Monoclonal antibody G 250 recognizes a determinant present in renal‐cell carcinoma and absent from normal kidney

International Journal of Cancer - Tập 38 Số 4 - Trang 489-494 - 1986
E. Oosterwdk1, D. J. Ruiter1, Ph. J. Hoedemaeker1, E. K. J. Pauwels2, Udo Jonas3, I. Zwartendijk3, S. O. Warnaar1
1Department of Pathology, University of Leiden, Wassenaarseweg 62, P.O. Box 9603, 2300 RC Leiden, The Netherlands
2Department of Nudear Medicine, University of Leiden, Wassenaarseweg 62, P.O. Box 9603, 2300 RC Leiden, The Netherlands
3Department of Urology, University of Leiden, Wassenaarseweg 62, P.O. Box 9603, 2300 RC Leiden, The Netherlands

Tóm tắt

AbstractThis report describes a monoclonal antibody designated G 250, subclass IgGI, that recognizes an antigen preferentially expressed on cell membranes of renalcell carcinoma cells (RCC) and not expressed in normal proximal tubular epithelium. G 250 antibody reacted with 46 of 47 primary RCC, with 7 of 8 RCC metastases and with a few other malignant tumors. The staining pattern of G 250 differs from that of other RCC‐related antibodies described. Preliminary experiments show that this antibody can be used to visualize RCC xenografts in nude mice by immunoscintigraphy.

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Tài liệu tham khảo

Chiou R.‐K., 1985, Localization of human renal cell carcinoma xenografts with a tumor‐preferential monoclonal antibody, Cancer Res., 45, 6140

10.1073/pnas.82.9.2955

10.1016/0022-1759(83)90311-3

HolthöFer H., 1983, Cellular origin and differentiation of renal carcinomas. A fluorescence microscopic study with kidney‐specific antibodies, anti‐intermediate filament antibodies, and lectins, Lab. Invest., 49, 319

10.1038/256495a0

Lockshin A., 1985, Exceptional lethality for nude mice of cells derived from a primary melanoma, Cancer Res., 45, 345

10.1089/hyb.1985.4.163

10.1038/186402a0

Old L. J., 1981, Cancer immunology: the search for specificity, Cancer Res., 41, 361

Oosterwijk E., 1986, Immunohistochemical analysis of monoclonal antibodies to renal antigens: application in the diagnosis of renal cell carcinoma, Amer. J. Path., 123, 301

Scharfe T., 1985, Tumor‐specific monoclonal antibodies for renal cell carcinoma, Europ. Urol., 11, 117, 10.1159/000472468

10.1073/pnas.76.3.1420

10.1126/science.6538699

10.1177/30.5.6176617

10.1073/pnas.76.9.4350

10.1073/pnas.78.8.5122

van Muijen G. N. P., 1984, Cytokeratin and neurofilament in lung carcinomas, Amer. J. Path., 114, 9

Vessella R. L., 1985, Monoclonal antibodies to human renal cell carcinoma: recognition of shared and restricted tissue antigens, Cancer Res., 45, 6131

10.1002/ijc.1985.36.3.379

10.1002/1097-0142(197204)29:4<977::AID-CNCR2820290444>3.0.CO;2-P

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International Journal of Cancer

Tập 38 Số 4

489-494

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