Endothelial cell activation and neovascularization are prominent in dermatomyositis Tập 3 Số 1 - 2006
Kanneboyina Nagaraju, Lisa G. Rider, Chenguang Fan, Yi Wen Chen, Megan Mitsak, Rashmi Rawat, Kathleen Patterson, Cecilia Grundtman, Frederick W. Miller, Paul H. Plötz, Eric P. Hoffman, Ingrid E. Lundberg
Abstract Background While vascular and immune abnormalities are common in
juvenile and adult dermatomyositis (DM), the molecular changes that contribute
to these abnormalities are not clear. Therefore, we investigated pathways that
facilitate new blood vessel formation and dendritic cell migration in
dermatomyositis. Methods Muscle biopsies from subjects with DM (9 children and 6
adults) and non-m... hiện toàn bộ
Association of Epstein-Barr virus antibody titers with a human IL-10 promoter polymorphism in Japanese women Tập 5 - Trang 1-5 - 2008
Yutaka Yasui, Nobuyuki Hamajima, Tsuneya Nakamura, Noha Sharaf El-Din, Kazuo Tajima, John D Potter
Multiple sclerosis (MS) risk, over 10-fold higher in Western than in Asian
countries, is associated with elevated IgG antibody titers against Epstein-Barr
viral capcid antigen (anti-EBVCA IgG titers). Given the 84% homology of the open
reading frame BCRF1 of Epstein-Barr virus (EBV) to human interleukin 10 (hIL-10)
and the remarkable Caucasian-vs.-Asian population differences in hIL-10 gene
promot... hiện toàn bộ
Virus-mediated autoimmunity in Multiple Sclerosis Tập 3 - Trang 1-8 - 2006
Nikolaos Grigoriadis, Georgios M Hadjigeorgiou
Epidemiological data suggest the notion that in Multiple Sclerosis (MS) is an
acquired autoimmune disease and the cause may be an environmental factor(s),
probably infectious, in genetically susceptible individuals. Several cases of
viral induced demyelinatimg encephalomyelitis in human beings and in
experimental models as well as the presence of IgG oligoclonal bands in the
cerebrospinal fluid in... hiện toàn bộ
Antibodies to soluble liver antigen and α-enolase in patients with autoimmune hepatitis Tập 1 - Trang 1-6 - 2004
Dimitrios-Petrou Bogdanos, Daniele Gilbert, Ilaria Bianchi, Simona Leoni, Ragai R Mitry, Yun Ma, Giorgina Mieli-Vergani, Diego Vergani
Antibodies to a cytosolic soluble liver antigen (SLA) are specifically detected
in patients with autoimmune hepatitis (AIH). The target of anti-SLA has been
identified as a ~50 kDa UGA serine tRNA-associated protein complex
(tRNP(Ser)Sec), through the screening of cDNA libraries. A recent report
questioned the identity of tRNP(Ser)Sec as the real SLA antigen. The latter
study identified α-enolase ... hiện toàn bộ
The revised international autoimmune hepatitis score in chronic liver diseases including autoimmune hepatitis/overlap syndromes and autoimmune hepatitis with concurrent other liver disorders Tập 4 - Trang 1-12 - 2007
Panagiotis A Papamichalis, Kalliopi Zachou, George K Koukoulis, Aikaterini Veloni, Efthimia G Karacosta, Lampros Kypri, Ioannis Mamaloudis, Stella Gabeta, Eirini I Rigopoulou, Ansgar W Lohse, George N Dalekos
We conducted a study in order to determine the usefulness and diagnostic value
of International Autoimmune Hepatitis Group (IAHG) score in non-autoimmune
hepatitis (AIH) hepatic disorders as well as in AIH/overlap syndromes and in
cases with coexistence of AIH and other liver diseases. We applied the IAHG
score in 423 patients with liver diseases excluding patients with AIH,
AIH/overlap syndromes ... hiện toàn bộ
Cerebrovascular disease associated with antiphospholipid antibodies: more questions than answers Tập 3 - Trang 1-7 - 2006
Carolyn Hawkins, Paul Gatenby, Roger Tuck, Gytis Danta, Colin Andrews
Neurological syndromes occur in a significant number of patients with
antiphospholipid antibodies. The optimal management for these patients however
remains uncertain. Our study is a descriptive analysis looking retrospectively
at 45 patients who presented to the principal tertiary referral centre in the
Australian Capital Territory, with either cerebral arterial or venous thrombosis
for which the... hiện toàn bộ
Autoantibodies against the chromosomal passenger protein INCENP found in a patient with Graham Little-Piccardi-Lassueur syndrome Tập 4 - Trang 1-7 - 2007
Beatriz Rodríguez-Bayona, Sandrine Ruchaud, Carmen Rodríguez, Mario Linares, Antonio Astola, Manuela Ortiz, William C Earnshaw, Manuel M Valdivia
Graham Little – Piccardi – Lassueur (GLPL) syndrome is a rare dermatosis
characterized by scarring alopecia, loss of pubic and axillary hair, and
progressive development of variously located follicular papules. We report a
first case ever of an autoimmune response in a patient suffering from GLPL
syndrome. Immunofluorescence and immunoblot analysis were used in a variety of
cell cultures including... hiện toàn bộ
Prevalence of antibodies to Ro-52 in a serologically defined population of patients with systemic sclerosis Tập 6 - Trang 1-6 - 2009
Jennifer C Parker, Rufus W Burlingame, Christopher C Bunn
Antibodies against Ro-52 have been described in patients with a broad spectrum
of autoimmune disease, most commonly in association with anti-Ro-60 in systemic
lupus erythematosus and Sjogrens syndrome. However, in inflammatory myositis
anti-Ro-52 is frequently present without anti-Ro-60 and is closely linked to the
presence of aminoacyl-tRNA synthetase (aats) antibodies. To date there have been
no... hiện toàn bộ
Are classification criteria for vasculitis useful in clinical practice? Observations and lessons from Colombia Tập 6 - Trang 1-10 - 2009
Paúl Alejandro Méndez Patarroyo, José Félix Restrepo, Samanda Adriana Rojas, Federico Rondón, Eric L Matteson, Antonio Iglesias-Gamarra
Idiopathic systemic vasculitis represents a group of clinical entities having
non-specific etiology with the common characteristic of acute or chronic
inflammatory compromise of the small and large vessels walls, associated with
fibrinoid necrosis. To describe the most common inflammatory vascular diseases
in a long historical cohort of patients from San Juan de Dios Hospital located
in Bogota, Co... hiện toàn bộ