Journal of Cachexia, Sarcopenia and Muscle
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Large-scale isolation of human skeletal muscle satellite cells from post-mortem tissue and development of quantitative assays to evaluate modulators of myogenesis
Journal of Cachexia, Sarcopenia and Muscle - Tập 4 - Trang 157-169 - 2013
During aging, there is a decreased ability to maintain skeletal muscle mass and function (sarcopenia). Such changes in skeletal muscle are also co-morbidities of diseases including cancer, congestive heart failure and chronic obstructive pulmonary disease. The loss of muscle mass results in decreased strength and exercise tolerance and reduced ability to perform daily activities. Pharmacological a...... hiện toàn bộ
Cardio-renal cachexia syndromes (CRCS): pathophysiological foundations of a vicious pathological circle
Journal of Cachexia, Sarcopenia and Muscle - Tập 2 - Trang 135-142 - 2011
Cardio-renal syndromes (CRS) are defined as disorders of the heart and kidney whereby acute or chronic dysfunction in one organ may induce acute or chronic dysfunction of the other. CRS have been classified into five categories, where types 2 and 4 represent respectively chronic cardio-renal and chronic reno-cardiac syndromes. In these conditions, the chronic disorder of either the heart or kidney...... hiện toàn bộ
Predicting survival in cancer patients: the role of cachexia and hormonal, nutritional and inflammatory markers
Journal of Cachexia, Sarcopenia and Muscle - Tập 3 - Trang 245-251 - 2012
Cancer can lead to weight loss, anorexia, and poor nutritional status, which are associated with decreased survival in cancer patients. Male cancer patients (n = 136) were followed for a mean time of 4.5 years. Variables were obtained at baseline: cancer stage, albumin, hemoglobin, tumor necrosis factor alpha (TNF-α), interleukin (IL)-6, bioavailable testosterone, appetite questionnaire, and weigh...... hiện toàn bộ
Effect of including historical height and radius BMD measurement on sarco‐osteoporosis prevalenceBackground A clinical need exists to improve identification of those who will sustain fragility fractures. Individuals with both osteoporosis (OP) and sarcopenia (SP), so‐called “sarco‐osteoporosis” (SOP), might be at higher fracture risk than those with OP or SP alone. Approaches to facilitate SOP identification, e.g., use of tallest historical rather tha...
Journal of Cachexia, Sarcopenia and Muscle - Tập 4 Số 1 - Trang 47-54 - 2013
Biomarkers of sarcopenia in clinical trials—recommendations from the International Working Group on Sarcopenia
Journal of Cachexia, Sarcopenia and Muscle - Tập 3 - Trang 181-190 - 2012
Sarcopenia, the age-related skeletal muscle decline, is associated with relevant clinical and socioeconomic negative outcomes in older persons. The study of this phenomenon and the development of preventive/therapeutic strategies represent public health priorities. The present document reports the results of a recent meeting of the International Working Group on Sarcopenia (a task force consisting...... hiện toàn bộ
Muscle wasting: an overview of recent developments in basic research
Journal of Cachexia, Sarcopenia and Muscle - Tập 5 - Trang 193-198 - 2014
The syndrome of cachexia, i.e., involuntary weight loss in patients with underlying diseases, sarcopenia, i.e., loss of muscle mass due to aging, and general muscle atrophy from disuse and/or prolonged bed rest have received more attention over the last decades. All lead to a higher morbidity and mortality in patients, and therefore, they represent a major socio-economic burden for the society tod...... hiện toàn bộ
Resistance exercise: an effective strategy to reverse muscle wasting in hemodialysis patients?Muscle wasting is a common complication afflicting maintenance hemodialysis (HD) patients, and it is associated with decreased muscle function, exercise performance, physical function, and quality of life. Meanwhile, numerous epidemiologic studies have consistently shown that greater muscle mass (ascertained by body anthropometry surrogates, body composition tests s...
Journal of Cachexia, Sarcopenia and Muscle - Tập 5 Số 3 - Trang 177-180 - 2014
Identifying recreational physical activities associated with muscle quality in men and women aged 50 years and over
Journal of Cachexia, Sarcopenia and Muscle - Tập 5 - Trang 221-228 - 2014
Several studies conducted in a laboratory-related environment have shown that exercise is associated with increased muscle quality in older adults. The aim of the present study was to investigate whether recreational exercise may also be associated with muscle quality in men and women aged 50 years and over. Data are from 312 individuals (215 women) aged 50 years and older. Body composition (dual-...... hiện toàn bộ
The effects of acute doxorubicin treatment on proteome lysine acetylation status and apical caspases in skeletal muscle of fasted animalsBackground Doxorubicin treatment is known to cause muscular weakness. However, the cellular mechanisms have not been elucidated. We aimed to determine the effects of acute doxorubicin treatment on proteome lysine acetylation status, an indication of the apoptotic and inflammatory environment, and the expression and activation of various apical caspases inv...
Journal of Cachexia, Sarcopenia and Muscle - Tập 4 Số 3 - Trang 239-243 - 2013
Why cachexia kills: examining the causality of poor outcomes in wasting conditions
Journal of Cachexia, Sarcopenia and Muscle - Tập 4 - Trang 89-94 - 2013
Weight loss is the hallmark of any progressive acute or chronic disease state. In its extreme form of significant lean body mass (including skeletal muscle) and fat loss, it is referred to as cachexia. It has been known for millennia that muscle and fat wasting leads to poor outcomes including death. On one hand, conditions and risk factors that lead to cachexia and inadequate nutrition may indepe...... hiện toàn bộ
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