Journal of Autoimmune Diseases

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Evaluation of antibodies against human HSP60 in patients with MPO-ANCA associated glomerulonephritis: a cohort study
Journal of Autoimmune Diseases - Tập 3 - Trang 1-7 - 2006
Marjan C Slot, Ruud Theunissen, Pieter van Paassen, Jan GMC Damoiseaux, Jan Willem Cohen Tervaert
Human Heat Shock Protein 60 (hHSP60) has been implicated in autoimmunity through molecular mimicry, based on the high degree of homology with HSP65 of micro-organisms leading to autoimmune recognition of the human protein. Additionally, sequence homology between hHSP60 and myeloperoxidase (MPO) has been described. MPO is a major autoantigen in vasculitis associated with antineutrophil cytoplasmic ...... hiện toàn bộ
The revised international autoimmune hepatitis score in chronic liver diseases including autoimmune hepatitis/overlap syndromes and autoimmune hepatitis with concurrent other liver disorders
Journal of Autoimmune Diseases - Tập 4 - Trang 1-12 - 2007
Panagiotis A Papamichalis, Kalliopi Zachou, George K Koukoulis, Aikaterini Veloni, Efthimia G Karacosta, Lampros Kypri, Ioannis Mamaloudis, Stella Gabeta, Eirini I Rigopoulou, Ansgar W Lohse, George N Dalekos
We conducted a study in order to determine the usefulness and diagnostic value of International Autoimmune Hepatitis Group (IAHG) score in non-autoimmune hepatitis (AIH) hepatic disorders as well as in AIH/overlap syndromes and in cases with coexistence of AIH and other liver diseases. We applied the IAHG score in 423 patients with liver diseases excluding patients with AIH, AIH/overlap syndromes ...... hiện toàn bộ
Lack of correlation between the levels of soluble cytotoxic T-lymphocyte associated antigen-4 (CTLA-4) and the CT-60 genotypes
Journal of Autoimmune Diseases - Tập 2 - Trang 1-6 - 2005
Sharad Purohit, Robert Podolsky, Christin Collins, Weipeng Zheng, Desmond Schatz, Andy Muir, Diane Hopkins, Yi-Hua Huang, Jin-Xiong She
Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) plays a critical role in downregulation of antigen-activated immune response and polymorphisms at the CTLA-4 gene have been shown to be associated with several autoimmune diseases including type-1 diabetes (T1D). The etiological mutation was mapped to the CT60-A/G single nucleotide polymorphism (SNP) that is believed to control the processing an...... hiện toàn bộ
Virus-mediated autoimmunity in Multiple Sclerosis
Journal of Autoimmune Diseases - Tập 3 - Trang 1-8 - 2006
Nikolaos Grigoriadis, Georgios M Hadjigeorgiou
Epidemiological data suggest the notion that in Multiple Sclerosis (MS) is an acquired autoimmune disease and the cause may be an environmental factor(s), probably infectious, in genetically susceptible individuals. Several cases of viral induced demyelinatimg encephalomyelitis in human beings and in experimental models as well as the presence of IgG oligoclonal bands in the cerebrospinal fluid in...... hiện toàn bộ
Insulin expressing hepatocytes not destroyed in transgenic NOD mice
Journal of Autoimmune Diseases - Tập 1 - Trang 1-12 - 2004
Muhammad T Tabiin, Christopher P White, Grant Morahan, Bernard E Tuch
The liver has been suggested as a suitable target organ for gene therapy of Type 1 diabetes. However, the fundamental issue whether insulin-secreting hepatocytes in vivo will be destroyed by the autoimmune processes that kill pancreatic β cells has not been fully addressed. It is possible that the insulin secreting liver cells will be destroyed by the immune system because hepatocytes express majo...... hiện toàn bộ
Prevalence of antibodies to Ro-52 in a serologically defined population of patients with systemic sclerosis
Journal of Autoimmune Diseases - Tập 6 - Trang 1-6 - 2009
Jennifer C Parker, Rufus W Burlingame, Christopher C Bunn
Antibodies against Ro-52 have been described in patients with a broad spectrum of autoimmune disease, most commonly in association with anti-Ro-60 in systemic lupus erythematosus and Sjogrens syndrome. However, in inflammatory myositis anti-Ro-52 is frequently present without anti-Ro-60 and is closely linked to the presence of aminoacyl-tRNA synthetase (aats) antibodies. To date there have been no...... hiện toàn bộ
Islet cell autoantibodies in African patients with Type 1 and Type 2 diabetes in Dar es Salaam Tanzania: a cross sectional study
Journal of Autoimmune Diseases - - 2007
Janet Lutale, Hrafnkell Thordarson, Pål Ivar Holm, Geir Egil Eide, K Vetvik
Association of Epstein-Barr virus antibody titers with a human IL-10 promoter polymorphism in Japanese women
Journal of Autoimmune Diseases - Tập 5 - Trang 1-5 - 2008
Yutaka Yasui, Nobuyuki Hamajima, Tsuneya Nakamura, Noha Sharaf El-Din, Kazuo Tajima, John D Potter
Multiple sclerosis (MS) risk, over 10-fold higher in Western than in Asian countries, is associated with elevated IgG antibody titers against Epstein-Barr viral capcid antigen (anti-EBVCA IgG titers). Given the 84% homology of the open reading frame BCRF1 of Epstein-Barr virus (EBV) to human interleukin 10 (hIL-10) and the remarkable Caucasian-vs.-Asian population differences in hIL-10 gene promot...... hiện toàn bộ
Analysis of the TCR alpha and beta chain CDR3 spectratypes in the peripheral blood of patients with Systemic Lupus Erythematosus
Journal of Autoimmune Diseases - Tập 5 - Trang 1-1 - 2008
Wei Luo, Li Ma, Qian Wen, Xin-Sheng Yao, Na Wang, Hong-Yun Zou, Ming-Qian Zhou, Ying Lin, Zhen-Qiang Wu, Xiao-Wei He, Ju-Fang Wang, Xiao-Ning Wang
Endothelial cell activation and neovascularization are prominent in dermatomyositis
Journal of Autoimmune Diseases - Tập 3 Số 1 - 2006
Kanneboyina Nagaraju, Lisa G. Rider, Chenguang Fan, Yi Wen Chen, Megan Mitsak, Rashmi Rawat, Kathleen Patterson, Cecilia Grundtman, Frederick W. Miller, Paul H. Plötz, Eric P. Hoffman, Ingrid E. Lundberg
Abstract Background While vascular and immune abnormalities are common in juvenile and adult dermatomyositis (DM), the molecular changes that contribute to these abnormalities are not clear. Therefore, we investigated pathways that facilitate new blood vessel formation and dendritic cell migratio...... hiện toàn bộ
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