Journal of Clinical Pharmacology

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A Comparison of THC, Nantradol, Nabilone, and Morphine in the Chronic Spinal Dog
Journal of Clinical Pharmacology - Tập 21 Số S1 - 1981
Paul E. Gilbert
Abstract: Morphine and Δ9‐tetrahydrocannabinol (THC) have been shown to have certain pharmacologic characteristics in common. Among these are antinociception, hypothermia, and the suppression of precipitated abstinence in morphine‐dependent rats. In the present study the effects of morphine were compared with the effects of THC and two synthetic...... hiện toàn bộ
Anidulafungin Does Not Require Dosage Adjustment in Subjects With Varying Degrees of Hepatic or Renal Impairment
Journal of Clinical Pharmacology - Tập 47 Số 4 - Trang 461-470 - 2007
James A. Dowell, Martin Stogniew, David Krause, Bharat Damle
Two open‐label studies assessed the effects of hepatic and renal impairment on anidulafungin pharmacokinetics. A single 50‐mg dose was administered intravenously to subjects with varying degrees of hepatic or renal insufficiency or with end‐stage renal disease; all were matched to normal healthy controls. Anidulafungin was well tolerated. AUC, CL, Cmax<...... hiện toàn bộ
Hawthorn
Journal of Clinical Pharmacology - Tập 42 Số 6 - Trang 605-612 - 2002
Qi Chang, Zhong Zuo, Francisco Harrison, Moses S. S. Chow
A review with 54 references covers all aspects of hawthorn, the genus Crataegus, including its traditional uses, chemical constituents, pharmacological activities, and clinical effects. Although the effectiveness of hawthorn on the treatment of cardiovascular diseases has received extensive attention worldwide, further scientific research on various areas such as pharmacokinetics, mechanis...... hiện toàn bộ
Population Pharmacokinetics and Exposure‐Response Modeling Analyses of Ustekinumab in Adults With Moderately to Severely Active Ulcerative Colitis
Journal of Clinical Pharmacology - Tập 60 Số 7 - Trang 889-902 - 2020
Yan Xu, Chuanpu Hu, Yang Chen, Xin Miao, Omoniyi J. Adedokun, Zhenhua Xu, Amarnath Sharma, Honghui Zhou
AbstractTo characterize the pharmacokinetics (PK) and exposure‐response (E‐R) relationship of ustekinumab, an anti‐interleukin‐12/interleukin‐23 (IL‐12/IL‐23) human monoclonal antibody, in the treatment of moderately to severely active ulcerative colitis (UC), population PK and E‐R modeling analyses were conducted based on the data from the pivotal phase 3 inductio...... hiện toàn bộ
Population Pharmacokinetic Analysis of Dalteparin in Pediatric Patients With Venous Thromboembolism
Journal of Clinical Pharmacology - Tập 61 Số 2 - Trang 172-180 - 2021
Bharat Damle, Frank C. Jen, Nancy Sherman, Darshana Jani, Kevin Sweeney
AbstractThis article describes the population pharmacokinetics (PK) of dalteparin in pediatric patients with venous thromboembolism (VTE). A prospective multicenter open‐label study was conducted in children who required anticoagulation for the treatment of VTE. The study population included children with and without cancer. The goal was to describe the pharmacokin...... hiện toàn bộ
Population Pharmacokinetics of Galcanezumab, an Anti‐CGRP Antibody, Following Subcutaneous Dosing to Healthy Individuals and Patients With Migraine
Journal of Clinical Pharmacology - Tập 60 Số 2 - Trang 229-239 - 2020
William Kielbasa, Tonya Quinlan
AbstractGalcanezumab is a humanized immunoglobulin G (IgG) monoclonal antibody (mAb) indicated for the prevention of migraine that binds to calcitonin gene‐related peptide. A population pharmacokinetic (PK) analysis was performed to characterize galcanezumab PK using data pooled from 7 clinical studies. Clinical studies included healthy individuals and patients wit...... hiện toàn bộ
Population Pharmacokinetics and Exposure‐Response Analyses to Guide Dosing of Icatibant in Pediatric Patients With Hereditary Angioedema
Journal of Clinical Pharmacology - Tập 61 Số 4 - Trang 555-564 - 2021
Yi Wang, Claudia Jomphe, Jean‐François Marier, Patrick Martin
AbstractElevated bradykinin levels are responsible for the development of clinical symptoms in patients with hereditary angioedema (HAE). Icatibant is a bradykinin type 2 receptor antagonist indicated for the acute treatment of HAE attacks. A population modeling and simulation approach was used to examine sources of variability impacting icatibant pharmacokinetics ...... hiện toàn bộ
Pediatric Pharmacodynamics of Midazolam Oral Syrup
Journal of Clinical Pharmacology - Tập 40 Số 6 - Trang 578-589 - 2000
James D. Marshall, Alexander Rodarte, J Blumer, Ko‐Chin Khoo, Bardia Akbari, Gregory L. Kearns
Pharmacodynamics and Safety of a New Calcium Sensitizer, Levosimendan, and Its Metabolites during an Extended Infusion in Patients with Severe Heart Failure
Journal of Clinical Pharmacology - Tập 42 Số 1 - Trang 43-51 - 2002
Matti Kivikko, Saila Antila, Jaan Eha, Lasse Lehtonen, Pertti J. Pentikäinen
Levosimendan is a new calcium sensitizer developed for the short‐term intravenous treatment of congestive heart failure. The aims of the present open‐label, nonrandomized study were to determine the tolerability, hemodynamic effects, and the basic pharmacokinetics of levosimendan and its metabolites during an extended continuous infusion of levosimendan. Twenty‐four patients with New York ...... hiện toàn bộ
Pharmacokinetics of Single‐Dose Oral and Intramuscular Ketorolac Tromethamine in the Young and Elderly
Journal of Clinical Pharmacology - Tập 30 Số 1 - Trang 76-81 - 1990
Nader S. Jallad, Dyal C. Garg, Juan José García Martínez, Edward J. Mroszczak, Donald J. Weidler
The elderly are likely candidates to receive analgesics for pain from a variety of etiologies. Ketorolac tromethamine is a nonsteroidal, analgesic, anti‐inflammatory, antipyretic investigational drug with anti‐prostaglandin synthetase activity. Sixteen healthy, young men (mean age 30 years and mean weight 75 kg) and 13 healthy, elderly subjects (11 men and two women; mean age ...... hiện toàn bộ
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