International Journal of Cancer

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Effective immunotherapy of rat glioblastoma with prolonged intratumoral delivery of exogenous heat shock protein Hsp70
International Journal of Cancer - Tập 135 Số 9 - Trang 2118-2128 - 2014
Maxim Shevtsov, A. V. Pozdnyakov, А. Л. Михрина, B. P. Nikolaev, А. В. Добродумов, Elena Y. Komarova, Darya A. Meshalkina, A. Ischenko, Emil Pitkin, Irina V. Guzhova, Т. Д. Власов
Chaperone Hsp70 can activate adaptive immunity suggesting its possible application as an antitumor vaccine. To assess the therapeutic capacity of Hsp70 we administered purified chaperone into a C6 glioblastoma brain tumor and explored the viability and tumor size as well as interferon gamma (IFNγ) production and cytotoxicity of lymphocytes in the treated animals. Targeted intratumoral inje...... hiện toàn bộ
Tumor ZAC1 expression is associated with the response to somatostatin analog therapy in patients with acromegaly
International Journal of Cancer - Tập 125 Số 9 - Trang 2122-2126 - 2009
Marily Theodoropoulou, María A. Tichomirowa, Caroline Sievers, Alexander Yassouridis, Thomas Arzberger, Olivier Hougrand, Manuel Deprez, Adrian Daly, Patrick Pétrossians, Uberto Pagotto, Albert Beckers, Günter K. Stalla
AbstractSomatostatin analogs (SSA) with their potent antisecretory and antiproliferative effects are the main medical treatment option for patients with neuroendocrine tumors, such as gastroenteropancreatic and acromegaly‐associated growth hormone secreting pituitary tumors. Although a good portion of acromegalic patients gets normalized after SSA treatment, strict...... hiện toàn bộ
Monoclonal antibody G 250 recognizes a determinant present in renal‐cell carcinoma and absent from normal kidney
International Journal of Cancer - Tập 38 Số 4 - Trang 489-494 - 1986
E. Oosterwdk, D. J. Ruiter, Ph. J. Hoedemaeker, E. K. J. Pauwels, Udo Jonas, I. Zwartendijk, S. O. Warnaar
AbstractThis report describes a monoclonal antibody designated G 250, subclass IgGI, that recognizes an antigen preferentially expressed on cell membranes of renalcell carcinoma cells (RCC) and not expressed in normal proximal tubular epithelium. G 250 antibody reacted with 46 of 47 primary RCC, with 7 of 8 RCC metastases and with a few other malignant tumors. The ...... hiện toàn bộ
An integrated humoral and cellular response is elicited in pancreatic cancer by α‐enolase, a novel pancreatic ductal adenocarcinoma‐associated antigen
International Journal of Cancer - Tập 125 Số 3 - Trang 639-648 - 2009
Paola Cappello, Barbara Tomaino, Roberto Chiarle, Paola Ceruti, Anna Novarino, Carlotta Castagnoli, Paola Migliorini, Giovanni Perconti, Agata Giallongo, Michèle Milella, Vladia Monsurrò, Stefano Barbi, Aldo Scarpa, Paola Nisticò, Mirella Giovarelli, Francesco Novelli
AbstractPancreatic ductal adenocarcinoma (PDAC) is a fatal disease with a very poor 5‐year survival rate. α‐Enolase is a glycolytic enzyme that also acts as a surface plasminogen receptor. We find that it is overexpressed in PDAC and present on the cell surface of PDAC cell lines. The clinical correlation of its expression with tumor status has been reported for lu...... hiện toàn bộ
Combination therapy with tumor‐lysate pulsed dendritic cells and antiangiogenic drug TNP‐470 for mouse pancreatic cancer
International Journal of Cancer - Tập 117 Số 3 - Trang 499-505 - 2005
Jun‐ichi Miyazaki, Yoshikazu Tsuzuki, Koji Matsuzaki, Ryota Hokari, Yoshikiyo Okada, Atsushi Kawaguchi, Shigeaki Nagao, Kazuro Itoh, Soichiro Miura
AbstractMost cases of pancreatic cancer are inoperable when diagnosed. Since immunotherapy and antiangiogenic therapy have been reported to be promising for pancreatic cancer, we examined whether the combination of immunotherapy with dendritic cells (DCs) and the antiangiogenic drug TNP‐470 induces tumor regression. Syngeneic mouse pancreatic adenocarcinoma cells w...... hiện toàn bộ
Estimates of the worldwide frequency of sixteen major cancers in 1980
International Journal of Cancer - Tập 41 Số 2 - Trang 184-197 - 1988
Parkin Dm, Esa Läärä, Calum S. Muir
AbstractThe numbers of new cancer cases in 16 common sites occurring in 1980 have been estimated for 24 areas of the world for which the United Nations produces population estimates. For the world as a whole, the total number of new cases was 6.35 million, almost exactly evenly divided between the developed and developing countries. In males, the most important sit...... hiện toàn bộ
Presence on a human melanoma of multiple antigens recognized by autologous CTL
International Journal of Cancer - Tập 44 Số 4 - Trang 634-640 - 1989
B. Den Van Eynde, Philippe Hainaut, M. Hérin, Alexander Knuth, C. Lemoine, P. Weynants, P. Der Van Bruggen, R Fauchet, Thierry Boon
AbstractWe derived from blood lymphocytes of a melanoma patient a large number of cytolytic T‐cell clones directed against a cell line of the autologous tumor. Three distinct groups of antigens were recognized by these CTL on the autologous melanoma cells: group A consisted of stable antigens present on all sublines, whereas antigens B and C appeared unstable and w...... hiện toàn bộ
In vivo evidence that secretion of HLA‐G by immunogenic tumor cells allows their evasion from immunosurveillance
International Journal of Cancer - Tập 135 Số 9 - Trang 2107-2117 - 2014
Laure Loumagne, Jérémy Baudhuin, Benoı̂t Favier, Florent Montespan, Edgardo D. Carosella, Nathalie Rouas‐Freiss
Human leukocyte antigen‐G (HLA‐G) expression by tumors has been evidenced in numerous malignancies in association with poor prognosis and resistance to immunotherapy in humans. Particularly, soluble form of HLA‐G was measured at high concentrations in malignant effusions and plasma from cancer patients, and inhibits antitumor immune cells in vitro through interac...... hiện toàn bộ
The antimicrobial peptide, lactoferricin B, is cytotoxic to neuroblastoma cells in vitro and inhibits xenograft growth in vivo
International Journal of Cancer - Tập 119 Số 3 - Trang 493-500 - 2006
Liv Tone Eliassen, Gerd Marit Berge, Arild Leknessund, Mari Wikman, Inger Lindin, Cecilie Løkke, Frida Ponthan, John Inge Johnsen, Baldur Sveinbjørnsson, Per Kogner, Trond Flægstad, Øystein Rekdal
AbstractAntimicrobial peptides have been shown to exert cytotoxic activity towards cancer cells through their ability to interact with negatively charged cell membranes. In this study the cytotoxic effect of the antimicrobial peptide, LfcinB was tested in a panel of human neuroblastoma cell lines. LfcinB displayed a selective cytotoxic activity against both MYCN‐am...... hiện toàn bộ
Children, family and cancer survival in Norway
International Journal of Cancer - Tập 105 Số 2 - Trang 261-266 - 2003
Øystein Kravdal
AbstractModels for all‐cause mortality among 45,000 men and women with cancer in 12 different sites were estimated, using register and census data for complete Norwegian birth cohorts. This observed‐survival method appeared to be an adequate approach. The results support the idea that women who were pregnant shortly before a breast cancer diagnosis may have a poore...... hiện toàn bộ
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