner. The essential thesis is that adrenergic control of lipid metabolism is responsible for the effect on lipids and lipoproteins of antihypertensive agents that ...... hiện toàn bộ
Anidulafungin Does Not Require Dosage Adjustment in Subjects With Varying Degrees of Hepatic or Renal Impairment
Journal of Clinical Pharmacology - Tập 47 Số 4 - Trang 461-470 - 2007
James A. Dowell, Martin Stogniew, David Krause, Bharat Damle
Two open‐label studies assessed the effects of hepatic and renal impairment on anidulafungin pharmacokinetics. A single 50‐mg dose was administered intravenously to subjects with varying degrees of hepatic or renal insufficiency or with end‐stage renal disease; all were matched to normal healthy controls. Anidulafungin was well tolerated. AUC, CL, Cmax<...... hiện toàn bộ
Comparative Pharmacokinetics of Lovastatin Extended‐Release Tablets and Lovastatin Immediate‐Release Tablets in Humans
Journal of Clinical Pharmacology - Tập 42 Số 2 - Trang 198-204 - 2002
Jim X. Sun, Robert Niecestro, Gale Phillips, Jiajian Shen, Peter Lukacsko, Lawrence Friedhoff
The pharmacokinetics of lovastatin and its active metabolite lovastatin acid was evaluated in 9 healthy subjects in a three‐period crossover study following a single oral dose of lovastatin extended‐release (ER) tablets and lovastatin immediate‐release (IR) tablets. Participants were dosed with lovastatin IR 40 mg tablets following a standard breakfast, lovastatin ER 40 mg tablets followin...... hiện toàn bộ
Hawthorn
Journal of Clinical Pharmacology - Tập 42 Số 6 - Trang 605-612 - 2002
Qi Chang, Zhong Zuo, Francisco Harrison, Moses S. S. Chow
A review with 54 references covers all aspects of hawthorn, the genus Crataegus, including its traditional uses, chemical constituents, pharmacological activities, and clinical effects. Although the effectiveness of hawthorn on the treatment of cardiovascular diseases has received extensive attention worldwide, further scientific research on various areas such as pharmacokinetics, mechanis...... hiện toàn bộ
Developmental Changes in Pharmacokinetics and Pharmacodynamics
Journal of Clinical Pharmacology - Tập 58 Số S10 - 2018
John van den Anker, Michael D. Reed, Karel Allegaert, Gregory L. Kearns
AbstractEffective drug therapy to optimally influence disease requires an understanding of a drug's pharmacokinetic, pharmacodynamic, and pharmacogenomic interrelationships. In pediatrics, age is a continuum that can and does add variability in drug disposition and effect. This article addresses the many important factors that influence drug disposition and effect ...... hiện toàn bộ
Exposure‐Response and Population Pharmacokinetic Analyses of a Novel Subcutaneous Formulation of Daratumumab Administered to Multiple Myeloma Patients
Journal of Clinical Pharmacology - Tập 61 Số 5 - Trang 614-627 - 2021
Man Luo, Saad Z. Usmani, María‐Victoria Mateos, Hareth Nahi, Ajai Chari, Jesús F. San Miguel, Cyrille Touzeau, Kenshi Suzuki, Martin Kaiser, Robin Carson, Christoph Heuck, Ming Qi, Honghui Zhou, Yu‐Nien Sun, Dolly A. Parasrampuria
AbstractWe report the population pharmacokinetic (PK) and exposure‐response analyses of a novel subcutaneous formulation of daratumumab (DARA) using data from 3 DARA subcutaneous monotherapy studies (PAVO Part 2, MMY1008, COLUMBA) and 1 combination therapy study (PLEIADES). Results were based on 5159 PK samples from 742 patients (DARA 1800 mg subcutaneously, n = 48...... hiện toàn bộ
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