A Comparison of THC, Nantradol, Nabilone, and Morphine in the Chronic Spinal DogJournal of Clinical Pharmacology - Tập 21 Số S1 - 1981
Paul E. Gilbert
Abstract: Morphine and Δ9‐tetrahydrocannabinol (THC) have been shown to have certain pharmacologic characteristics in common. Among these are antinociception, hypothermia, and the suppression of precipitated abstinence in morphine‐dependent rats. In the present study the effects of morphine were compared with the effects of THC and two synthetic...... hiện toàn bộ
Anidulafungin Does Not Require Dosage Adjustment in Subjects With Varying Degrees of Hepatic or Renal ImpairmentJournal of Clinical Pharmacology - Tập 47 Số 4 - Trang 461-470 - 2007
James A. Dowell, Martin Stogniew, David Krause, Bharat Damle
Two open‐label studies assessed the effects of hepatic and renal impairment on anidulafungin pharmacokinetics. A single 50‐mg dose was administered intravenously to subjects with varying degrees of hepatic or renal insufficiency or with end‐stage renal disease; all were matched to normal healthy controls. Anidulafungin was well tolerated. AUC, CL, Cmax<...... hiện toàn bộ
HawthornJournal of Clinical Pharmacology - Tập 42 Số 6 - Trang 605-612 - 2002
Qi Chang, Zhong Zuo, Francisco Harrison, Moses S. S. Chow
A review with 54 references covers all aspects of hawthorn, the genus Crataegus, including its traditional uses, chemical constituents, pharmacological activities, and clinical effects. Although the effectiveness of hawthorn on the treatment of cardiovascular diseases has received extensive attention worldwide, further scientific research on various areas such as pharmacokinetics, mechanis...... hiện toàn bộ
Population Pharmacokinetics and Exposure‐Response Modeling Analyses of Ustekinumab in Adults With Moderately to Severely Active Ulcerative ColitisJournal of Clinical Pharmacology - Tập 60 Số 7 - Trang 889-902 - 2020
Yan Xu, Chuanpu Hu, Yang Chen, Xin Miao, Omoniyi J. Adedokun, Zhenhua Xu, Amarnath Sharma, Honghui Zhou
AbstractTo characterize the pharmacokinetics (PK) and exposure‐response (E‐R) relationship of ustekinumab, an anti‐interleukin‐12/interleukin‐23 (IL‐12/IL‐23) human monoclonal antibody, in the treatment of moderately to severely active ulcerative colitis (UC), population PK and E‐R modeling analyses were conducted based on the data from the pivotal phase 3 inductio...... hiện toàn bộ
Population Pharmacokinetic Analysis of Dalteparin in Pediatric Patients With Venous ThromboembolismJournal of Clinical Pharmacology - Tập 61 Số 2 - Trang 172-180 - 2021
Bharat Damle, Frank C. Jen, Nancy Sherman, Darshana Jani, Kevin Sweeney
AbstractThis article describes the population pharmacokinetics (PK) of dalteparin in pediatric patients with venous thromboembolism (VTE). A prospective multicenter open‐label study was conducted in children who required anticoagulation for the treatment of VTE. The study population included children with and without cancer. The goal was to describe the pharmacokin...... hiện toàn bộ
Pharmacokinetics of Single‐Dose Oral and Intramuscular Ketorolac Tromethamine in the Young and ElderlyJournal of Clinical Pharmacology - Tập 30 Số 1 - Trang 76-81 - 1990
Nader S. Jallad, Dyal C. Garg, Juan José García Martínez, Edward J. Mroszczak, Donald J. Weidler
The elderly are likely candidates to receive analgesics for pain from a variety of etiologies. Ketorolac tromethamine is a nonsteroidal, analgesic, anti‐inflammatory, antipyretic investigational drug with anti‐prostaglandin synthetase activity. Sixteen healthy, young men (mean age 30 years and mean weight 75 kg) and 13 healthy, elderly subjects (11 men and two women; mean age ...... hiện toàn bộ