Mechanisms of Action of Adrenergic Receptor Blockers on Lipids During Antihypertensive Drug Treatment

Journal of Clinical Pharmacology - Tập 33 Số 3 - Trang 286-291 - 1993
Rabkin Sw1
1Department of Medicine, University Hospital (Shaughnessy), University of British Columbia, Vancouver, Canada.

Tóm tắt

The objective of this article is to focus on the antihypertensive agents blocking adrenergic receptors, both alpha and beta blockers, and attempt to construct potential explanations for their effects on lipids in a mechanistic manner. The essential thesis is that adrenergic control of lipid metabolism is responsible for the effect on lipids and lipoproteins of antihypertensive agents that block adrenergic receptors. Agonists and antagonists show the opposite action on lipoprotein lipase, lecithin: cholesterol acyltransferase (LCAT) and LDL‐cholesterol uptake by LDL receptors in a manner that might explain the findings of increases in triglycerides and LDL cholesterol with decreases in HDL cholesterol in patients receiving beta blockers without intrinsic sympathomimetic activity and the reverse in patients on treatment with alpha adrenergic receptor blockers.

Từ khóa


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Thông tin
Thông tin xuất bản

Journal of Clinical Pharmacology

Tập 33 Số 3

286-291

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