Mechanistic insight from thermal activation parameters for oxygenation reactions of different substrates with biomimetic iron porphyrin models for compounds I and IIJBIC Journal of Biological Inorganic Chemistry - Tập 17 Số 1 - Trang 27-36 - 2012
Fertinger, Christoph, Franke, Alicja, van Eldik, Rudi
Compound I, an oxo–iron(IV) porphyrin π-cation radical species, and its one-electron-reduced form compound II are regarded as key intermediates in reactions catalyzed by cytochrome P450. Although both reactive intermediates can be easily produced from model systems such as iron(III) meso-tetra(2,4,6-trimethylphenyl)porphyrin hydroxide by selecting appropriate reaction conditions, there are on...... hiện toàn bộ
The reduction rates of DEPC-modified mutant Thermus thermophilus Rieske proteins differ when there is a negative charge proximal to the clusterJBIC Journal of Biological Inorganic Chemistry - Tập 19 - Trang 1121-1135 - 2014
Nicholas E. Karagas, Christie N. Jones, Deborah J. Osborn, Anika L. Dzierlenga, Paul Oyala, Mary E. Konkle, Emily M. Whitney, R. David Britt, Laura M. Hunsicker-Wang
Rieske and Rieske-type proteins are electron transport proteins involved in key biological
processes such as respiration, photosynthesis, and detoxification. They have a [2Fe–2S] cluster ligated by two cysteines and two histidines. A series of mutations, L135E, L135R, L135A, and Y158F, of the Rieske protein from Thermus thermophilus has been produced which probe the effects of the neighboring res...... hiện toàn bộ
Silver ciprofloxacin (CIPAG): a multitargeted metallodrug in the development of breast cancer therapyJBIC Journal of Biological Inorganic Chemistry - - 2024
Christina N. Banti, Foteini D. Kalousi, Anna-Maria G. Psarra, Eleni E. Moushi, Demetres D. Leonidas, Sotiris K. Hadjikakou
The anti-proliferative activity of the known metalloantibiotic {[Ag(CIPH)2]NO3∙0.75MeOH∙1.2H2O} (CIPAG) (CIPH = ciprofloxacin) against the human breast adenocarcinoma cancer cells MCF-7 (hormone dependent (HD)) and MDA-MB-231 (hormone independent (HI)) is evaluated. The in vitro toxicity and genotoxicity of the metalloantibiotic were estimated toward fetal lung fibroblast (MRC-5) cells. The molecu...... hiện toàn bộ
The oxo/peroxo debate: a nonheme iron perspectiveJBIC Journal of Biological Inorganic Chemistry - Tập 9 - Trang 684-690 - 2004
Lawrence Que
The oxygen activation mechanisms proposed for nonheme iron systems generally follow the heme paradigm in invoking the involvement of iron-peroxo and iron-oxo species in their catalytic cycles. However, the nonheme ligand environments allow for end-on and side-on dioxygen coordination and impart greater flexibility in the modes of dioxygen activation. The currently available evidence for nonheme ir...... hiện toàn bộ
Thymine-metal ion interactions: relevance for thymine quartet structuresJBIC Journal of Biological Inorganic Chemistry - Tập 6 - Trang 378-389 - 2001
Eva Freisinger, Arnd Schimanski, Bernhard Lippert
Apart from their function as counter ions for the charge neutralization of nucleic acids, alkali metal ions play important roles in stabilizing particular multistranded nucleic acids, e.g. guanine quartets in telomeres and uracil (U) or thymine (T) quartets. Here X-ray crystal structure determinations of a series of alkali metal ions (Na+, K+, Rb+, Cs+) as well as of Mg2+ and H5O2
...... hiện toàn bộ
Structural and spectroscopic studies of a model for catechol oxidaseJBIC Journal of Biological Inorganic Chemistry - Tập 13 - Trang 499-510 - 2008
Sarah J. Smith, Christopher J. Noble, Randahl C. Palmer, Graeme R. Hanson, Gerhard Schenk, Lawrence R. Gahan, Mark J. Riley
A binuclear copper complex, [Cu2(BPMP)(OAc)2][ClO4]·H2O, has been prepared using the binucleating ligand 2,6-bis[bis(pyridin-2-ylmethylamino)methyl]-4-methylphenol (H-BPMP). The X-ray crystal structure reveals the copper centers to have a five-coordinate square pyramidal geometry, with the acetate ligands bound terminally. The bridging phenolate occupies the apical position of the square-based pyr...... hiện toàn bộ
A theoretical study of the cis-dihydroxylation mechanism in naphthalene 1,2-dioxygenaseJBIC Journal of Biological Inorganic Chemistry - Tập 9 - Trang 439-452 - 2004
Arianna Bassan, Margareta R. A. Blomberg, Per E. M. Siegbahn
The catalytic mechanism of naphthalene 1,2-dioxygenase has been investigated by means of hybrid density functional theory. This Rieske-type enzyme, which contains an active site hosting a mononuclear non-heme iron(II) complex, uses dioxygen and two electrons provided by NADH to carry out the cis-dihydroxylation of naphthalene. Since a (hydro)peroxo-iron(III) moiety has been proposed to be involved...... hiện toàn bộ