International Journal of Cancer
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New short‐chain analogs of a substance‐P antagonist inhibit proliferation of human small‐cell lung‐cancer cells in vitro and in vivoAbstract Human small‐cell lung‐cancer cells (SCLC) produce and secrete gastrin‐releasing peptide (GRP), the mammalian equivalent of bombesin (BN). There is some evidence to suggest that GRP is an autocrine regulator of SCLC cell growth. In the search for potent BN antagonists, several substance‐P (SP) analogs were found to inhibit the growth of SCLC cells. We found ... ... hiện toàn bộ
International Journal of Cancer - Tập 60 Số 1 - Trang 82-87 - 1995
Do all roads lead to Rome? Routes to metastasis developmentAbstract Metastasis, the life‐threatening aspect of cancer, is a systemic disease process. Considerable progress has been made in recent years regarding how tumor cells circulating in the blood and lymphatic systems interact with and extravasate into secondary sites, and what determines whether these disseminated tumors cells survive, remain dormant or go on to form... ... hiện toàn bộ
International Journal of Cancer - Tập 128 Số 11 - Trang 2511-2526 - 2011
Cadherin switching in ovarian cancer progressionAbstract The roles of the cadherins in the progression of ovarian cancer to the late stages of the disease state when malignant cells have disseminated within the peritoneal cavity remain poorly understood. In view of these observations, we have undertaken a comprehensive survey of the cadherin subtypes present in normal ovarian surface epithelium and peritoneum and... ... hiện toàn bộ
International Journal of Cancer - Tập 106 Số 2 - Trang 172-177 - 2003
Enhanced expression of NADPH oxidase Nox4 in human gliomas and its roles in cell proliferation and survivalAbstract Reactive oxygen species (ROS) have been attracting attention as mediators of various cell‐signaling pathways. Nox‐family NADPH oxidases have proven to be a major source of ROS production in various cell types and have crucial roles in various physiological and pathological processes. In this study, we show that Nox4, a member of Nox family, is prominently e... ... hiện toàn bộ
International Journal of Cancer - Tập 123 Số 4 - Trang 787-792 - 2008
Beyond a tumor suppressor: Soluble E ‐cadherin promotes the progression of cancerE‐cadherin (E‐cad) plays important roles in tumorigenesis as well as in tumor progression, invasion and metastasis. This protein exists in two forms: a membrane‐tethered form and a soluble form. Full‐length E‐cad is membrane tethered. As a type I transmembrane glycoprotein, E‐cad mainly mediates adherens junctions between cells and is involved in maintaining the normal structure of epithel... ... hiện toàn bộ
International Journal of Cancer - Tập 138 Số 12 - Trang 2804-2812 - 2016
Genetic alterations in cervical carcinomas: Frequent low‐level amplifications of oncogenes are associated with human papillomavirus infectionAbstract The development of cervical carcinoma is closely associated with HPV infection. However, other genetic alterations also play an important role. In this study, we analyzed copy number alterations of several oncogene loci in a panel of 84 cervical tumors. Sixty‐five (77%) tumors were HPV DNA‐positive, and most were infected with type 16 or type 18 or both. Th... ... hiện toàn bộ
International Journal of Cancer - Tập 101 Số 5 - Trang 427-433 - 2002
Mechanisms of genomic instability in human cancer: Insights from studies with human papillomavirus oncoproteinsAbstract Genomic instability is a hallmark of most human cancers including high‐risk human papillomavirus (HPV)‐associated anogenital neoplasia. The two HPV‐encoded oncoproteins, E6 and E7, can independently induce chromosomal abnormalities. We summarize the current state of knowledge concerning HPV‐induced genomic instability and discuss its significance in the con... ... hiện toàn bộ
International Journal of Cancer - Tập 109 Số 2 - Trang 157-162 - 2004
Environmental and heritable causes of cancer among 9.6 million individuals in the Swedish family‐cancer databaseAbstract The genetic and environmental components in 15 common cancers were estimated using the nationwide Swedish Family‐Cancer Database. Tetrachoric correlations were used to describe similarity in cancer liability among family members. Structural equation modeling was used to derive estimates of the importance of genetic and environmental effects. Statistically s... ... hiện toàn bộ
International Journal of Cancer - Tập 99 Số 2 - Trang 260-266 - 2002
Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic and allogeneic tumors. I. Distribution of reactivity and specificityAbstract Lymphoid cells from many normal mice of a variety of inbred strains were found to have reactivity, in a 51 Cr release cytotoxicity assay, against several syngeneic and allogeneic tumors. Very high reactivity was seen with effector cells from athymic nude mice, which was consistent with other evidence that the reactivity was not T‐cell de... ... hiện toàn bộ
International Journal of Cancer - Tập 16 Số 2 - Trang 216-229 - 1975
Long‐term risk of second malignant neoplasms after neuroblastoma in childhood: Role of treatmentAbstract The aim of our study was to quantify the risk of second malignant neoplasms (SMNs) among long‐term survivors of neuroblastoma and to study the influence of treatment on this risk. We studied data from 544 5‐year survival patients diagnosed with neuroblastoma before age 16 years at 8 French and British treatment centres from 1948 to 1986. After an average fo... ... hiện toàn bộ
International Journal of Cancer - Tập 107 Số 5 - Trang 791-796 - 2003
Tổng số: 462
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