Journal of Clinical Pharmacology

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A Comparison of THC, Nantradol, Nabilone, and Morphine in the Chronic Spinal Dog
Journal of Clinical Pharmacology - Tập 21 Số S1 - 1981
Paul E. Gilbert
Abstract: Morphine and Δ9‐tetrahydrocannabinol (THC) have been shown to have certain pharmacologic characteristics in common. Among these are antinociception, hypothermia, and the suppression of precipitated abstinence in morphine‐dependent rats. In the present study the effects of morphine were compared with the effects of THC and two synthetic...... hiện toàn bộ
Anidulafungin Does Not Require Dosage Adjustment in Subjects With Varying Degrees of Hepatic or Renal Impairment
Journal of Clinical Pharmacology - Tập 47 Số 4 - Trang 461-470 - 2007
James A. Dowell, Martin Stogniew, David Krause, Bharat Damle
Two open‐label studies assessed the effects of hepatic and renal impairment on anidulafungin pharmacokinetics. A single 50‐mg dose was administered intravenously to subjects with varying degrees of hepatic or renal insufficiency or with end‐stage renal disease; all were matched to normal healthy controls. Anidulafungin was well tolerated. AUC, CL, Cmax<...... hiện toàn bộ
Hawthorn
Journal of Clinical Pharmacology - Tập 42 Số 6 - Trang 605-612 - 2002
Qi Chang, Zhong Zuo, Francisco Harrison, Moses S. S. Chow
A review with 54 references covers all aspects of hawthorn, the genus Crataegus, including its traditional uses, chemical constituents, pharmacological activities, and clinical effects. Although the effectiveness of hawthorn on the treatment of cardiovascular diseases has received extensive attention worldwide, further scientific research on various areas such as pharmacokinetics, mechanis...... hiện toàn bộ
Population Pharmacokinetic Analysis of Dalteparin in Pediatric Patients With Venous Thromboembolism
Journal of Clinical Pharmacology - Tập 61 Số 2 - Trang 172-180 - 2021
Bharat Damle, Frank C. Jen, Nancy Sherman, Darshana Jani, Kevin Sweeney
AbstractThis article describes the population pharmacokinetics (PK) of dalteparin in pediatric patients with venous thromboembolism (VTE). A prospective multicenter open‐label study was conducted in children who required anticoagulation for the treatment of VTE. The study population included children with and without cancer. The goal was to describe the pharmacokin...... hiện toàn bộ
Population Pharmacokinetics of Galcanezumab, an Anti‐CGRP Antibody, Following Subcutaneous Dosing to Healthy Individuals and Patients With Migraine
Journal of Clinical Pharmacology - Tập 60 Số 2 - Trang 229-239 - 2020
William Kielbasa, Tonya Quinlan
AbstractGalcanezumab is a humanized immunoglobulin G (IgG) monoclonal antibody (mAb) indicated for the prevention of migraine that binds to calcitonin gene‐related peptide. A population pharmacokinetic (PK) analysis was performed to characterize galcanezumab PK using data pooled from 7 clinical studies. Clinical studies included healthy individuals and patients wit...... hiện toàn bộ
Population Pharmacokinetics and Exposure‐Response Analyses to Guide Dosing of Icatibant in Pediatric Patients With Hereditary Angioedema
Journal of Clinical Pharmacology - Tập 61 Số 4 - Trang 555-564 - 2021
Yi Wang, Claudia Jomphe, Jean‐François Marier, Patrick Martin
AbstractElevated bradykinin levels are responsible for the development of clinical symptoms in patients with hereditary angioedema (HAE). Icatibant is a bradykinin type 2 receptor antagonist indicated for the acute treatment of HAE attacks. A population modeling and simulation approach was used to examine sources of variability impacting icatibant pharmacokinetics ...... hiện toàn bộ
Safety, Pharmacokinetics, and Pharmacodynamics of Single Doses of LXR‐623, a Novel Liver X‐Receptor Agonist, in Healthy Participants
Journal of Clinical Pharmacology - Tập 49 Số 6 - Trang 643-649 - 2009
Amy K. Katz, Chandrasekhar Udata, Elyssa Ott, Lisa Hickey, Michael E. Burczynski, Peter H. Burghart, O. Vesterqvist, Meng Xu
Liver X‐receptor (LXR) agonists have been postulated to enhance reverse cholesterol transport (RCT), a process believed to shuttle cholesterol from the periphery back to the liver. Enhancing RCT via the upregulation of cholesterol transporters such as the adenosine triphosphate—binding cassettes ABCA1 and ABCG1 could therefore inhibit the progression of atherosclerosis. LXR‐623 is a synthe...... hiện toàn bộ
Correlation of Antifactor Xa Concentrations with Renal Function in Patients on Enoxaparin
Journal of Clinical Pharmacology - Tập 43 Số 6 - Trang 586-590 - 2003
Sheryl L. Chow, Kimberly Zammit, Kathleen West, MaryAnne Dannenhoffer, Angel López‐Candales
Enoxaparin is a low molecular weight heparin (LMWH) that has been shown to be effective in deep vein thrombosis, pulmonary embolism, and unstable angina. Because renal function plays an important role in the clearance of LMWH, the authors sought to investigate the effect of renal function on enoxaparin. This prospective multiple‐dose study evaluated 18 patients with varying degrees of rena...... hiện toàn bộ
Isotretinoin Embryopathy—A Continuing Problem
Journal of Clinical Pharmacology - Tập 29 Số 5 - Trang 463-465 - 1989
Elizabeth B. Rappaport, Mary M. Knapp
First trimester exposure to isotretinoin is associated with an estimated 20% risk of major fetal malformations. Product labeling in force up to August 1988 included a statement that the drug is contraindicated in pregnancy and suggested procedures for prescribing physicians to follow to prevent inadvertent first trimester exposure to the product. This limited educational intervention did n...... hiện toàn bộ
Penfluridol in the Maintenance Treatment of Schizophrenic Patients Newly Discharged from A Brief Therapy Unit
Journal of Clinical Pharmacology - Tập 17 Số 2-3 - Trang 162-167 - 1977
Guy Chouinard, L Annable, THOMAS N. L. KOLIVAKIS
Tổng số: 74   
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