JBIC Journal of Biological Inorganic Chemistry

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Spin distribution of the H-cluster in the Hox–CO state of the [FeFe] hydrogenase from Desulfovibrio desulfuricans: HYSCORE and ENDOR study of 14N and 13C nuclear interactions
JBIC Journal of Biological Inorganic Chemistry - Tập 14 - Trang 301-313 - 2008
Alexey Silakov, Brian Wenk, Eduard Reijerse, Simon P. J. Albracht, Wolfgang Lubitz
Hydrogenases are enzymes which catalyze the reversible cleavage of molecular hydrogen into protons and electrons. In [FeFe] hydrogenases the active center is a 6Fe6S cluster, referred to as the “H-cluster.” It consists of the redox-active binuclear subcluster ([2Fe]H) coordinated by CN− and CO ligands and the cubane-like [4Fe–4S]H subcluster which is connected to the protein via Cys ligands. One o...... hiện toàn bộ
The reduction rates of DEPC-modified mutant Thermus thermophilus Rieske proteins differ when there is a negative charge proximal to the cluster
JBIC Journal of Biological Inorganic Chemistry - Tập 19 - Trang 1121-1135 - 2014
Nicholas E. Karagas, Christie N. Jones, Deborah J. Osborn, Anika L. Dzierlenga, Paul Oyala, Mary E. Konkle, Emily M. Whitney, R. David Britt, Laura M. Hunsicker-Wang
Rieske and Rieske-type proteins are electron transport proteins involved in key biological processes such as respiration, photosynthesis, and detoxification. They have a [2Fe–2S] cluster ligated by two cysteines and two histidines. A series of mutations, L135E, L135R, L135A, and Y158F, of the Rieske protein from Thermus thermophilus has been produced which probe the effects of the neighboring res...... hiện toàn bộ
Silver ciprofloxacin (CIPAG): a multitargeted metallodrug in the development of breast cancer therapy
JBIC Journal of Biological Inorganic Chemistry - - 2024
Christina N. Banti, Foteini D. Kalousi, Anna-Maria G. Psarra, Eleni E. Moushi, Demetres D. Leonidas, Sotiris K. Hadjikakou
The anti-proliferative activity of the known metalloantibiotic {[Ag(CIPH)2]NO3∙0.75MeOH∙1.2H2O} (CIPAG) (CIPH = ciprofloxacin) against the human breast adenocarcinoma cancer cells MCF-7 (hormone dependent (HD)) and MDA-MB-231 (hormone independent (HI)) is evaluated. The in vitro toxicity and genotoxicity of the metalloantibiotic were estimated toward fetal lung fibroblast (MRC-5) cells. The molecu...... hiện toàn bộ
Role of protein-glutathione contacts in defining glutaredoxin-3 [2Fe–2S] cluster chirality, ligand exchange and transfer chemistry
JBIC Journal of Biological Inorganic Chemistry - Tập 22 Số 7 - Trang 1075-1087 - 2017
Sambuddha Sen, J. A. Cowan
The oxo/peroxo debate: a nonheme iron perspective
JBIC Journal of Biological Inorganic Chemistry - Tập 9 - Trang 684-690 - 2004
Lawrence Que
The oxygen activation mechanisms proposed for nonheme iron systems generally follow the heme paradigm in invoking the involvement of iron-peroxo and iron-oxo species in their catalytic cycles. However, the nonheme ligand environments allow for end-on and side-on dioxygen coordination and impart greater flexibility in the modes of dioxygen activation. The currently available evidence for nonheme ir...... hiện toàn bộ
Thymine-metal ion interactions: relevance for thymine quartet structures
JBIC Journal of Biological Inorganic Chemistry - Tập 6 - Trang 378-389 - 2001
Eva Freisinger, Arnd Schimanski, Bernhard Lippert
Apart from their function as counter ions for the charge neutralization of nucleic acids, alkali metal ions play important roles in stabilizing particular multistranded nucleic acids, e.g. guanine quartets in telomeres and uracil (U) or thymine (T) quartets. Here X-ray crystal structure determinations of a series of alkali metal ions (Na+, K+, Rb+, Cs+) as well as of Mg2+ and H5O2 ...... hiện toàn bộ
Structural and spectroscopic studies of a model for catechol oxidase
JBIC Journal of Biological Inorganic Chemistry - Tập 13 - Trang 499-510 - 2008
Sarah J. Smith, Christopher J. Noble, Randahl C. Palmer, Graeme R. Hanson, Gerhard Schenk, Lawrence R. Gahan, Mark J. Riley
A binuclear copper complex, [Cu2(BPMP)(OAc)2][ClO4]·H2O, has been prepared using the binucleating ligand 2,6-bis[bis(pyridin-2-ylmethylamino)methyl]-4-methylphenol (H-BPMP). The X-ray crystal structure reveals the copper centers to have a five-coordinate square pyramidal geometry, with the acetate ligands bound terminally. The bridging phenolate occupies the apical position of the square-based pyr...... hiện toàn bộ
Density functional theory investigations of NiN2S2 reactivity as a function of nitrogen donor type and N–H···S hydrogen bonding inspired by nickel-containing superoxide dismutase
JBIC Journal of Biological Inorganic Chemistry - - 2006
Christopher S. Mullins, Craig A. Grapperhaus, Pawel M. Kozłowski
A theoretical study of the cis-dihydroxylation mechanism in naphthalene 1,2-dioxygenase
JBIC Journal of Biological Inorganic Chemistry - Tập 9 - Trang 439-452 - 2004
Arianna Bassan, Margareta R. A. Blomberg, Per E. M. Siegbahn
The catalytic mechanism of naphthalene 1,2-dioxygenase has been investigated by means of hybrid density functional theory. This Rieske-type enzyme, which contains an active site hosting a mononuclear non-heme iron(II) complex, uses dioxygen and two electrons provided by NADH to carry out the cis-dihydroxylation of naphthalene. Since a (hydro)peroxo-iron(III) moiety has been proposed to be involved...... hiện toàn bộ
Sự liên kết của một phức hợp porphyrin mangan dimer với albumin huyết tương: hướng tới một chất đối quang MRI T1 không chứa gadolinium Dịch bởi AI
JBIC Journal of Biological Inorganic Chemistry - Tập 19 - Trang 229-235 - 2014
Weiran Cheng, Tameshwar Ganesh, Francisco Martinez, Jolie Lam, Hyung Yoon, Robert B. Macgregor, Timothy J. Scholl, Hai-Ling Margaret Cheng, Xiao-an Zhang
Gadolinium Dimer Gadofosveset là tác nhân đối quang MRI đầu tiên đã được phê duyệt lâm sàng, được thiết kế để liên kết với albumin huyết tương người (HSA) một cách hồi phục, kéo dài thời gian lưu hành trong máu. Tuy nhiên, đặc điểm dược động học quý giá này cần thiết cho việc hình ảnh hóa mạch máu lại làm tăng nguy cơ giải phóng và tích tụ gadolinium trong cơ thể. Việc gadofosveset liên kết với HS...... hiện toàn bộ
#gadofosveset #albumin huyết tương #mangan #porphyrin #chất đối quang MRI #tính năng dược động học #hình ảnh hóa mạch máu #từ trường #ứng dụng lâm sàng
Tổng số: 1,971   
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