Journal of Clinical Pharmacology
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Population Pharmacokinetics of Ibuprofen Enantiomers in Very Premature Neonates
Journal of Clinical Pharmacology - Tập 44 Số 10 - Trang 1114-1124 - 2004
The objective of the present study was to evaluate the pharmacokinetic
parameters for both S‐ and R‐ibuprofen enantiomers in very premature neonates
(gestational age strictly inferior to 28 weeks) and possible relationships
between the pharmacokinetic parameters and various covariates. Newborns were
randomized to receive ibuprofen or placebo for the prophylactic treatment of
patent ductus arterios...
The Antinociceptive Effects of Intrathecally Administered Levonantradol and Desacetyllevonantradol in the Rat
Journal of Clinical Pharmacology - Tập 21 Số S1 - 1981
Abstract: Levonantradol and its desacetylated metabolite
(desacetyllevonantradol) produced a dose‐dependent increase in the hot plate and
tail flick response latencies following intrathecal administration in a dose
range from 4 to 40 μg. No difference in potency between the two drugs was
observed, as defined by the ED50 values obtained in either test. The duration of
the effect of either drug was ...
A Comparison of THC, Nantradol, Nabilone, and Morphine in the Chronic Spinal Dog
Journal of Clinical Pharmacology - Tập 21 Số S1 - 1981
Abstract: Morphine and Δ9‐tetrahydrocannabinol (THC) have been shown to have
certain pharmacologic characteristics in common. Among these are
antinociception, hypothermia, and the suppression of precipitated abstinence in
morphine‐dependent rats. In the present study the effects of morphine were
compared with the effects of THC and two synthetic cannabinoids, nantradol and
nabilone, in both nondep...
Multiple‐Dose, Linear, Dose‐Proportional Pharmacokinetics of Retigabine in Healthy Volunteers
Journal of Clinical Pharmacology - Tập 42 Số 2 - Trang 175-182 - 2002
Retigabine, a first‐in‐class selective M‐current potassium channel opener, is a
novel antiepileptic compound currently in clinical development. The purpose of
this randomized placebo‐controlled study was to assess retigabine oral safety
and pharmacokinetics in healthy male volunteers (N = 45). Subjects received one
dose on day 1 and doses every 12 hours for the next 14 days. Fixed doses were
given...
Mechanisms of Action of Adrenergic Receptor Blockers on Lipids During Antihypertensive Drug Treatment
Journal of Clinical Pharmacology - Tập 33 Số 3 - Trang 286-291 - 1993
The objective of this article is to focus on the antihypertensive agents
blocking adrenergic receptors, both alpha and beta blockers, and attempt to
construct potential explanations for their effects on lipids in a mechanistic
manner. The essential thesis is that adrenergic control of lipid metabolism is
responsible for the effect on lipids and lipoproteins of antihypertensive agents
that block ad...
Anidulafungin Does Not Require Dosage Adjustment in Subjects With Varying Degrees of Hepatic or Renal Impairment
Journal of Clinical Pharmacology - Tập 47 Số 4 - Trang 461-470 - 2007
Two open‐label studies assessed the effects of hepatic and renal impairment on
anidulafungin pharmacokinetics. A single 50‐mg dose was administered
intravenously to subjects with varying degrees of hepatic or renal insufficiency
or with end‐stage renal disease; all were matched to normal healthy controls.
Anidulafungin was well tolerated. AUC, CL, Cmax, tmax, t1/2, and Vss between
renally impaired...
Comparative Pharmacokinetics of Lovastatin Extended‐Release Tablets and Lovastatin Immediate‐Release Tablets in Humans
Journal of Clinical Pharmacology - Tập 42 Số 2 - Trang 198-204 - 2002
The pharmacokinetics of lovastatin and its active metabolite lovastatin acid was
evaluated in 9 healthy subjects in a three‐period crossover study following a
single oral dose of lovastatin extended‐release (ER) tablets and lovastatin
immediate‐release (IR) tablets. Participants were dosed with lovastatin IR 40 mg
tablets following a standard breakfast, lovastatin ER 40 mg tablets following a
stan...
Hawthorn
Journal of Clinical Pharmacology - Tập 42 Số 6 - Trang 605-612 - 2002
A review with 54 references covers all aspects of hawthorn, the genus Crataegus,
including its traditional uses, chemical constituents, pharmacological
activities, and clinical effects. Although the effectiveness of hawthorn on the
treatment of cardiovascular diseases has received extensive attention worldwide,
further scientific research on various areas such as pharmacokinetics, mechanism
of act...
Developmental Changes in Pharmacokinetics and Pharmacodynamics
Journal of Clinical Pharmacology - Tập 58 Số S10 - 2018
AbstractEffective drug therapy to optimally influence disease requires an
understanding of a drug's pharmacokinetic, pharmacodynamic, and pharmacogenomic
interrelationships. In pediatrics, age is a continuum that can and does add
variability in drug disposition and effect. This article addresses the many
important factors that influence drug disposition and effect relative to age.
What is known ab...
Exposure‐Response and Population Pharmacokinetic Analyses of a Novel Subcutaneous Formulation of Daratumumab Administered to Multiple Myeloma Patients
Journal of Clinical Pharmacology - Tập 61 Số 5 - Trang 614-627 - 2021
AbstractWe report the population pharmacokinetic (PK) and exposure‐response
analyses of a novel subcutaneous formulation of daratumumab (DARA) using data
from 3 DARA subcutaneous monotherapy studies (PAVO Part 2, MMY1008, COLUMBA) and
1 combination therapy study (PLEIADES). Results were based on 5159 PK samples
from 742 patients (DARA 1800 mg subcutaneously, n = 487 [monotherapy, n = 288;
combinat...
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