Journal of Autoimmune Diseases
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Evaluation of antibodies against human HSP60 in patients with MPO-ANCA associated glomerulonephritis: a cohort study
Journal of Autoimmune Diseases - Tập 3 - Trang 1-7 - 2006
Human Heat Shock Protein 60 (hHSP60) has been implicated in autoimmunity through
molecular mimicry, based on the high degree of homology with HSP65 of
micro-organisms leading to autoimmune recognition of the human protein.
Additionally, sequence homology between hHSP60 and myeloperoxidase (MPO) has
been described. MPO is a major autoantigen in vasculitis associated with
antineutrophil cytoplasmic ...
The revised international autoimmune hepatitis score in chronic liver diseases including autoimmune hepatitis/overlap syndromes and autoimmune hepatitis with concurrent other liver disorders
Journal of Autoimmune Diseases - Tập 4 - Trang 1-12 - 2007
We conducted a study in order to determine the usefulness and diagnostic value
of International Autoimmune Hepatitis Group (IAHG) score in non-autoimmune
hepatitis (AIH) hepatic disorders as well as in AIH/overlap syndromes and in
cases with coexistence of AIH and other liver diseases. We applied the IAHG
score in 423 patients with liver diseases excluding patients with AIH,
AIH/overlap syndromes ...
Lack of correlation between the levels of soluble cytotoxic T-lymphocyte associated antigen-4 (CTLA-4) and the CT-60 genotypes
Journal of Autoimmune Diseases - Tập 2 - Trang 1-6 - 2005
Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) plays a critical role in
downregulation of antigen-activated immune response and polymorphisms at the
CTLA-4 gene have been shown to be associated with several autoimmune diseases
including type-1 diabetes (T1D). The etiological mutation was mapped to the
CT60-A/G single nucleotide polymorphism (SNP) that is believed to control the
processing an...
Virus-mediated autoimmunity in Multiple Sclerosis
Journal of Autoimmune Diseases - Tập 3 - Trang 1-8 - 2006
Epidemiological data suggest the notion that in Multiple Sclerosis (MS) is an
acquired autoimmune disease and the cause may be an environmental factor(s),
probably infectious, in genetically susceptible individuals. Several cases of
viral induced demyelinatimg encephalomyelitis in human beings and in
experimental models as well as the presence of IgG oligoclonal bands in the
cerebrospinal fluid in...
Insulin expressing hepatocytes not destroyed in transgenic NOD mice
Journal of Autoimmune Diseases - Tập 1 - Trang 1-12 - 2004
The liver has been suggested as a suitable target organ for gene therapy of Type
1 diabetes. However, the fundamental issue whether insulin-secreting hepatocytes
in vivo will be destroyed by the autoimmune processes that kill pancreatic β
cells has not been fully addressed. It is possible that the insulin secreting
liver cells will be destroyed by the immune system because hepatocytes express
majo...
Prevalence of antibodies to Ro-52 in a serologically defined population of patients with systemic sclerosis
Journal of Autoimmune Diseases - Tập 6 - Trang 1-6 - 2009
Antibodies against Ro-52 have been described in patients with a broad spectrum
of autoimmune disease, most commonly in association with anti-Ro-60 in systemic
lupus erythematosus and Sjogrens syndrome. However, in inflammatory myositis
anti-Ro-52 is frequently present without anti-Ro-60 and is closely linked to the
presence of aminoacyl-tRNA synthetase (aats) antibodies. To date there have been
no...
Islet cell autoantibodies in African patients with Type 1 and Type 2 diabetes in Dar es Salaam Tanzania: a cross sectional study
Journal of Autoimmune Diseases - - 2007
Association of Epstein-Barr virus antibody titers with a human IL-10 promoter polymorphism in Japanese women
Journal of Autoimmune Diseases - Tập 5 - Trang 1-5 - 2008
Multiple sclerosis (MS) risk, over 10-fold higher in Western than in Asian
countries, is associated with elevated IgG antibody titers against Epstein-Barr
viral capcid antigen (anti-EBVCA IgG titers). Given the 84% homology of the open
reading frame BCRF1 of Epstein-Barr virus (EBV) to human interleukin 10 (hIL-10)
and the remarkable Caucasian-vs.-Asian population differences in hIL-10 gene
promot...
Analysis of the TCR alpha and beta chain CDR3 spectratypes in the peripheral blood of patients with Systemic Lupus Erythematosus
Journal of Autoimmune Diseases - Tập 5 - Trang 1-1 - 2008
Endothelial cell activation and neovascularization are prominent in dermatomyositis
Journal of Autoimmune Diseases - Tập 3 Số 1 - 2006
Abstract Background While vascular and immune abnormalities are common in
juvenile and adult dermatomyositis (DM), the molecular changes that contribute
to these abnormalities are not clear. Therefore, we investigated pathways that
facilitate new blood vessel formation and dendritic cell migration in
dermatomyositis. Methods Muscle biopsies from subjects with DM (9 children and 6
adults) and non-m...
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