Journal of Cachexia, Sarcopenia and Muscle
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Reductions in C-reactive protein in older adults with type 2 diabetes are related to improvements in body composition following a randomized controlled trial of resistance training
Journal of Cachexia, Sarcopenia and Muscle - Tập 5 - Trang 111-120 - 2014
Reductions in skeletal muscle mass and increased adiposity are key elements in
the aging process and in the pathophysiology of several chronic diseases.
Systemic low grade inflammation associated with obesity has been shown to
accelerate the age-related decline in skeletal muscle. The aim of this
investigation was to determine the effects of 12 months of progressive
resistance training (PRT) on sy...
Psychosocial impact of cancer cachexia
Journal of Cachexia, Sarcopenia and Muscle - Tập 5 - Trang 89-94 - 2014
Cancer cachexia has impact on patients and their family members. Patients
experience loss of weight often accompanied by anorexia and other debilitating
symptoms that have clinical impact and impact everyday life. The importance of
understanding this impact lies in (1) the alleviation of cachexia-related
suffering and (2) its implications for treating cachexia. Two decades of
exploratory investiga...
Effect of colon cancer and surgical resection on skeletal muscle mitochondrial enzyme activity in colon cancer patients: a pilot study
Journal of Cachexia, Sarcopenia and Muscle - Tập 4 Số 1 - Trang 71-77 - 2013
BackgroundColon cancer (CC) patients commonly suffer declines in muscle mass and
aerobic function. We hypothesised that CC would be associated with reduced
muscle mass and mitochondrial enzyme activity and that curative resection would
exacerbate these changes.MethodsWe followed age‐matched healthy controls and CC
patients without distant metastasis on radiological imaging before and 6 weeks
after...
Protective effects of an anti-melanocortin-4 receptor scFv derivative in lipopolysaccharide-induced cachexia in rats
Journal of Cachexia, Sarcopenia and Muscle - Tập 4 - Trang 79-88 - 2012
Cachexia is a complex syndrome defined by weight loss due to an ongoing loss of
skeletal muscle mass with or without loss of body fat. It is often associated
with anorexia. Numerous results from experimental studies suggest that blockade
of the melanocortin-4 receptor (MC4R) could be an effective treatment for
anorexia and cachexia. In a previous study, we reported the basic
pharmacological proper...
Cardio-renal cachexia syndromes (CRCS): pathophysiological foundations of a vicious pathological circle
Journal of Cachexia, Sarcopenia and Muscle - Tập 2 - Trang 135-142 - 2011
Cardio-renal syndromes (CRS) are defined as disorders of the heart and kidney
whereby acute or chronic dysfunction in one organ may induce acute or chronic
dysfunction of the other. CRS have been classified into five categories, where
types 2 and 4 represent respectively chronic cardio-renal and chronic
reno-cardiac syndromes. In these conditions, the chronic disorder of either the
heart or kidney...
The anabolic catabolic transforming agent (ACTA) espindolol increases muscle mass and decreases fat mass in old rats
Journal of Cachexia, Sarcopenia and Muscle - Tập 5 - Trang 149-158 - 2013
Sarcopenia, the age-related, progressive loss of skeletal muscle mass, strength,
and function, is a considerable socioeconomic burden by increasing risks of
falls, fractures, and frailty. Moreover, sarcopenic patients are often obese and
therapeutic options are very limited. Here, we assessed the efficacy of
espindolol on muscle mass in 19-month-old male Wistar Han rats (weight,
555 ± 18 g), inclu...
Erratum to: Recent developments in the treatment of cachexia: highlights from the 6th Cachexia Conference
Journal of Cachexia, Sarcopenia and Muscle - Tập 3 - Trang 143-143 - 2012
Clinical use of amino acids as dietary supplement: pros and cons
Journal of Cachexia, Sarcopenia and Muscle - Tập 2 - Trang 75-80 - 2011
Nitrogen supply is pivotal for the maintenance of life. Amino acids can be
utilized to synthesize both glucose and lipids. The opposite, i.e., production
of amino acids from either one of them, is not possible in the absence of other
amino acids as donors of nitrogen. The quality of amino acid content in protein
has been re-evaluated recently, and the relevance of essential amino acids has
been re...
An overview of sarcopenia: facts and numbers on prevalence and clinical impact
Journal of Cachexia, Sarcopenia and Muscle - Tập 1 - Trang 129-133 - 2010
Human muscle undergoes constant changes. After about age 50, muscle mass
decreases at an annual rate of 1–2%. Muscle strength declines by 1.5% between
ages 50 and 60 and by 3% thereafter. The reasons for these changes include
denervation of motor units and a net conversion of fast type II muscle fibers
into slow type I fibers with resulting loss in muscle power necessary for
activities of daily li...
Evidence for an effect of ACE inhibitors on cancer cachexia
Journal of Cachexia, Sarcopenia and Muscle - Tập 3 - Trang 139-139 - 2012
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