Reductions in C-reactive protein in older adults with type 2 diabetes are related to improvements in body composition following a randomized controlled trial of resistance trainingJournal of Cachexia, Sarcopenia and Muscle - Tập 5 - Trang 111-120 - 2014
Yorgi Mavros, Shelley Kay, Kylie A. Simpson, Michael K. Baker, Yi Wang, Ren R. Zhao, Jacinda Meiklejohn, Mike Climstein, Anthony J. O’Sullivan, Nathan de Vos, Bernhard T. Baune, Steven N. Blair, David Simar, Kieron Rooney, Nalin A. Singh, Maria A. Fiatarone Singh
Reductions in skeletal muscle mass and increased adiposity are key elements in the aging process and in the pathophysiology of several chronic diseases. Systemic low grade inflammation associated with obesity has been shown to accelerate the age-related decline in skeletal muscle. The aim of this investigation was to determine the effects of 12 months of progressive resistance training (PRT) on sy...... hiện toàn bộ
Psychosocial impact of cancer cachexiaJournal of Cachexia, Sarcopenia and Muscle - Tập 5 - Trang 89-94 - 2014
Jane B. Hopkinson
Cancer cachexia has impact on patients and their family members. Patients experience loss of weight often accompanied by anorexia and other debilitating symptoms that have clinical impact and impact everyday life. The importance of understanding this impact lies in (1) the alleviation of cachexia-related suffering and (2) its implications for treating cachexia. Two decades of exploratory investiga...... hiện toàn bộ
Effect of colon cancer and surgical resection on skeletal muscle mitochondrial enzyme activity in colon cancer patients: a pilot studyJournal of Cachexia, Sarcopenia and Muscle - Tập 4 Số 1 - Trang 71-77 - 2013
Bethan E. Phillips, Kenneth T. Smith, Sarah Liptrot, Philip J. Atherton, Krishna K. Varadhan, Michael J. Rennie, Michael Larvin, Jonathan N. Lund, John P. Williams
BackgroundColon cancer (CC) patients commonly suffer declines in muscle mass and aerobic function. We hypothesised that CC would be associated with reduced muscle mass and mitochondrial enzyme activity and that curative resection would exacerbate these changes.MethodsWe followed age‐matched he...... hiện toàn bộ
Protective effects of an anti-melanocortin-4 receptor scFv derivative in lipopolysaccharide-induced cachexia in ratsJournal of Cachexia, Sarcopenia and Muscle - Tập 4 - Trang 79-88 - 2012
Jean-Christophe Peter, Hélène Rossez, Marjorie Weckering, Géraldine Zipfel, Anne-Catherine Lecourt, Joshua B. Owen, William A. Banks, Karl G. Hofbauer
Cachexia is a complex syndrome defined by weight loss due to an ongoing loss of skeletal muscle mass with or without loss of body fat. It is often associated with anorexia. Numerous results from experimental studies suggest that blockade of the melanocortin-4 receptor (MC4R) could be an effective treatment for anorexia and cachexia. In a previous study, we reported the basic pharmacological proper...... hiện toàn bộ
Cardio-renal cachexia syndromes (CRCS): pathophysiological foundations of a vicious pathological circleJournal of Cachexia, Sarcopenia and Muscle - Tập 2 - Trang 135-142 - 2011
Mariantonietta Cicoira, Stefan D. Anker, Claudio Ronco
Cardio-renal syndromes (CRS) are defined as disorders of the heart and kidney whereby acute or chronic dysfunction in one organ may induce acute or chronic dysfunction of the other. CRS have been classified into five categories, where types 2 and 4 represent respectively chronic cardio-renal and chronic reno-cardiac syndromes. In these conditions, the chronic disorder of either the heart or kidney...... hiện toàn bộ
The anabolic catabolic transforming agent (ACTA) espindolol increases muscle mass and decreases fat mass in old ratsJournal of Cachexia, Sarcopenia and Muscle - Tập 5 - Trang 149-158 - 2013
Mareike S. Pötsch, Anika Tschirner, Sandra Palus, Stephan von Haehling, Wolfram Doehner, John Beadle, Andrew J. S. Coats, Stefan D. Anker, Jochen Springer
Sarcopenia, the age-related, progressive loss of skeletal muscle mass, strength, and function, is a considerable socioeconomic burden by increasing risks of falls, fractures, and frailty. Moreover, sarcopenic patients are often obese and therapeutic options are very limited. Here, we assessed the efficacy of espindolol on muscle mass in 19-month-old male Wistar Han rats (weight, 555 ± 18 g), inclu...... hiện toàn bộ
Clinical use of amino acids as dietary supplement: pros and consJournal of Cachexia, Sarcopenia and Muscle - Tập 2 - Trang 75-80 - 2011
Francesco S. Dioguardi
Nitrogen supply is pivotal for the maintenance of life. Amino acids can be utilized to synthesize both glucose and lipids. The opposite, i.e., production of amino acids from either one of them, is not possible in the absence of other amino acids as donors of nitrogen. The quality of amino acid content in protein has been re-evaluated recently, and the relevance of essential amino acids has been re...... hiện toàn bộ
An overview of sarcopenia: facts and numbers on prevalence and clinical impactJournal of Cachexia, Sarcopenia and Muscle - Tập 1 - Trang 129-133 - 2010
Stephan von Haehling, John E. Morley, Stefan D. Anker
Human muscle undergoes constant changes. After about age 50, muscle mass decreases at an annual rate of 1–2%. Muscle strength declines by 1.5% between ages 50 and 60 and by 3% thereafter. The reasons for these changes include denervation of motor units and a net conversion of fast type II muscle fibers into slow type I fibers with resulting loss in muscle power necessary for activities of daily li...... hiện toàn bộ