Mitochondria and ageing: role in heart, skeletal muscle and adipose tissue Tập 8 Số 3 - Trang 349-369 - 2017
Kerstin Boengler, Maik Kosiol, Manuel Mayr, Rainer Schulz, Susanne Rohrbach
AbstractAge is the most important risk factor for most diseases. Mitochondria play a central role in bioenergetics and metabolism. In addition, several lines of evidence indicate the impact of mitochondria in lifespan determination and ageing. The best‐known hypothesis to explain ageing is the free radical theory, which proposes that cells, organs, and organisms ag...... hiện toàn bộ Osteosarcopenic obesity: the role of bone, muscle, and fat on health - 2014
Michael J. Ormsbee, Carla M. Prado, Jasminka Z. Ilich, Sarah A. Purcell, Mario Siervo, Abbey Folsom, Lynn B. Panton
Osteopenia/osteoporosis, sarcopenia, and obesity are commonly observed in the process of aging, and recent evidence suggests a potential interconnection of these syndromes with common pathophysiology. The term osteosarcopenic obesity has been coined to describe the concurrent appearance of obesity in individuals with low bone and muscle mass. Although our understand...... hiện toàn bộ Cancer cachexia: impact, mechanisms and emerging treatments Tập 4 Số 2 - Trang 95-109 - 2013
Vanessa Vaughan, Peter Martin, Paul Lewandowski
Many forms of cancer present with a complex metabolic profile characterised by loss of lean body mass known as cancer cachexia. The physical impact of cachexia contributes to decreased patient quality of life, treatment success and survival due to gross alterations in protein metabolism, increased oxidative stress and systemic inflammation. The psychological impact ...... hiện toàn bộ Elevated serum myostatin level is associated with worse survival in patients with liver cirrhosis Tập 8 Số 6 - Trang 915-925 - 2017
Hiroki Nishikawa, Hirayuki Enomoto, Akio Ishii, Yoshinori Iwata, Yoshikazu Miyamoto, Noriko Ishii, Yukihisa Yuri, Kunihiro Hasegawa, Chikage Nakano, Takashi Nishimura, Kazunori Yoh, Nobuhiro Aizawa, Yoshiyuki Sakai, Naoto Ikeda, Tomoyuki Takashima, Ryo Takata, Hiroko Iijima, Shuhei Nishiguchi
AbstractBackgroundWe aimed to elucidate the relationship between serum myostatin levels and other markers including skeletal muscle mass and to investigate the influence of serum myostatin levels on survival for patients with liver cirrhosis (LC).MethodsA total of 198 ...... hiện toàn bộ Cancer cachexia prevention via physical exercise: molecular mechanisms Tập 4 Số 2 - Trang 111-124 - 2013
Douglas W. Gould, Ian Lahart, Amtul R. Carmichael, Yiannis Koutedakis, George S. Metsios
Cancer cachexia is a debilitating consequence of disease progression, characterised by the significant weight loss through the catabolism of both skeletal muscle and adipose tissue, leading to a reduced mobility and muscle function, fatigue, impaired quality of life and ultimately death occurring with 25–30 % total body weight loss. Degradation of proteins and decre...... hiện toàn bộ Role and potential mechanisms of anabolic resistance in sarcopenia - 2012
Prashanth H. Haran, Donato A. Rivas, Roger A. Fielding
There is pressing need to understand the aging process to better cope with its associated physical and societal costs. The age‐related muscle wasting known as sarcopenia is a major contributor to the problems faced by the elderly. By hindering mobility and reducing strength, it greatly diminishes independence and quality of life. In studying the factors that contrib...... hiện toàn bộ Potential therapeutic interventions for chronic kidney disease‐associated sarcopenia via indoxyl sulfate‐induced mitochondrial dysfunction Tập 8 Số 5 - Trang 735-747 - 2017
Yuki Enoki, Hiroshi Watanabe, Riho Arake, Rui Fujimura, Kana Ishiodori, Tadashi Imafuku, Kento Nishida, Ryusei Sugimoto, Saori Nagao, Shigeyuki Miyamura, Yu Ishima, Motoko Tanaka, Kazutaka Matsushita, Hirotaka Komaba, Masafumi Fukagawa, Masaki Otagiri, Toru Maruyama
AbstractBackgroundChronic kidney disease (CKD) patients experience skeletal muscle wasting and decreased exercise endurance. Our previous study demonstrated that indoxyl sulfate (IS), a uremic toxin, accelerates skeletal muscle atrophy. The purpose of this study was to examine the issue of whether IS causes mitochondria dysfunctio...... hiện toàn bộ