International Journal of Cancer

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Over‐expression of p53 nuclear oncoprotein in transitional‐cell bladder cancer and its prognostic value
International Journal of Cancer - Tập 53 Số 3 - Trang 365-370 - 1993
P. Lipponen
AbstractTwo hundred and twelve archival bladder‐cancer biopsy specimens were analyzed immunohistochemically to detect over‐expression of p53 protein. The results of immunohistochemical analysis were correlated to established histological and quantitative prognostic factors and survival of patients during a mean follow‐up period of more than 10 years. Twentynine percent of tumours were positive for... hiện toàn bộ
Sex differences in lung‐cancer risk associated with cigarette smoking
International Journal of Cancer - Tập 54 Số 1 - Trang 44-48 - 1993
Kathryn Osann, Hoda Anton‐Culver, Tom Kurosaki, Thomas H. Taylor
AbstractThe importance of cigarette smoking as a risk factor for specific histologic types of lung cancer in men and women has been examined in a case‐control analysis of data from the Cancer Surveillance Program of Orange County, a population‐based registry. Smoking habits were abstracted from medical records for 1153 men and 833 women diagnosed with primary lung cancer in 1984–1986 and 1851 men ... hiện toàn bộ
Clinical role of MMP‐2/TIMP‐2 imbalance in hepatocellular carcinoma
International Journal of Cancer - Tập 97 Số 4 - Trang 425-431 - 2002
Gianluigi Giannelli, Carlo Bergamini, Felice Marinosci, Emilia Fransvea, Michele Quaranta, L. Lupo, O Schiraldi, Salvatore Antonaci
AbstractAn imbalance between the proteolytic activity of matrix metalloproteinase‐2 (MMP‐2) and the tissue inhibitor of MMP‐2 (TIMP‐2) is responsible for degradation of extracellular matrix (ECM) components and plays a critical role in tumor invasion and in metastasis formation. The occurrence of intra‐hepatic metastasis, which severely affects prognosis and long‐term survival, is commonly observe... hiện toàn bộ
Effective immunotherapy of rat glioblastoma with prolonged intratumoral delivery of exogenous heat shock protein Hsp70
International Journal of Cancer - Tập 135 Số 9 - Trang 2118-2128 - 2014
Maxim Shevtsov, A. V. Pozdnyakov, А. Л. Михрина, B. P. Nikolaev, А. В. Добродумов, Elena Y. Komarova, Darya A. Meshalkina, A. Ischenko, Emil Pitkin, Irina V. Guzhova, Т. Д. Власов
Chaperone Hsp70 can activate adaptive immunity suggesting its possible application as an antitumor vaccine. To assess the therapeutic capacity of Hsp70 we administered purified chaperone into a C6 glioblastoma brain tumor and explored the viability and tumor size as well as interferon gamma (IFNγ) production and cytotoxicity of lymphocytes in the treated animals. Targeted intratumoral injection of... hiện toàn bộ
Incidence trends of human papillomavirus‐related head and neck cancer in Taiwan, 1995–2009
International Journal of Cancer - Tập 137 Số 2 - Trang 395-408 - 2015
Tzer‐Zen Hwang, Jenn‐Ren Hsiao, Chia‐Rung Tsai, Jeffrey S. Chang
Recent studies suggested that human papillomavirus (HPV) is an emerging risk factor of head and neck cancer (HNC), particularly for oropharyngeal cancer. Studies from the West showed a rising trend of HPV‐related HNC despite a decrease of the overall HNC incidence. In contrast, the overall HNC incidence in Taiwan has continued to rise. It is not clear whether the incidence trends of HPV‐related HN... hiện toàn bộ
Tumor ZAC1 expression is associated with the response to somatostatin analog therapy in patients with acromegaly
International Journal of Cancer - Tập 125 Số 9 - Trang 2122-2126 - 2009
Marily Theodoropoulou, María A. Tichomirowa, Caroline Sievers, Alexander Yassouridis, Thomas Arzberger, Olivier Hougrand, Manuel Deprez, Adrian Daly, Patrick Pétrossians, Uberto Pagotto, Albert Beckers, Günter K. Stalla
AbstractSomatostatin analogs (SSA) with their potent antisecretory and antiproliferative effects are the main medical treatment option for patients with neuroendocrine tumors, such as gastroenteropancreatic and acromegaly‐associated growth hormone secreting pituitary tumors. Although a good portion of acromegalic patients gets normalized after SSA treatment, strict hormonal control is not achieved... hiện toàn bộ
Monoclonal antibody G 250 recognizes a determinant present in renal‐cell carcinoma and absent from normal kidney
International Journal of Cancer - Tập 38 Số 4 - Trang 489-494 - 1986
E. Oosterwdk, D. J. Ruiter, Ph. J. Hoedemaeker, E. K. J. Pauwels, Udo Jonas, I. Zwartendijk, S. O. Warnaar
AbstractThis report describes a monoclonal antibody designated G 250, subclass IgGI, that recognizes an antigen preferentially expressed on cell membranes of renalcell carcinoma cells (RCC) and not expressed in normal proximal tubular epithelium. G 250 antibody reacted with 46 of 47 primary RCC, with 7 of 8 RCC metastases and with a few other malignant tumors. The staining pattern of G 250 differs... hiện toàn bộ
Tamoxifen resistance in MCF7 cells promotes EMT-like behaviour and involves modulation of β-catenin phosphorylation
International Journal of Cancer - Tập 118 Số 2 - Trang 290-301 - 2006
Stephen Hiscox, Jiang Jiang, Kathrin Obermeier, KM Taylor, Laura Morgan, Rajpal S. Burmi, Denise Barrow, Robert I. Nicholson
An integrated humoral and cellular response is elicited in pancreatic cancer by α‐enolase, a novel pancreatic ductal adenocarcinoma‐associated antigen
International Journal of Cancer - Tập 125 Số 3 - Trang 639-648 - 2009
Paola Cappello, Barbara Tomaino, Roberto Chiarle, Paola Ceruti, Anna Novarino, Carlotta Castagnoli, Paola Migliorini, Giovanni Perconti, Agata Giallongo, Michèle Milella, Vladia Monsurrò, Stefano Barbi, Aldo Scarpa, Paola Nisticò, Mirella Giovarelli, Francesco Novelli
AbstractPancreatic ductal adenocarcinoma (PDAC) is a fatal disease with a very poor 5‐year survival rate. α‐Enolase is a glycolytic enzyme that also acts as a surface plasminogen receptor. We find that it is overexpressed in PDAC and present on the cell surface of PDAC cell lines. The clinical correlation of its expression with tumor status has been reported for lung and hepatocellular carcinoma. ... hiện toàn bộ
The clinical significance of MAGEA3 expression in pancreatic cancer
International Journal of Cancer - Tập 118 Số 9 - Trang 2269-2275 - 2006
Joseph Kim, Howard A. Reber, O. Joe Hines, Kevork Kazanjian, Andy N. Tran, Xing Ye, Farin Amersi, Steve R. Martinez, Sarah Dry, Anton J. Bilchik, Dave S.B. Hoon
AbstractThe MAGEA gene family that encodes cancer testis antigens is differentially expressed in many cancers. Though MAGEA3 expression has been detected in gastrointestinal malignancies, its role in pancreatic ductal adenocarcinoma (PDAC) has not been well established. We assessed 57 patients who underwent intent‐to‐cure surgery for PDAC. Total RNA from paraffin‐embedded pancreatic tumors was ext... hiện toàn bộ
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